{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T11:38:15Z","timestamp":1776166695687,"version":"3.50.1"},"reference-count":66,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T00:00:00Z","timestamp":1770595200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001409","name":"Department of Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001409","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001407","name":"Department of Biotechnology","doi-asserted-by":"publisher","award":["BT\/PR47642\/CMD\/150\/24\/2023"],"award-info":[{"award-number":["BT\/PR47642\/CMD\/150\/24\/2023"]}],"id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.bmc.2026.118587","type":"journal-article","created":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T07:06:32Z","timestamp":1770534392000},"page":"118587","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Machine learning-driven computational drug repurposing to identify new tubulin inhibitors against cancer"],"prefix":"10.1016","volume":"136","author":[{"given":"Neelima","family":"Neelima","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-9776-5476","authenticated-orcid":false,"given":"Hussein","family":"Elrewey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sneha","family":"Smarakan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amalia","family":"Ruiz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad","family":"Wahajuddin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gaurav","family":"Joshi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vibhu","family":"Jha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmc.2026.118587_bb0005","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1038\/34465","article-title":"Structure of the \u03b1\u03b2 tubulin dimer by electron crystallography","volume":"391","author":"Nogales","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.bmc.2026.118587_bb0010","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1038\/nature01600","article-title":"Dynamics and mechanics of the microtubule plus end","volume":"422","author":"Howard","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.bmc.2026.118587_bb0015","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1083\/jcb.201407095","article-title":"The contribution of \u03b1\u03b2-tubulin curvature to microtubule dynamics","volume":"207","author":"Brouhard","year":"2014","journal-title":"J Cell Biol"},{"key":"10.1016\/j.bmc.2026.118587_bb0020","doi-asserted-by":"crossref","DOI":"10.3390\/cells8101294","article-title":"Tubulin: structure, functions and roles in disease","volume":"8","author":"Binarov\u00e1","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.bmc.2026.118587_bb0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2020.101511","article-title":"The mechanism of tubulin assembly into microtubules: insights from structural studies","volume":"23","author":"Knossow","year":"2020","journal-title":"IScience"},{"key":"10.1016\/j.bmc.2026.118587_bb0030","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/0891-5849(91)90192-6","article-title":"Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes","volume":"11","author":"Esterbauer","year":"1991","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.bmc.2026.118587_bb0035","doi-asserted-by":"crossref","DOI":"10.3390\/cells10040745","article-title":"The game of tubulins","volume":"10","author":"Kristensson","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.bmc.2026.118587_bb0040","doi-asserted-by":"crossref","first-page":"5980","DOI":"10.1038\/s41467-023-41615-w","article-title":"Structural insights into the mechanism of GTP initiation of microtubule assembly","volume":"14","author":"Zhou","year":"2023","journal-title":"Nat Commun"},{"key":"10.1016\/j.bmc.2026.118587_bb0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejcb.2020.151075","article-title":"Microtubule-targeting agents and their impact on cancer treatment","volume":"99","author":"\u010cerm\u00e1k","year":"2020","journal-title":"Eur J Cell Biol"},{"key":"10.1016\/j.bmc.2026.118587_bb0050","doi-asserted-by":"crossref","first-page":"11765","DOI":"10.1074\/jbc.M110.162214","article-title":"Hallmarks of molecular action of microtubule stabilizing agents: effects of epothilone B, ixabepilone, peloruside A, and laulimalide on microtubule conformation *","volume":"286","author":"Khrapunovich-Baine","year":"2011","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bmc.2026.118587_bb0055","doi-asserted-by":"crossref","DOI":"10.3390\/cancers13225650","article-title":"Microtubule targeting agents in disease: classic drugs, novel roles","volume":"13","author":"Wordeman","year":"2021","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.bmc.2026.118587_bb0060","doi-asserted-by":"crossref","unstructured":"X. Wang, B. Gigant, X. Zheng, Q. Chen, Microtubule-targeting agents for cancer treatment: seven binding sites and three strategies, MedComm \u2013 Oncology 2 (2023) e46. doi:https:\/\/doi.org\/10.1002\/mog2.46.","DOI":"10.1002\/mog2.46"},{"key":"10.1016\/j.bmc.2026.118587_bb0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.molstruc.2022.132723","article-title":"Microtubules destabilizing agents binding sites in tubulin","volume":"1259","author":"Alp\u00edzar-Pedraza","year":"2022","journal-title":"J Mol Struct"},{"key":"10.1016\/j.bmc.2026.118587_bb0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmc.2025.118488","article-title":"Repurposing the USFDA-approved small molecules for their affinity against the colchicine binding site (CBS) in the tubulin: corroborating the in-silico findings through biological assessment","volume":"133","author":"Rohit","year":"2026","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.bmc.2026.118587_bb0075","doi-asserted-by":"crossref","first-page":"eabg4168","DOI":"10.1126\/sciadv.abg4168","article-title":"Cevipabulin-tubulin complex reveals a novel agent binding site on \u03b1-tubulin with tubulin degradation effect","volume":"7","author":"Yang","year":"2025","journal-title":"Sci Adv"},{"key":"10.1016\/j.bmc.2026.118587_bb0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2021.105486","article-title":"Discovery of novel tubulin inhibitors targeting the colchicine binding site via virtual screening, structural optimization and antitumor evaluation","volume":"118","author":"Liu","year":"2022","journal-title":"Bioorg Chem"},{"key":"10.1016\/j.bmc.2026.118587_bb0085","doi-asserted-by":"crossref","first-page":"29448","DOI":"10.1021\/acsomega.3c02979","article-title":"Effect of colchicine binding site inhibitors on the tubulin Intersubunit interaction","volume":"8","author":"Sargsyan","year":"2023","journal-title":"ACS Omega"},{"key":"10.1016\/j.bmc.2026.118587_bb0090","doi-asserted-by":"crossref","first-page":"2943","DOI":"10.1007\/s11095-012-0828-z","article-title":"An overview of tubulin inhibitors that interact with the colchicine binding site","volume":"29","author":"Lu","year":"2012","journal-title":"Pharm Res"},{"key":"10.1016\/j.bmc.2026.118587_bb0095","doi-asserted-by":"crossref","first-page":"4060","DOI":"10.1016\/j.apsb.2023.05.035","article-title":"Small molecules targeting protein\u2013protein interactions for cancer therapy","volume":"13","author":"Wu","year":"2023","journal-title":"Acta Pharm Sin B"},{"key":"10.1016\/j.bmc.2026.118587_bb0100","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/s41392-020-00315-3","article-title":"Recent advances in the development of protein\u2013protein interactions modulators: mechanisms and clinical trials","volume":"5","author":"Lu","year":"2020","journal-title":"Signal Transduct Target Ther"},{"key":"10.1016\/j.bmc.2026.118587_bb0105","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.chembiol.2013.01.014","article-title":"The binding sites of microtubule-stabilizing agents","volume":"20","author":"Field","year":"2013","journal-title":"Chem Biol"},{"key":"10.1016\/j.bmc.2026.118587_bb0110","doi-asserted-by":"crossref","first-page":"6396","DOI":"10.1021\/acs.jcim.3c00939","article-title":"Identification of novel \u03b2-tubulin inhibitors using a combined in silico\/in vitro approach","volume":"63","author":"Horgan","year":"2023","journal-title":"J Chem Inf Model"},{"key":"10.1016\/j.bmc.2026.118587_bb0115","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.drudis.2021.12.001","article-title":"Molecular interactions at the colchicine binding site in tubulin: an X-ray crystallography perspective","volume":"27","author":"Wang","year":"2022","journal-title":"Drug Discov Today"},{"key":"10.1016\/j.bmc.2026.118587_bb0120","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1021\/acs.jnatprod.9b00105","article-title":"Microtubule-targeting drugs: more than Antimitotics","volume":"82","author":"Kaul","year":"2019","journal-title":"J