{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T00:33:05Z","timestamp":1774917185043,"version":"3.50.1"},"reference-count":38,"publisher":"Elsevier BV","issue":"24","license":[{"start":{"date-parts":[[2006,12,1]],"date-time":"2006-12-01T00:00:00Z","timestamp":1164931200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,12,1]],"date-time":"2006-12-01T00:00:00Z","timestamp":1164931200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic &amp; Medicinal Chemistry Letters"],"published-print":{"date-parts":[[2006,12]]},"DOI":"10.1016\/j.bmcl.2006.09.022","type":"journal-article","created":{"date-parts":[[2006,9,27]],"date-time":"2006-09-27T07:39:02Z","timestamp":1159342742000},"page":"6204-6208","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":33,"title":["Carbonic anhydrase inhibitors: X-ray crystallographic studies for the binding of 5-amino-1,3,4-thiadiazole-2-sulfonamide and 5-(4-amino-3-chloro-5-fluorophenylsulfonamido)-1,3,4-thiadiazole-2-sulfonamide to human isoform II"],"prefix":"10.1016","volume":"16","author":[{"given":"Valeria","family":"Menchise","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppina De","family":"Simone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna Di","family":"Fiore","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Scozzafava","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudiu T.","family":"Supuran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmcl.2006.09.022_bib1","series-title":"Carbonic Anhydrase\u2014Its Inhibitors and Activators","author":"Supuran","year":"2004"},{"key":"10.1016\/j.bmcl.2006.09.022_bib2_1","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1080\/14756360410001689540","volume":"19","author":"Pastorekova","year":"2004","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"10.1016\/j.bmcl.2006.09.022_bib2_2","series-title":"Carbonic Anhydrase\u2014Its Inhibitors and Activators","first-page":"67","article-title":"Development of Sulfonamide Carbonic Anhydrase Inhibitors","author":"Supuran","year":"2004"},{"key":"10.1016\/j.bmcl.2006.09.022_bib3_1","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1002\/med.10025","volume":"23","author":"Supuran","year":"2003","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.bmcl.2006.09.022_bib3_2","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1517\/13543776.14.5.667","volume":"14","author":"Scozzafava","year":"2004","journal-title":"Expert Opin. Ther. Pat."},{"key":"10.1016\/j.bmcl.2006.09.022_bib4","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1002\/med.20021","volume":"25","author":"Winum","year":"2005","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.bmcl.2006.09.022_bib5","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1517\/13543776.16.1.27","volume":"16","author":"Winum","year":"2006","journal-title":"Expert Opin. Ther. Pat."},{"key":"10.1016\/j.bmcl.2006.09.022_bib6","doi-asserted-by":"crossref","unstructured":"Winum, J.-Y.; Scozzafava, A.; Montero, J.-L.; Supuran, C.T. Med. Res. Rev. 2006, 26, in press.","DOI":"10.1002\/med.20068"},{"key":"10.1016\/j.bmcl.2006.09.022_bib7","doi-asserted-by":"crossref","first-page":"8329","DOI":"10.1021\/ja061574s","volume":"128","author":"Alterio","year":"2006","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bmcl.2006.09.022_bib8","doi-asserted-by":"crossref","first-page":"5721","DOI":"10.1021\/jm050333c","volume":"48","author":"Menchise","year":"2005","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmcl.2006.09.022_bib9_1","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.1016\/j.bmcl.2005.03.032","volume":"15","author":"De Simone","year":"2005","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2006.09.022_bib9_2","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/S0960-894X(03)00029-5","volume":"13","author":"Casini","year":"2003","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2006.09.022_bib9_3","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.bmcl.2003.09.062","volume":"14","author":"Abbate","year":"2004","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2006.09.022_bib10","doi-asserted-by":"crossref","first-page":"3583","DOI":"10.1021\/jm011131t","volume":"45","author":"Abbate","year":"2002","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmcl.2006.09.022_bib11_1","doi-asserted-by":"crossref","first-page":"2286","DOI":"10.1021\/jm00013a004","volume":"38","author":"Boriack","year":"1995","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmcl.2006.09.022_bib11_2","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1002\/pro.5560070303","volume":"7","author":"Stams","year":"1998","journal-title":"Protein Sci."},{"key":"10.1016\/j.bmcl.2006.09.022_bib11_3","doi-asserted-by":"crossref","first-page":"12125","DOI":"10.1021\/ja002627n","volume":"122","author":"Kim","year":"2000","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bmcl.2006.09.022_bib11_4","doi-asserted-by":"crossref","first-page":"9545","DOI":"10.1073\/pnas.161301298","volume":"98","author":"Whittington","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bmcl.2006.09.022_bib12","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/0141-8130(93)90004-6","volume":"15","author":"Vidgren","year":"1993","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.bmcl.2006.09.022_bib13_1","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.bmcl.2003.09.064","volume":"14","author":"Abbate","year":"2004","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2006.09.022_bib13_2","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1042\/BJ20041037","volume":"385","author":"Lloyd","year":"2005","journal-title":"Biochem. J."