{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T18:16:18Z","timestamp":1770833778721,"version":"3.50.1"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100010002","name":"Ministry of Education","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["NSTC 112-2628-B-038-009-MY3"],"award-info":[{"award-number":["NSTC 112-2628-B-038-009-MY3"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004700","name":"Taipei Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic &amp; Medicinal Chemistry"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.bmc.2026.118570","type":"journal-article","created":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T00:37:09Z","timestamp":1768610229000},"page":"118570","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Targeting epithelial-mesenchymal transition and apoptosis: novel histone methyltransferase inhibitors for colon cancer suppression"],"prefix":"10.1016","volume":"135","author":[{"given":"Hsueh-Yun","family":"Lee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chia-Hsuan","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi-Ting","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deepa Rohidas","family":"Landge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tzu-Ying","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Er-Chieh","family":"Cho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmc.2026.118570_bb0005","doi-asserted-by":"crossref","first-page":"2025","DOI":"10.3390\/cancers13092025","article-title":"A review of colorectal cancer in terms of epidemiology, risk factors, development, symptoms and diagnosis","volume":"13","author":"Sawicki","year":"2021","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.bmc.2026.118570_bb0010","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1136\/gutjnl-2015-310912","article-title":"Global patterns and trends in colorectal cancer incidence and mortality","volume":"66","author":"Arnold","year":"2017","journal-title":"Gut"},{"key":"10.1016\/j.bmc.2026.118570_bb0015","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1177\/1756283X16671287","article-title":"Targeting histone methylation for colorectal cancer","volume":"10","author":"Huang","year":"2017","journal-title":"Ther Adv Gastroenterol"},{"key":"10.1016\/j.bmc.2026.118570_bb0020","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.gendis.2019.10.013","article-title":"Molecular subtypes of colorectal cancer: an emerging therapeutic opportunity for personalized medicine","volume":"8","author":"Singh","year":"2021","journal-title":"Genes Dis"},{"key":"10.1016\/j.bmc.2026.118570_bb0025","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/s10555-017-9726-5","article-title":"Mutations of key driver genes in colorectal cancer progression and metastasis","volume":"37","author":"Huang","year":"2018","journal-title":"Cancer Metastasis Rev"},{"key":"10.1016\/j.bmc.2026.118570_bb0030","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1038\/s41573-020-0077-5","article-title":"Targeting the epigenetic regulation of antitumour immunity","volume":"19","author":"Hogg","year":"2020","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.bmc.2026.118570_bb0035","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1053\/j.gastro.2020.09.058","article-title":"Epigenetic alterations in the gastrointestinal tract: current and emerging use for biomarkers of cancer","volume":"160","author":"Grady","year":"2021","journal-title":"Gastroenterology"},{"key":"10.1016\/j.bmc.2026.118570_bb0040","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/s41575-019-0230-y","article-title":"Epigenetics of colorectal cancer: biomarker and therapeutic potential","volume":"17","author":"Jung","year":"2020","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.bmc.2026.118570_bb0045","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1038\/s41580-019-0143-1","article-title":"The roles of DNA, RNA and histone methylation in ageing and cancer","volume":"20","author":"Michalak","year":"2019","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.bmc.2026.118570_bb0050","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/nrg3173","article-title":"Histone methylation: a dynamic mark in health, disease and inheritance","volume":"13","author":"Greer","year":"2012","journal-title":"Nat Rev Genet"},{"key":"10.1016\/j.bmc.2026.118570_bb0055","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.molcel.2012.11.006","article-title":"Histone lysine methylation dynamics: establishment, regulation, and biological impact","volume":"48","author":"Black","year":"2012","journal-title":"Mol Cell"},{"key":"10.1016\/j.bmc.2026.118570_bb0060","doi-asserted-by":"crossref","DOI":"10.1038\/emm.2017.11","article-title":"Writing, erasing and reading histone lysine methylations","volume":"49","author":"Hyun","year":"2017","journal-title":"Exp Mol Med"},{"key":"10.1016\/j.bmc.2026.118570_bb0065","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/s41392-020-00252-1","article-title":"The role of histone methylation in the development of digestive cancers: a