{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T16:43:56Z","timestamp":1787244236103,"version":"build-2736575974"},"reference-count":82,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007374","name":"Universidade Federal de Minas Gerais","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007374","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","award":["REDE-00110-23"],"award-info":[{"award-number":["REDE-00110-23"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006507","name":"Funda\u00e7\u00e3o Oswaldo Cruz","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006507","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["302041\/2022-2"],"award-info":[{"award-number":["302041\/2022-2"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["310748\/2021-6"],"award-info":[{"award-number":["310748\/2021-6"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic &amp; Medicinal Chemistry"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.bmc.2025.118471","type":"journal-article","created":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T17:37:41Z","timestamp":1761673061000},"page":"118471","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Design of arylfurans as potential FAAH inhibitors: therapeutic potential in pain management"],"prefix":"10.1016","volume":"132","author":[{"given":"Pedro Augusto Lemos","family":"Santana","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael Christian","family":"de Matos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Fl\u00e1via Alvarenga","family":"Bitencourt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vin\u00edcius Gon\u00e7alves","family":"Maltarollo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta Marques Gontijo","family":"de Aguiar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renes Resende","family":"Machado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata Barbosa","family":"de Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"39","key":"10.1016\/j.bmc.2025.118471_bb0005","first-page":"13999","article-title":"Binding and inactivation mechanism of a humanized fatty acid amide hydrolase by \u03b1-ketoheterocycle inhibitors revealed from cocrystal structures","volume":"131","author":"Mileni","year":"2009","journal-title":"J Am Chem Soc"},{"issue":"3","key":"10.1016\/j.bmc.2025.118471_bb0010","first-page":"372","article-title":"Discovery and characterization of a highly selective FAAH inhibitor that reduces inflammatory pain","volume":"16","author":"Ahn","year":"2009","journal-title":"Chem Biol"},{"issue":"1","key":"10.1016\/j.bmc.2025.118471_bb0015","first-page":"48","article-title":"In silico and in vitro analysis of major cannabis-derived compounds as fatty acid amide hydrolase inhibitors","volume":"26","author":"Pereira","year":"2021","journal-title":"Molecules"},{"issue":"12","key":"10.1016\/j.bmc.2025.118471_bb0020","doi-asserted-by":"crossref","first-page":"3247","DOI":"10.1021\/ci200371z","article-title":"Approximating protein flexibility through dynamic pharmacophore models: application to fatty acid amide hydrolase (FAAH)","volume":"51","author":"Bowman","year":"2011","journal-title":"J Chem Inf Model"},{"issue":"1","key":"10.1016\/j.bmc.2025.118471_bb0025","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.apsb.2011.04.003","article-title":"Pharmacophore modeling and virtual screening for the discovery of new fatty acid amide hydrolase inhibitors","volume":"1","author":"Zhao","year":"2011","journal-title":"Acta Pharm Sin B"},{"key":"10.1016\/j.bmc.2025.118471_bb0030","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1007\/s00044-023-03170-3","article-title":"Discovery of novel fatty acid amide hydrolase (FAAH) inhibitors as anti-Alzheimer\u2019s agents through pharmacophore-based virtual screening, molecular docking and experimental validation","volume":"33","author":"Jain","year":"2024","journal-title":"Med Chem Res"},{"issue":"7","key":"10.1016\/j.bmc.2025.118471_bb0035","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1080\/17460441.2020.1751118","article-title":"Advances