{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T22:16:13Z","timestamp":1783116973699,"version":"3.54.6"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100007869","name":"National University of the South General Secretariat of Science and Technology","doi-asserted-by":"publisher","award":["PGI 24\/B361"],"award-info":[{"award-number":["PGI 24\/B361"]}],"id":[{"id":"10.13039\/501100007869","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007869","name":"National University of the South General Secretariat of Science and Technology","doi-asserted-by":"publisher","award":["PGI 24\/B344"],"award-info":[{"award-number":["PGI 24\/B344"]}],"id":[{"id":"10.13039\/501100007869","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007869","name":"National University of the South General Secretariat of Science and Technology","doi-asserted-by":"publisher","award":["PGI 24\/Q138"],"award-info":[{"award-number":["PGI 24\/Q138"]}],"id":[{"id":"10.13039\/501100007869","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005740","name":"Universidad Nacional del Sur","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005740","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010268","name":"Consejo Nacional para Investigaciones Cient\u00edficas y Tecnol\u00f3gicas","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010268","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002923","name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","doi-asserted-by":"publisher","award":["PIP 10100251"],"award-info":[{"award-number":["PIP 10100251"]}],"id":[{"id":"10.13039\/501100002923","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.bmc.2026.118727","type":"journal-article","created":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T16:35:07Z","timestamp":1780331707000},"page":"118727","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["A sustainable approach to 1,3-Oxathiolan-5-ones and their identification as a new anthelmintic scaffold"],"prefix":"10.1016","volume":"140","author":[{"given":"Fernando J.","family":"Lorenzo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tania V.","family":"Veuthey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Jos\u00e9","family":"De Rosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romina A.","family":"Ocampo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dar\u00edo C.","family":"Gerbino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmc.2026.118727_bb0005","doi-asserted-by":"crossref","first-page":"10257","DOI":"10.1021\/jm501100b","article-title":"Analysis of the structural diversity, substitution patterns, and frequency of nitrogen heterocycles among U.S. FDA-approved pharmaceuticals","volume":"57","author":"Vitaku","year":"2014","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2026.118727_bb0010","article-title":"Biological significance of sulfur-containing heterocycles: an overview of pharmacologically relevant scaffolds","volume":"225","author":"Kaur","year":"2021","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2026.118727_bb0015","article-title":"Oxygen- and sulfur-containing five-membered heterocycles in medicinal chemistry: recent advances","volume":"119","author":"Sachdeva","year":"2022","journal-title":"Bioorg Chem"},{"key":"10.1016\/j.bmc.2026.118727_bb0020","first-page":"1407","article-title":"Synthetic approaches and biological relevance of thiolactones and related sulfur\u2013oxygen heterocycles","volume":"118","author":"Shakya","year":"2018","journal-title":"Chem Rev"},{"key":"10.1016\/j.bmc.2026.118727_bb0025","first-page":"36","article-title":"Antiviral agents active against HIV infections: the impact of lamivudine and emtricitabine","volume":"163","author":"De Clercq","year":"2019","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.bmc.2026.118727_bb0030","first-page":"39","article-title":"The synthesis and medicinal chemistry of 1,3-oxathiolane nucleoside analogues: from early development to approved antiviral