{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T09:00:08Z","timestamp":1781254808691,"version":"3.54.1"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004000","name":"Guangzhou Municipal Science and Technology Program key projects","doi-asserted-by":"publisher","award":["2023A04J1082"],"award-info":[{"award-number":["2023A04J1082"]}],"id":[{"id":"10.13039\/501100004000","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82500745"],"award-info":[{"award-number":["82500745"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82371774"],"award-info":[{"award-number":["82371774"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015920","name":"Guangxi University of Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100015920","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic &amp; Medicinal Chemistry"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.bmc.2025.118518","type":"journal-article","created":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T00:26:56Z","timestamp":1764980816000},"page":"118518","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Broad-spectrum anti-influenza activity of the NMPA-approved drug Pamiparib is uncovered by virtual docking to the evolutionarily conserved domain of IAV-M2 protein"],"prefix":"10.1016","volume":"133","author":[{"given":"Min","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huifang","family":"Jiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dandan","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhuan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengcheng","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunpeng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/j.bmc.2025.118518_bb0005","first-page":"751","article-title":"Influenza: diagnosis and treatment","volume":"100","author":"Gaitonde","year":"2019","journal-title":"Am Fam Physician"},{"issue":"9","key":"10.1016\/j.bmc.2025.118518_bb0010","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1002243","article-title":"Sequential bottlenecks drive viral evolution in early acute hepatitis C virus infection","volume":"7","author":"Bull","year":"2011","journal-title":"PLoS Pathog"},{"issue":"13","key":"10.1016\/j.bmc.2025.118518_bb0015","doi-asserted-by":"crossref","first-page":"6403","DOI":"10.1128\/JVI.02389-10","article-title":"Evolution of drug-resistant viral populations during interruption of antiretroviral therapy","volume":"85","author":"Wang","year":"2011","journal-title":"J Virol"},{"issue":"1","key":"10.1016\/j.bmc.2025.118518_bb0020","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1038\/s44259-025-00125-z","article-title":"Strategies and efforts in circumventing the emergence of antiviral resistance against conventional antivirals","volume":"3","author":"Aw","year":"2025","journal-title":"npj antimicrobials and resistance"},{"issue":"3","key":"10.1016\/j.bmc.2025.118518_bb0025","doi-asserted-by":"crossref","DOI":"10.1002\/rmv.2533","article-title":"Passive immunotherapies for the next influenza pandemic","volume":"34","author":"Focosi","year":"2024","journal-title":"Rev Med Virol"},{"issue":"2","key":"10.1016\/j.bmc.2025.118518_bb0030","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.molmed.2020.09.014","article-title":"Influenza A Viruses: Understanding Human Host Determinants","volume":"27","author":"Ciminski","year":"2021","journal-title":"Trends Mol Med"},{"issue":"4","key":"10.1016\/j.bmc.2025.118518_bb0035","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1055\/s-0036-1584801","article-title":"Human influenza virus infections","volume":"37","author":"Peteranderl","year":"2016","journal-title":"Semin Respir Crit Care Med"},{"issue":"11","key":"10.1016\/j.bmc.2025.118518_bb0040","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1038\/s41564-019-0513-7","article-title":"The structure of the influenza a virus genome","volume":"4","author":"Dadonaite","year":"2019","journal-title":"Nat Microbiol"},{"issue":"1","key":"10.1016\/j.bmc.2025.118518_bb0045","doi-asserted-by":"crossref","first-page":"4427","DOI":"10.1038\/s41467-021-24724-2","article-title":"MARCH8 inhibits influenza a virus infection by targeting viral M2 protein for ubiquitination-dependent degradation in lysosomes","volume":"12","author":"Liu","year":"2021","journal-title":"Nat