in the discovery of fatty acid amide hydrolase inhibitors: what does the future hold?","volume":"15","author":"Fazio","year":"2020","journal-title":"Expert Opin Drug Discov"},{"issue":"9","key":"10.1016\/j.bmc.2025.118471_bb0040","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1016\/j.pain.2012.04.020","volume":"153","author":"Huggins","year":"2012","journal-title":"Pain"},{"issue":"5","key":"10.1016\/j.bmc.2025.118471_bb0045","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1007\/s40263-019-00627-1","article-title":"The potential of cannabinoid-based treatments in Tourette syndrome","volume":"33","author":"Artukoglu","year":"2019","journal-title":"CNS Drugs"},{"key":"10.1016\/j.bmc.2025.118471_bb0050","unstructured":"ClinicalTrials.gov. (n.d.). Study of PF-04457845 in Patients with Knee Osteoarthritis Pain (NCT00981357). ClinicalTrials.gov. Available at: https:\/\/clinicaltrials.gov\/study\/NCT00981357?term=PF-04457845&rank=1&tab=history. Accessed December 27, 2024."},{"issue":"6","key":"10.1016\/j.bmc.2025.118471_bb0055","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1021\/jm049614v","article-title":"Discovery of a potent, selective, and efficacious class of reversible \u03b1-ketoheterocycle inhibitors of fatty acid amide hydrolase effective as analgesics","volume":"48","author":"Boger","year":"2005","journal-title":"J Med Chem"},{"issue":"1","key":"10.1016\/j.bmc.2025.118471_bb0060","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1021\/acs.jmedchem.6b00538","article-title":"Therapeutic potential of fatty acid amide hydrolase, monoacylglycerol lipase, and N-acylethanolamine acid amidase inhibitors","volume":"60","author":"Tuo","year":"2017","journal-title":"J Med Chem"},{"issue":"39","key":"10.1016\/j.bmc.2025.118471_bb0065","first-page":"13949","article-title":"Binding and inactivation mechanism of a humanized fatty acid amide hydrolase by \u03b1-ketoheterocycle inhibitors revealed from cocrystal structures","volume":"131","author":"Mileni","year":"2009","journal-title":"J Am Chem Soc"},{"issue":"2","key":"10.1016\/j.bmc.2025.118471_bb0070","doi-asserted-by":"crossref","first-page":"110","DOI":"10.2174\/1574884711666160418105339","article-title":"Endocannabinoid system: a multi-facet therapeutic target","volume":"11","author":"Kaur","year":"2016","journal-title":"Curr Clin Pharmacol"},{"issue":"6","key":"10.1016\/j.bmc.2025.118471_bb0075","doi-asserted-by":"crossref","first-page":"393","DOI":"10.4103\/ijp.ijp_860_22","article-title":"Translational research: bridging the gap between preclinical and clinical research","volume":"54","author":"Mahalmani","year":"2022","journal-title":"Indian J Pharmacol"},{"issue":"7","key":"10.1016\/j.bmc.2025.118471_bb0080","first-page":"1002","article-title":"Do alternatives to animal experimentation replace preclinical research?","volume":"55","author":"Mahalmani","year":"2023","journal-title":"Indian J Pharmacol"},{"key":"10.1016\/j.bmc.2025.118471_bb0085","doi-asserted-by":"crossref","first-page":"2751","DOI":"10.2174\/1385272823666191029114830","article-title":"A review of cationic arylfurans and their isosteres: synthesis and biological importance","volume":"23","author":"Ismail","year":"2019","journal-title":"Curr Org Chem"},{"issue":"1","key":"10.1016\/j.bmc.2025.118471_bb0090","doi-asserted-by":"crossref","first-page":"9","DOI":"10.3390\/futurepharmacol5010009","article-title":"Discovery of arylfuran and carbohydrate derivatives from the BraCoLi library as potential Zika virus NS3pro inhibitors","volume":"5","author":"Marcelino","year":"2025","journal-title":"Fut Pharmacol"},{"issue":"3","key":"10.1016\/j.bmc.2025.118471_bb0095","first-page":"9318","article-title":"Synthesis and evaluation of potential antitumor activity of arylfuran derivatives","volume":"5","author":"Santana","year":"2022","journal-title":"Br J Health Rev"},{"key":"10.1016\/j.bmc.2025.118471_bb0100","unstructured":"Papa, A. (2023). Exploration of the selective and multitarget inhibition of the endocannabinoid system catabolic enzymes as pharmacological tools for central nervous system disorders [PhD thesis, University of Siena]. 