{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T10:07:39Z","timestamp":1791799659264,"version":"4.3.4"},"reference-count":37,"publisher":"Elsevier BV","issue":"24","license":[{"start":{"date-parts":[[2005,12,1]],"date-time":"2005-12-01T00:00:00Z","timestamp":1133395200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2005,12,1]],"date-time":"2005-12-01T00:00:00Z","timestamp":1133395200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry Letters"],"published-print":{"date-parts":[[2005,12]]},"DOI":"10.1016\/j.bmcl.2005.09.012","type":"journal-article","created":{"date-parts":[[2005,10,11]],"date-time":"2005-10-11T07:23:11Z","timestamp":1129015391000},"page":"5365-5369","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":37,"title":["Screening of electrophilic compounds yields an aziridinyl peptide as new active-site directed SARS-CoV main protease inhibitor"],"prefix":"10.1016","volume":"15","author":[{"given":"Erika","family":"Martina","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaus","family":"Stiefl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bj\u00f6rn","family":"Degel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franziska","family":"Schulz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Breuning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Schiller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radim","family":"Vicik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Knut","family":"Baumann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Ziebuhr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanja","family":"Schirmeister","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmcl.2005.09.012_bib1","first-page":"823","article-title":"Coronaviruses, Toroviruses, and Arteriviruses","volume":"Vol. 1","author":"Siddell","year":"2005"},{"key":"10.1016\/j.bmcl.2005.09.012_bib2","doi-asserted-by":"crossref","first-page":"1967","DOI":"10.1056\/NEJMoa030747","volume":"348","author":"Drosten","year":"2003","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bmcl.2005.09.012_bib3","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1056\/NEJMoa030781","volume":"348","author":"Ksiazek","year":"2003","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bmcl.2005.09.012_bib4","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1016\/S0140-6736(03)13077-2","volume":"361","author":"Peiris","year":"2003","journal-title":"Lancet"},{"key":"10.1016\/j.bmcl.2005.09.012_bib5","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.mib.2004.06.007","volume":"7","author":"Ziebuhr","year":"2004","journal-title":"Curr. Opin. Microbiol."},{"key":"10.1016\/j.bmcl.2005.09.012_bib6","first-page":"57","volume":"287","author":"Ziebuhr","year":"2005","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"10.1016\/j.bmcl.2005.09.012_bib7","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1099\/0022-1317-81-4-853","volume":"8","author":"Ziebuhr","year":"2000","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.bmcl.2005.09.012_bib8","doi-asserted-by":"crossref","first-page":"3213","DOI":"10.1093\/emboj\/cdf327","volume":"21","author":"Anand","year":"2002","journal-title":"EMBO J."},{"key":"10.1016\/j.bmcl.2005.09.012_bib9","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1126\/science.1085658","volume":"300","author":"Anand","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.bmcl.2005.09.012_bib10","doi-asserted-by":"crossref","first-page":"13190","DOI":"10.1073\/pnas.1835675100","volume":"100","author":"Yang","year":"2003","journal-title":"Proc. Natl. Acad Sci. U.S.A."},{"key":"10.1016\/j.bmcl.2005.09.012_bib11","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1002\/jcc.20186","volume":"26","author":"Liu","year":"2005","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.bmcl.2005.09.012_bib12","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.bbrc.2004.06.155","volume":"321","author":"Rajnarayanan","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bmcl.2005.09.012_bib13","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/S0006-291X(03)01342-1","volume":"308","author":"Chou","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bmcl.2005.09.012_bib14","doi-asserted-by":"crossref","first-page":"3989","DOI":"10.1016\/j.bmcl.2003.08.066","volume":"13","author":"Jenwitheesuk","year":"2003","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2005.09.012_bib15","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.ejmech.2004.09.013","volume":"40","author":"Zhang","year":"2005","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bmcl.2005.09.012_bib16","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.ab.2004.10.003","volume":"337","author":"Du","year":"2005","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.bmcl.2005.09.012_bib17","first-page":"497","volume":"24","author":"Xiong","year":"2003","journal-title":"Acta. Pharmacol. Sin."