{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T14:43:24Z","timestamp":1793457804496,"version":"4.5.0"},"reference-count":57,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100017610","name":"Shenzhen Science and Technology Innovation Program","doi-asserted-by":"publisher","award":["RCBS20221008093232045"],"award-info":[{"award-number":["RCBS20221008093232045"]}],"id":[{"id":"10.13039\/501100017610","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82202857"],"award-info":[{"award-number":["82202857"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82473764"],"award-info":[{"award-number":["82473764"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.bmc.2025.118469","type":"journal-article","created":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T02:35:12Z","timestamp":1761618912000},"page":"118469","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Design, synthesis and biological evaluation of novel glutaminyl cyclase inhibitors targeting the CD47-SIRP\u03b1 axis in breast cancer cells"],"prefix":"10.1016","volume":"132","author":[{"given":"Rong","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Feng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan-Bo","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenyi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanjun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingying","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo-Bo","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Jiao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingling","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua-Li","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"50","key":"10.1016\/j.bmc.2025.118469_bb0005","doi-asserted-by":"crossref","first-page":"11831","DOI":"10.1021\/bi9018835","article-title":"Glutaminyl cyclases display significant catalytic proficiency for glutamyl substrates","volume":"48","author":"Seifert","year":"2009","journal-title":"Biochemistry"},{"key":"10.1016\/j.bmc.2025.118469_bb0010","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1038\/1971299a0","article-title":"Enzymatic cyclization of L-glutamine and L-glutaminyl peptides","volume":"197","author":"Messer","year":"1963","journal-title":"Nature"},{"issue":"10","key":"10.1016\/j.bmc.2025.118469_bb0015","doi-asserted-by":"crossref","first-page":"6549","DOI":"10.1021\/acs.jmedchem.1c00325","article-title":"Glutaminyl cyclase, diseases, and development of Glutaminyl cyclase inhibitors","volume":"64","author":"Xu","year":"2021","journal-title":"J Med Chem"},{"issue":"5","key":"10.1016\/j.bmc.2025.118469_bb0020","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1016\/j.jmb.2008.03.078","article-title":"Isolation of an isoenzyme of human glutaminyl cyclase: retention in the Golgi complex suggests involvement in the protein maturation machinery","volume":"379","author":"Cynis","year":"2008","journal-title":"J Mol Biol"},{"issue":"22","key":"10.1016\/j.bmc.2025.118469_bb0025","doi-asserted-by":"crossref","first-page":"6522","DOI":"10.1111\/j.1742-4658.2009.07337.x","article-title":"Mammalian glutaminyl cyclases and their isoenzymes have identical enzymatic characteristics","volume":"276","author":"Stephan","year":"2009","journal-title":"FEBS J"},{"issue":"50","key":"10.1016\/j.bmc.2025.118469_bb0030","doi-asserted-by":"crossref","first-page":"49773","DOI":"10.1074\/jbc.M309077200","article-title":"Identification of human glutaminyl cyclase as a metalloenzyme. Potent inhibition by imidazole derivatives and heterocyclic chelators","volume":"278","author":"Schilling","year":"2003","journal-title":"J Biol Chem"},{"issue":"10","key":"10.1016\/j.bmc.2025.118469_bb0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.drudis.2023.103644","article-title":"Therapeutic potential of glutaminyl cyclases: current status and emerging trends","volume":"28","author":"Coimbra","year":"2023","journal-title":"Drug Discov Today"},{"issue":"4","key":"10.1016\/j.bmc.2025.118469_bb0040","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1038\/s41590-022-01153-x","article-title":"Loss of the intracellular enzyme QPCTL limits chemokine function and reshapes myeloid infiltration to augment tumor immunity","volume":"23","author":"Barreira da Silva","year":"2022","journal-title":"Nat Immunol"},{"key":"10.1016\/j.bmc.2025.118469_bb0045","article-title":"The potential therapeutic targets of glutamine metabolism in head and neck squamous cell carcinoma","volume":"176","author":"Guo","year":"2024","journal-title":"Biomed