10.25434\/alessandro-papa_phd2023."},{"issue":"23","key":"10.1016\/j.bmc.2025.118471_bb0105","doi-asserted-by":"crossref","first-page":"7287","DOI":"10.1021\/jm800311k","article-title":"Discovery and development of fatty acid amide hydrolase (FAAH) inhibitors","volume":"51","author":"Seierstad","year":"2008","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2025.118471_bb0110","article-title":"Transition state isosteres of the \u03b3-glutamyl peptide bond hydrolysis: synthesis and characterization of the \u03c8[CH\u2082NH] pseudopeptide analogue of glutathione","author":"Cacciatore","year":"2003","journal-title":"J Pept Sci"},{"issue":"12","key":"10.1016\/j.bmc.2025.118471_bb0115","doi-asserted-by":"crossref","first-page":"3777","DOI":"10.1016\/j.bmc.2011.04.057","article-title":"New FAAH inhibitors based on 3-carboxamido-5-aryl-isoxazole scaffold that protect against experimental colitis","volume":"19","author":"Andrzejak","year":"2011","journal-title":"Bioorg Med Chem"},{"issue":"3","key":"10.1016\/j.bmc.2025.118471_bb0120","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1006\/jmbi.1996.0897","article-title":"Development and validation of a genetic algorithm for flexible docking","volume":"267","author":"Jones","year":"1997","journal-title":"J Mol Biol"},{"issue":"2","key":"10.1016\/j.bmc.2025.118471_bb0125","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/jcc.21334","article-title":"AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading","volume":"31","author":"Trott","year":"2009","journal-title":"J Comput Chem"},{"issue":"8","key":"10.1016\/j.bmc.2025.118471_bb0130","doi-asserted-by":"crossref","first-page":"3891","DOI":"10.1021\/acs.jcim.1c00203","article-title":"AutoDock Vina 1.2.0: new docking methods, expanded force field, and Python bindings","volume":"61","author":"Eberhardt","year":"2021","journal-title":"J Chem Inf Model"},{"key":"10.1016\/j.bmc.2025.118471_bb0135","article-title":"DockThor-VS: a free platform for receptor-ligand virtual screening","volume":"168548","author":"Guedes","year":"2024","journal-title":"J Mol Biol"},{"key":"10.1016\/j.bmc.2025.118471_bb0140","series-title":"Client 2020","author":"DISCOVERY STUDIO; BIOVIA, Dassault Syst\u00e8mes.","year":"2020"},{"key":"10.1016\/j.bmc.2025.118471_bb0145","author":"QUACPAC"},{"issue":"4","key":"10.1016\/j.bmc.2025.118471_bb0150","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1021\/ci100031x","article-title":"Conformer generation with OMEGA: algorithm and validation using high quality structures from the protein databank and Cambridge structural database","volume":"50","author":"Hawkins","year":"2010","journal-title":"J Chem Inf Model"},{"key":"10.1016\/j.bmc.2025.118471_bb0155","author":"OMEGA"},{"issue":"4","key":"10.1016\/j.bmc.2025.118471_bb0160","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/j.jmb.2010.05.034","article-title":"Crystal structures of fatty acid amide hydrolase bound to the carbamate inhibitor URB597: discovery of a deacylating water molecule and insight into enzyme inactivation","volume":"400","author":"Mileni","year":"2010","journal-title":"J Mol Biol"},{"key":"10.1016\/j.bmc.2025.118471_bb0165","series-title":"Computer-Aided and Machine Learning-Driven Drug Design","first-page":"123","article-title":"Molecular docking: State-of-the-art scoring functions and search algorithms","volume":"Vol. 3","author":"de Angelo","year":"2024"},{"issue":"1","key":"10.1016\/j.bmc.2025.118471_bb0170","doi-asserted-by":"crossref","first-page":"136","DOI":"10.3390\/molecules22010136","article-title":"The performance of several docking programs at reproducing protein\u2013macrolide-like crystal structures","volume":"22","author":"Castro-Alvarez","year":"2017","journal-title":"Molecules"},{"issue":"6","key":"10.1016\/j.bmc.2025.118471_bb0175","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1080\/07391102.2016.1176603","article-title":"Application