{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T09:12:36Z","timestamp":1788599556003,"version":"build-2803163510"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI114114"],"award-info":[{"award-number":["AI114114"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI172739"],"award-info":[{"award-number":["AI172739"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.bmc.2026.118759","type":"journal-article","created":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T23:36:31Z","timestamp":1785800191000},"page":"118759","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["An investigation into uptake and delivery of oligonucleotides in Candida"],"prefix":"10.1016","volume":"142","author":[{"suffix":"Jr.","given":"Antwine W.","family":"McFarland","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra P.","family":"Story","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dev P.","family":"Arya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmc.2026.118759_bb0005","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/s11274-020-02940-0","article-title":"The use of nanoparticles as alternative therapeutic agents against Candida infections: an up-to-date overview and future perspectives","volume":"36","author":"Mba","year":"2020","journal-title":"World J Microbiol Biotechnol"},{"key":"10.1016\/j.bmc.2026.118759_bb0010","doi-asserted-by":"crossref","DOI":"10.20473\/jr.v7-I.3.2021.127-133","article-title":"Candidiasis as Secondary Infection in Post COVID-19: A New Problem?","volume":"7","author":"Nathania","year":"2021","journal-title":"Jurnal Respirasi"},{"key":"10.1016\/j.bmc.2026.118759_bb0015","article-title":"Candida albicans-The Virulence Factors and Clinical Manifestations of Infection","volume":"7","author":"Talapko","year":"2021","journal-title":"J Fungi (Basel)"},{"key":"10.1016\/j.bmc.2026.118759_bb0020","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1002\/jimd.12251","article-title":"Opportunities and challenges for antisense oligonucleotide therapies","volume":"44","author":"Kuijper","year":"2021","journal-title":"J Inherit Metab Dis"},{"key":"10.1016\/j.bmc.2026.118759_bb0025","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines9040433","article-title":"The Challenges and Strategies of Antisense Oligonucleotide Drug Delivery","volume":"9","author":"Gagliardi","year":"2021","journal-title":"Biomedicines"},{"key":"10.1016\/j.bmc.2026.118759_bb0030","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1124\/pr.120.019554","article-title":"Rna Drugs and RNA Targets for Small Molecules: Principles, Progress, and Challenges","volume":"72","author":"Yu","year":"2020","journal-title":"Pharmacol Rev"},{"key":"10.1016\/j.bmc.2026.118759_bb0035","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.addr.2014.12.006","article-title":"Mirna inhibition in tissue engineering and regenerative medicine","volume":"88","author":"Beavers","year":"2015","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1016\/j.bmc.2026.118759_bb0040","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0167-4781(99)00138-4","article-title":"2\u2032-Carbohydrate modifications in antisense oligonucleotide therapy: importance of conformation, configuration and conjugation","volume":"1489","author":"Manoharan","year":"1999","journal-title":"Biochimica et Biophysica Acta (BBA) \u2013 Gene Struct Express"},{"key":"10.1016\/j.bmc.2026.118759_bb0045","series-title":"A Specificity Comparison of Four Antisense Types: Morpholino, 2\u2032-O-Methyl RNA, DNA, and Phosphorothioate DNA","first-page":"151","volume":"7","author":"Stein","year":"2009"},{"issue":"6","key":"10.1016\/j.bmc.2026.118759_bb0050","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1038\/sj.gt.3302654","article-title":"Anti-mirna oligonucleotides (AMOS): ammunition to target miRNAs implicated in human disease?","volume":"13","author":"Weiler","year":"2005","journal-title":"Gene Ther"},{"key":"10.1016\/j.bmc.2026.118759_bb0055","doi-asserted-by":"crossref","first-page":"5235","DOI":"10.1093\/nar\/gkaa299","article-title":"Phosphorothioate modified oligonucleotide-protein