{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T20:26:58Z","timestamp":1783110418000,"version":"3.54.6"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100011074","name":"Universit\u00e9 de Lyon","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011074","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.bmc.2026.118709","type":"journal-article","created":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T14:47:42Z","timestamp":1779029262000},"page":"118709","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Design and evaluation of the bactericidal activity of new hydroxamic acid and hydrazide derivatives against mature S. aureus biofilms"],"prefix":"10.1016","volume":"139","author":[{"given":"Ma\u00ebva","family":"Corneiller","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison","family":"Faure","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00e9my","family":"Tisserand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathilde","family":"Bion","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayat","family":"Dahi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manon","family":"Garcia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Hall\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Soler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Leblond-Bourget","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9r\u00f4me","family":"Josse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Lomberget","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"Radix","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Garrido","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.bmc.2026.118709_bb0005","doi-asserted-by":"crossref","first-page":"2546","DOI":"10.1021\/acs.biomac.0c00449","article-title":"Hydroxamic acid: an underrated moiety? Marrying bioinorganic chemistry and polymer science","volume":"21","author":"Keth","year":"2020","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.bmc.2026.118709_bb0010","doi-asserted-by":"crossref","DOI":"10.1002\/hlca.202300133","article-title":"Hydroxamic acids as PARP-1 inhibitors: molecular design and anticancer activity of novel phenanthridinones","author":"Bondar","year":"2023","journal-title":"Helv Chim Acta"},{"key":"10.1016\/j.bmc.2026.118709_bb0015","doi-asserted-by":"crossref","DOI":"10.1002\/9780470682531.pat0515","article-title":"Hydroxamic acids: biological properties and potential uses as therapeutic agents","author":"Mai","year":"2010","journal-title":"Patai\u2019s Chemistry of Functional Groups"},{"key":"10.1016\/j.bmc.2026.118709_bb0020","first-page":"75","article-title":"A review on hydroxamic acids: wide spectrum chemotherapeutic agents","volume":"14","author":"Syed","year":"2020","journal-title":"Int J Biol Biomed Eng"},{"key":"10.1016\/j.bmc.2026.118709_bb0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmcl.2025.130257","article-title":"Design and synthesis of novel sulfanilamide derivatives as aminopeptidase N inhibitors","volume":"124","author":"Zhu","year":"2025","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmc.2026.118709_bb0030","article-title":"Drug discovery for histone deacetylase inhibition: past, present and future of zinc-binding groups","volume":"18","author":"Salgado Pires","year":"2025","journal-title":"Pharmaceuticals Basel"},{"issue":"34","key":"10.1016\/j.bmc.2026.118709_bb0035","doi-asserted-by":"crossref","first-page":"21843","DOI":"10.1021\/acsomega.1c03628","article-title":"Hydroxamic acid derivatives: from synthetic strategies to medicinal chemistry applications","volume":"6","author":"Citarella","year":"2021","journal-title":"ACS Omega"},{"key":"10.1016\/j.bmc.2026.118709_bb0040","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2023.1210747","article-title":"Potential additional effects of iron chelators on antimicrobial- impregnated central venous catheters","volume":"14","author":"Itoh","year":"2023","journal-title":"Front Microbiol"},{"issue":"8","key":"10.1016\/j.bmc.2026.118709_bb0045","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/microorganisms8081222","article-title":"Targeting biofilms therapy: current research strategies and development hurdles","volume":"8","author":"Jiang","year":"2020","journal-title":"Microorganisms"},{"issue":"21","key":"10.1016\/j.bmc.2026.118709_bb0050","doi-asserted-by":"crossref","first-page":"4933","DOI":"10.1016\/j.bmcl.2015.04.099","article-title":"Syntheses and evaluation of substituted aromatic hydroxamates and hydroxamic acids that target Mycobacterium tuberculosis","volume":"25","author":"Majewski","year":"2015","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmc.2026.118709_bb0055","doi-asserted-by":"crossref","first-page":"6210","DOI":"10.1021\/acs.jmedchem.4c02517","article-title":"Hybrid molecules of benzothiazole and hydroxamic acid as dual-acting biofilm inhibitors with antibacterial synergistic effect against Pseudomonas aeruginosa infections","volume":"68","author":"Zhang","year":"2025","journal-title":"J Med Chem"},{"issue":"1","key":"10.1016\/j.bmc.2026.118709_bb0060","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1080\/21505594.2017.1313372","article-title":"Strategies for combating bacterial biofilms: a focus on anti-biofilm agents and their mechanisms of action","volume":"9","author":"Roy","year":"2017","journal-title":"Virulence"},{"issue":"1","key":"10.1016\/j.bmc.2026.118709_bb0065","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41522-023-00427-y","article-title":"Strategy to combat biofilms: a focus on biofilm dispersal enzymes","volume":"9","author":"Wang","year":"2023","journal-title":"NPJ Biofilms Microbiomes"},{"issue":"1","key":"10.1016\/j.bmc.2026.118709_bb0070","doi-asserted-by":"crossref","DOI":"10.1038\/s44259-024-00046-3","article-title":"Mechanisms of antimicrobial resistance in biofilms","volume":"2","author":"Liu","year":"2024","journal-title":"npj Antimicrob Resist"},{"issue":"6","key":"10.1016\/j.bmc.2026.118709_bb0075","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1093\/jac\/dkaa061","article-title":"Antibiofilm and intraosteoblastic activities