of bioisosterism in design of the semicarbazone derivatives as cruzain inhibitors: a theoretical and experimental study","volume":"35","author":"Vital","year":"2017","journal-title":"J Biomol Struct Dyn"},{"issue":"11","key":"10.1016\/j.bmc.2025.118471_bb0180","doi-asserted-by":"crossref","first-page":"959","DOI":"10.4155\/fmc-2023-0034","article-title":"Structure-based discovery of thiosemicarbazones as SARS-CoV-2 main protease inhibitors","volume":"15","author":"Maltarollo","year":"2023","journal-title":"Future Med Chem"},{"issue":"3","key":"10.1016\/j.bmc.2025.118471_bb0185","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1021\/acsptsci.0c00216","article-title":"Identification of inhibitors of SARS-CoV-2 3CL-pro enzymatic activity using a small molecule in vitro repurposing screen","volume":"4","author":"Kuzikov","year":"2021","journal-title":"ACS Pharmacol Transl Sci"},{"key":"10.1016\/j.bmc.2025.118471_bb0190","unstructured":"Delano Scientific LLC. (2006). PyMOL Molecular Graphics System (Version 0.99). South San Francisco, California."},{"issue":"11","key":"10.1016\/j.bmc.2025.118471_bb0195","doi-asserted-by":"crossref","first-page":"3099","DOI":"10.1021\/ci300367a","article-title":"admetSAR: a comprehensive source and free tool for assessment of chemical ADMET properties","volume":"52","author":"Cheng","year":"2012","journal-title":"J Chem Inf Model"},{"key":"10.1016\/j.bmc.2025.118471_bb0200","doi-asserted-by":"crossref","unstructured":"Gu, Y., Lou, C., & Tang, Y. (2023). admetSAR\u2014A valuable tool for assisting safety evaluation. In Elsevier eBooks (pp. 187\u2013201). https:\/\/doi.org\/10.1016\/b978-0-443-15339-6.00004-7.","DOI":"10.1016\/B978-0-443-15339-6.00004-7"},{"issue":"8","key":"10.1016\/j.bmc.2025.118471_bb0205","doi-asserted-by":"crossref","first-page":"4066","DOI":"10.1021\/acs.jmedchem.5b00104","article-title":"pkCSM: predicting small-molecule pharmacokinetic and toxicity properties using graph-based signatures","volume":"58","author":"Pires","year":"2015","journal-title":"J Med Chem"},{"issue":"W1","key":"10.1016\/j.bmc.2025.118471_bb0210","doi-asserted-by":"crossref","first-page":"W257","DOI":"10.1093\/nar\/gky318","article-title":"ProTox-II: a webserver for the prediction of toxicity of chemicals","volume":"46","author":"Banerjee","year":"2018","journal-title":"Nucleic Acids Res"},{"issue":"2","key":"10.1016\/j.bmc.2025.118471_bb0215","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1517\/17425255.2015.980814","article-title":"Applying machine learning techniques for ADME-Tox prediction: a review","volume":"11","author":"Maltarollo","year":"2015","journal-title":"Expert Opin Drug Metab Toxicol"},{"issue":"3","key":"10.1016\/j.bmc.2025.118471_bb0220","article-title":"Recent advances in the prediction of pharmacokinetics properties in drug design studies: a review","volume":"17","author":"Pantale\u00e3o","year":"2022","journal-title":"ChemMedChem"},{"issue":"2","key":"10.1016\/j.bmc.2025.118471_bb0225","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/0304-3959(83)90201-4","article-title":"Ethical guidelines for investigations of experimental pain in conscious animals","volume":"16","author":"Zimmermann","year":"1983","journal-title":"Pain"},{"issue":"5","key":"10.1016\/j.bmc.2025.118471_bb0230","article-title":"Electrochemical evidence of nitrate release from the nitrooxy compound 4-((nitrooxy)methyl)-3-nitrobenzoic acid and its antinociceptive and anti-inflammatory activities in mice","volume":"41","author":"Braga","year":"2020","journal-title":"Biopharm Drug Dispos"},{"issue":"1","key":"10.1016\/j.bmc.2025.118471_bb0235","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/S0022-3565(25)20136-7","article-title":"Antinociceptive action of 2-(4-bromobenzoyl)-3-methyl-4,6-dimethoxy benzofuran, a novel xanthoxyline derivative on chemical and thermal models of nociception in