{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T00:15:35Z","timestamp":1783124135935,"version":"3.54.6"},"reference-count":59,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2020JJ5786"],"award-info":[{"award-number":["2020JJ5786"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002822","name":"Central South University","doi-asserted-by":"publisher","award":["2024ZZTS0334"],"award-info":[{"award-number":["2024ZZTS0334"]}],"id":[{"id":"10.13039\/501100002822","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002822","name":"Central South University","doi-asserted-by":"publisher","award":["2026ZZTS0159"],"award-info":[{"award-number":["2026ZZTS0159"]}],"id":[{"id":"10.13039\/501100002822","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81903470"],"award-info":[{"award-number":["81903470"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic &amp; Medicinal Chemistry"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.bmc.2026.118719","type":"journal-article","created":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T05:30:37Z","timestamp":1780119037000},"page":"118719","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Design, synthesis, and evaluation of 4-(aminomethyl)-2-(phenylamino)pyridine derivatives as novel lysyl oxidase-like 2 inhibitors against metastatic melanoma"],"prefix":"10.1016","volume":"140","author":[{"given":"Geng","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaoren","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dejun","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guishan","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongsheng","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youchao","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fenghua","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmc.2026.118719_bb0005","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.pathol.2022.11.006","article-title":"Metastatic melanoma and rare melanoma variants: a review","volume":"55","author":"Lowe","year":"2023","journal-title":"Pathology"},{"key":"10.1016\/j.bmc.2026.118719_bb0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.preteyeres.2022.101041","article-title":"Metastatic uveal melanoma: the final frontier","volume":"90","author":"Rantala","year":"2022","journal-title":"Prog Retin Eye Res"},{"key":"10.1016\/j.bmc.2026.118719_bb0015","doi-asserted-by":"crossref","first-page":"22474","DOI":"10.18632\/aging.203554","article-title":"Identification of genes and pathways leading to metastasis and poor prognosis in melanoma","volume":"13","author":"Zhang","year":"2021","journal-title":"Aging-Us"},{"key":"10.1016\/j.bmc.2026.118719_bb0020","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.critrevonc.2018.03.005","article-title":"Recent developments and obstacles in the treatment of melanoma with BRAF and MEK inhibitors","volume":"125","author":"Wahid","year":"2018","journal-title":"Crit Rev Oncol Hematol"},{"key":"10.1016\/j.bmc.2026.118719_bb0025","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1007\/s40257-025-00969-1","article-title":"The challenge of treating anti-PD-1-resistant advanced melanoma","volume":"26","author":"Vestergaard","year":"2025","journal-title":"Am J Clin Dermatol"},{"key":"10.1016\/j.bmc.2026.118719_bb0030","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.abb.2013.12.022","article-title":"Human copper-dependent amine oxidases","volume":"546","author":"Finney","year":"2014","journal-title":"Arch Biochem Biophys"},{"key":"10.1016\/j.bmc.2026.118719_bb0035","doi-asserted-by":"crossref","first-page":"1900119","DOI":"10.1002\/adtp.201900119","article-title":"Lysyl oxidase like-2 (LOXL2): an emerging oncology target","volume":"3","author":"Chopra","year":"2020","journal-title":"Adv Ther"},{"key":"10.1016\/j.bmc.2026.118719_bb0040","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1073\/pnas.61.2.708","article-title":"The cross-linking of collagen and elastin: enzymatic conversion of lysine in peptide linkage to alpha-aminoadipic-delta-semialdehyde (allysine) by an extract from bone","volume":"61","author":"Pinnell","year":"1968","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.bmc.2026.118719_bb0045","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1007\/s12672-025-02456-9","article-title":"The