Pharmacother = Biomedecine & pharmacotherapie"},{"issue":"3","key":"10.1016\/j.bmc.2025.118469_bb0050","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1111\/iep.12020","article-title":"Inhibition of Glutaminyl Cyclases alleviates CCL2-mediated inflammation of non-alcoholic fatty liver disease in mice","volume":"94","author":"Cynis","year":"2013","journal-title":"Int J Exp Pathol"},{"key":"10.1016\/j.bmc.2025.118469_bb0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2022.175178","article-title":"Glutaminyl cyclases, the potential targets of cancer and neurodegenerative diseases","volume":"931","author":"Zhang","year":"2022","journal-title":"Eur J Pharmacol"},{"issue":"4","key":"10.1016\/j.bmc.2025.118469_bb0060","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1515\/revneuro-2023-0100","article-title":"Diversity of amyloid beta peptide actions","volume":"35","author":"Mardanyan","year":"2024","journal-title":"Rev Neurosci"},{"issue":"4","key":"10.1016\/j.bmc.2025.118469_bb0065","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1007\/s00401-015-1395-2","article-title":"Isoglutaminyl cyclase contributes to CCL2-driven neuroinflammation in Alzheimer\u2019s disease","volume":"129","author":"Hartlage-R\u00fcbsamen","year":"2015","journal-title":"Acta Neuropathol"},{"issue":"3","key":"10.1016\/j.bmc.2025.118469_bb0070","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S0197-4580(00)00124-X","article-title":"Inflammation and Alzheimer\u2019s disease","volume":"21","author":"Akiyama","year":"2000","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.bmc.2025.118469_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2019.104342","article-title":"Human glutaminyl cyclase: structure, function, inhibitors and involvement in Alzheimer\u2019s disease","volume":"147","author":"Vijayan","year":"2019","journal-title":"Pharmacol Res"},{"issue":"2","key":"10.1016\/j.bmc.2025.118469_bb0080","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1021\/acs.jmedchem.4c02247","article-title":"Targeting QPCTL: an emerging therapeutic opportunity","volume":"68","author":"Yu","year":"2025","journal-title":"J Med Chem"},{"issue":"1","key":"10.1016\/j.bmc.2025.118469_bb0085","doi-asserted-by":"crossref","DOI":"10.1080\/2162402X.2022.2049486","article-title":"QPCTL regulates macrophage and monocyte abundance and inflammatory signatures in the tumor microenvironment","volume":"11","author":"Bresser","year":"2022","journal-title":"Oncoimmunology"},{"issue":"9","key":"10.1016\/j.bmc.2025.118469_bb0090","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1002\/emmm.201100158","article-title":"The isoenzyme of glutaminyl cyclase is an important regulator of monocyte infiltration under inflammatory conditions","volume":"3","author":"Cynis","year":"2011","journal-title":"EMBO Mol Med"},{"key":"10.1016\/j.bmc.2025.118469_bb0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.gene.2024.149153","article-title":"Role of glutaminyl-peptide cyclo-transferase-like protein (QPCTL) in cancer: from molecular mechanisms to immunotherapy","volume":"937","author":"Felix Oghenemaro","year":"2025","journal-title":"Gene"},{"issue":"1","key":"10.1016\/j.bmc.2025.118469_bb0100","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1038\/s41392-023-01365-z","article-title":"Emerging phagocytosis checkpoints in cancer immunotherapy","volume":"8","author":"Liu","year":"2023","journal-title":"Signal Transd Targeted Ther"},{"key":"10.1016\/j.bmc.2025.118469_bb0105","doi-asserted-by":"crossref","unstructured":"M. Li, L. Lu, Q. Xiao, A.A. Maalim, B. Nie, Y. Liu, U.D. Kahlert, K. Shu, T. Lei, M. Zhu, Bioengineer Mesenchymal Stem Cell for Treatment of Glioma by IL-12 Mediated Microenvironment Reprogramming and nCD47-SLAMF7 Mediated Phagocytosis Regulation of Macrophages, Exploration (Beijing, China) Vol. 4(6) (2024) 20240027.doi:https:\/\/doi.org\/10.1002\/exp.20240027.","DOI":"10.1002\/EXP.20240027"},{"issue":"9","key":"10.1016\/j.bmc.2025.118469_bb0110","doi-asserted-by":"crossref","first-page":"2370","DOI":"10.1039\/D2BM00216G","article-title":"An enzyme-responsive and NIR-triggered lipid-polymer hybrid nanoplatform for synergistic photothermal\/chemo cancer therapy","volume":"10","author":"Tang","year":"2022","journal-title":"Biomater Sci"},{"key":"10.1016\/j.bmc.2025.118469_bb0115","doi-asserted-by":"crossref","unstructured":"L. Tang, Y. Yin, Y. Cao, C. Fu, H. Liu, J. Feng, W. Wang, X.J. Liang, Extracellular vesicles-derived hybrid