{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T09:30:27Z","timestamp":1790069427894,"version":"4.0.1"},"reference-count":18,"publisher":"Elsevier BV","issue":"18","license":[{"start":{"date-parts":[[2005,9,1]],"date-time":"2005-09-01T00:00:00Z","timestamp":1125532800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2005,9,1]],"date-time":"2005-09-01T00:00:00Z","timestamp":1125532800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry Letters"],"published-print":{"date-parts":[[2005,9]]},"DOI":"10.1016\/j.bmcl.2005.06.018","type":"journal-article","created":{"date-parts":[[2005,7,6]],"date-time":"2005-07-06T18:02:27Z","timestamp":1120672947000},"page":"4118-4124","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"title":["Trichloroacetaldehyde modified oligonucleotides"],"prefix":"10.1016","volume":"15","author":[{"given":"Hans","family":"Gaus","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phil","family":"Olsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kent Van","family":"Sooy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claus","family":"Rentel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brett","family":"Turney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen L.","family":"Walker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James V.","family":"McArdle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel C.","family":"Capaldi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmcl.2005.06.018_bib1","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0167-4781(99)00148-7","volume":"1489","author":"Crooke","year":"1999","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bmcl.2005.06.018_bib2","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0076-6879(00)13003-4","volume":"313","author":"Crooke","year":"2000","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.bmcl.2005.06.018_bib3","series-title":"Antisense Drug Technology: Principles, Strategies, and Applications","author":"Crooke","year":"2001"},{"key":"10.1016\/j.bmcl.2005.06.018_bib5","doi-asserted-by":"crossref","first-page":"4539","DOI":"10.1093\/nar\/12.11.4539","volume":"12","author":"Sinha","year":"1984","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bmcl.2005.06.018_bib7","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1021\/op990077b","volume":"4","author":"Cheruvallath","year":"2000","journal-title":"Org. Process Res. Dev."},{"key":"10.1016\/j.bmcl.2005.06.018_bib8","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1021\/op9900333","volume":"3","author":"Capaldi","year":"1999","journal-title":"Org. Process Res. Dev."},{"key":"10.1016\/j.bmcl.2005.06.018_bib9","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/S0968-0896(98)00253-3","volume":"7","author":"Krotz","year":"1999","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmcl.2005.06.018_bib10","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1080\/07328319708006239","volume":"16","author":"Andrade","year":"1997","journal-title":"Nucleosides Nucleotides"},{"key":"10.1016\/j.bmcl.2005.06.018_bib11","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1021\/op020090n","volume":"7","author":"Capaldi","year":"2003","journal-title":"Org. Process Res. Dev."},{"key":"10.1016\/j.bmcl.2005.06.018_bib12","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1021\/op020068u","volume":"7","author":"Krotz","year":"2003","journal-title":"Org. Proc. Res. Dev."},{"key":"10.1016\/j.bmcl.2005.06.018_bib13","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1081\/NCN-120019499","volume":"22","author":"Krotz","year":"2003","journal-title":"Nucleosides Nucleotides Nucleic Acids"},{"key":"10.1016\/j.bmcl.2005.06.018_bib23","doi-asserted-by":"crossref","first-page":"12085","DOI":"10.1021\/ja00078a054","volume":"115","author":"McLuckey","year":"1993","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bmcl.2005.06.018_bib26","doi-asserted-by":"crossref","first-page":"2897","DOI":"10.1016\/S0040-4039(01)81320-4","volume":"25","author":"Guga","year":"1984","journal-title":"Tetrahedron Lett."},{"key":"10.1016\/j.bmcl.2005.06.018_bib27","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1055\/s-1999-3586","volume":"10","author":"Ingrassia","year":"1999","journal-title":"Synthesis"},{"key":"10.1016\/j.bmcl.2005.06.018_bib28","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1039\/a607869i","volume":"2","author":"Crampton","year":"1997","journal-title":"J. Chem. Soc. Perkin Trans."},{"key":"10.1016\/j.bmcl.2005.06.018_bib29","doi-asserted-by":"crossref","first-page":"2050","DOI":"10.3891\/acta.chem.scand.22-2050","volume":"22","author":"Jensen","year":"1968","journal-title":"Acta Chem. Scand."},{"key":"10.1016\/j.bmcl.2005.06.018_bib30","doi-asserted-by":"crossref","first-page":"359","DOI":"10.3891\/acta.chem.scand.19-0359","volume":"19","author":"Forsen","year":"1965","journal-title":"Acta Chem. Scand."},{"key":"10.1016\/j.bmcl.2005.06.018_bib33","unstructured":"Krotz, A., Capaldi, D., Gaus, H.-J.; Turney, B. Unpublished observations."}],"container-title":["Bioorganic & Medicinal Chemistry Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X05007778?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X05007778?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T05:34:06Z","timestamp":1760765646000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960894X05007778"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,9]]},"references-count":18,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2005,9]]}},"alternative-id":["S0960894X05007778"],"URL":"https:\/\/doi.org\/10.1016\/j.bmcl.2005.06.018","relation":{},"ISSN":["0960-894X"],"issn-type":[{"value":"0960-894X","type":"print"}],"subject":[],"published":{"date-parts":[[2005,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Trichloroacetaldehyde modified oligonucleotides","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmcl.2005.06.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2005 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}