increased matrix stiffness caused by LOXL2 activates piezo1 channels to promote the migration and invasion of cervical cancer cells","volume":"16","author":"Liu","year":"2025","journal-title":"Discov Oncol"},{"key":"10.1016\/j.bmc.2026.118719_bb0050","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1158\/0008-5472.CAN-23-0127","article-title":"Correction: lysyl oxidase-like protein LOXL2 promotes lung metastasis of breast cancer","volume":"83","author":"Salvador","year":"2023","journal-title":"Cancer Res"},{"key":"10.1016\/j.bmc.2026.118719_bb0055","series-title":"Correction: tumor-secreted LOXL2 activates fibroblasts through FAK signaling, Mol Cancer Res","first-page":"2141","volume":"17","year":"2019"},{"key":"10.1016\/j.bmc.2026.118719_bb0060","doi-asserted-by":"crossref","DOI":"10.1177\/0300060520931242","article-title":"Epithelial-mesenchymal transition and metastasis of colon cancer cells induced by the FAK pathway in cancer-associated fibroblasts","volume":"48","author":"Xuefeng","year":"2020","journal-title":"J Int Med Res"},{"key":"10.1016\/j.bmc.2026.118719_bb0065","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.ejbt.2023.01.002","article-title":"LOXL2 promotes tumor proliferation and metastasis by FAK\/src signaling in esophageal squamous cell carcinoma","volume":"63","author":"Liu","year":"2023","journal-title":"Electron J Biotechnol"},{"key":"10.1016\/j.bmc.2026.118719_bb0070","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/j.cell.2009.10.027","article-title":"Matrix crosslinking forces tumor progression by enhancing integrin signaling","volume":"139","author":"Levental","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.bmc.2026.118719_bb0075","doi-asserted-by":"crossref","first-page":"2699","DOI":"10.2147\/OTT.S164056","article-title":"Clinical relevance of lysyl oxidase-like 2 and functional mechanisms in glioma","volume":"11","author":"Du","year":"2018","journal-title":"Onco Targets Ther"},{"key":"10.1016\/j.bmc.2026.118719_bb0080","doi-asserted-by":"crossref","first-page":"8947","DOI":"10.2147\/OTT.S217794","article-title":"LOXL 2 promotes the epithelial-mesenchymal transition and malignant progression of cervical cancer","volume":"12","author":"Tian","year":"2019","journal-title":"Onco Targets Ther"},{"key":"10.1016\/j.bmc.2026.118719_bb0085","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1097\/CMR.0b013e328336edfe","article-title":"Lysyl oxidase expression and inhibition in uveal melanoma","volume":"20","author":"Abourbih","year":"2010","journal-title":"Melanoma Res"},{"key":"10.1016\/j.bmc.2026.118719_bb0090","doi-asserted-by":"crossref","first-page":"20713","DOI":"10.1002\/jcp.28677","article-title":"Prognostic utility and clinical significance of lysyl oxidase-like 2 protein expression in digestive system cancers","volume":"234","author":"Zhang","year":"2019","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.bmc.2026.118719_bb0095","doi-asserted-by":"crossref","first-page":"80325","DOI":"10.18632\/oncotarget.18170","article-title":"Role of LOXL2 in the epithelial-mesenchymal transition and colorectal cancer metastasis","volume":"8","author":"Park","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.bmc.2026.118719_bb0100","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1093\/carcin\/bgp178","article-title":"Secreted LOXL2 is a novel therapeutic target that promotes gastric cancer metastasis via the src\/FAK pathway","volume":"30","author":"Peng","year":"2009","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.bmc.2026.118719_bb0105","doi-asserted-by":"crossref","first-page":"312","DOI":"10.3390\/antiox10020312","article-title":"LOXL2 inhibitors and breast cancer progression","volume":"10","author":"Ferreira","year":"2021","journal-title":"Antioxidants(Basel)."