Nanoplatforms for amplified CD47 blockade-based Cancer immunotherapy, Advanced materials (Deerfield Beach, Fla.) 35(35) (2023) e2303835.doi:https:\/\/doi.org\/10.1002\/adma.202303835.","DOI":"10.1002\/adma.202303835"},{"issue":"1","key":"10.1016\/j.bmc.2025.118469_bb0120","doi-asserted-by":"crossref","first-page":"7306","DOI":"10.1038\/s41467-023-42972-2","article-title":"Nanomedicine-based co-delivery of a calcium channel inhibitor and a small molecule targeting CD47 for lung cancer immunotherapy","volume":"14","author":"Guo","year":"2023","journal-title":"Nat Commun"},{"issue":"6","key":"10.1016\/j.bmc.2025.118469_bb0125","doi-asserted-by":"crossref","first-page":"2573","DOI":"10.1021\/acs.jmedchem.7b00098","article-title":"Discovery of potent human Glutaminyl cyclase inhibitors as anti-Alzheimer\u2019s agents based on rational design","volume":"60","author":"Hoang","year":"2017","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2025.118469_bb0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2021.113819","article-title":"Discovery of highly potent human glutaminyl cyclase (QC) inhibitors as anti-Alzheimer\u2019s agents by the combination of pharmacophore-based and structure-based design","volume":"226","author":"Van Manh","year":"2021","journal-title":"Eur J Med Chem"},{"issue":"17","key":"10.1016\/j.bmc.2025.118469_bb0135","doi-asserted-by":"crossref","first-page":"8011","DOI":"10.1021\/acs.jmedchem.9b00751","article-title":"Discovery of Conformationally restricted human Glutaminyl cyclase inhibitors as potent anti-Alzheimer\u2019s agents by structure-based design","volume":"62","author":"Hoang","year":"2019","journal-title":"J Med Chem"},{"issue":"22","key":"10.1016\/j.bmc.2025.118469_bb0140","doi-asserted-by":"crossref","first-page":"7069","DOI":"10.1021\/jm900969p","article-title":"Inhibitors for human glutaminyl cyclase by structure based design and bioisosteric replacement","volume":"52","author":"Buchholz","year":"2009","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2025.118469_bb0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2023.115089","article-title":"Design, synthesis and anti-AD effects of dual inhibitor targeting glutaminyl cyclase\/GSK-3\u03b2","volume":"248","author":"Xie","year":"2023","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2025.118469_bb0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmc.2023.117542","article-title":"Discovery of potential scaffolds for glutaminyl cyclase inhibitors: virtual screening, synthesis, and evaluation","volume":"97","author":"Zhou","year":"2024","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.bmc.2025.118469_bb0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2024.117019","article-title":"Design, synthesis, and evaluation of 4-(4-methyl-4H-1,2,4-triazol-3-yl)piperidine derivatives as potential glutaminyl cyclase isoenzyme inhibitors for the treatment of cancer","volume":"281","author":"Zhou","year":"2025","journal-title":"Eur J Med Chem"},{"issue":"17","key":"10.1016\/j.bmc.2025.118469_bb0160","doi-asserted-by":"crossref","first-page":"6613","DOI":"10.1021\/jm4001709","article-title":"Structure-activity relationships of benzimidazole-based glutaminyl cyclase inhibitors featuring a heteroaryl scaffold","volume":"56","author":"Ramsbeck","year":"2013","journal-title":"J Med Chem"},{"issue":"8","key":"10.1016\/j.bmc.2025.118469_bb0165","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1007\/s00775-018-1605-1","article-title":"The structure of the human glutaminyl cyclase-SEN177 complex indicates routes for developing new potent inhibitors as possible agents for the treatment of neurological disorders","volume":"23","author":"Pozzi","year":"2018","journal-title":"J Biol Inorg Chem: JBIC : Publ Soc Biol Inorg Chem"},{"issue":"1","key":"10.1016\/j.bmc.2025.118469_bb0170","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1038\/s41392-023-01715-x","article-title":"Development of a potent benzonitrile-based inhibitor of glutaminyl-peptide cyclotransferase-like protein (QPCTL) with antitumor efficacy","volume":"8","author":"Yu","year":"2023","journal-title":"Signal transduction and targeted therapy"},{"issue":"8","key":"10.1016\/j.bmc.2025.118469_bb0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.tranon.2021.101129","article-title":"Luteolin promotes macrophage-mediated phagocytosis by inhibiting CD47 pyroglutamation","volume":"14","author":"Li","year":"2021","journal-title":"Transl