{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T20:20:02Z","timestamp":1777494002744,"version":"3.51.4"},"reference-count":53,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2006,4,1]],"date-time":"2006-04-01T00:00:00Z","timestamp":1143849600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,4,1]],"date-time":"2006-04-01T00:00:00Z","timestamp":1143849600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["9770363"],"award-info":[{"award-number":["9770363"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011103","name":"Sixth Framework Programme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011103","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry Letters"],"published-print":{"date-parts":[[2006,4]]},"DOI":"10.1016\/j.bmcl.2006.01.044","type":"journal-article","created":{"date-parts":[[2006,2,4]],"date-time":"2006-02-04T10:52:58Z","timestamp":1139050378000},"page":"2182-2188","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":39,"title":["Carbonic anhydrase inhibitors: Cloning and sulfonamide inhibition studies of a carboxyterminal truncated \u03b1-carbonic anhydrase from Helicobacter pylori"],"prefix":"10.1016","volume":"16","author":[{"given":"Isao","family":"Nishimori","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Vullo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoko","family":"Minakuchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaori","family":"Morimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saburo","family":"Onishi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Scozzafava","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudiu T.","family":"Supuran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmcl.2006.01.044_bib1","series-title":"Carbonic Anhydrase\u2014Its Inhibitors and Activators","author":"Supuran","year":"2004"},{"key":"10.1016\/j.bmcl.2006.01.044_bib2","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1146\/annurev.bi.64.070195.002111","volume":"64","author":"Sly","year":"1995","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.bmcl.2006.01.044_bib3","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1080\/14756360410001689540","volume":"19","author":"Pastorekova","year":"2004","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"10.1016\/j.bmcl.2006.01.044_bib4_1","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1002\/med.10025","volume":"23","author":"Supuran","year":"2003","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.bmcl.2006.01.044_bib4_2","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1517\/13543776.16.1.27","volume":"16","author":"Winum","year":"2006","journal-title":"Expert Opin. Ther. Pat."},{"key":"10.1016\/j.bmcl.2006.01.044_bib5","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1517\/13543776.14.5.667","volume":"14","author":"Scozzafava","year":"2004","journal-title":"Expert Opin. Ther. Pat."},{"key":"10.1016\/j.bmcl.2006.01.044_bib6","doi-asserted-by":"crossref","first-page":"2719","DOI":"10.1074\/jbc.M308984200","volume":"279","author":"Lehtonen","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bmcl.2006.01.044_bib7","doi-asserted-by":"crossref","first-page":"21228","DOI":"10.1074\/jbc.274.30.21228","volume":"274","author":"Fujikawa-Adachi","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bmcl.2006.01.044_bib8","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1006\/geno.1999.5938","volume":"61","author":"Fujikawa-Adachi","year":"1999","journal-title":"Genomics"},{"key":"10.1016\/j.bmcl.2006.01.044_bib9a","doi-asserted-by":"crossref","first-page":"7860","DOI":"10.1021\/jm050483n","volume":"48","author":"Nishimori","year":"2005","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmcl.2006.01.044_bib9_2","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1021\/jm031057+","volume":"47","author":"Vullo","year":"2004","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmcl.2006.01.044_bib9_3","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1517\/13543776.13.10.1545","volume":"13","author":"Supuran","year":"2003","journal-title":"Expert Opin. Ther. Pat."