mice","volume":"278","author":"Vaz","year":"1996","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.bmc.2025.118471_bb0240","series-title":"Toxicity\u2013UP, Acute Oral. OECD Guideline for Testing of Chemicals","author":"Organization for Economic Co-Operation and Development (OECD)","year":"2001"},{"issue":"22","key":"10.1016\/j.bmc.2025.118471_bb0245","first-page":"7054","article-title":"X-ray crystallographic analysis of alpha-ketoheterocycle inhibitors bound to a humanized variant of fatty acid amide hydrolase","volume":"52","author":"Mileni","year":"2009","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2025.118471_bb0250","article-title":"Integration of LBDD and SBDD studies on drug design: a fatty acid amide hydrolase (FAAH) case study","volume":"47(1), e20240117","author":"Santana","year":"2024","journal-title":"Qu\u00edmica Nova"},{"issue":"2","key":"10.1016\/j.bmc.2025.118471_bb0255","doi-asserted-by":"crossref","DOI":"10.1590\/S0100-40422008000200013","article-title":"S\u00edntese, avalia\u00e7\u00e3o biol\u00f3gica e modelagem molecular de arilfuranos como inibidores da enzima tripanotiona redutase","volume":"31","author":"De Oliveira","year":"2008","journal-title":"Qu\u00edmica Nova"},{"key":"10.1016\/j.bmc.2025.118471_bb0260","doi-asserted-by":"crossref","unstructured":"Meerwein, H., B\u00fcchner, E., & van Emster, K. (1939). \u00dcber die Einwirkung aromatischer Diazoverbindungen auf \u03b1,\u03b2-unges\u00e4ttigte Carbonylverbindungen. Praktische Chemie, 15(7), 205\u2013215. https:\/\/doi.org\/10.1002\/prac.19391520705.","DOI":"10.1002\/prac.19391520705"},{"key":"10.1016\/j.bmc.2025.118471_bb0265","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1134\/S1070428009090103","article-title":"Mechanism of Meerwein arylation of furan derivatives","volume":"45","author":"Obushak","year":"2009","journal-title":"Russ J Org Chem"},{"issue":"3","key":"10.1016\/j.bmc.2025.118471_bb0270","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1163\/156856000750260504","article-title":"Central components in the antinociceptive activity of dipyrone in mice","volume":"8","author":"Kili\u00e7","year":"2000","journal-title":"Inflammopharmacology"},{"issue":"4","key":"10.1016\/j.bmc.2025.118471_bb0275","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/S0031-6997(24)01514-X","article-title":"Animal models of nociception","volume":"53","author":"Le Bars","year":"2001","journal-title":"Pharmacol Rev"},{"issue":"2","key":"10.1016\/j.bmc.2025.118471_bb0280","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1124\/jpet.104.069401","article-title":"Reversible inhibitors of fatty acid amide hydrolase that promote analgesia: evidence for an unprecedented combination of potency and selectivity","volume":"311","author":"Lichtman","year":"2004","journal-title":"J Pharmacol Exp Ther"},{"issue":"4","key":"10.1016\/j.bmc.2025.118471_bb0290","first-page":"255","article-title":"The modulatory role played by TNF-alpha and IL-1 beta in the inflammatory responses induced by carrageenan in the mouse model of pleurisy","volume":"13","author":"Fr\u00f6de","year":"2001","journal-title":"Cytokine"},{"issue":"1","key":"10.1016\/j.bmc.2025.118471_bb0295","first-page":"1","article-title":"Biological properties of carrageenan","volume":"24","author":"Di Rosa","year":"1972","journal-title":"J Pharm Pharmacol"},{"key":"10.1016\/j.bmc.2025.118471_bb0300","doi-asserted-by":"crossref","first-page":"96","DOI":"10.3389\/fped.2017.00096","article-title":"The role of carrageenan and carboxymethylcellulose in the development of intestinal inflammation","volume":"5","author":"Martino","year":"2017","journal-title":"Front Pediatr"},{"issue":"1","key":"10.1016\/j.bmc.2025.118471_bb0305","first-page":"101","article-title":"Local and systemic profiles of inflammatory cytokines in carrageenan-induced paw inflammation in rats","volume":"25","author":"Annamalai","year":"2017","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.bmc.2025.118471_bb0310","first-page":"2609","article-title":"Measuring