{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T02:45:45Z","timestamp":1790736345977,"version":"4.1.0"},"reference-count":37,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic &amp; Medicinal Chemistry Letters"],"published-print":{"date-parts":[[2004,1]]},"DOI":"10.1016\/j.bmcl.2003.09.064","type":"journal-article","created":{"date-parts":[[2003,11,15]],"date-time":"2003-11-15T07:00:19Z","timestamp":1068879619000},"page":"231-234","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":122,"title":["Carbonic anhydrase inhibitors: X-ray crystallographic structure of the adduct of human isozyme II with EMATE, a dual inhibitor of carbonic anhydrases and steroid sulfatase"],"prefix":"10.1016","volume":"14","author":[{"given":"Francesco","family":"Abbate","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Yves","family":"Winum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barry V.L.","family":"Potter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Casini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Louis","family":"Montero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Scozzafava","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudiu T.","family":"Supuran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmcl.2003.09.064_BIB1_1","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1021\/jm021124k","volume":"46","author":"Winum","year":"2003","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmcl.2003.09.064_BIB1_2","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/S0960-894X(03)00009-X","volume":"13","author":"Vicker","year":"2003","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2003.09.064_BIB1_3","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1016\/S0006-291X(03)00865-9","volume":"305","author":"Ho","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bmcl.2003.09.064_BIB2_1","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1002\/med.10025","volume":"23","author":"Supuran","year":"2003","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.bmcl.2003.09.064_BIB2_2","doi-asserted-by":"crossref","first-page":"61","DOI":"10.2174\/1568013013359131","volume":"1","author":"Supuran","year":"2001","journal-title":"Curr. Med. Chem. Imm., Endoc. Metab. Agents"},{"key":"10.1016\/j.bmcl.2003.09.064_BIB3_1","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1517\/13543776.12.2.217","volume":"12","author":"Supuran","year":"2002","journal-title":"Exp. Opin. Ther. Pat."},{"key":"10.1016\/j.bmcl.2003.09.064_BIB3_2","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1517\/13543776.10.5.575","volume":"10","author":"Supuran","year":"2000","journal-title":"Exp. Opin. Ther. Pat."},{"key":"10.1016\/j.bmcl.2003.09.064_BIB4_1","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1517\/13543776.11.5.789","volume":"11","author":"Smith","year":"2001","journal-title":"Exp. Opin. Ther. Pat."},{"key":"10.1016\/j.bmcl.2003.09.064_BIB4_2","doi-asserted-by":"crossref","first-page":"263","DOI":"10.2174\/0929867023371210","volume":"9","author":"Ahmed","year":"2002","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.bmcl.2003.09.064_BIB4_3","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1021\/jm970527v","volume":"41","author":"Woo","year":"1998","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmcl.2003.09.064_BIB5_1","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/S1074-5521(00)00023-5","volume":"7","author":"Woo","year":"2000","journal-title":"Chem. Biol."},{"key":"10.1016\/j.bmcl.2003.09.064_BIB5_2","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1517\/13543776.9.8.1083","volume":"9","author":"Poirier","year":"1999","journal-title":"Exp. Opin. Ther. Pat."},{"key":"10.1016\/j.bmcl.2003.09.064_BIB5_3","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/S0960-0760(02)00024-9","volume":"80","author":"Ciobanu","year":"2002","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.bmcl.2003.09.064_BIB5_4","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0960-0760(00)00178-3","volume":"75","author":"Malini","year":"2000","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.bmcl.2003.09.064_BIB6","doi-asserted-by":"crossref","first-page":"925","DOI":"10.2174\/0929867033457647","volume":"10","author":"Scozzafava","year":"2003","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.bmcl.2003.09.064_BIB7","doi-asserted-by":"crossref","first-page":"55","DOI":"10.2174\/1568009023334060","volume":"2","author":"Casini","year":"2002","journal-title":"Curr. Cancer Drug Targets"},{"key":"10.1016\/j.bmcl.2003.09.064_BIB8","series-title":"Gene Families: Studies of DNA, RNA, Enzymes and Proteins","first-page":"157","article-title":"The roles of carbonic anhydrase isozymes in cancer","author":"Chegwidden","year":"2001"},{"key":"10.1016\/j.bmcl.2003.09.064_BIB9_1","first-page":"2877","volume":"9","author":"Pastorek","year":"1994","journal-title":"Oncogene"},{"key":"10.1016\/j.bmcl.2003.09.064_BIB9_2","first-page":"7075","volume":"60","author":"Wykoff","year":"2000","journal-title":"Cancer Res."