},{"key":"10.1016\/j.bmc.2026.118719_bb0110","doi-asserted-by":"crossref","first-page":"11745","DOI":"10.3390\/ijms241411745","article-title":"Multiple roles of LOXL2 in the progression of hepatocellular carcinoma and its potential for therapeutic targeting","volume":"24","author":"Radi\u0107","year":"2023","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.bmc.2026.118719_bb0115","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1038\/nrc3319","article-title":"The rationale for targeting the LOX family in cancer","volume":"12","author":"Barker","year":"2012","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.bmc.2026.118719_bb0120","doi-asserted-by":"crossref","first-page":"2308","DOI":"10.1021\/acs.jmedchem.9b01112","article-title":"2-aminomethylene-5-sulfonylthiazole inhibitors of lysyl oxidase (LOX) and LOXL2 show significant efficacy in delaying tumor growth","volume":"63","author":"Smithen","year":"2020","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2026.118719_bb0125","doi-asserted-by":"crossref","first-page":"5863","DOI":"10.1021\/acs.jmedchem.9b00335","article-title":"Anti-metastatic inhibitors of lysyl oxidase (LOX): design and structure-activity relationships","volume":"62","author":"Leung","year":"2019","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2026.118719_bb0130","doi-asserted-by":"crossref","first-page":"9874","DOI":"10.1021\/acs.jmedchem.9b01283","article-title":"Identification and optimization of mechanism-based fluoroallylamine inhibitors of lysyl oxidase-like 2\/3","volume":"62","author":"Findlay","year":"2019","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2026.118719_bb0135","doi-asserted-by":"crossref","first-page":"26066","DOI":"10.18632\/oncotarget.15257","article-title":"Pre-clinical evaluation of small molecule LOXL2 inhibitors in breast cancer","volume":"8","author":"Chang","year":"2017","journal-title":"Oncotarget"},{"issue":"3","key":"10.1016\/j.bmc.2026.118719_bb0140","doi-asserted-by":"crossref","first-page":"491","DOI":"10.3390\/cancers13030491","article-title":"Targeting lysyl oxidase family meditated matrix cross-linking as an anti-stromal therapy in solid tumours","volume":"13","author":"Setargew","year":"2021","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.bmc.2026.118719_bb0145","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1111\/jcmm.14074","article-title":"The lysyl oxidase like 2\/3 enzymatic inhibitor, PXS-5153a, reduces crosslinks and ameliorates fibrosis","volume":"23","author":"Schilter","year":"2019","journal-title":"J Cell Mol Med"},{"key":"10.1016\/j.bmc.2026.118719_bb0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.jinorgbio.2020.111204","article-title":"Reaction mechanism of lysyl oxidase-like 2 (LOXL2) studied by computational methods","volume":"211","author":"Dong","year":"2020","journal-title":"J Inorg Biochem"},{"key":"10.1016\/j.bmc.2026.118719_bb0155","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.bioorg.2014.07.003","article-title":"Human lysyl oxidase-like 2","volume":"57","author":"Moon","year":"2014","journal-title":"Bioorg Chem"},{"key":"10.1016\/j.bmc.2026.118719_bb0160","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1021\/acsmedchemlett.7b00014","article-title":"Small molecule lysyl oxidase-like 2 (LOXL2) inhibitors: the identification of an inhibitor selective for LOXL2 over LOX","volume":"8","author":"Hutchinson","year":"2017","journal-title":"ACS Med Chem Lett"},{"key":"10.1016\/j.bmc.2026.118719_bb0165","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/0022-4804(79)90134-3","article-title":"Effects of low-dose BAPN on wound healing","volume":"27","author":"Arem","year":"1979","journal-title":"J Surg Res"},{"key":"10.1016\/j.bmc.2026.118719_bb0170","first-page":"2664","article-title":"Significance of lysyl oxidase-like 2 gene expression on the epithelial-mesenchymal status of hepatocellular carcinoma","volume":"39","author":"Ninomiya","year":"2018","journal-title":"Oncol Rep"},{"key":"10.1016\/j.bmc.2026.118719_bb0175","doi-asserted-by":"crossref","first-page":"26547","DOI":"10.1021\/acs.jmedchem.5c03039","article-title":"Design and optimization of LOXL2 and sGC dual-target regulators targeting extracellular matrix dysregulation and vasodilation for the treatment of pulmonary arterial hypertension","volume":"68","author":"Hu","year":"2025","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2026.118719_bb0180","doi-asserted-by":"crossref","first-page":"4403","DOI":"10.1021\/acs.jmedchem.7b00345","article-title":"Identification of 