potential direction for cancer management","volume":"5","author":"Chen","year":"2020","journal-title":"Signal Transduct Target Ther"},{"key":"10.1016\/j.bmc.2026.118570_bb0070","series-title":"Advances in Genetics","first-page":"57","article-title":"3 - histone modifications and Cancer","author":"Sawan","year":"2010"},{"key":"10.1016\/j.bmc.2026.118570_bb0075","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1056\/NEJMra1805035","article-title":"Epigenetic therapies for Cancer","volume":"383","author":"Bates","year":"2020","journal-title":"N Engl J Med"},{"key":"10.1016\/j.bmc.2026.118570_bb0080","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/s41568-019-0109-9","article-title":"Epigenetic therapy in immune-oncology","volume":"19","author":"Jones","year":"2019","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.bmc.2026.118570_bb0085","doi-asserted-by":"crossref","first-page":"3059","DOI":"10.1007\/s12325-020-01379-x","article-title":"The promise for histone methyltransferase inhibitors for epigenetic therapy in clinical oncology: a narrative review","volume":"37","author":"Rugo","year":"2020","journal-title":"Adv Ther"},{"key":"10.1016\/j.bmc.2026.118570_bb0090","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1186\/s13045-020-00937-8","article-title":"EZH2: a novel target for cancer treatment","volume":"13","author":"Duan","year":"2020","journal-title":"J Hematol Oncol"},{"key":"10.1016\/j.bmc.2026.118570_bb0095","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1182\/blood-2013-04-497644","article-title":"Potent inhibition of DOT1L as treatment of MLL-fusion leukemia","volume":"122","author":"Daigle","year":"2013","journal-title":"Blood"},{"key":"10.1016\/j.bmc.2026.118570_bb0100","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.1038\/leu.2014.169","article-title":"The emerging roles of DOT1L in leukemia and normal development","volume":"28","author":"McLean","year":"2014","journal-title":"Leukemia"},{"key":"10.1016\/j.bmc.2026.118570_bb0105","doi-asserted-by":"crossref","first-page":"2661","DOI":"10.1182\/blood-2017-12-818948","article-title":"The DOT1L inhibitor pinometostat reduces H3K79 methylation and has modest clinical activity in adult acute leukemia","volume":"131","author":"Stein","year":"2018","journal-title":"Blood"},{"key":"10.1016\/j.bmc.2026.118570_bb0110","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1038\/nchembio.1810","article-title":"A selective inhibitor of PRMT5 with in vivo and in vitro potency in MCL models","volume":"11","author":"Chan-Penebre","year":"2015","journal-title":"Nat Chem Biol"},{"key":"10.1016\/j.bmc.2026.118570_bb0115","doi-asserted-by":"crossref","DOI":"10.1093\/annonc\/mdz244","article-title":"438O - METEOR-1: a phase I study of GSK3326595, a first-in-class protein arginine methyltransferase 5 (PRMT5) inhibitor, in advanced solid tumours","volume":"30","author":"Siu","year":"2019","journal-title":"Ann Oncol"},{"key":"10.1016\/j.bmc.2026.118570_bb0120","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.bbrc.2015.01.068","article-title":"Inhibition of H3K9 methyltransferase G9a induces autophagy and apoptosis in oral squamous cell carcinoma","volume":"459","author":"Ren","year":"2015","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.bmc.2026.118570_bb0125","doi-asserted-by":"crossref","first-page":"21315","DOI":"10.18632\/oncotarget.15528","article-title":"Histone lysine methyltransferase G9a is a novel epigenetic target for the treatment of hepatocellular carcinoma","volume":"8","author":"Yokoyama","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.bmc.2026.118570_bb0130","doi-asserted-by":"crossref","first-page":"3093","DOI":"10.1021\/acschembio.6b00308","article-title":"Structure of the epigenetic oncogene MMSET and inhibition by N-alkyl sinefungin derivatives","volume":"11","author":"Tisi","year":"2016","journal-title":"ACS Chem Biol"},{"key":"10.1016\/j.bmc.2026.118570_bb0135","doi-asserted-by":"crossref","first-page":"13750","DOI":"10.1074\/jbc.RA118.004274","article-title":"High-throughput screening with nucleosome substrate identifies small-molecule inhibitors of the human histone lysine methyltransferase NSD2","volume":"293","author":"Coussens","year":"2018","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bmc.2026.118570_bb0140","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0197082","article-title":"Identification of a peptide inhibitor for the histone methyltransferase WHSC1","volume":"13","author":"Morrison","year":"2018","journal-title":"PLoS ONE"},{"key":"10.1016\/j.bmc.2026.118570_bb0145","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.bbrc.2018.11.037","article-title":"Identification of LEM-14 inhibitor of the oncoprotein NSD2","volume":"508","author":"Shen","year":"2019","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.bmc.2026.118570_bb0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.diamond.2025.111946","article-title":"Molecular characterizations of nanodiamond and related carbon-based nanomaterials in the human cell line and zebrafish