Nat Prod"},{"key":"10.1016\/j.bmc.2026.118587_bb0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2021.105320","article-title":"Microtubule associated proteins as targets for anticancer drug development","volume":"116","author":"Khwaja","year":"2021","journal-title":"Bioorg Chem"},{"key":"10.1016\/j.bmc.2026.118587_bb0130","doi-asserted-by":"crossref","first-page":"2076","DOI":"10.1016\/j.drudis.2019.06.014","article-title":"Drug repurposing: a promising tool to accelerate the drug discovery process","volume":"24","author":"Parvathaneni","year":"2019","journal-title":"Drug Discov Today"},{"key":"10.1016\/j.bmc.2026.118587_bb0135","series-title":"Drug Repurposing","author":"Poduri","year":"2023"},{"key":"10.1016\/j.bmc.2026.118587_bb0140","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/nrd.2018.168","article-title":"Drug repurposing: progress, challenges and recommendations","volume":"18","author":"Pushpakom","year":"2019","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.bmc.2026.118587_bb0145","doi-asserted-by":"crossref","DOI":"10.3389\/fddsv.2024.1460100","article-title":"How drug repurposing can advance drug discovery: challenges and opportunities","volume":"4","author":"Pinzi","year":"2024","journal-title":"Front Drug Discov"},{"key":"10.1016\/j.bmc.2026.118587_bb0150","doi-asserted-by":"crossref","DOI":"10.1111\/cbdd.14639","article-title":"Exploring the artificial intelligence and its impact in pharmaceutical sciences: insights toward the horizons where technology meets tradition","volume":"104","author":"Bharadwaj","year":"2024","journal-title":"Chem Biol Drug Des"},{"key":"10.1016\/j.bmc.2026.118587_bb0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejps.2022.106324","article-title":"CADD, AI and ML in drug discovery: a comprehensive review","volume":"181","author":"Vemula","year":"2023","journal-title":"Eur J Pharm Sci"},{"key":"10.1016\/j.bmc.2026.118587_bb0160","doi-asserted-by":"crossref","first-page":"2691","DOI":"10.2147\/DDDT.S424991","article-title":"The coming of age of AI\/ML in drug discovery, development, clinical testing, and manufacturing: the FDA perspectives","author":"Niazi","year":"2023","journal-title":"Drug Des Devel Ther"},{"key":"10.1016\/j.bmc.2026.118587_bb0165","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1038\/s41420-025-02679-3","article-title":"Discovery of a novel potent tubulin inhibitor through virtual screening and target validation for cancer chemotherapy","volume":"11","author":"Shan","year":"2025","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.bmc.2026.118587_bb0170","doi-asserted-by":"crossref","first-page":"4138","DOI":"10.1039\/D4MD00461B","article-title":"Repurposing of USFDA-approved drugs to identify leads for inhibition of acetylcholinesterase enzyme: a plausible utility as an anti-Alzheimer agent","volume":"15","author":"Goel","year":"2024","journal-title":"RSC Med Chem"},{"key":"10.1016\/j.bmc.2026.118587_bb0175","doi-asserted-by":"crossref","first-page":"D930","DOI":"10.1093\/nar\/gky1075","article-title":"ChEMBL: towards direct deposition of bioassay data","volume":"47","author":"Mendez","year":"2019","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.bmc.2026.118587_bb0180","series-title":"Schr\u00f6dinger Release 2024\u20132: LigPrep","year":"2024"},{"key":"10.1016\/j.bmc.2026.118587_bb0185","series-title":"Schr\u00f6dinger Release 2024\u20132: Maestro","year":"2024"},{"key":"10.1016\/j.bmc.2026.118587_bb0190","doi-asserted-by":"crossref","first-page":"6582","DOI":"10.1021\/jm300687e","article-title":"Directory of useful decoys, enhanced (DUD-E): better ligands and decoys for better benchmarking","volume":"55","author":"Mysinger","year":"2012","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2026.118587_bb0195","doi-asserted-by":"crossref","first-page":"6734","DOI":"10.1021\/acs.jmedchem.9b00706","article-title":"Structure-guided design, synthesis, and biological evaluation of (2-(1H-Indol-3-yl)-1H-imidazol-4-yl)(3,4,5-trimethoxyphenyl) Methanone (ABI-231) analogues targeting the colchicine binding site in tubulin","volume":"62","author":"Wang","year":"2019","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2026.118587_bb0200","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1093\/nar\/28.1.235","article-title":"The Protein Data