Oncol"},{"issue":"9","key":"10.1016\/j.bmc.2025.118469_bb0180","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1021\/acsmedchemlett.2c00256","article-title":"2-Amino-1,3,4-thiadiazoles as Glutaminyl Cyclases inhibitors increase phagocytosis through modification of CD47-SIRP\u03b1 checkpoint","volume":"13","author":"Park","year":"2022","journal-title":"ACS Med Chem Lett"},{"key":"10.1016\/j.bmc.2025.118469_bb0185","doi-asserted-by":"crossref","unstructured":"W. Zhao, X. Hu, W. Li, R. Li, J. Chen, L. Zhou, S. Qiang, W. Wu, S. Shi, C. Dong, M2-like TAMs function reversal contributes to breast Cancer eradication by combination dual immune checkpoint blockade and Photothermal therapy, small (Weinheim an der Bergstrasse, Germany) 17(13) (2021) e2007051.doi:https:\/\/doi.org\/10.1002\/smll.202007051.","DOI":"10.1002\/smll.202007051"},{"issue":"10","key":"10.1016\/j.bmc.2025.118469_bb0190","doi-asserted-by":"crossref","first-page":"4581","DOI":"10.7150\/thno.72310","article-title":"Promising alternatives of CD47 monoclonal antibody: an injectable degradable hydrogel loaded with PQ912 for postoperative immunotherapy effectively blocks CD47-SIRP\u03b1 signal","volume":"12","author":"Li","year":"2022","journal-title":"Theranostics"},{"issue":"1","key":"10.1016\/j.bmc.2025.118469_bb0195","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1186\/s13195-021-00882-9","article-title":"Rationale and study design of a randomized, placebo-controlled, double-blind phase 2b trial to evaluate efficacy, safety, and tolerability of an oral glutaminyl cyclase inhibitor varoglutamstat (PQ912) in study participants with MCI and mild AD-VIVIAD","volume":"13","author":"Vijverberg","year":"2021","journal-title":"Alzheimer\u2019s Res Ther"},{"issue":"1","key":"10.1016\/j.bmc.2025.118469_bb0200","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1124\/jpet.117.240614","article-title":"Glutaminyl cyclase inhibitor PQ912 improves cognition in mouse models of Alzheimer\u2019s disease-studies on relation to effective target occupancy","volume":"362","author":"Hoffmann","year":"2017","journal-title":"J Pharmacol Exp Ther"},{"issue":"11","key":"10.1016\/j.bmc.2025.118469_bb0205","doi-asserted-by":"crossref","first-page":"8730","DOI":"10.1021\/acs.jmedchem.4c00049","article-title":"X-ray structure-guided discovery of a potent Benzimidazole Glutaminyl cyclase inhibitor that shows activity in a Parkinson\u2019s disease mouse model","volume":"67","author":"Mou","year":"2024","journal-title":"J Med Chem"},{"issue":"37","key":"10.1016\/j.bmc.2025.118469_bb0210","doi-asserted-by":"crossref","first-page":"13117","DOI":"10.1073\/pnas.0504184102","article-title":"Crystal structures of human glutaminyl cyclase, an enzyme responsible for protein N-terminal pyroglutamate formation","volume":"102","author":"Huang","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"issue":"1","key":"10.1016\/j.bmc.2025.118469_bb0215","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1042\/BJ20071073","article-title":"A conserved hydrogen-bond network in the catalytic Centre of animal glutaminyl cyclases is critical for catalysis","volume":"411","author":"Huang","year":"2008","journal-title":"Biochem J"},{"issue":"11","key":"10.1016\/j.bmc.2025.118469_bb0220","doi-asserted-by":"crossref","first-page":"7210","DOI":"10.1021\/acs.jmedchem.1c00416","article-title":"Target-based evaluation of \u201cdrug-like\u201d properties and ligand efficiencies","volume":"64","author":"Leeson","year":"2021","journal-title":"J Med Chem"},{"issue":"5","key":"10.1016\/j.bmc.2025.118469_bb0225","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/nchembio.1790","article-title":"siRNA screen identifies QPCT as a druggable target for Huntington\u2019s disease","volume":"11","author":"Jimenez-Sanchez","year":"2015","journal-title":"Nat Chem Biol"},{"issue":"5","key":"10.1016\/j.bmc.2025.118469_bb0230","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1016\/j.immuni.2020.04.011","article-title":"The CD47-SIRP\u03b1 immune checkpoint","volume":"52","author":"Logtenberg","year":"2020","journal-title":"Immunity"},{"issue":"1","key":"10.1016\/j.bmc.2025.118469_bb0235","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.gendis.2022.12.008","article-title":"Targeting CD47-SIRP\u03b1 axis for Hodgkin and non-Hodgkin lymphoma immunotherapy","volume":"11","author":"Zhao","year":"2024","journal-title":"Genes Dis"},{"issue":"2","key":"10.1016\/j.bmc.2025.118469_bb0240","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.cell.2009.05.046","article-title":"CD47 is