agents","volume":"123","author":"Storer","year":"2015","journal-title":"Antivir Res"},{"key":"10.1016\/j.bmc.2026.118727_bb0035","first-page":"6023","article-title":"Cyclocondensation of 2-mercaptoacetic acid with aldehydes: a classical route to oxathiolanones","volume":"37","author":"Goti","year":"1996","journal-title":"Tetrahedron Lett"},{"key":"10.1016\/j.bmc.2026.118727_bb0040","first-page":"4455","article-title":"Synthesis of 1,3-oxathiolan-5-ones via \u03b1-haloketone cyclization under Lewis acid catalysis","volume":"30","author":"Kato","year":"2000","journal-title":"Synth Commun"},{"key":"10.1016\/j.bmc.2026.118727_bb0045","first-page":"1449","article-title":"Advances in thiolactone synthesis: methods and applications","volume":"2009","author":"V\u00e1vrov\u00e1","year":"2009","journal-title":"Synthesis"},{"key":"10.1016\/j.bmc.2026.118727_bb0050","series-title":"Green Chemistry: Theory and Practice","author":"Anastas","year":"1998"},{"key":"10.1016\/j.bmc.2026.118727_bb0055","doi-asserted-by":"crossref","first-page":"6250","DOI":"10.1002\/anie.200400655","article-title":"Microwave-assisted organic synthesis: a critical assessment of recent progress","volume":"43","author":"Kappe","year":"2004","journal-title":"Angew Chem Int Ed"},{"key":"10.1016\/j.bmc.2026.118727_bb0060","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1039\/a808223e","article-title":"Solvent-free and microwave-assisted reactions: a sustainable approach to heterocyclic chemistry","volume":"1","author":"Varma","year":"1999","journal-title":"Green Chem"},{"key":"10.1016\/j.bmc.2026.118727_bb0065","doi-asserted-by":"crossref","first-page":"9225","DOI":"10.1016\/S0040-4020(01)00906-1","article-title":"Microwave-assisted organic synthesis\u2014a review","volume":"57","author":"Lidstr\u00f6m","year":"2001","journal-title":"Tetrahedron"},{"key":"10.1016\/j.bmc.2026.118727_bb0070","series-title":"Microwave Synthesis: Chemistry at the Speed of Light","author":"Hayes","year":"2002"},{"key":"10.1016\/j.bmc.2026.118727_bb0075","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S0040-4039(00)83996-9","article-title":"The use of microwave ovens for rapid organic synthesis","volume":"27","author":"Gedye","year":"1986","journal-title":"Tetrahedron Lett"},{"key":"10.1016\/j.bmc.2026.118727_bb0080","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1016\/S0140-6736(09)60233-6","article-title":"Helminth infections: the great neglected tropical diseases","volume":"373","author":"Hotez","year":"2008","journal-title":"Lancet"},{"key":"10.1016\/j.bmc.2026.118727_bb0085","unstructured":"World Health Organization. Soil-transmitted helminth infections: key facts. WHO Fact Sheet (2024 update)."},{"key":"10.1016\/j.bmc.2026.118727_bb0090","first-page":"258","article-title":"Anthelmintic resistance in human helminths: emerging concerns","volume":"14","author":"Geerts","year":"2001","journal-title":"Clin Microbiol Rev"},{"key":"10.1016\/j.bmc.2026.118727_bb0095","first-page":"447","article-title":"Challenges in the maintenance and study of parasitic nematodes","volume":"31","author":"Ward","year":"2015","journal-title":"Trends Parasitol"},{"key":"10.1016\/j.bmc.2026.118727_bb0100","first-page":"1","article-title":"Anthelmintic drug action and resistance in nematodes: C. Elegans as a model","volume":"63","author":"Holden-Dye","year":"2007","journal-title":"Adv Parasitol"},{"key":"10.1016\/j.bmc.2026.118727_bb0105","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.vetpar.2011.05.020","article-title":"Application of C. Elegans in anthelmintic screening","volume":"182","author":"Katiki","year":"2011","journal-title":"Vet Parasitol"},{"key":"10.1016\/j.bmc.2026.118727_bb0110","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.ijpara.2014.01.008","article-title":"Phenotypic assays using C. Elegans for parasitic nematode research","volume":"44","author":"Kumarasingha","year":"2014","journal-title":"Int J Parasitol"},{"key":"10.1016\/j.bmc.2026.118727_bb0115","doi-asserted-by":"crossref","first-page":"e00721","DOI":"10.1002\/prp2.721","article-title":"Drug