},{"key":"10.1016\/j.bmcl.2005.09.012_bib18","doi-asserted-by":"crossref","first-page":"2517","DOI":"10.1016\/j.bmc.2004.03.035","volume":"12","author":"Zhang","year":"2004","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmcl.2005.09.012_bib19","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1021\/jm034137m","volume":"47","author":"Toney","year":"2004","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmcl.2005.09.012_bib20","doi-asserted-by":"crossref","first-page":"10012","DOI":"10.1073\/pnas.0403596101","volume":"101","author":"Wu","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bmcl.2005.09.012_bib21","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1016\/j.chembiol.2004.08.011","volume":"11","author":"Blanchard","year":"2004","journal-title":"Chem. Biol."},{"key":"10.1016\/j.bmcl.2005.09.012_bib22","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.febslet.2004.09.026","volume":"576","author":"Kao","year":"2004","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bmcl.2005.09.012_bib23","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.febslet.2004.08.015","volume":"574","author":"Hsu","year":"2004","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bmcl.2005.09.012_bib24","doi-asserted-by":"crossref","first-page":"4906","DOI":"10.1021\/bi0361766","volume":"43","author":"Bacha","year":"2004","journal-title":"Biochemistry"},{"key":"10.1016\/j.bmcl.2005.09.012_bib25","unstructured":"K\u00e4ppler, U.; Stiefl, N.; Schiller, M.; Vicik, R.; Breuning, A.; Schmitz , W.; Rupprecht, D.; Schmuck, C.; Baumann, K.; Ziebuhr, J.; Schirmeister, T.; J. Med. Chem. 2005 accepted."},{"key":"10.1016\/j.bmcl.2005.09.012_bib26","doi-asserted-by":"crossref","first-page":"585","DOI":"10.2174\/1389557033487935","volume":"3","author":"Schirmeister","year":"2003","journal-title":"Mini Rev. Med. Chem."},{"key":"10.1016\/j.bmcl.2005.09.012_bib27","unstructured":"Vicik, R.; Busemann, M.; Gelhaus, C.; Stiefl, N.; Scheiber, J.; Schmitz, W.; Schulz, F.; Mladenovic, M.; Engels, B.; Leippe, M.; Baumann, K.; Schirmeister, T.; J. Med. Chem. 2005 in revision."},{"key":"10.1016\/j.bmcl.2005.09.012_bib28","doi-asserted-by":"crossref","first-page":"4639","DOI":"10.1021\/cr010182v","volume":"102","author":"Powers","year":"2002","journal-title":"Chem. Rev."},{"key":"10.1016\/j.bmcl.2005.09.012_bib29","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1034\/j.1399-3011.1999.00112.x","volume":"54","author":"Ro","year":"1999","journal-title":"J. Pept. Res."},{"key":"10.1016\/j.bmcl.2005.09.012_bib30","first-page":"537","volume":"42","author":"Hanada","year":"1978","journal-title":"Agric. Biol. Chem."},{"key":"10.1016\/j.bmcl.2005.09.012_bib32","doi-asserted-by":"crossref","first-page":"7168","DOI":"10.1128\/jvi.66.12.7168-7175.1992","volume":"66","author":"Kleina","year":"1992","journal-title":"J. Virol."},{"key":"10.1016\/j.bmcl.2005.09.012_bib33","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1099\/0022-1317-78-1-71","volume":"78","author":"Seybert","year":"1997","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.bmcl.2005.09.012_bib34","doi-asserted-by":"crossref","first-page":"3992","DOI":"10.1128\/jvi.71.5.3992-3997.1997","volume":"71","author":"Ziebuhr","year":"1997","journal-title":"J. Virol."},{"key":"10.1016\/j.bmcl.2005.09.012_bib35","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1099\/0022-1317-83-3-595","volume":"83","author":"Hegyi","year":"2002","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.bmcl.2005.09.012_bib36","doi-asserted-by":"crossref","first-page":"11398","DOI":"10.1021\/jp047026n","volume":"108","author":"Schirmeister","year":"2004","journal-title":"J. Phys. Chem. A"},{"key":"10.1016\/j.bmcl.2005.09.012_bib38","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1002\/ardp.19963290504","volume":"329","author":"Schirmeister","year":"1996","journal-title":"Arch. Pharm. Pharm. Med. Chem."},{"key":"10.1016\/j.bmcl.2005.09.012_bib40","doi-asserted-by":"crossref","first-page":"14958","DOI":"10.1021\/bi0490237","volume":"43","author":"Chou","year":"2004","journal-title":"Biochemistry"}],"container-title":["Bioorganic & Medicinal Chemistry Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X05011595?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X05011595?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T05:35:53Z","timestamp":1760765753000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960894X05011595"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,12]]},"references-count":37,"journal-issue":{"issue":"24","published-print":{"date-parts":[[2005,12]]}},"alternative-id":["S0960894X05011595"],"URL":"https:\/\/doi.org\/10.1016\/j.bmcl.2005.09.012","relation":{},"ISSN":["0960-894X"],"issn-type":[{"value":"0960-894X","type":"print"}],"subject":[],"published":{"date-parts":[[2005,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Screening of electrophilic compounds yields an aziridinyl peptide as new active-site directed SARS-CoV main protease inhibitor","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmcl.2005.09.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2005 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}