{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:19:24Z","timestamp":1790727564122,"version":"4.1.0"},"reference-count":23,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T00:00:00Z","timestamp":1767571200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000016","name":"U.S. Department of Health and Human Services","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000016","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000865","name":"Gates Foundation","doi-asserted-by":"publisher","award":["INV-001727"],"award-info":[{"award-number":["INV-001727"]}],"id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006492","name":"National Institute of Allergy and Infectious Diseases Division of Intramural Research","doi-asserted-by":"publisher","award":["AI000693"],"award-info":[{"award-number":["AI000693"]}],"id":[{"id":"10.13039\/100006492","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.bmc.2026.118549","type":"journal-article","created":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T16:48:37Z","timestamp":1767631717000},"page":"118549","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Structure-activity relationship study of a new class of 2-amino-3,4-dihydroquinazolines as antitubercular agents"],"prefix":"10.1016","volume":"134","author":[{"given":"Lena","family":"Trifonov","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena I.","family":"Boshoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose Santinni O.","family":"Roma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixuan","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He Eun","family":"Forbes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"Clifton E.","family":"Barry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sangmi","family":"Oh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmc.2026.118549_bb0005","unstructured":"World Health Organization: Geneva S: Global Tuberculosis Report 2023. ISBN 978\u201392\u20134-008385-1 2023."},{"issue":"2","key":"10.1016\/j.bmc.2026.118549_bb0010","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1002\/emmm.201201772","article-title":"Tuberculosis drug discovery in the post-post-genomic era","volume":"6","author":"Lechartier","year":"2014","journal-title":"EMBO Mol Med"},{"key":"10.1016\/j.bmc.2026.118549_bb0015","doi-asserted-by":"crossref","unstructured":"Singh A, Ottavi S, Krieger I, Planck K, Perkowski A, Kaneko T, Davis AM, Suh C, Zhang D, Goullieux L et al: Redirecting raltitrexed from cancer cell thymidylate synthase to mycobacterium tuberculosis phosphopantetheinyl transferase. Sci Adv 2024, 10(11):eadj6406.","DOI":"10.1126\/sciadv.adj6406"},{"key":"10.1016\/j.bmc.2026.118549_bb0020","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2021.611304","article-title":"Tuberculosis drug discovery: a decade of hit assessment for defined targets","volume":"11","author":"Oh","year":"2021","journal-title":"Front Cell Infect Microbiol"},{"key":"10.1016\/j.bmc.2026.118549_bb0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmcl.2022.128543","article-title":"Synthesis, radiolabeling, and evaluation of a potent beta-site APP cleaving enzyme (BACE1) inhibitor for PET imaging of BACE1 in vivo","volume":"59","author":"Pan","year":"2022","journal-title":"Bioorg Med Chem Lett"},{"issue":"17","key":"10.1016\/j.bmc.2026.118549_bb0030","doi-asserted-by":"crossref","first-page":"5460","DOI":"10.1016\/j.bmcl.2012.07.043","article-title":"Structure-based design, synthesis, and biological evaluation of dihydroquinazoline-derived potent beta-secretase inhibitors","volume":"22","author":"Ghosh","year":"2012","journal-title":"Bioorg Med Chem Lett"},{"issue":"18","key":"10.1016\/j.bmc.2026.118549_bb0035","doi-asserted-by":"crossref","first-page":"4261","DOI":"10.1021\/jm0705408","article-title":"2-Amino-3,4-dihydroquinazolines as inhibitors of BACE-1 (beta-site APP cleaving enzyme): use of structure based design to convert a micromolar hit into a nanomolar lead","volume":"50","author":"Baxter","year":"2007","journal-title":"J Med Chem"},{"issue":"8","key":"10.1016\/j.bmc.2026.118549_bb0040","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1002\/ardp.201600020","article-title":"Quinazolinones, Quinazolinthiones, and Quinazolinimines as nitric oxide synthase inhibitors: synthetic study and biological evaluation","volume":"349","author":"Camacho","year":"2016","journal-title":"Arch Pharm (Weinheim)"},{"issue":"1","key":"10.1016\/j.bmc.2026.118549_bb0045","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.bmcl.2007.10.080","article-title":"Cyclic guanidines as dual 5-HT5A\/5-HT7 receptor ligands: structure-activity relationship elucidation","volume":"18","author":"Peters","year":"2008","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmc.2026.118549_bb0050","unstructured":"Fran\u00e7ois Paul BISHOFF MB, Serge Maria Aloysius Pieters, Marc Hubert Mercken, Hans Louis Jos De Winter, Dieder Jean-Claude Berthelot: 2-amino-quinazoline derivatives useful as inhibitors of b-secretase (bace). In.; 2006."},{"key":"10.1016\/j.bmc.2026.118549_bb0055","unstructured":"William A. Kinney ECL, Shyamali Ghosh, Diane K. Luci, David F. McComsey: urotensin II receptor antagonists. In.; 2013."