discovery: insights from the invertebrate Caenorhabditis elegans","volume":"9","author":"Giunti","year":"2021","journal-title":"Pharmacol Res Perspect"},{"key":"10.1016\/j.bmc.2026.118727_bb0120","first-page":"193","article-title":"Genetics and genomics of C. Elegans as a biomedical model","volume":"7","author":"Kaletta","year":"2006","journal-title":"Nat Rev Genet"},{"key":"10.1016\/j.bmc.2026.118727_bb0125","first-page":"1435","article-title":"Functional insights into nematode physiology from C. Elegans","volume":"17","author":"Markaki","year":"2010","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.bmc.2026.118727_bb0130","first-page":"501","article-title":"Mechanisms of action of anthelmintics in C. Elegans","volume":"121","author":"Driscoll","year":"1989","journal-title":"Genetics"},{"key":"10.1016\/j.bmc.2026.118727_bb0135","first-page":"385","article-title":"The effects of anthelmintic agents on nematode neuromuscular physiology","volume":"66","author":"Lewis","year":"1980","journal-title":"Comp Biochem Physiol C"},{"key":"10.1016\/j.bmc.2026.118727_bb0140","article-title":"Ion channels as anthelmintic targets: insights from C. Elegans","volume":"9","author":"Rufener","year":"2013","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.bmc.2026.118727_bb0145","doi-asserted-by":"crossref","first-page":"7485","DOI":"10.1038\/ncomms8485","article-title":"Caenorhabditis elegans is a useful model for anthelmintic discovery","volume":"6","author":"Burns","year":"2015","journal-title":"Nat Commun"},{"issue":"12","key":"10.1016\/j.bmc.2026.118727_bb0150","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0007021","article-title":"Diisopropylphenyl-imidazole (DII): a new compound that exerts anthelmintic activity through novel molecular mechanisms","volume":"12","author":"Blanco","year":"2018","journal-title":"PLoS Negl Trop Dis"},{"issue":"3","key":"10.1016\/j.bmc.2026.118727_bb0155","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1021\/acsmedchemlett.3c00537","article-title":"Selective recognition of c-KIT 1 G-Quadruplex by structural tuning of Heteroaromatic scaffolds and side chains","volume":"15","author":"Fatma","year":"2024","journal-title":"ACS Med Chem Lett"},{"issue":"19","key":"10.1016\/j.bmc.2026.118727_bb0160","doi-asserted-by":"crossref","first-page":"20060","DOI":"10.1021\/acs.jmedchem.5c00736","article-title":"Dual transcriptional repression of oncogenic c-KIT and KRAS by G4-targeting Triazolyl-indole scaffolds induces synthetic lethality in leukemia cells","volume":"68","author":"Bhattacharyya","year":"2025","journal-title":"J Med Chem"},{"issue":"9","key":"10.1016\/j.bmc.2026.118727_bb0165","first-page":"1429","article-title":"Solvent-free efficient synthesis of new 4-thiazolidinones with a fructose scaffold through a microwave-assisted cascade multicomponent reaction","volume":"56","author":"Lorenzo","year":"2023","journal-title":"Synthesis"},{"key":"10.1016\/j.bmc.2026.118727_bb0170","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1039\/c39760000734","article-title":"Rules for ring closure","author":"Baldwin","year":"1976","journal-title":"J Chem Soc Chem Commun"},{"key":"10.1016\/j.bmc.2026.118727_bb0175","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1038\/nbt.2786","article-title":"Clinical development success rates for investigational drugs","volume":"32","author":"Hay","year":"2014","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.bmc.2026.118727_bb0180","first-page":"1061","article-title":"The essential roles of chemistry in high-throughput screening triage","volume":"20","author":"Dahlin","year":"2015","journal-title":"Drug Discov Today"},{"key":"10.1016\/j.bmc.2026.118727_bb0185","doi-asserted-by":"crossref","first-page":"42717","DOI":"10.1038\/srep42717","article-title":"SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness, and medicinal chemistry friendliness of small molecules","volume":"7","author":"Daina","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.bmc.2026.118727_bb0190","article-title":"Computational