4-(aminomethyl)-6-(trifluoromethyl)-2-(phenoxy)pyridine derivatives as potent, selective, and orally efficacious inhibitors of the copper-dependent amine oxidase, lysyl oxidase-like 2 (LOXL2)","volume":"60","author":"Rowbottom","year":"2017","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2026.118719_bb0185","first-page":"3","article-title":"A novel polyamine-targeted therapy for BRAF mutant melanoma tumors","volume":"6","author":"Peters","year":"2018","journal-title":"Med Sci (Basel Switz)"},{"key":"10.1016\/j.bmc.2026.118719_bb0190","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.3724\/abbs.2025030","article-title":"Antitumor potential of polyamines in cancer","volume":"57","author":"Liu","year":"2025","journal-title":"Acta Bioch Bioph Sin"},{"key":"10.1016\/j.bmc.2026.118719_bb0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2020.112951","article-title":"Design, synthesis and antitumor evaluation of new 1,8-naphthalimide derivatives targeting nuclear DNA","volume":"210","author":"Liang","year":"2021","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2026.118719_bb0200","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1016\/j.jtho.2020.09.001","article-title":"Safety, efficacy, and pharmacokinetics of almonertinib (HS-10296) in pretreated patients with EGFR-mutated advanced NSCLC: a multicenter, open-label, phase 1 trial","volume":"15","author":"Yang","year":"2020","journal-title":"J Thorac Oncol"},{"key":"10.1016\/j.bmc.2026.118719_bb0205","doi-asserted-by":"crossref","first-page":"2339","DOI":"10.2147\/CMAR.S177623","article-title":"UNBS5162 and amonafide inhibits tumor progression in human melanoma by the AKT\/mTOR pathway","volume":"11","author":"Ye","year":"2019","journal-title":"Cancer Manag Res"},{"issue":"22","key":"10.1016\/j.bmc.2026.118719_bb0210","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1039\/p29910001411","article-title":"Photochemically induced electron transfer from aniline derivatives to pyridine-2,4-dicarbonitrile: synthetic and mechanistic aspects","volume":"2","author":"Bernardi","year":"1991","journal-title":"J Chem Soc Perkin Trans"},{"key":"10.1016\/j.bmc.2026.118719_bb0215","doi-asserted-by":"crossref","first-page":"3233","DOI":"10.1016\/j.tetlet.2013.03.085","article-title":"Efficient synthesis of 2-arylamino substituted pyridinyl nitriles by buchwald\u2013hartwig amination","volume":"54","author":"Guo","year":"2013","journal-title":"Tetrahedron Lett"},{"key":"10.1016\/j.bmc.2026.118719_bb0220","doi-asserted-by":"crossref","first-page":"962","DOI":"10.3390\/cancers14040962","article-title":"Modeling the role of cancer-associated fibroblasts in tumor cell invasion","volume":"14","author":"Poon","year":"2022","journal-title":"Cancers"},{"key":"10.1016\/j.bmc.2026.118719_bb0225","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.cell.2011.09.024","article-title":"Tumor metastasis: molecular insights and evolving paradigms","volume":"147","author":"Valastyan","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.bmc.2026.118719_bb0230","doi-asserted-by":"crossref","first-page":"4171","DOI":"10.1039\/C7LC00555E","article-title":"Cell migration in microengineered tumor environments","volume":"17","author":"Um","year":"2017","journal-title":"Lab Chip"},{"key":"10.1016\/j.bmc.2026.118719_bb0235","doi-asserted-by":"crossref","first-page":"5576","DOI":"10.3390\/cancers13215576","article-title":"Metastasis and tumor cell migration of solid tumors","volume":"13","author":"Hoeppner","year":"2021","journal-title":"Cancers"},{"key":"10.1016\/j.bmc.2026.118719_bb0240","doi-asserted-by":"crossref","first-page":"3194","DOI":"10.1002\/hep4.1966","article-title":"Inhibition of lysyl oxidase-like 2 overcomes adhesion-dependent drug resistance in the collagen-enriched liver cancer microenvironment","volume":"6","author":"Gong","year":"2022","journal-title":"Hepatol Commun"},{"key":"10.1016\/j.bmc.2026.118719_bb0245","doi-asserted-by":"crossref","DOI":"10.1016\/j.jtbi.2024.111965","article-title":"A theoretical model for focal adhesion and cytoskeleton formation in non-motile cells","volume":"596","author":"McNicol","year":"2025","journal-title":"J Theor Biol"},{"key":"10.1016\/j.bmc.2026.118719_bb0250","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1038\/nrc3080","article-title":"The