},{"key":"10.1016\/j.bmcl.2006.01.044_bib10_1","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1021\/jm030912m","volume":"47","author":"Weber","year":"2004","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmcl.2006.01.044_bib10_2","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/j.bmcl.2003.12.029","volume":"14","author":"Pastorekova","year":"2004","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2006.01.044_bib11_1","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/j.bmcl.2004.12.052","volume":"15","author":"Vullo","year":"2005","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2006.01.044_bib11b","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.1016\/j.bmcl.2005.03.032","volume":"15","author":"De Simone","year":"2005","journal-title":"Biorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2006.01.044_bib12_1","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1016\/j.bmcl.2004.12.053","volume":"15","author":"Vullo","year":"2005","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2006.01.044_bib12_2","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1039\/B417327A","volume":"3","author":"Blackburn","year":"2005","journal-title":"Org. Biomol. Chem."},{"key":"10.1016\/j.bmcl.2006.01.044_bib12_3","doi-asserted-by":"crossref","first-page":"5429","DOI":"10.1016\/j.bmcl.2005.08.113","volume":"15","author":"Poulsen","year":"2005","journal-title":"Biorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2006.01.044_bib13_1","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.febslet.2004.10.043","volume":"577","author":"Svastova","year":"2004","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bmcl.2006.01.044_bib13_2","doi-asserted-by":"crossref","first-page":"4834","DOI":"10.1021\/jm0501073","volume":"48","author":"Cecchi","year":"2005","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmcl.2006.01.044_bib13_3","doi-asserted-by":"crossref","first-page":"5721","DOI":"10.1021\/jm050333c","volume":"48","author":"Menchise","year":"2005","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmcl.2006.01.044_bib14","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.bmc.2004.10.015","volume":"13","author":"Krungkrai","year":"2005","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmcl.2006.01.044_bib15_1","doi-asserted-by":"crossref","first-page":"18782","DOI":"10.1074\/jbc.M414348200","volume":"280","author":"Suarez Covarrubias","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bmcl.2006.01.044_bib15_2","unstructured":"Suarez Covarrubias, A.; Bergfors, T.; Jones, T.A.; Hogbom, M. J. Biol. Chem. 2006, in press."},{"key":"10.1016\/j.bmcl.2006.01.044_bib16","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.1016\/j.cub.2005.10.040","volume":"15","author":"Klengel","year":"2005","journal-title":"Curr. Biol."},{"key":"10.1016\/j.bmcl.2006.01.044_bib17","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1016\/j.cub.2005.09.047","volume":"15","author":"Bahn","year":"2005","journal-title":"Curr. Biol."},{"key":"10.1016\/j.bmcl.2006.01.044_bib18_1","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1016\/S0140-6736(84)91816-6","volume":"16","author":"Marshall","year":"1984","journal-title":"Lancet"},{"key":"10.1016\/j.bmcl.2006.01.044_bib18_2","first-page":"S116","volume":"89","author":"Marshall","year":"1994","journal-title":"Am. J. Gastroenterol."},{"key":"10.1016\/j.bmcl.2006.01.044_bib19","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/ncponc0081","volume":"2","author":"Moss","year":"2005","journal-title":"J. Nat. Clin. Pract. Oncol."},{"key":"10.1016\/j.bmcl.2006.01.044_bib20","doi-asserted-by":"crossref","first-page":"269","DOI":"10.3184\/003685004783238481","volume":"87","author":"O\u2019Mahony","year":"2004","journal-title":"Sci. Prog."},{"key":"10.1016\/j.bmcl.2006.01.044_bib21","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1111\/j.1523-5378.2005.00324.x","volume":"10","author":"Gisbert","year":"2005","journal-title":"Helicobacter"},{"key":"10.1016\/j.bmcl.2006.01.044_bib22","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1586\/14787210.2.4.599","volume":"2","author":"Nakayama","year":"2004","journal-title":"Expert Rev. Anti. Infect. Ther."},{"key":"10.1016\/j.bmcl.2006.01.044_bib23","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.2165\/00003495-200464170-00003","volume":"64","author":"Megraud","year":"2004","journal-title":"Drugs"},{"key":"10.1016\/j.bmcl.2006.01.044_bib24","first-page":"429","volume":"20","author":"Sachs","year":"2005","journal-title":"Physiology (Bethesda)"},{"key":"10.1016\/j.bmcl.2006.01.044_bib25","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1128\/JB.187.2.729-738.2005","volume":"187","author":"Marcus","year":"2005","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.bmcl.2006.01.044_bib26","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.femsim.2004.10.021","volume":"44","author":"Stahler","year":"2005","journal-title":"FEMS Immunol. Med. Microbiol."