},{"key":"10.1016\/j.bmcl.2006.09.022_bib13_3","doi-asserted-by":"crossref","first-page":"6858","DOI":"10.1021\/bi047692e","volume":"44","author":"Lloyd","year":"2005","journal-title":"Biochemistry"},{"key":"10.1016\/j.bmcl.2006.09.022_bib14_1","doi-asserted-by":"crossref","first-page":"3588","DOI":"10.1021\/jm011112j","volume":"45","author":"Gruneberg","year":"2002","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmcl.2006.09.022_bib14_2","series-title":"Carbonic Anhydrase\u2014Its Inhibitors and Activators","first-page":"45","article-title":"Multiple Binding Modes Observed in X-ray Structures of Carbonic Anhydrase Inhibitor Complexes and Other Systems: Consequences for Structure-Based Drug Design","author":"Antel","year":"2004"},{"key":"10.1016\/j.bmcl.2006.09.022_bib15_1","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.febslet.2004.10.043","volume":"577","author":"Svastova","year":"2004","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bmcl.2006.09.022_bib15_2","doi-asserted-by":"crossref","first-page":"4834","DOI":"10.1021\/jm0501073","volume":"48","author":"Cecchi","year":"2005","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmcl.2006.09.022_bib16","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/S0223-5234(98)80042-1","volume":"33","author":"Supuran","year":"1998","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bmcl.2006.09.022_bib17","series-title":"Orphan Drugs","first-page":"89","article-title":"Benzolamide\u2014A Renal Carbonic Anhydrase Inhibitor","author":"Maren","year":"1982"},{"key":"10.1016\/j.bmcl.2006.09.022_bib18","doi-asserted-by":"crossref","first-page":"2867","DOI":"10.1016\/S0960-894X(03)00580-8","volume":"13","author":"Casini","year":"2003","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2006.09.022_bib19_1","doi-asserted-by":"crossref","first-page":"4542","DOI":"10.1021\/jm000296j","volume":"43","author":"Scozzafava","year":"2000","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmcl.2006.09.022_bib19_2","doi-asserted-by":"crossref","first-page":"2796","DOI":"10.1021\/jm031116j","volume":"47","author":"de Leval","year":"2004","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmcl.2006.09.022_bib20","doi-asserted-by":"crossref","first-page":"2357","DOI":"10.1016\/j.bmcl.2004.01.096","volume":"14","author":"Abbate","year":"2004","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2006.09.022_bib21","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1021\/jm021123s","volume":"46","author":"Ilies","year":"2003","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmcl.2006.09.022_bib22","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1002\/prot.340040406","volume":"4","author":"Eriksson","year":"1988","journal-title":"Proteins Struct. Funct."},{"key":"10.1016\/j.bmcl.2006.09.022_bib24","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0076-6879(97)76066-X","volume":"276","author":"Otwinowski","year":"1997","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.bmcl.2006.09.022_bib25","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1107\/S0907444998003254","volume":"54","author":"Br\u00fcnger","year":"1998","journal-title":"Acta Crystallogr. Sect. D"},{"key":"10.1016\/j.bmcl.2006.09.022_bib26","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1107\/S0108767390010224","volume":"47","author":"Jones","year":"1991","journal-title":"Acta Crystallogr. Sect. A"},{"key":"10.1016\/j.bmcl.2006.09.022_bib27","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1107\/S0021889892009944","volume":"26","author":"Laskowski","year":"1993","journal-title":"J. Appl. Crystallogr."}],"container-title":["Bioorganic &amp; Medicinal Chemistry Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X06010845?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X06010845?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T05:44:20Z","timestamp":1760766260000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960894X06010845"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,12]]},"references-count":38,"journal-issue":{"issue":"24","published-print":{"date-parts":[[2006,12]]}},"alternative-id":["S0960894X06010845"],"URL":"https:\/\/doi.org\/10.1016\/j.bmcl.2006.09.022","relation":{},"ISSN":["0960-894X"],"issn-type":[{"value":"0960-894X","type":"print"}],"subject":[],"published":{"date-parts":[[2006,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Carbonic anhydrase inhibitors: X-ray crystallographic studies for the binding of 5-amino-1,3,4-thiadiazole-2-sulfonamide and 5-(4-amino-3-chloro-5-fluorophenylsulfonamido)-1,3,4-thiadiazole-2-sulfonamide to human isoform II","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmcl.2006.09.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}