models","volume":"152","author":"Li","year":"2025","journal-title":"Diam Relat Mater"},{"key":"10.1016\/j.bmc.2026.118570_bb0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmc.2024.117792","article-title":"Enhancing anti-cancer capacity: novel class I\/II HDAC inhibitors modulate EMT, cell cycle, and apoptosis pathways","volume":"109","author":"Lee","year":"2024","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.bmc.2026.118570_bb0160","doi-asserted-by":"crossref","first-page":"11983","DOI":"10.1039\/D4TB01206B","article-title":"Post-therapy via integrated curcumin and doxorubicin modified cerium-based UiO-66 MOFs using an antioxidant and anticancer therapeutic strategy","volume":"12","author":"Liu","year":"2024","journal-title":"J Mater Chem B"},{"key":"10.1016\/j.bmc.2026.118570_bb0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2021.109778","article-title":"A novel HDAC1\/2 inhibitor suppresses colorectal cancer through apoptosis induction and cell cycle regulation","volume":"352","author":"Lee","year":"2022","journal-title":"Chem Biol Interact"},{"key":"10.1016\/j.bmc.2026.118570_bb0170","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.bbrc.2021.06.034","article-title":"Multiple myeloma driving factor WHSC1 is a transcription target of oncogene HMGA2 that facilitates colon cancer proliferation and metastasis","volume":"567","author":"Liu","year":"2021","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.bmc.2026.118570_bb0175","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1080\/14756366.2021.1941920","article-title":"Ring size changes in the development of class I HDAC inhibitors","volume":"36","author":"Cho","year":"2021","journal-title":"J Enzyme Inhibit Med Chem"},{"key":"10.1016\/j.bmc.2026.118570_bb0180","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1016\/j.bbrc.2020.01.147","article-title":"Dicoumarol suppresses HMGA2-mediated oncogenic capacities and inhibits cell proliferation by inducing apoptosis in colon cancer","volume":"524","author":"Chen","year":"2020","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.bmc.2026.118570_bb0185","doi-asserted-by":"crossref","DOI":"10.3390\/genes13112111","article-title":"Mitochondrial factor C20orf7 facilitates the EMT-mediated Cancer cell migration and the proliferation of Colon Cancer in vitro and in vivo","volume":"13","author":"Liu","year":"2022","journal-title":"Genes"},{"key":"10.1016\/j.bmc.2026.118570_bb0190","first-page":"27","article-title":"2-Mercaptoimidazole selectively etching and thiol-functionalized ZIF-8 metal-organic framework to serve as a multifaceted platform for radical scavenging and au loading. Materials today","author":"Chen","year":"2023","journal-title":"Chemistry"},{"key":"10.1016\/j.bmc.2026.118570_bb0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2025.145734","article-title":"Exploration of RGD peptide-modified targeted delivery of doxorubicin using chitosan oligosaccharide-coated GQD carriers with different complexity","volume":"320","author":"Yeh","year":"2025","journal-title":"Int J Biol Macromol"},{"key":"10.1016\/j.bmc.2026.118570_bb0200","article-title":"MOF-derived spinel NiMn2O4\/CoMn2O4 heterojunction and its application in a high-performance photocatalyst and supercapacitor. Journal of environmental","volume":"11","author":"Lee","year":"2023","journal-title":"Chem Eng"},{"key":"10.1016\/j.bmc.2026.118570_bb0205","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.molcel.2007.01.017","article-title":"Reversal of H3K9me2 by a small-molecule inhibitor for the G9a histone methyltransferase","volume":"25","author":"Kubicek","year":"2007","journal-title":"Mol Cell"},{"key":"10.1016\/j.bmc.2026.118570_bb0210","article-title":"Menin-MLL1 interaction small molecule inhibitors: a potential therapeutic strategy for Leukemia and cancers","volume":"28","author":"Shi","year":"2023","journal-title":"Molecules"},{"key":"10.1016\/j.bmc.2026.118570_bb0215","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1089\/adt.2014.573","article-title":"Three-dimensional cell culture systems and their applications in drug discovery and cell-based biosensors","volume":"12","author":"Edmondson","year":"2014","journal-title":"ASSAY Drug Dev Technol"}],"container-title":["Bioorganic &amp; Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S096808962600026X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S096808962600026X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T17:25:09Z","timestamp":1770830709000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S096808962600026X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":43,"alternative-id":["S096808962600026X"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2026.118570","relation":{},"ISSN":["0968-0896"],"issn-type":[{"value":"0968-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Targeting epithelial-mesenchymal transition and apoptosis: novel histone methyltransferase inhibitors for colon cancer suppression","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2026.118570","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"118570"}}