interactions","volume":"48","author":"Crooke","year":"2020","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.bmc.2026.118759_bb0060","doi-asserted-by":"crossref","first-page":"myac030","DOI":"10.1093\/mmy\/myac030","article-title":"Cationic lipid-based formulations for encapsulation and delivery of anti-EFG1 2\u2032 O methylRNA oligomer","volume":"60","author":"Ara\u00fajo","year":"2022","journal-title":"Med Mycol"},{"key":"10.1016\/j.bmc.2026.118759_bb0065","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/s11046-023-00734-0","article-title":"Combined application of antisense oligomers to control transcription factors of Candida albicans biofilm formation","volume":"188","author":"Ara\u00fajo","year":"2023","journal-title":"Mycopathologia"},{"key":"10.1016\/j.bmc.2026.118759_bb0070","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1042\/bj3400393","article-title":"Cationic liposome-encapsulated antisense oligonucleotide mediates efficient killing of intracellular Leishmania","volume":"340","author":"Chakraborty","year":"1999","journal-title":"Biochem J"},{"key":"10.1016\/j.bmc.2026.118759_bb0075","doi-asserted-by":"crossref","first-page":"784","DOI":"10.2174\/1567201812666150817123528","article-title":"Efficient transfection of phosphorothioate oligodeoxyribonucleotides by lipofectamine2000 into different bacteria","volume":"13","author":"Chen","year":"2016","journal-title":"Curr Drug Deliv"},{"key":"10.1016\/j.bmc.2026.118759_bb0080","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/S0005-2736(01)00392-3","article-title":"Encapsulation of DNA in negatively charged liposomes and inhibition of bacterial gene expression with fluid liposome-encapsulated antisense oligonucleotides","volume":"1515","author":"Fillion","year":"2001","journal-title":"Biochimica et Biophysica Acta (BBA)-Biomembranes"},{"key":"10.1016\/j.bmc.2026.118759_bb0085","doi-asserted-by":"crossref","first-page":"989","DOI":"10.3390\/pharmaceutics13070989","article-title":"Lipoplexes to deliver oligonucleotides in gram-positive and gram-negative bacteria: towards treatment of blood infections","volume":"13","author":"Pereira","year":"2021","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.bmc.2026.118759_bb0090","doi-asserted-by":"crossref","first-page":"57","DOI":"10.3390\/pharmaceutics10020057","article-title":"Impact of particle size and polydispersity index on the clinical applications of lipidic nanocarrier systems","volume":"10","author":"Danaei","year":"2018","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.bmc.2026.118759_bb0095","series-title":"Developments in liposomal drug delivery systems","author":"Maurer","year":"2005"},{"key":"10.1016\/j.bmc.2026.118759_bb0100","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.cclet.2021.08.020","article-title":"Liposome-based delivery of biological drugs","volume":"33","author":"Thapa Magar","year":"2022","journal-title":"Chin Chem Lett"},{"key":"10.1016\/j.bmc.2026.118759_bb0105","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.ejpb.2015.06.026","article-title":"Predicting the influence of liposomal lipid composition on liposome size, zeta potential and liposome-induced dendritic cell maturation using a design of experiments approach","volume":"94","author":"Soema","year":"2015","journal-title":"Eur J Pharm Biopharm"},{"key":"10.1016\/j.bmc.2026.118759_bb0110","series-title":"Gene Delivery Strategies. Guide to Research Techniques in Neuroscience","author":"Carter","year":"2015"},{"key":"10.1016\/j.bmc.2026.118759_bb0115","doi-asserted-by":"crossref","DOI":"10.3390\/pathogens6040062","article-title":"Liposomal and Deoxycholate Amphotericin B Formulations: Effectiveness against Biofilm Infections of Candida spp","volume":"6","author":"Rodrigues","year":"2017","journal-title":"Pathogens"},{"key":"10.1016\/j.bmc.2026.118759_bb0120","first-page":"12","article-title":"Liposomes-based drug delivery systems of anti-biofilm agents to combat bacterial biofilm formation","author":"Makhlouf","year":"2023","journal-title":"Antibiotics (Basel)"},{"key":"10.1016\/j.bmc.2026.118759_bb0125","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1111\/j.1567-1364.2010.00618.x","article-title":"Liposomal