{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T10:15:20Z","timestamp":1789294520156,"version":"build-2803163510"},"reference-count":22,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry Letters"],"published-print":{"date-parts":[[2007,1]]},"DOI":"10.1016\/j.bmcl.2006.09.048","type":"journal-article","created":{"date-parts":[[2006,10,6]],"date-time":"2006-10-06T09:16:35Z","timestamp":1160126195000},"page":"266-271","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":50,"title":["Discovery of low nanomolar non-hydroxamate inhibitors of tumor necrosis factor-\u03b1 converting enzyme (TACE)"],"prefix":"10.1016","volume":"17","author":[{"given":"James J.-W.","family":"Duan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihua","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhonghui","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoyuki","family":"Asakawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"II","given":"James E.","family":"Sheppeck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui-Qin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryanne B.","family":"Covington","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Pitts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soong-Hoon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl P.","family":"Decicco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmcl.2006.09.048_bib1a","doi-asserted-by":"crossref","first-page":"2911","DOI":"10.2174\/0929867043364018","volume":"11","author":"Skiles","year":"2004","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.bmcl.2006.09.048_bib1b","doi-asserted-by":"crossref","first-page":"2963","DOI":"10.2174\/092986705774462851","volume":"12","author":"Le","year":"2005","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.bmcl.2006.09.048_bib2","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1517\/13543776.15.3.253","volume":"15","author":"Breuer","year":"2005","journal-title":"Expert Opin. Ther. Patents"},{"key":"10.1016\/j.bmcl.2006.09.048_bib3","doi-asserted-by":"crossref","first-page":"2970","DOI":"10.1016\/j.bmcl.2005.04.039","volume":"15","author":"Duan","year":"2005","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2006.09.048_bib4_1","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/S0960-894X(01)00104-4","volume":"11","author":"Foley","year":"2001","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2006.09.048_bib4_2","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1515\/BC.2001.159","volume":"382","author":"Grams","year":"2001","journal-title":"Biol. Chem."},{"key":"10.1016\/j.bmcl.2006.09.048_bib4_3","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1110\/ps.48401","volume":"10","author":"Dunten","year":"2001","journal-title":"Protein Sci."},{"key":"10.1016\/j.bmcl.2006.09.048_bib4_4","doi-asserted-by":"crossref","first-page":"17405","DOI":"10.1074\/jbc.M007475200","volume":"276","author":"Brandstetter","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bmcl.2006.09.048_bib4_5","series-title":"Matrix Metalloproteinase Inhibitors in Cancer Therapy","first-page":"223","author":"Grams","year":"2001"},{"key":"10.1016\/j.bmcl.2006.09.048_bib4_6","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1016\/j.bmcl.2005.02.038","volume":"15","author":"Blagg","year":"2005","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2006.09.048_bib4_7","doi-asserted-by":"crossref","first-page":"2970","DOI":"10.1016\/j.bmcl.2005.04.039","volume":"15","author":"Kim","year":"2005","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2006.09.048_bib5_1","doi-asserted-by":"crossref","first-page":"4954","DOI":"10.1021\/jm0255670","volume":"45","author":"Duan","year":"2002","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmcl.2006.09.048_bib5_2","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S1074-5521(03)00044-9","volume":"10","author":"Wasserman","year":"2003","journal-title":"Chem. Biol."},{"key":"10.1016\/j.bmcl.2006.09.048_bib6","doi-asserted-by":"crossref","first-page":"1702","DOI":"10.1021\/jm00088a004","volume":"35","author":"Young","year":"1992","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmcl.2006.09.048_bib7","doi-asserted-by":"crossref","first-page":"2924","DOI":"10.1021\/jo00296a067","volume":"55","author":"Miller","year":"1990","journal-title":"J. Org. Chem."},{"key":"10.1016\/j.bmcl.2006.09.048_bib9","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1002\/jlac.1990199001187","author":"Montforts","year":"1990","journal-title":"Liebigs. Ann. Chem."},{"key":"10.1016\/j.bmcl.2006.09.048_bib10","unstructured":"Gregory R. Ott, unpublished result."},{"key":"10.1016\/j.bmcl.2006.09.048_bib11","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1002\/jhet.5570240356","volume":"24","author":"Brana","year":"1987","journal-title":"J. Heterocycl. Chem."},{"key":"10.1016\/j.bmcl.2006.09.048_bib12_1","doi-asserted-by":"crossref","first-page":"2636","DOI":"10.1021\/jm010127e","volume":"44","author":"Xue","year":"2001","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmcl.2006.09.048_bib12_2","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/S0003-2697(02)00638-3","volume":"314","author":"Miller","year":"2003","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.bmcl.2006.09.048_bib13_1","doi-asserted-by":"crossref","first-page":"4524","DOI":"10.4049\/jimmunol.159.9.4524","volume":"159","author":"Solomon","year":"1997","journal-title":"J. Immunol."},{"key":"10.1016\/j.bmcl.2006.09.048_bib13_2","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1042\/bj3470131","volume":"347","author":"Schlondorff","year":"2000","journal-title":"Biochem. J."}],"container-title":["Bioorganic & Medicinal Chemistry Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X06011073?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X06011073?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T05:45:42Z","timestamp":1760766342000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960894X06011073"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,1]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,1]]}},"alternative-id":["S0960894X06011073"],"URL":"https:\/\/doi.org\/10.1016\/j.bmcl.2006.09.048","relation":{},"ISSN":["0960-894X"],"issn-type":[{"value":"0960-894X","type":"print"}],"subject":[],"published":{"date-parts":[[2007,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Discovery of low nanomolar non-hydroxamate inhibitors of tumor necrosis factor-\u03b1 converting enzyme (TACE)","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmcl.2006.09.048","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}