physics of cancer: the role of physical interactions and mechanical forces in metastasis","volume":"11","author":"Wirtz","year":"2011","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.bmc.2026.118719_bb0255","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/s13046-023-02929-1","article-title":"RNA-binding protein RPS7 promotes hepatocellular carcinoma progression via LOXL2-dependent activation of ITGB1\/FAK\/SRC signaling","volume":"43","author":"Zhou","year":"2024","journal-title":"J Exp Clin Canc Res"},{"key":"10.1016\/j.bmc.2026.118719_bb0260","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1016\/j.cellsig.2014.05.010","article-title":"Lysyl oxidase-like 2 (LOXL2) controls tumor-associated cell proliferation through the interaction with MARCKSL1","volume":"26","author":"Kim","year":"2014","journal-title":"Cell Signal"},{"key":"10.1016\/j.bmc.2026.118719_bb0265","doi-asserted-by":"crossref","first-page":"2487","DOI":"10.1007\/s12094-023-03133-5","article-title":"Phosphorylation of AKT by lysyl oxidase-like 2 activates the PI3k\/AKT signaling pathway to promote proliferation, invasion and metastasis in esophageal squamous carcinoma","volume":"25","author":"Fan","year":"2023","journal-title":"Clin Transl Oncol"},{"key":"10.1016\/j.bmc.2026.118719_bb0270","doi-asserted-by":"crossref","first-page":"3446","DOI":"10.1038\/sj.emboj.7600781","article-title":"A molecular role for lysyl oxidase-like 2 enzyme in snail regulation and tumor progression","volume":"24","author":"Peinado","year":"2005","journal-title":"EMBO J"},{"key":"10.1016\/j.bmc.2026.118719_bb0275","doi-asserted-by":"crossref","first-page":"4541","DOI":"10.1158\/0008-5472.CAN-07-6345","article-title":"Lysyl oxidase-like 2 as a new poor prognosis marker of squamous cell carcinomas","volume":"68","author":"Peinado","year":"2008","journal-title":"Cancer Res"},{"key":"10.1016\/j.bmc.2026.118719_bb0280","doi-asserted-by":"crossref","first-page":"2822","DOI":"10.1002\/jcp.27100","article-title":"Resveratrol inhibits erk1\/2-mediated adhesion of cancer cells via activating PP2a-PTEN signaling network","volume":"234","author":"Chen","year":"2019","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.bmc.2026.118719_bb0285","doi-asserted-by":"crossref","first-page":"1648","DOI":"10.1248\/bpb.b24-00403","article-title":"Timosaponin AIII disrupts cell-extracellular matrix interactions through the inhibition of endocytic pathways","volume":"47","author":"Terabayashi","year":"2024","journal-title":"Biol Pharm Bull"},{"key":"10.1016\/j.bmc.2026.118719_bb0290","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2023.115192","article-title":"Design, synthesis and evaluation of nitric oxide releasing derivatives of 2,4-diaminopyrimidine as novel FAK inhibitors for intervention of metastatic triple-negative breast cancer","volume":"250","author":"Zhang","year":"2023","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2026.118719_bb0295","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmc.2022.116809","article-title":"Discovery of novel chloropyramine-cinnamic acid hybrids as potential FAK inhibitors for intervention of metastatic triple-negative breast cancer","volume":"66","author":"Yang","year":"2022","journal-title":"Bioorgan Med Chem"}],"container-title":["Bioorganic &amp; Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089626001756?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089626001756?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T23:17:31Z","timestamp":1783120651000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0968089626001756"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":59,"alternative-id":["S0968089626001756"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2026.118719","relation":{},"ISSN":["0968-0896"],"issn-type":[{"value":"0968-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Design, synthesis, and evaluation of 4-(aminomethyl)-2-(phenylamino)pyridine derivatives as novel lysyl oxidase-like 2 inhibitors against metastatic melanoma","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2026.118719","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"118719"}}