amphotericin B eradicates Candida albicans biofilm in a continuous catheter flow model","volume":"10","author":"Seidler","year":"2010","journal-title":"FEMS Yeast Res"},{"key":"10.1016\/j.bmc.2026.118759_bb0130","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1007\/s11274-020-02911-5","article-title":"Yeast biofilm in food realms: occurrence and control","volume":"36","author":"Zara","year":"2020","journal-title":"World J Microbiol Biotechnol"},{"key":"10.1016\/j.bmc.2026.118759_bb0135","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1128\/CMR.00064-16","article-title":"Polymyxins: Antibacterial Activity, Susceptibility Testing, and Resistance Mechanisms Encoded by Plasmids or Chromosomes","author":"Poirel","year":"2017","journal-title":"Clin Microbiol Rev"},{"key":"10.1016\/j.bmc.2026.118759_bb0140","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.3389\/fphar.2019.01049","article-title":"A new antisense phosphoryl guanidine oligo-2\u2032-O-methylribonucleotide penetrates into intracellular mycobacteria and suppresses target gene expression","volume":"10","author":"Skvortsova","year":"2019","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.bmc.2026.118759_bb0145","doi-asserted-by":"crossref","DOI":"10.1080\/08982100500528842","article-title":"Reducing Liposome Size with Ultrasound: Bimodal Size Distributions Ultrasound on Liposome Size Distribution","volume":"16","author":"Woodbury","year":"2006","journal-title":"J Liposome Res"},{"key":"10.1016\/j.bmc.2026.118759_bb0150","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2022.855229","article-title":"Efg1, everyone\u2019s favorite gene in Candida albicans: a comprehensive literature review","volume":"12","author":"Glazier","year":"2022","journal-title":"Front Cell Infect Microbiol"},{"key":"10.1016\/j.bmc.2026.118759_bb0155","doi-asserted-by":"crossref","first-page":"4090","DOI":"10.1128\/JB.183.13.4090-4093.2001","article-title":"Efg1, a morphogenetic regulator in Candida albicans, is a sequence-specific DNA binding protein","volume":"183","author":"Leng","year":"2001","journal-title":"J Bacteriol"},{"key":"10.1016\/j.bmc.2026.118759_bb0160","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1046\/j.1365-2958.2003.03300.x","article-title":"Efg1 is a major regulator of cell wall dynamics in Candida albicans as revealed by DNA microarrays","volume":"47","author":"Sohn","year":"2003","journal-title":"Mol Microbiol"},{"key":"10.1016\/j.bmc.2026.118759_bb0165","first-page":"286","article-title":"Nano-based drug delivery or targeting to eradicate bacteria for infection mitigation: a review of recent advances","volume":"1","author":"Feczk\u00f3","year":"2020","journal-title":"Front Chem"},{"key":"10.1016\/j.bmc.2026.118759_bb0170","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1590\/S1517-83822013005000050","article-title":"In vitro and in vivo inhibition of rabies virus replication by RNA interference","volume":"44","author":"Ono","year":"2013","journal-title":"Braz J Microbiol"},{"key":"10.1016\/j.bmc.2026.118759_bb0175","doi-asserted-by":"crossref","first-page":"2993","DOI":"10.3389\/fmicb.2019.02993","article-title":"The fungal cell wall: candida, cryptococcus, and aspergillus species","volume":"10","author":"Garcia-Rubio","year":"2019","journal-title":"Front Microbiol"},{"key":"10.1016\/j.bmc.2026.118759_bb0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.carres.2024.109059","article-title":"Synthesis of a unique mannose \u03b1-1-phosphate side chain moiety found in Candida auris cell wall mannan","volume":"537","author":"Ma","year":"2024","journal-title":"Carbohydr Res"},{"key":"10.1016\/j.bmc.2026.118759_bb0185","doi-asserted-by":"crossref","first-page":"7079","DOI":"10.1073\/pnas.85.19.7079","article-title":"Oligodeoxynucleoside phosphoramidates and phosphorothioates as inhibitors of human immunodeficiency virus","volume":"85","author":"Agrawal","year":"1988","journal-title":"Proc Natl Acad Sci"},{"key":"10.1016\/j.bmc.2026.118759_bb0190","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1146\/annurev.bi.54.070185.002055","article-title":"Nucleoside