{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T17:10:02Z","timestamp":1776791402122,"version":"3.51.2"},"reference-count":17,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2006,4,1]],"date-time":"2006-04-01T00:00:00Z","timestamp":1143849600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,4,1]],"date-time":"2006-04-01T00:00:00Z","timestamp":1143849600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry Letters"],"published-print":{"date-parts":[[2006,4]]},"DOI":"10.1016\/j.bmcl.2005.12.092","type":"journal-article","created":{"date-parts":[[2006,2,4]],"date-time":"2006-02-04T10:52:58Z","timestamp":1139050378000},"page":"1950-1953","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["Biological evaluation of a multi-targeted small molecule inhibitor of tumor-induced angiogenesis"],"prefix":"10.1016","volume":"16","author":[{"given":"Lee A.","family":"McDermott","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian","family":"Higgins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary","family":"Simcox","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kin-Chun","family":"Luk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tom","family":"Nevins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth","family":"Kolinsky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa","family":"Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia K.","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingsi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"June","family":"Ke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Navita","family":"Mallalieu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tom","family":"Egan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stan","family":"Kolis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aruna","family":"Railkar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louise","family":"Gerber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin-Jun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fred","family":"Konzelmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhuming","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tom","family":"Flynn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omar","family":"Morales","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmcl.2005.12.092_bib1","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1038\/scientificamerican0576-58","volume":"234","author":"Folkman","year":"1976","journal-title":"Sci. Am."},{"key":"10.1016\/j.bmcl.2005.12.092_bib2_1","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1146\/annurev.pharmtox.44.101802.121650","volume":"44","author":"Bicknell","year":"2004","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.bmcl.2005.12.092_bib2_2","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1023\/A:1023002216413","volume":"68","author":"Lutsenko","year":"2003","journal-title":"Biochemistry (Moscow)"},{"key":"10.1016\/j.bmcl.2005.12.092_bib2_3","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1038\/35025215","volume":"407","author":"Yancopoulos","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.bmcl.2005.12.092_bib3_1","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1517\/14656566.6.10.1701","volume":"6","author":"Rhee","year":"2005","journal-title":"Expert Opin. Pharmacother."},{"key":"10.1016\/j.bmcl.2005.12.092_bib3_2","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1517\/14728214.10.2.403","volume":"10","author":"Verheul","year":"2005","journal-title":"Expert Opin. Emerg. Drugs"},{"key":"10.1016\/j.bmcl.2005.12.092_bib3_3","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1517\/13543784.12.6.923","volume":"12","author":"Scappaticci","year":"2003","journal-title":"Expert Opin. Investig. Drugs"},{"key":"10.1016\/j.bmcl.2005.12.092_bib4_1","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.cbpa.2004.06.009","volume":"8","author":"Mazitscheck","year":"2004","journal-title":"Curr. Opin. Chem. Biol."},{"key":"10.1016\/j.bmcl.2005.12.092_bib4_2","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1517\/14728222.7.2.215","volume":"7","author":"Traxler","year":"2003","journal-title":"Expert Opin. Ther. Targets"},{"key":"10.1016\/j.bmcl.2005.12.092_bib4_3","doi-asserted-by":"crossref","first-page":"567","DOI":"10.2174\/1381612033391487","volume":"9","author":"Magnetti","year":"2003","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.bmcl.2005.12.092_bib4_4","doi-asserted-by":"crossref","first-page":"973","DOI":"10.2174\/1568026023393273","volume":"2","author":"Boyer","year":"2002","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.bmcl.2005.12.092_bib6_1","unstructured":"Rossman, P.; Luk, K.; Cai, J.; Chen, Y.; Daniewski, A. R.; Dermatakis, A.; Flynn, T.; Garofalo, L.; Gillespie, P.; Goodnow, R.; Graves, B.; Harris, W.; Huby, N.; Jackson, N.; Kabat, M.; Konzelmann, F.; Li, S.; Liu, J.-J.; Liu, W.; Lukacs, C.; Michoud, C.; Perrotta, A.; Portland, L.; Qiao, J.; Roberts, J.; Schutt, A.; Simcox, M.; So, S.-S.; Tamborini, B.; Toth, K.; Wen, Y.; Xiang, Q.; Yang, H.; Zhang, Z. Abstracts of Papers, 95th National Meeting of the American Association for Cancer Research, Orlando, FL, USA, 2004; Abst. 2478."},{"key":"10.1016\/j.bmcl.2005.12.092_bib6_2","unstructured":"Rossman, P.; Luk, K.; Chen, Y.; Garofalo, L.; Graves, B.; Jackson, N.; Kabat, M.; Konzelmann, F.; Liu, J.-J.; Lukacs, C.; McDermott, L. A.; Michoud, C.; Portland, L.; Roberts, J.; Schutt, A.; Simcox, M.; So, S.-S.; Tamborini, B.; Yang, H. Abstracts of Papers, 229th National Meeting of the American Chemical Society, San Diego, CA, USA, March 13\u201317, 2005; MEDI-124."},{"key":"10.1016\/j.bmcl.2005.12.092_bib8_1","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1096\/fj.03-0271fje","volume":"18","author":"Erber","year":"2004","journal-title":"FASEB"},{"key":"10.1016\/j.bmcl.2005.12.092_bib8_2","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1172\/JCI200317929","volume":"111","author":"Bergers","year":"2003","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bmcl.2005.12.092_bib8_3","first-page":"1464","volume":"61","author":"Shaheen","year":"2001","journal-title":"Cancer Res."},{"key":"10.1016\/j.bmcl.2005.12.092_bib12","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1373\/49.1.32","volume":"49","author":"Auerbach","year":"2003","journal-title":"Clin. Chem."}],"container-title":["Bioorganic & Medicinal Chemistry Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X06000382?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X06000382?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T05:39:33Z","timestamp":1760765973000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960894X06000382"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,4]]},"references-count":17,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2006,4]]}},"alternative-id":["S0960894X06000382"],"URL":"https:\/\/doi.org\/10.1016\/j.bmcl.2005.12.092","relation":{},"ISSN":["0960-894X"],"issn-type":[{"value":"0960-894X","type":"print"}],"subject":[],"published":{"date-parts":[[2006,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Biological evaluation of a multi-targeted small molecule inhibitor of tumor-induced angiogenesis","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmcl.2005.12.092","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}