upregulated on circulating hematopoietic stem cells and leukemia cells to avoid phagocytosis","volume":"138","author":"Jaiswal","year":"2009","journal-title":"Cell"},{"issue":"5","key":"10.1016\/j.bmc.2025.118469_bb0245","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1021\/acschemneuro.3c00740","article-title":"Beyond CSF and neuroimaging assessment: evaluating plasma miR-145-5p as a potential biomarker for mild cognitive impairment and Alzheimer\u2019s disease","volume":"15","author":"Wen","year":"2024","journal-title":"ACS Chem Neurosci"},{"issue":"8","key":"10.1016\/j.bmc.2025.118469_bb0250","doi-asserted-by":"crossref","first-page":"3029","DOI":"10.1111\/cas.14999","article-title":"Enhancement of epidermal growth factor receptor antibody tumor immunotherapy by glutaminyl cyclase inhibition to interfere with CD47\/signal regulatory protein alpha interactions","volume":"112","author":"Baumann","year":"2021","journal-title":"Cancer Sci"},{"issue":"4","key":"10.1016\/j.bmc.2025.118469_bb0255","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1038\/s41591-019-0356-z","article-title":"Glutaminyl cyclase is an enzymatic modifier of the CD47- SIRP\u03b1 axis and a target for cancer immunotherapy","volume":"25","author":"Logtenberg","year":"2019","journal-title":"Nat Med"},{"issue":"6","key":"10.1016\/j.bmc.2025.118469_bb0260","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1038\/s41422-019-0177-0","article-title":"Identification of Glutaminyl cyclase isoenzyme isoQC as a regulator of SIRP\u03b1-CD47 axis","volume":"29","author":"Wu","year":"2019","journal-title":"Cell Res"},{"issue":"15","key":"10.1016\/j.bmc.2025.118469_bb0265","doi-asserted-by":"crossref","first-page":"6664","DOI":"10.1021\/acs.jmedchem.7b00648","article-title":"Synthesis and evaluation of diphenyl conjugated imidazole derivatives as potential Glutaminyl cyclase inhibitors for treatment of Alzheimer\u2019s disease","volume":"60","author":"Li","year":"2017","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2025.118469_bb0270","doi-asserted-by":"crossref","unstructured":"H. \u015eenol, F. \u00c7ak\u0131r, 3-amino-thiophene-2-carbohydrazide derivatives as anti Colon Cancer agents: synthesis, characterization, In-silico and in-vitro biological activity studies, 8(39) (2023) e202302448.doi:https:\/\/doi.org\/10.1002\/slct.202302448.","DOI":"10.1002\/slct.202302448"},{"key":"10.1016\/j.bmc.2025.118469_bb0275","doi-asserted-by":"crossref","unstructured":"H. \u015eenol, M. Ghaffari-Moghaddam, \u015e. Bulut, F. Akba\u015f, A. K\u00f6se, G. Top\u00e7u, Synthesis and Anticancer Activity of Novel Derivatives of \u03b1,\u03b2-Unsaturated Ketones Based on Oleanolic Acid: in Vitro and in Silico Studies against Prostate Cancer Cells, Chem Biodivers 20(9) (2023) e202301089.doi:https:\/\/doi.org\/10.1002\/cbdv.202301089.","DOI":"10.1002\/cbdv.202301089"},{"key":"10.1016\/j.bmc.2025.118469_bb0280","doi-asserted-by":"crossref","DOI":"10.1016\/j.saa.2025.126820","article-title":"Synthesis of 7-hydroxy coumarin derivatives and interaction with bovine serum albumin by multi-spectroscopic studies and molecular docking","volume":"345","author":"Meletli","year":"2026","journal-title":"Spectrochim Acta Part A, Mol Biomol Spectrosc"},{"key":"10.1016\/j.bmc.2025.118469_bb0285","doi-asserted-by":"crossref","DOI":"10.1016\/j.molstruc.2024.140702","article-title":"Novel 4-((3-fluorobenzyl)oxy)benzohydrazide derivatives as promising anti-prostate cancer agents: synthesis, characterization and in vitro & in silico biological activity studies","volume":"1322","author":"\u00c7ak\u0131r","year":"2025","journal-title":"J Mol Struct"}],"container-title":["Bioorganic & Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089625004109?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089625004109?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T05:06:46Z","timestamp":1780636006000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0968089625004109"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":57,"alternative-id":["S0968089625004109"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2025.118469","relation":{},"ISSN":["0968-0896"],"issn-type":[{"value":"0968-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Design, synthesis and biological evaluation of novel glutaminyl cyclase inhibitors targeting the CD47-SIRP\u03b1 axis in breast cancer cells","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2025.118469","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"118469"}}