{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T08:02:06Z","timestamp":1769155326074,"version":"3.49.0"},"reference-count":13,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2006,2,1]],"date-time":"2006-02-01T00:00:00Z","timestamp":1138752000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,2,1]],"date-time":"2006-02-01T00:00:00Z","timestamp":1138752000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry Letters"],"published-print":{"date-parts":[[2006,2]]},"DOI":"10.1016\/j.bmcl.2005.11.002","type":"journal-article","created":{"date-parts":[[2005,11,22]],"date-time":"2005-11-22T07:31:26Z","timestamp":1132644686000},"page":"884-886","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"title":["Thyroid receptor ligands. Part 4: 4\u2032-amido bioisosteric ligands selective for the thyroid hormone receptor beta"],"prefix":"10.1016","volume":"16","author":[{"given":"Yi-Lin","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chris","family":"Litten","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konrad F.","family":"Koehler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karin","family":"Mellstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neeraj","family":"Garg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Maria","family":"Garcia Collazo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathias","family":"F\u00e4rneg\u00e5rd","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marlena","family":"Grynfarb","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bolette","family":"Husman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johnny","family":"Sandberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johan","family":"Malm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmcl.2005.11.002_bib1_1","doi-asserted-by":"crossref","unstructured":"Talbert, R. L. National Cholesterol Education Program Adult treatment panel III. Am. J. Health. Syst. Pharm. 2003, S3, quiz S25.","DOI":"10.1093\/ajhp\/60.suppl_2.S3"},{"key":"10.1016\/j.bmcl.2005.11.002_bib1_2","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1177\/15353702-0322807-01","volume":"228","author":"Friday","year":"2003","journal-title":"Exp. Biol. Med. (Maywood)"},{"key":"10.1016\/j.bmcl.2005.11.002_bib1_3","doi-asserted-by":"crossref","first-page":"10F","DOI":"10.1016\/S0002-9149(01)01871-9","volume":"88","author":"Waters","year":"2001","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.bmcl.2005.11.002_bib2_1","doi-asserted-by":"crossref","first-page":"3522","DOI":"10.2174\/1381612043382873","volume":"10","author":"Malm","year":"2004","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.bmcl.2005.11.002_bib2_2","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1517\/13543784.13.5.489","volume":"13","author":"Webb","year":"2004","journal-title":"Exp. Opin. Invest. Drugs"},{"key":"10.1016\/j.bmcl.2005.11.002_bib3a","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1021\/jm021080f","volume":"46","author":"Ye","year":"2003","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmcl.2005.11.002_bib3_2","doi-asserted-by":"crossref","first-page":"10067","DOI":"10.1073\/pnas.1633737100","volume":"100","author":"Grover","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bmcl.2005.11.002_bib4a","doi-asserted-by":"crossref","first-page":"3549","DOI":"10.1016\/j.bmcl.2004.04.032","volume":"14","author":"Hangeland","year":"2004","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2005.11.002_bib4_2","doi-asserted-by":"crossref","unstructured":"TR\u03b2-selectivity within the same range as 3 has been disclosed within two other series of R3\u2032-substituted thyromimetics. R1-position 6-azauracil derivatives: Dow, R. L.; Schneider, S. R.; Paight, E. S.; Hank, R. F.; Chaing, P.; Cornelius, P.; Lee, E.; Newsome, W. P.; Swick, A.; Spitzer, J.; Hargrove, D. E.; Patterson, T. A.; Pandit, J.; Chrunyk, B. A.; LeMotte, P. K.; Danley, D. E.; Rosner, M. H.; Ammirati, M.J.; Simones, S. P.; Schulte, G. K.; Tate, B. F.; DaSilva-Jardine, P. Bioorg. Med. Chem. Lett. 2003, 13, 379; and the R1-acetoxy derivative GC-24: Borngraeber, S.; Budny, M. J.; Chiellini, G.; Cunha-Lima, S. T.; Togashi, M.; Webb, P.; Baxter, J. D.; Scanlan, T. S.; Fletterick, R. J. Proc. Natl. Acad. Sci. U.S.A. 2003, 100, 15358.","DOI":"10.1016\/S0960-894X(02)00947-2"},{"key":"10.1016\/j.bmcl.2005.11.002_bib5","unstructured":"This work was in part based on data disclosed in: PCT Int. Appl., 86 pp., 2001. Application: WO01\/98256. Priority: GB00\/15205. CAN 136:54021. While compiling this communication, investigators from Bayer AG disclosed a number of novel outer ring heterocycle-fused thyromimetics, carrying indoles or indazoles instead of the phenolic group in L-T3 in: Haning, H.; Woltering, M.; Mueller, U.; Schmidt, G.; Schmeck, C.; Voehringer, V.; Kretschmer, A.; Pernerstorfer, J. Bioorg. Med. Chem. Lett. 2005, 15, 1835. These ligands were, however, only moderately TR\u03b2-selective, but clearly represent a highly novel approach."},{"key":"10.1016\/j.bmcl.2005.11.002_bib7_1","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1039\/p19750001300","author":"Entwistle","year":"1975","journal-title":"Chem. Soc. Perkin Trans. 1"},{"key":"10.1016\/j.bmcl.2005.11.002_bib7_2","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1021\/jm00148a003","volume":"28","author":"Ishikawa","year":"1985","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmcl.2005.11.002_bib7_3","first-page":"54","author":"Anwer","year":"1989","journal-title":"J. Org. Chem."}],"container-title":["Bioorganic & Medicinal Chemistry Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X05014198?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X05014198?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T05:37:16Z","timestamp":1760765836000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960894X05014198"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,2]]},"references-count":13,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2006,2]]}},"alternative-id":["S0960894X05014198"],"URL":"https:\/\/doi.org\/10.1016\/j.bmcl.2005.11.002","relation":{},"ISSN":["0960-894X"],"issn-type":[{"value":"0960-894X","type":"print"}],"subject":[],"published":{"date-parts":[[2006,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Thyroid receptor ligands. Part 4: 4\u2032-amido bioisosteric ligands selective for the thyroid hormone receptor beta","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmcl.2005.11.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2005 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}