},{"issue":"4","key":"10.1016\/j.bmc.2026.118549_bb0060","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1021\/acsmedchemlett.0c00570","article-title":"Identification of Piperidine-3-carboxamide derivatives inducing senescence-like phenotype with Antimelanoma activities","volume":"12","author":"Oh","year":"2021","journal-title":"ACS Med Chem Lett"},{"issue":"51","key":"10.1016\/j.bmc.2026.118549_bb0065","doi-asserted-by":"crossref","first-page":"16995","DOI":"10.1021\/jp808288p","article-title":"Influence of sequential guanidinium methylation on the energetics of the guanidinium..Guanine dimer and guanidinium...Guanine...Cytosine trimer: implications for the control of protein...DNA interactions by arginine methyltransferases","volume":"112","author":"Shearer","year":"2008","journal-title":"J Phys Chem B"},{"issue":"11","key":"10.1016\/j.bmc.2026.118549_bb0070","doi-asserted-by":"crossref","first-page":"6962","DOI":"10.1128\/AAC.03486-14","article-title":"Respiratory flexibility in response to inhibition of cytochrome C oxidase in mycobacterium tuberculosis","volume":"58","author":"Arora","year":"2014","journal-title":"Antimicrob Agents Chemother"},{"issue":"11","key":"10.1016\/j.bmc.2026.118549_bb0075","doi-asserted-by":"crossref","first-page":"6748","DOI":"10.1128\/AAC.01178-16","article-title":"Bioluminescent reporters for rapid mechanism of action assessment in tuberculosis drug discovery","volume":"60","author":"Naran","year":"2016","journal-title":"Antimicrob Agents Chemother"},{"issue":"2","key":"10.1016\/j.bmc.2026.118549_bb0080","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1093\/toxsci\/kfm052","article-title":"Circumventing the Crabtree effect: replacing media glucose with galactose increases susceptibility of HepG2 cells to mitochondrial toxicants","volume":"97","author":"Marroquin","year":"2007","journal-title":"Toxicol Sci"},{"issue":"4","key":"10.1016\/j.bmc.2026.118549_bb0085","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1038\/ja.2015.107","article-title":"Natural product-derived quaternary ammonium compounds with potent antimicrobial activity","volume":"69","author":"Joyce","year":"2016","journal-title":"J Antibiot (Tokyo)"},{"issue":"9","key":"10.1016\/j.bmc.2026.118549_bb0090","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25094649","article-title":"Advances in the synthesis of biologically active quaternary ammonium compounds","volume":"25","author":"Fedorowicz","year":"2024","journal-title":"Int J Mol Sci"},{"issue":"1","key":"10.1016\/j.bmc.2026.118549_bb0095","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s13756-023-01241-z","article-title":"Quaternary ammonium disinfectants and antiseptics: tolerance, resistance and potential impact on antibiotic resistance","volume":"12","author":"Boyce","year":"2023","journal-title":"Antimicrob Resist Infect Control"},{"issue":"31","key":"10.1016\/j.bmc.2026.118549_bb0100","doi-asserted-by":"crossref","first-page":"10692","DOI":"10.1021\/ja103081n","article-title":"Investigation of the mechanism of C(sp3)-H bond cleavage in Pd(0)-catalyzed intramolecular alkane arylation adjacent to amides and sulfonamides","volume":"132","author":"Rousseaux","year":"2010","journal-title":"J Am Chem Soc"},{"key":"10.1016\/j.bmc.2026.118549_bb0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2019.103135","article-title":"4-substituted 2-amino-3,4-dihydroquinazolines with a 3-hairpin turn side chain as novel inhibitors of BACE-1","volume":"95","author":"Jagtap","year":"2020","journal-title":"Bioorg Chem"},{"issue":"4","key":"10.1016\/j.bmc.2026.118549_bb0110","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1128\/AAC.05708-11","article-title":"SQ109 targets MmpL3, a membrane transporter of trehalose monomycolate involved in mycolic acid donation to the cell wall core of mycobacterium tuberculosis","volume":"56","author":"Tahlan","year":"2012","journal-title":"Antimicrob Agents Chemother"},{"issue":"12","key":"10.1016\/j.bmc.2026.118549_bb0115","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.3002852","article-title":"Environmental sphagnum-associated fungi target thiol homeostasis to compete with Mycobacterium tuberculosis","volume":"22","author":"Malhotra","year":"2024","journal-title":"PLoS Biol."}],"container-title":["Bioorganic & Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089626000052?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089626000052?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T02:52:10Z","timestamp":1769655130000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0968089626000052"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":23,"alternative-id":["S0968089626000052"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2026.118549","relation":{},"ISSN":["0968-0896"],"issn-type":[{"value":"0968-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Structure-activity relationship study of a new class of 2-amino-3,4-dihydroquinazolines as antitubercular agents","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2026.118549","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"118549"}}