Bank","volume":"28","author":"Berman","year":"2000","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.bmc.2026.118587_bb0205","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/s10822-013-9644-8","article-title":"Protein and ligand preparation: parameters, protocols, and influence on virtual screening enrichments","volume":"27","author":"Madhavi Sastry","year":"2013","journal-title":"J Comput Aided Mol Des"},{"key":"10.1016\/j.bmc.2026.118587_bb0210","doi-asserted-by":"crossref","DOI":"10.1021\/acsomega.2c08025","article-title":"Binding analysis and structure-based design of tricyclic coumarin-derived MTHFD2 inhibitors as anticancer agents: insights from computational modeling","author":"Jha","year":"2023","journal-title":"ACS Omega"},{"key":"10.1016\/j.bmc.2026.118587_bb0215","series-title":"Schr\u00f6dinger Release 2024-2: Protein Preparation Wizard; Epik, Schr\u00f6dinger, LLC, New York, NY, 2024","year":"2023"},{"key":"10.1016\/j.bmc.2026.118587_bb0220","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1007\/s10822-010-9349-1","article-title":"Towards the comprehensive, rapid, and accurate prediction of the favorable tautomeric states of drug-like molecules in aqueous solution","volume":"24","author":"Greenwood","year":"2010","journal-title":"J Comput Aided Mol Des"},{"key":"10.1016\/j.bmc.2026.118587_bb0225","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1007\/s10822-007-9133-z","article-title":"Epik: a software program for pKaprediction and protonation state generation for drug-like molecules","volume":"21","author":"Shelley","year":"2007","journal-title":"J Comput Aided Mol Des"},{"key":"10.1016\/j.bmc.2026.118587_bb0230","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1021\/ct100578z","article-title":"PROPKA3: consistent treatment of internal and surface residues in empirical pKa predictions","volume":"7","author":"Olsson","year":"2011","journal-title":"J Chem Theory Comput"},{"key":"10.1016\/j.bmc.2026.118587_bb0235","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1472-6807-11-6","article-title":"Graphical analysis of pH-dependent properties of proteins predicted using PROPKA","volume":"11","author":"Rostkowski","year":"2011","journal-title":"BMC Struct Biol"},{"key":"10.1016\/j.bmc.2026.118587_bb0240","doi-asserted-by":"crossref","first-page":"4291","DOI":"10.1021\/acs.jctc.1c00302","article-title":"OPLS4: improving force Field accuracy on challenging regimes of chemical space","volume":"17","author":"Lu","year":"2021","journal-title":"J Chem Theory Comput"},{"key":"10.1016\/j.bmc.2026.118587_bb0245","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1021\/ja00214a001","article-title":"The OPLS [optimized potentials for liquid simulations] potential functions for proteins, energy minimizations for crystals of cyclic peptides and crambin","volume":"110","author":"Jorgensen","year":"1988","journal-title":"J Am Chem Soc"},{"key":"10.1016\/j.bmc.2026.118587_bb0250","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1021\/jm0306430","article-title":"Glide: a new approach for rapid, accurate docking and scoring. 1. Method and assessment of docking accuracy","volume":"47","author":"Friesner","year":"2004","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2026.118587_bb0255","doi-asserted-by":"crossref","first-page":"6177","DOI":"10.1021\/jm051256o","article-title":"Extra precision glide: docking and scoring incorporating a model of hydrophobic enclosure for protein\u2212ligand complexes","volume":"49","author":"Friesner","year":"2006","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2026.118587_bb0260","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1023\/A:1008763014207","article-title":"Combined molecular mechanical and continuum solvent approach (MM-PBSA\/GBSA) to predict ligand binding","volume":"18","author":"Massova","year":"2000","journal-title":"Perspect Drug Discovery Des"},{"key":"10.1016\/j.bmc.2026.118587_bb0265","series-title":"SC \u201806: Proceedings of the 2006 ACM\/IEEE Conference on Supercomputing","first-page":"43","article-title":"Scalable Algorithms for Molecular Dynamics Simulations on Commodity Clusters","author":"Bowers","year":"2006"},{"key":"10.1016\/j.bmc.2026.118587_bb0270","series-title":"Schr\u00f6dinger Release 2024-2: Desmond Molecular Dynamics System, D. E. Shaw Research, New York, NY, 