},{"key":"10.1016\/j.bmcl.2003.09.064_BIB9_3","first-page":"5262","volume":"61","author":"Beasley","year":"2001","journal-title":"Cancer Res."},{"key":"10.1016\/j.bmcl.2003.09.064_BIB10_1","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1517\/13543784.12.2.283","volume":"12","author":"Supuran","year":"2003","journal-title":"Exp. Opin. Investig. Drugs"},{"key":"10.1016\/j.bmcl.2003.09.064_BIB10_2","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/S0968-0896(00)00288-1","volume":"9","author":"Supuran","year":"2001","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmcl.2003.09.064_BIB11_1","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1021\/jm021123s","volume":"46","author":"Ilies","year":"2003","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmcl.2003.09.064_BIB11_2","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/S0960-894X(03)00091-X","volume":"13","author":"Vullo","year":"2003","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2003.09.064_BIB11_3","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1080\/1475636031000138778","volume":"18","author":"Franchi","year":"2003","journal-title":"J. Enz. Inhib. Med. Chem."},{"key":"10.1016\/j.bmcl.2003.09.064_BIB12","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1046\/j.1365-2567.1997.00254.x","volume":"91","author":"Suitters","year":"1997","journal-title":"Immunology"},{"key":"10.1016\/j.bmcl.2003.09.064_BIB13_1","doi-asserted-by":"crossref","first-page":"3583","DOI":"10.1021\/jm011131t","volume":"45","author":"Abbate","year":"2002","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmcl.2003.09.064_BIB13_2","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/S0960-894X(03)00029-5","volume":"13","author":"Casini","year":"2003","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2003.09.064_BIB14","unstructured":"Leslie, A.G.W. Joint CCP4+ESF-EAMCB Newsletter on Protein Crystallography, No. 26, 1992."},{"key":"10.1016\/j.bmcl.2003.09.064_BIB15","series-title":"SHELX97","author":"Sheldrick","year":"1997"},{"key":"10.1016\/j.bmcl.2003.09.064_BIB16","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1107\/S0108767390010224","volume":"A47","author":"Jones","year":"1991","journal-title":"Acta Crystallogr."},{"key":"10.1016\/j.bmcl.2003.09.064_BIB18","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1016\/0022-2836(92)90531-N","volume":"227","author":"Hakansson","year":"1992","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.bmcl.2003.09.064_BIB19_1","doi-asserted-by":"crossref","first-page":"9620","DOI":"10.1021\/ja011034p","volume":"123","author":"Kim","year":"2001","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bmcl.2003.09.064_BIB19_2","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1002\/1521-3773(20010119)40:2<389::AID-ANIE389>3.0.CO;2-#","volume":"40","author":"Gruneberg","year":"2001","journal-title":"Angew. Chem., Int. Ed."},{"key":"10.1016\/j.bmcl.2003.09.064_BIB20","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1080\/1475636031000119337","volume":"18","author":"Abbate","year":"2003","journal-title":"J. Enz. Inhib. Med. Chem."},{"key":"10.1016\/j.bmcl.2003.09.064_BIB21","doi-asserted-by":"crossref","first-page":"2759","DOI":"10.1016\/S0960-894X(03)00508-0","volume":"13","author":"Casini","year":"2003","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2003.09.064_BIB22","unstructured":"The coordinates of the hCA II\u2013EMATE adduct are available immediately from claudiu.supuran@unifi.it."}],"container-title":["Bioorganic &amp; Medicinal Chemistry Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X03010448?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X03010448?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T05:25:07Z","timestamp":1760765107000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960894X03010448"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,1]]},"references-count":37,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2004,1]]}},"alternative-id":["S0960894X03010448"],"URL":"https:\/\/doi.org\/10.1016\/j.bmcl.2003.09.064","relation":{},"ISSN":["0960-894X"],"issn-type":[{"value":"0960-894X","type":"print"}],"subject":[],"published":{"date-parts":[[2004,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Carbonic anhydrase inhibitors: X-ray crystallographic structure of the adduct of human isozyme II with EMATE, a dual inhibitor of carbonic anhydrases and steroid sulfatase","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmcl.2003.09.064","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2003 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}