motor coordination in mice","volume":"60","author":"Deacon","year":"2012","journal-title":"J Vis Exp"},{"key":"10.1016\/j.bmc.2025.118471_bb0315","doi-asserted-by":"crossref","DOI":"10.3389\/fvets.2023.1168335","article-title":"Quantification of phenobarbital-induced ataxia in dogs with idiopathic epilepsy","volume":"10","author":"Sherif","year":"2023","journal-title":"Front Vet Sci"},{"issue":"1","key":"10.1016\/j.bmc.2025.118471_bb0320","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1038\/sj.bjp.0706773","article-title":"Inhibition of fatty acid amide hydrolase produces analgesia by multiple mechanisms","volume":"148","author":"Chang","year":"2006","journal-title":"Br J Pharmacol"},{"issue":"3","key":"10.1016\/j.bmc.2025.118471_bb0325","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1124\/jpet.109.155465","article-title":"Blockade of endocannabinoid-degrading enzymes attenuates neuropathic pain","volume":"330","author":"Kinsey","year":"2009","journal-title":"J Pharmacol Exp Ther"},{"issue":"4","key":"10.1016\/j.bmc.2025.118471_bb0330","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/j.jmb.2010.05.034","article-title":"Crystal structures of fatty acid amide hydrolase bound to the carbamate inhibitor URB597: discovery of a deacylating water molecule and insight into enzyme inactivation","volume":"400","author":"Mileni","year":"2010","journal-title":"J Mol Biol"},{"issue":"1\u20133","key":"10.1016\/j.bmc.2025.118471_bb0335","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.ejphar.2008.08.005","article-title":"Modulation of opioids via protection of anandamide degradation by fatty acid amide hydrolase","volume":"600","author":"Haller","year":"2008","journal-title":"Eur J Pharmacol"},{"issue":"1","key":"10.1016\/j.bmc.2025.118471_bb0340","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1208\/s12248-008-9075-y","article-title":"Targeting fatty acid amide hydrolase (FAAH) to treat pain and inflammation","volume":"11","author":"Schlosburg","year":"2009","journal-title":"AAPS J"},{"issue":"3","key":"10.1016\/j.bmc.2025.118471_bb0345","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1124\/jpet.105.093286","volume":"316","author":"Maione","year":"2006","journal-title":"J Pharmacol Exp Ther"},{"issue":"8","key":"10.1016\/j.bmc.2025.118471_bb0350","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1016\/j.neuropharm.2008.06.023","article-title":"The analgesic effect of N-arachidonoyl-serotonin, a FAAH inhibitor and TRPV1 receptor antagonist, associated with changes in rostral ventromedial medulla and locus coeruleus cell activity in rats","volume":"55","author":"de Novellis","year":"2008","journal-title":"Neuropharmacology"},{"issue":"4","key":"10.1016\/j.bmc.2025.118471_bb0355","first-page":"319","article-title":"The dual fatty acid amide hydrolase\/TRPV1 blocker, N-arachidonoyl-serotonin, relieves carrageenan-induced inflammation and hyperalgesia in mice","volume":"61","author":"Costa","year":"2010","journal-title":"Pharmacol Res"},{"key":"10.1016\/j.bmc.2025.118471_bb0360","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.bbi.2017.02.016","article-title":"Pharmacological inhibition of FAAH modulates TLR-induced neuroinflammation, but not sickness behaviour: an effect partially mediated by central TRPV1","volume":"62","author":"Henry","year":"2017","journal-title":"Brain Behav Immun"},{"issue":"6","key":"10.1016\/j.bmc.2025.118471_bb0365","first-page":"376","article-title":"Defining body-weight reduction as a humane endpoint: a critical appraisal","volume":"47","author":"Talbot","year":"2019","journal-title":"Altern Lab Anim"},{"key":"10.1016\/j.bmc.2025.118471_bb0370","article-title":"Clinical hematological and biochemical parameters in Swiss, BALB\/c, C57BL\/6 and B6D2F1 Mus musculus","volume":"10","author":"Silva-Santana","year":"2024","journal-title":"Acta Medica Educativa"},{"key":"10.1016\/j.bmc.2025.118471_bb0375","doi-asserted-by":"crossref","unstructured":"Santos, E. W., Oliveira, D. C. de, Hastreiter, A., Silva, G. B. da, Beltran, J. S. de O., Tsujita, M., et al. (2016). Hematological and biochemical reference values for C57BL\/6, Swiss Webster and BALB\/c mice. Braz J Vet Res Anim Sci, 53(2), 138\u2013145. 