2021","year":"2024"},{"key":"10.1016\/j.bmc.2026.118587_bb0275","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1063\/1.445869","article-title":"Comparison of simple potential functions for simulating liquid water","volume":"79","author":"Jorgensen","year":"1983","journal-title":"J Chem Phys"},{"key":"10.1016\/j.bmc.2026.118587_bb0280","doi-asserted-by":"crossref","first-page":"2635","DOI":"10.1063\/1.463940","article-title":"Nos\u00e9\u2013Hoover chains: the canonical ensemble via continuous dynamics","volume":"97","author":"Martyna","year":"1992","journal-title":"J Chem Phys"},{"key":"10.1016\/j.bmc.2026.118587_bb0285","doi-asserted-by":"crossref","first-page":"2358","DOI":"10.1103\/PhysRevB.44.2358","article-title":"Invariant molecular-dynamics approach to structural phase transitions","volume":"44","author":"Wentzcovitch","year":"1991","journal-title":"Phys Rev B"},{"key":"10.1016\/j.bmc.2026.118587_bb0290","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1063\/1.447334","article-title":"A unified formulation of the constant temperature molecular dynamics methods","volume":"81","author":"Nos\u00e9","year":"1984","journal-title":"J Chem Phys"},{"key":"10.1016\/j.bmc.2026.118587_bb0295","first-page":"165109008","article-title":"Mechanism-guided discovery of chromene-chalcone hybrids targeting PKM2 and microtubules for breast cancer therapy","author":"Katiyar","year":"2025","journal-title":"Bioorg Chem"},{"key":"10.1016\/j.bmc.2026.118587_bb0300","doi-asserted-by":"crossref","first-page":"1996","DOI":"10.1080\/14756366.2021.1975695","article-title":"Discovery of facile amides-functionalized rhodanine-3-acetic acid derivatives as potential anticancer agents by disrupting microtubule dynamics","volume":"36","author":"Zhou","year":"2021","journal-title":"J Enzyme Inhib Med Chem"},{"key":"10.1016\/j.bmc.2026.118587_bb0305","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2019.103409","article-title":"E-pharmacophore guided discovery of pyrazolo [1, 5-c] quinazolines as dual inhibitors of topoisomerase-I and histone deacetylase","volume":"94","author":"Joshi","year":"2020","journal-title":"Bioorg Chem"},{"key":"10.1016\/j.bmc.2026.118587_bb0310","doi-asserted-by":"crossref","first-page":"2849","DOI":"10.1021\/acs.jmedchem.4c02135","article-title":"Design and synthesis of topoisomerases-histone deacetylase dual targeted quinoline-bridged hydroxamates as anticancer agents","volume":"68","author":"Joshi","year":"2025","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2026.118587_bb0315","series-title":"Cell Viability Assays: Methods and Protocols","first-page":"1","article-title":"Basic colorimetric proliferation assays: MTT, WST, and resazurin","author":"Pr\u00e4bst","year":"2017"},{"key":"10.1016\/j.bmc.2026.118587_bb0320","article-title":"Standard operating procedure to optimize resazurin-based viability assays","volume":"14","author":"Petiti","year":"2024","journal-title":"Biosensors (Basel)"},{"key":"10.1016\/j.bmc.2026.118587_bb0325","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.78330","article-title":"Microtubules restrict F-actin polymerization to the immune synapse via GEF-H1 to maintain polarity in lymphocytes","volume":"11","author":"Pineau","year":"2022","journal-title":"Elife"},{"key":"10.1016\/j.bmc.2026.118587_bb0330","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.4155\/fmc-2016-0093","article-title":"Autoqsar: an automated machine learning tool for best-practice quantitative structure\u2013activity relationship modeling","volume":"8","author":"Dixon","year":"2016","journal-title":"Future Med Chem"}],"container-title":["Bioorganic & Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S096808962600043X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S096808962600043X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T10:29:52Z","timestamp":1776162592000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S096808962600043X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":66,"alternative-id":["S096808962600043X"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2026.118587","relation":{},"ISSN":["0968-0896"],"issn-type":[{"value":"0968-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Machine learning-driven computational drug repurposing to identify new tubulin inhibitors against cancer","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2026.118587","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"118587"}}