Commun"},{"issue":"2","key":"10.1016\/j.bmc.2025.118518_bb0050","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1128\/JVI.02718-14","article-title":"Cocirculation of two distinct genetic and antigenic lineages of proposed influenza D virus in cattle","volume":"89","author":"Collin","year":"2015","journal-title":"J Virol"},{"issue":"3","key":"10.1016\/j.bmc.2025.118518_bb0055","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/0092-8674(85)90211-9","article-title":"Influenza virus M2 protein is an integral membrane protein expressed on the infected-cell surface","volume":"40","author":"Lamb","year":"1985","journal-title":"Cell"},{"issue":"4","key":"10.1016\/j.bmc.2025.118518_bb0060","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.1128\/JVI.03253-14","article-title":"Influenza virus M2 protein ion channel activity helps to maintain pandemic 2009 H1N1 virus hemagglutinin fusion competence during transport to the cell surface","volume":"89","author":"Alvarado-Facundo","year":"2015","journal-title":"J Virol"},{"issue":"13","key":"10.1016\/j.bmc.2025.118518_bb0065","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1056\/NEJM199709253371302","article-title":"Efficacy and safety of the neuraminidase inhibitor zanamivir in the treatment of influenzavirus infections. GG167 influenza study group","volume":"337","author":"Hayden","year":"1997","journal-title":"N Engl J Med"},{"issue":"18","key":"10.1016\/j.bmc.2025.118518_bb0070","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1056\/NEJM199910283411802","article-title":"Use of the selective oral neuraminidase inhibitor oseltamivir to prevent influenza","volume":"341","author":"Hayden","year":"1999","journal-title":"N Engl J Med"},{"issue":"13","key":"10.1016\/j.bmc.2025.118518_bb0075","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1001\/jama.282.13.1240","article-title":"Use of the oral neuraminidase inhibitor oseltamivir in experimental human influenza: randomized controlled trials for prevention and treatment","volume":"282","author":"Hayden","year":"1999","journal-title":"Jama"},{"key":"10.1016\/j.bmc.2025.118518_bb0080","doi-asserted-by":"crossref","first-page":"450","DOI":"10.3389\/fmicb.2016.00450","article-title":"Peramivir: a novel intravenous neuraminidase inhibitor for treatment of acute influenza infections","volume":"7","author":"Alame","year":"2016","journal-title":"Front Microbiol"},{"issue":"2","key":"10.1016\/j.bmc.2025.118518_bb0085","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1073\/pnas.0909603107","article-title":"T-705 (favipiravir) activity against lethal H5N1 influenza a viruses","volume":"107","author":"Kiso","year":"2010","journal-title":"Proc Natl Acad Sci USA"},{"issue":"6","key":"10.1016\/j.bmc.2025.118518_bb0090","doi-asserted-by":"crossref","first-page":"2517","DOI":"10.1128\/AAC.01739-09","article-title":"In vitro antiviral activity of favipiravir (T-705) against drug-resistant influenza and 2009 a(H1N1) viruses","volume":"54","author":"Sleeman","year":"2010","journal-title":"Antimicrob Agents Chemother"},{"issue":"10","key":"10.1016\/j.bmc.2025.118518_bb0095","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1056\/NEJMoa1716197","article-title":"Baloxavir Marboxil for uncomplicated influenza in adults and adolescents","volume":"379","author":"Hayden","year":"2018","journal-title":"N Engl J Med"},{"issue":"38","key":"10.1016\/j.bmc.2025.118518_bb0100","doi-asserted-by":"crossref","first-page":"5115","DOI":"10.2174\/0929867324666170920165926","article-title":"Influenza virus: small molecule therapeutics and mechanisms of antiviral resistance","volume":"25","author":"Han","year":"2018","journal-title":"Curr Med Chem"},{"key":"10.1016\/j.bmc.2025.118518_bb0105","author":"Takashita","year":"2016"},{"issue":"3","key":"10.1016\/j.bmc.2025.118518_bb0110","first-page":"346","article-title":"Treatment-emergent influenza variant viruses with reduced Baloxavir susceptibility: impact on clinical and virologic outcomes in uncomplicated influenza","volume":"221","author":"Uehara","year":"2020","journal-title":"J Infect Dis"},{"issue":"3","key":"10.1016\/j.bmc.2025.118518_bb0115","doi-asserted-by":"crossref","first-page":"e219","DOI":"10.1016\/j.ddtec.2012.07.009","article-title":"In silico virtual screening approaches for anti-viral drug