phosphorothioates","volume":"54","author":"Eckstein","year":"1985","journal-title":"Annu Rev Biochem"},{"key":"10.1016\/j.bmc.2026.118759_bb0195","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1089\/nat.2014.0506","article-title":"Phosphorothioates, essential components of therapeutic oligonucleotides","volume":"24","author":"Eckstein","year":"2014","journal-title":"Nucl Acid Ther"},{"key":"10.1016\/j.bmc.2026.118759_bb0200","doi-asserted-by":"crossref","first-page":"4693","DOI":"10.1021\/jo00302a039","article-title":"The automated synthesis of sulfur-containing oligodeoxyribonucleotides using 3H-1, 2-benzodithiol-3-one 1, 1-dioxide as a sulfur-transfer reagent","volume":"55","author":"Iyer","year":"1990","journal-title":"J Org Chem"},{"key":"10.1016\/j.bmc.2026.118759_bb0205","doi-asserted-by":"crossref","first-page":"3209","DOI":"10.1093\/nar\/16.8.3209","article-title":"Physicochemical properties of phospborothioate oligodeoxynucleotides","volume":"16","author":"Stein","year":"1988","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.bmc.2026.118759_bb0210","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1021\/acsinfecdis.3c00645","article-title":"Understanding Antisense Oligonucleotide Efficiency in Inhibiting Prokaryotic Gene Expression","volume":"10","author":"Story","year":"2024","journal-title":"ACS Infectious Diseases"},{"key":"10.1016\/j.bmc.2026.118759_bb0215","doi-asserted-by":"crossref","DOI":"10.3390\/molecules28114484","article-title":"Change in Lipofectamine Carrier as a Tool to Fine-Tune Immunostimulation of Nucleic Acid Nanoparticles","volume":"28","author":"Newton","year":"2023","journal-title":"Molecules"},{"issue":"6","key":"10.1016\/j.bmc.2026.118759_bb0220","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1038\/sj.gt.3300596","article-title":"Time-dependent maturation of cationic liposome\u2013DNA complex for serum resistance","volume":"13","author":"Yang","year":"1998","journal-title":"Gene Ther"},{"key":"10.1016\/j.bmc.2026.118759_bb0225","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2020.119096","article-title":"A novel, quorum sensor-infused liposomal drug delivery system suppresses Candida albicans biofilms","volume":"578","author":"Bandara","year":"2020","journal-title":"Int J Pharm"},{"key":"10.1016\/j.bmc.2026.118759_bb0230","doi-asserted-by":"crossref","first-page":"1","DOI":"10.26685\/urncst.673","article-title":"Exploring the Potential of Antisense Technologies to Enhance Traditional Antifungal Treatments for Candida albicans Biofilms","volume":"8","author":"Badawy","year":"2024","journal-title":"Undergraduate Res Nat Clin Sci Technol J"},{"key":"10.1016\/j.bmc.2026.118759_bb0235","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1093\/mmy\/myab033","article-title":"The combined application of the anti-RAS1 and anti-RIM101 2'-O MethylRNA oligomers enhances Candida albicans filamentation control","volume":"59","author":"Barbosa","year":"2021","journal-title":"Med Mycol"},{"key":"10.1016\/j.bmc.2026.118759_bb0240","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1128\/EC.3.3.675-684.2004","article-title":"Lipid raft polarization contributes to hyphal growth in Candida albicans","volume":"3","author":"Martin","year":"2004","journal-title":"Eukaryot Cell"}],"container-title":["Bioorganic & Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089626002154?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089626002154?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T08:37:48Z","timestamp":1788597468000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0968089626002154"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":48,"alternative-id":["S0968089626002154"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2026.118759","relation":{},"ISSN":["0968-0896"],"issn-type":[{"value":"0968-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"An investigation into uptake and delivery of oligonucleotides in Candida","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2026.118759","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"118759"}}