{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T22:06:44Z","timestamp":1790633204203,"version":"4.1.0"},"reference-count":27,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T00:00:00Z","timestamp":1172707200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T00:00:00Z","timestamp":1172707200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100007449","name":"Takeda Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007449","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry Letters"],"published-print":{"date-parts":[[2007,3]]},"DOI":"10.1016\/j.bmcl.2006.12.010","type":"journal-article","created":{"date-parts":[[2006,12,16]],"date-time":"2006-12-16T07:14:33Z","timestamp":1166253273000},"page":"1270-1273","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":124,"title":["Identification of arylsulfonamides as Aquaporin 4 inhibitors"],"prefix":"10.1016","volume":"17","author":[{"given":"Vincent J.","family":"Huber","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mika","family":"Tsujita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maya","family":"Yamazaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Sakimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsutomu","family":"Nakada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmcl.2006.12.010_bib1","doi-asserted-by":"crossref","first-page":"5497","DOI":"10.1016\/S0021-9258(17)37486-0","volume":"269","author":"Hasegawa","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bmcl.2006.12.010_bib2","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1513\/pats.200510-109JH","volume":"3","author":"Agre","year":"2006","journal-title":"Proc. Am. Thor. Soc."},{"key":"10.1016\/j.bmcl.2006.12.010_bib3","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1186\/gb-2006-7-2-206","volume":"7","author":"Kruse","year":"2006","journal-title":"Gen. Bio."},{"key":"10.1016\/j.bmcl.2006.12.010_bib4","doi-asserted-by":"crossref","first-page":"13052","DOI":"10.1073\/pnas.91.26.13052","volume":"91","author":"Jung","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bmcl.2006.12.010_bib5","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/S1359-6446(05)03390-8","volume":"10","author":"Castle","year":"2005","journal-title":"DDT"},{"key":"10.1016\/j.bmcl.2006.12.010_bib6","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/j.neuroscience.2004.06.088","volume":"129","author":"Manley","year":"2004","journal-title":"Neuroscience"},{"key":"10.1016\/j.bmcl.2006.12.010_bib7","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1097\/00001756-200402090-00009","volume":"15","author":"Binder","year":"2004","journal-title":"Neuroreport"},{"key":"10.1016\/j.bmcl.2006.12.010_bib8","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1073\/pnas.0409308102","volume":"102","author":"Eid","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bmcl.2006.12.010_bib9","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1093\/hmg\/8.9.1729","volume":"8","author":"Williams","year":"1999","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bmcl.2006.12.010_bib10","doi-asserted-by":"crossref","first-page":"3037","DOI":"10.1093\/hmg\/10.26.3037","volume":"10","author":"Paunio","year":"2001","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bmcl.2006.12.010_bib11","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1096\/fj.04-3281fje","volume":"19","author":"Nicchia","year":"2005","journal-title":"FASEB J.: FJ Express"},{"key":"10.1016\/j.bmcl.2006.12.010_bib12","doi-asserted-by":"crossref","first-page":"14207","DOI":"10.1074\/jbc.M513072200","volume":"281","author":"Detmers","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bmcl.2006.12.010_bib13","unstructured":"Deen, P. M. T.; Detmers, F. J. M.; Hohmann, S.; Nielsen, S.; Fr\u00f8kiaer, J.; Engel, A.; Grubm\u00fcller, K. H.; de Grot, B. L.; M\u00fcller, E. M.; Flitsch, S. L.; Brown, F. K.; Werten, P. J. L. PCT Patent Application WO 2005\/094806 A1, 2005."},{"key":"10.1016\/j.bmcl.2006.12.010_bib14","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1080\/14756360410001689540","volume":"19","author":"Pastorekova","year":"2004","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"10.1016\/j.bmcl.2006.12.010_bib15","first-page":"90","volume":"25","author":"Ma","year":"2004","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.bmcl.2006.12.010_bib16","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.ab.2006.01.003","volume":"350","author":"Gao","year":"2006","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.bmcl.2006.12.010_bib17","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1038\/sj.bjp.0704159","volume":"133","author":"Fan","year":"2001","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.bmcl.2006.12.010_bib18","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/0304-3940(94)90736-6","volume":"165","author":"Koh","year":"1994","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.bmcl.2006.12.010_bib19","first-page":"F685","volume":"277","author":"Tsukaguchi","year":"1999","journal-title":"Am. Physiol."},{"key":"10.1016\/j.bmcl.2006.12.010_bib20","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1095\/biolreprod.102.010017","volume":"68","author":"Cheung","year":"2003","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.bmcl.2006.12.010_bib21","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1074\/jbc.M008664200","volume":"276","author":"Yang","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bmcl.2006.12.010_bib22","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1007\/s002390010169","volume":"52","author":"Zardoya","year":"2001","journal-title":"J. Mol. Evol."},{"key":"10.1016\/j.bmcl.2006.12.010_bib23","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/j.jmb.2005.10.081","volume":"355","author":"Hiroaki","year":"2006","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.bmcl.2006.12.010_bib26","doi-asserted-by":"crossref","first-page":"10908","DOI":"10.1073\/pnas.93.20.10908","volume":"93","author":"Lu","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bmcl.2006.12.010_bib28","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/0014-5793(90)80452-O","volume":"272","author":"Sakimura","year":"1990","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bmcl.2006.12.010_bib29","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/S0026-895X(24)26513-5","volume":"57","author":"Brooks","year":"2000","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.bmcl.2006.12.010_bib31","doi-asserted-by":"crossref","first-page":"4862","DOI":"10.1016\/j.bmcl.2005.08.048","volume":"15","author":"\u00d6zensoy","year":"2005","journal-title":"Bioorg. Med. Chem. Lett."}],"container-title":["Bioorganic & Medicinal Chemistry Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X06013953?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X06013953?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T05:46:31Z","timestamp":1760766391000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960894X06013953"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,3]]},"references-count":27,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2007,3]]}},"alternative-id":["S0960894X06013953"],"URL":"https:\/\/doi.org\/10.1016\/j.bmcl.2006.12.010","relation":{},"ISSN":["0960-894X"],"issn-type":[{"value":"0960-894X","type":"print"}],"subject":[],"published":{"date-parts":[[2007,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Identification of arylsulfonamides as Aquaporin 4 inhibitors","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmcl.2006.12.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}