discovery","volume":"9","author":"Murgueitio","year":"2012","journal-title":"Drug Discov Today Technol"},{"issue":"4","key":"10.1016\/j.bmc.2025.118518_bb0120","doi-asserted-by":"crossref","first-page":"437","DOI":"10.4155\/fmc.10.292","article-title":"Novel neuraminidase inhibitors: identification, biological evaluation and investigations of the binding mode","volume":"3","author":"Kirchmair","year":"2011","journal-title":"Future Med Chem"},{"issue":"24","key":"10.1016\/j.bmc.2025.118518_bb0125","doi-asserted-by":"crossref","first-page":"15541","DOI":"10.1021\/acs.jmedchem.0c01346","article-title":"Discovery of Pamiparib (BGB-290), a potent and selective poly (ADP-ribose) polymerase (PARP) inhibitor in clinical development","volume":"63","author":"Wang","year":"2020","journal-title":"J Med Chem"},{"issue":"11","key":"10.1016\/j.bmc.2025.118518_bb0130","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1007\/s40265-021-01552-8","article-title":"Pamiparib: first approval","volume":"81","author":"Markham","year":"2021","journal-title":"Drugs"},{"issue":"8","key":"10.1016\/j.bmc.2025.118518_bb0135","doi-asserted-by":"crossref","first-page":"3891","DOI":"10.1021\/acs.jcim.1c00203","article-title":"AutoDock Vina 1.2.0: new docking methods, expanded force field, and Python bindings","volume":"61","author":"Eberhardt","year":"2021","journal-title":"J Chem Inf Model"},{"issue":"2","key":"10.1016\/j.bmc.2025.118518_bb0140","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/jcc.21334","article-title":"AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading","volume":"31","author":"Trott","year":"2010","journal-title":"J Comput Chem"},{"issue":"16","key":"10.1016\/j.bmc.2025.118518_bb0145","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1002\/jcc.20291","article-title":"GROMACS: fast, flexible, and free","volume":"26","author":"Van Der Spoel","year":"2005","journal-title":"J Comput Chem"},{"issue":"8016","key":"10.1016\/j.bmc.2025.118518_bb0150","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/s41586-024-07487-w","article-title":"Accurate structure prediction of biomolecular interactions with AlphaFold 3","volume":"630","author":"Abramson","year":"2024","journal-title":"Nature"},{"issue":"8","key":"10.1016\/j.bmc.2025.118518_bb0155","doi-asserted-by":"crossref","first-page":"3513","DOI":"10.1016\/j.apsb.2024.05.005","article-title":"Suppressing FXR promotes antiviral effects of bile acids via enhancing the interferon transcription","volume":"14","author":"Liang","year":"2024","journal-title":"Acta Pharm Sin B"},{"issue":"3","key":"10.1016\/j.bmc.2025.118518_bb0160","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.1007\/s12013-024-01325-6","article-title":"Unveiling the pharmacological role of human deubiquitinating enzymes in temozolomide response of glioblastoma cells","volume":"82","author":"Yang","year":"2024","journal-title":"Cell Biochem Biophys"},{"issue":"42","key":"10.1016\/j.bmc.2025.118518_bb0165","doi-asserted-by":"crossref","first-page":"39880","DOI":"10.1074\/jbc.M206582200","article-title":"The gate of the influenza virus M2 proton channel is formed by a single tryptophan residue","volume":"277","author":"Tang","year":"2002","journal-title":"J Biol Chem"},{"issue":"1","key":"10.1016\/j.bmc.2025.118518_bb0170","doi-asserted-by":"crossref","first-page":"9","DOI":"10.3201\/eid1201.051254","article-title":"Influenza pandemics of the 20th century","volume":"12","author":"Kilbourne","year":"2006","journal-title":"Emerg Infect Dis"},{"key":"10.1016\/j.bmc.2025.118518_bb0175","article-title":"Antigenic patterns and evolution of the human influenza a (H1N1) virus","volume":"5","author":"Liu","year":"2015","journal-title":"Sci Rep"},{"key":"10.1016\/j.bmc.2025.118518_bb0180","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1146\/annurev-animal-031412-103733","article-title":"Cross talk between animal and human influenza viruses","volume":"1","author":"Ozawa","year":"2013","journal-title":"Annu Rev Anim Biosci"},{"key":"10.1016\/j.bmc.2025.118518_bb0185","doi-asserted-by":"crossref","DOI":"10.1017\/S1462399410001705","article-title":"Influenza a virus transmission: contributing factors and clinical implications","volume":"12","author":"Belser","year":"2010","journal-title":"Expert Rev Mol Med"},{"key":"10.1016\/j.bmc.2025.118518_bb0190","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/978-1-4614-0204-6_8","article-title":"Influenza