of rifamycins against staphylococcus aureus: promising in vitro profile of rifabutin","volume":"75","author":"Abad","year":"2020","journal-title":"J Antimicrob Chemother"},{"issue":"16","key":"10.1016\/j.bmc.2026.118709_bb0080","doi-asserted-by":"crossref","first-page":"13512","DOI":"10.1021\/acs.jmedchem.4c00541","article-title":"Hydrazides as inhibitors of histone deacetylases","volume":"67","author":"do Carreiras","year":"2024","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2026.118709_bb0085","doi-asserted-by":"crossref","first-page":"14171","DOI":"10.1021\/acs.jmedchem.5c01677","article-title":"Advancements in hydrazide-based HDAC inhibitors: a review of recent developments and therapeutic potential","volume":"68","author":"Raucci","year":"2025","journal-title":"J Med Chem"},{"issue":"4","key":"10.1016\/j.bmc.2026.118709_bb0090","doi-asserted-by":"crossref","first-page":"349","DOI":"10.2174\/1389557033488114","article-title":"Molecular diversity of hydroxamic acids: Part I. Solution- and solid-phase synthesis","volume":"3","author":"Yang","year":"2005","journal-title":"Mini-Rev Med Chem"},{"issue":"9","key":"10.1016\/j.bmc.2026.118709_bb0095","doi-asserted-by":"crossref","first-page":"978","DOI":"10.2174\/1385272823666190424142821","article-title":"Methods for hydroxamic acid synthesis","volume":"23","author":"Alam","year":"2019","journal-title":"Curr Org Chem"},{"issue":"24","key":"10.1016\/j.bmc.2026.118709_bb0100","doi-asserted-by":"crossref","first-page":"5685","DOI":"10.1021\/jo00259a014","article-title":"Synthesis of 2-substituted imidazoles and benzimidazoles and of 3-substituted pyrazoles by lithiation of N-(dialkylamino)methyl heterocycles","volume":"53","author":"Katritzky","year":"1988","journal-title":"J Org Chem"},{"issue":"1","key":"10.1016\/j.bmc.2026.118709_bb0105","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1038\/s44259-023-00016-1","article-title":"Tackling the outer membrane: facilitating compound entry into Gram-negative bacterial pathogens","volume":"1","author":"Saxena","year":"2023","journal-title":"npj Antimicrob Resist"},{"issue":"3","key":"10.1016\/j.bmc.2026.118709_bb0110","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1128\/MMBR.00013-14","article-title":"Biofilm-related infections: bridging the gap between clinical management and fundamental aspects of recalcitrance toward antibiotics","volume":"78","author":"Lebeaux","year":"2014","journal-title":"Microbiol Mol Biol Rev"},{"issue":"6","key":"10.1016\/j.bmc.2026.118709_bb0115","doi-asserted-by":"crossref","first-page":"549","DOI":"10.3390\/antibiotics13060549","article-title":"Stability studies of the dilution series of different antibiotic stock solutions in culture medium incubated at 37\u00b0C","volume":"13","author":"Kerek","year":"2024","journal-title":"Antibiotics"},{"key":"10.1016\/j.bmc.2026.118709_bb0120","doi-asserted-by":"crossref","DOI":"10.3389\/fmedt.2023.1195529","article-title":"Toxic or not toxic? The specifications of the standard ISO 10993-5 are not explicit enough to yield comparable results in the cytotoxicity assessment of an identical medical device","volume":"5","author":"Gruber","year":"2023","journal-title":"Front Med Technol"},{"issue":"7","key":"10.1016\/j.bmc.2026.118709_bb0125","doi-asserted-by":"crossref","first-page":"2719","DOI":"10.1021\/jm901137j","article-title":"New substructure filters for removal of Pan assay interference compounds (PAINS) from screening libraries and for their exclusion in bioassays","volume":"53","author":"Baell","year":"2010","journal-title":"J Med Chem"},{"issue":"9","key":"10.1016\/j.bmc.2026.118709_bb0130","doi-asserted-by":"crossref","first-page":"2176","DOI":"10.1021\/om100106e","article-title":"NMR chemical shifts of trace impurities: common laboratory solvents, organics, and gases in deuterated solvents relevant to the organometallic chemist","volume":"29","author":"Fulmer","year":"2010","journal-title":"Organometallics"},{"issue":"2","key":"10.1016\/j.bmc.2026.118709_bb0135","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/S0968-0896(00)00265-0","article-title":"New antimetastatic hypoxic cell radiosensitizers: design, synthesis, and biological activities of 2-nitroimidazole-acetamide, TX-1877, and its analogues","volume":"9","author":"Kasai","year":"2001","journal-title":"Bioorg Med Chem"},{"issue":"5","key":"10.1016\/j.bmc.2026.118709_bb0140","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1021\/acschembio.0c00894","article-title":"Endogenous enzymes enable antimicrobial activity","volume":"16","author":"Hetrick","year":"2021","journal-title":"ACS Chem Biol"},{"issue":"1","key":"10.1016\/j.bmc.2026.118709_bb0145","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-018-31437-y","article-title":"A steam-based method to investigate biofilm","volume":"8","author":"Tasse","year":"2018","journal-title":"Sci Rep"},{"issue":"2","key":"10.1016\/j.bmc.2026.118709_bb0150","doi-asserted-by":"crossref","first-page":"89","DOI":"10.2165\/00003088-200948020-00002","article-title":"Penetration of antibacterials into bone: pharmacokinetic, pharmacodynamic and bioanalytical considerations","volume":"48","author":"Landersdorfer","year":"2009","journal-title":"Clin Pharmacokinet"}],"container-title":["Bioorganic & Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089626001653?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089626001653?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T20:09:48Z","timestamp":1783109388000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0968089626001653"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":30,"alternative-id":["S0968089626001653"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2026.118709","relation":{},"ISSN":["0968-0896"],"issn-type":[{"value":"0968-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Design and evaluation of the bactericidal activity of new hydroxamic acid and hydrazide derivatives against mature S. aureus biofilms","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2026.118709","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"118709"}}