},{"key":"10.1016\/j.bmcl.2006.01.044_bib27_1","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0167-4838(00)00204-1","volume":"1544","author":"Chirica","year":"2001","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bmcl.2006.01.044_bib27_2","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/S1570-9639(02)00467-3","volume":"1601","author":"Chirica","year":"2002","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bmcl.2006.01.044_bib29","series-title":"Carbonic anhydrase\u2014Its inhibitors and activators","first-page":"67","article-title":"Development of sulfonamide carbonic anhydrase inhibitors","author":"Supuran","year":"2004"},{"key":"10.1016\/j.bmcl.2006.01.044_bib30","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/S0960-894X(03)00029-5","volume":"13","author":"Casini","year":"2003","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2006.01.044_bib31","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.bmcl.2003.11.014","volume":"14","author":"Abbate","year":"2004","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2006.01.044_bib32","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.bmcl.2003.09.062","volume":"14","author":"Abbate","year":"2004","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2006.01.044_bib33","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1021\/jm021123s","volume":"46","author":"Ilies","year":"2003","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmcl.2006.01.044_bib34","doi-asserted-by":"crossref","first-page":"3690","DOI":"10.1021\/jm9901879","volume":"42","author":"Scozzafava","year":"1999","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmcl.2006.01.044_bib35","doi-asserted-by":"crossref","first-page":"2641","DOI":"10.1021\/jm9900523","volume":"42","author":"Scozzafava","year":"1999","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmcl.2006.01.044_bib36","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1080\/14756360410001689603","volume":"19","author":"Supuran","year":"2004","journal-title":"J. Enzyme. Inhib. Med. Chem."},{"key":"10.1016\/j.bmcl.2006.01.044_bib37","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.1021\/jm0494826","volume":"48","author":"Winum","year":"2005","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmcl.2006.01.044_bib39","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1159\/000048857","volume":"64","author":"Sano","year":"2001","journal-title":"Digestion"},{"key":"10.1016\/j.bmcl.2006.01.044_bib40","doi-asserted-by":"crossref","first-page":"2241","DOI":"10.1021\/bi00629a031","volume":"16","author":"Khalifah","year":"1977","journal-title":"Biochemistry"},{"key":"10.1016\/j.bmcl.2006.01.044_bib41","doi-asserted-by":"crossref","first-page":"2561","DOI":"10.1016\/S0021-9258(18)62326-9","volume":"246","author":"Khalifah","year":"1971","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bmcl.2006.01.044_bib42","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1111\/j.1749-6632.1984.tb12392.x","volume":"429","author":"Puscas","year":"1984","journal-title":"Ann. N.Y. Acad. Sci."},{"key":"10.1016\/j.bmcl.2006.01.044_bib43","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1152\/physrev.1967.47.4.595","volume":"47","author":"Maren","year":"1967","journal-title":"Physiol. Rev."}],"container-title":["Bioorganic & Medicinal Chemistry Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X06000801?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X06000801?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T05:38:07Z","timestamp":1760765887000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960894X06000801"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,4]]},"references-count":53,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2006,4]]}},"alternative-id":["S0960894X06000801"],"URL":"https:\/\/doi.org\/10.1016\/j.bmcl.2006.01.044","relation":{},"ISSN":["0960-894X"],"issn-type":[{"value":"0960-894X","type":"print"}],"subject":[],"published":{"date-parts":[[2006,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Carbonic anhydrase inhibitors: Cloning and sulfonamide inhibition studies of a carboxyterminal truncated \u03b1-carbonic anhydrase from Helicobacter pylori","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmcl.2006.01.044","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}