pandemics","volume":"719","author":"Elderfield","year":"2011","journal-title":"Adv Exp Med Biol"},{"issue":"2","key":"10.1016\/j.bmc.2025.118518_bb0195","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/s41579-018-0115-z","article-title":"Host and viral determinants of influenza a virus species specificity","volume":"17","author":"Long","year":"2019","journal-title":"Nat Rev Microbiol"},{"issue":"2","key":"10.1016\/j.bmc.2025.118518_bb0200","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1128\/JVI.06322-11","article-title":"Structural characterization of the hemagglutinin receptor specificity from the 2009 H1N1 influenza pandemic","volume":"86","author":"Xu","year":"2012","journal-title":"J Virol"},{"issue":"5665","key":"10.1016\/j.bmc.2025.118518_bb0205","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.1126\/science.1093155","article-title":"The structure and receptor binding properties of the 1918 influenza hemagglutinin","volume":"303","author":"Gamblin","year":"2004","journal-title":"Science (New York, NY)"},{"issue":"18","key":"10.1016\/j.bmc.2025.118518_bb0210","doi-asserted-by":"crossref","first-page":"8502","DOI":"10.1128\/JVI.74.18.8502-8512.2000","article-title":"Early alterations of the receptor-binding properties of H1, H2, and H3 avian influenza virus hemagglutinins after their introduction into mammals","volume":"74","author":"Matrosovich","year":"2000","journal-title":"J Virol"},{"issue":"4","key":"10.1016\/j.bmc.2025.118518_bb0215","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1128\/jvi.67.4.1761-1764.1993","article-title":"A single amino acid in the PB2 gene of influenza a virus is a determinant of host range","volume":"67","author":"Subbarao","year":"1993","journal-title":"J Virol"},{"issue":"1","key":"10.1016\/j.bmc.2025.118518_bb0220","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1000252","article-title":"Transmission of influenza virus in a mammalian host is increased by PB2 amino acids 627K or 627E\/701N","volume":"5","author":"Steel","year":"2009","journal-title":"PLoS Pathog"},{"issue":"7","key":"10.1016\/j.bmc.2025.118518_bb0225","doi-asserted-by":"crossref","DOI":"10.3390\/v16071129","article-title":"Exploring potential intermediates in the cross-species transmission of influenza a virus to humans","volume":"16","author":"Lee","year":"2024","journal-title":"Viruses"},{"issue":"7","key":"10.1016\/j.bmc.2025.118518_bb0230","doi-asserted-by":"crossref","DOI":"10.1128\/jvi.00154-23","article-title":"Impact of Baloxavir resistance-associated substitutions on influenza virus growth and drug susceptibility","volume":"97","author":"Hickerson","year":"2023","journal-title":"J Virol"},{"issue":"5983","key":"10.1016\/j.bmc.2025.118518_bb0235","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1126\/science.1187816","article-title":"Permissive secondary mutations enable the evolution of influenza oseltamivir resistance","volume":"328","author":"Bloom","year":"2010","journal-title":"Science (New York, NY)"},{"issue":"8","key":"10.1016\/j.bmc.2025.118518_bb0240","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1001\/jama.295.8.joc60020","article-title":"Adamantane resistance among influenza a viruses isolated early during the 2005-2006 influenza season in the United States","volume":"295","author":"Bright","year":"2006","journal-title":"Jama"}],"container-title":["Bioorganic &amp; Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089625004602?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089625004602?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T08:41:07Z","timestamp":1781253667000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0968089625004602"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":48,"alternative-id":["S0968089625004602"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2025.118518","relation":{},"ISSN":["0968-0896"],"issn-type":[{"value":"0968-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Broad-spectrum anti-influenza activity of the NMPA-approved drug Pamiparib is uncovered by virtual docking to the evolutionarily conserved domain of IAV-M2 protein","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2025.118518","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"118518"}}