10.11606\/issn.1678-4456.v53i2p138-145.","DOI":"10.11606\/issn.1678-4456.v53i2p138-145"},{"key":"10.1016\/j.bmc.2025.118471_bb0380","doi-asserted-by":"crossref","unstructured":"Barbosa, B. de S., Praxedes, \u00c9. A., Lima, M. A., Pimentel, M. M. L., Santos, F. A., Brito, P. D., et al. (2017). Haematological and biochemical profile of Balb-c mice. Acta Sci Vet, 45, 1\u20135. 10.22456\/1679-9216.80473.","DOI":"10.22456\/1679-9216.80473"},{"issue":"1","key":"10.1016\/j.bmc.2025.118471_bb0385","first-page":"22","article-title":"Experimental infection with Trypanosoma cruzi in mice: influence of exercise versus strains and sexes","volume":"18","author":"Soares","year":"2012","journal-title":"Rev Bras Med Esporte"},{"issue":"1","key":"10.1016\/j.bmc.2025.118471_bb0390","doi-asserted-by":"crossref","first-page":"19814","DOI":"10.1038\/s41598-020-76391-w","article-title":"Comparing distress of mouse models for liver damage","volume":"10","author":"Tang","year":"2020","journal-title":"Sci Rep"},{"issue":"3","key":"10.1016\/j.bmc.2025.118471_bb0395","doi-asserted-by":"crossref","first-page":"904","DOI":"10.3390\/pharmaceutics15030904","article-title":"Emetic tartar-loaded liposomes as a new strategy for Leishmaniasis treatment","volume":"15","author":"Coelho","year":"2023","journal-title":"Pharmaceutics"},{"issue":"3","key":"10.1016\/j.bmc.2025.118471_bb0400","first-page":"339","article-title":"Valores de refer\u00eancia dos teores s\u00e9ricos da ureia e creatinina em bovinos da ra\u00e7a Jersey criados no estado de S\u00e3o Paulo. Influ\u00eancia dos fatores et\u00e1rios, sexuais e da infec\u00e7\u00e3o pelo v\u00edrus da leucose dos bovinos","volume":"71","author":"Santos","year":"2004","journal-title":"Arquivos Brasileiros de Medicina Veterin\u00e1ria e Zootecnia"},{"key":"10.1016\/j.bmc.2025.118471_bb0405","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/872827","article-title":"Establishing standards for studying renal function in mice through measurements of body size-adjusted creatinine and urea levels","volume":"2014","author":"Rodrigues","year":"2014","journal-title":"Biomed Res Int"},{"issue":"6","key":"10.1016\/j.bmc.2025.118471_bb0410","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1007\/BF02850226","article-title":"Clinical importance of elevated CK-MB and troponin I levels in congestive heart failure","volume":"23","author":"Yilmaz","year":"2006","journal-title":"Adv Ther"},{"key":"10.1016\/j.bmc.2025.118471_bb0415","unstructured":"U.S. Food and Drug Administration. (n.d.). Credibility of Computational Models Program: Research on Computational Models and Simulation Associated with Medical Devices [Internet]. Silver Spring (MD): FDA. Retrieved April 4, 2025, from https:\/\/www.fda.gov\/medical-devices\/medical-device-regulatory-science-research-programs-conducted-osel\/credibility-computational-models-program-research-computational-models-and-simulation-associated."}],"container-title":["Bioorganic &amp; Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089625004122?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089625004122?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T05:01:49Z","timestamp":1780635709000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0968089625004122"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":82,"alternative-id":["S0968089625004122"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2025.118471","relation":{},"ISSN":["0968-0896"],"issn-type":[{"value":"0968-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Design of arylfurans as potential FAAH inhibitors: therapeutic potential in pain management","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2025.118471","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"118471"}}