analysis of physicochemical and pharmacokinetic properties of bioactive natural products","volume":"151","author":"Bakchi","year":"2022","journal-title":"Comput Biol Med"},{"key":"10.1016\/j.bmc.2026.118727_bb0195","doi-asserted-by":"crossref","first-page":"3164","DOI":"10.1021\/jm0492002","article-title":"A bioavailability score","volume":"48","author":"Martin","year":"2005","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2026.118727_bb0200","first-page":"1","article-title":"Drug-likeness and molecular docking studies on benzothiazole derivatives","volume":"14","author":"Masood","year":"2018","journal-title":"Expert Opin Drug Metab Toxicol"},{"key":"10.1016\/j.bmc.2026.118727_bb0205","first-page":"4320","article-title":"Structure-based evaluation of molecular properties relevant to pharmaceutical profiles","volume":"25","author":"Bojarska","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.bmc.2026.118727_bb0210","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.molcata.2013.02.010","article-title":"Cobalt-doped ZnS nanoparticles as a recyclable catalyst for solvent-free synthesis of heterocyclic privileged medicinal scaffolds under infrared irradiation","volume":"373","author":"Dandia","year":"2013","journal-title":"J Mol Catal A Chem"},{"issue":"5","key":"10.1016\/j.bmc.2026.118727_bb0215","doi-asserted-by":"crossref","first-page":"349","DOI":"10.2174\/157017808784872089","article-title":"Microwave-assisted synthesis of 1,3-thiazolidin-4-ones and 2-aryl-1,3-oxathiolan-5-ones","volume":"5","author":"Cunico","year":"2008","journal-title":"Lett Org Chem"},{"issue":"47","key":"10.1016\/j.bmc.2026.118727_bb0220","doi-asserted-by":"crossref","first-page":"6108","DOI":"10.1016\/j.tetlet.2010.09.052","article-title":"Molecular iodine in [bmim][BF\u2084]: a highly efficient green catalytic system for one-pot synthesis of 1,3-oxathiolan-5-one","volume":"51","author":"Dewan","year":"2010","journal-title":"Tetrahedron Lett"},{"issue":"1","key":"10.1016\/j.bmc.2026.118727_bb0225","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1021\/jo981437g","article-title":"Electrolytic partial fluorination of organic compounds. 30.1 drastic improvement of anodic monofluorination of 2-substituted 1,3-oxathiolan-5-ones using et\u2084NF\u00b74HF","volume":"64","author":"Higashiya","year":"1999","journal-title":"J Org Chem"},{"key":"10.1016\/j.bmc.2026.118727_bb0230","doi-asserted-by":"crossref","DOI":"10.1002\/slct.202500717","article-title":"Zeolite-catalyzed stereoselective synthesis of glycosylated 4-thiazolidinones with selective anticancer activity against rhabdomyosarcoma","volume":"10","author":"Lorenzo","year":"2025","journal-title":"ChemistrySelect"},{"issue":"1","key":"10.1016\/j.bmc.2026.118727_bb0235","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1093\/genetics\/77.1.71","article-title":"The genetics of Caenorhabditis elegans","volume":"77","author":"Brenner","year":"1974","journal-title":"Genetics"},{"key":"10.1016\/j.bmc.2026.118727_bb0240","series-title":"WormBook","first-page":"1","article-title":"Maintenance of C. Elegans","author":"Stiernagle","year":"2006"}],"container-title":["Bioorganic & Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089626001835?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089626001835?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T21:21:01Z","timestamp":1783113661000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0968089626001835"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":48,"alternative-id":["S0968089626001835"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2026.118727","relation":{},"ISSN":["0968-0896"],"issn-type":[{"value":"0968-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A sustainable approach to 1,3-Oxathiolan-5-ones and their identification as a new anthelmintic scaffold","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2026.118727","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"118727"}}