{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T19:17:27Z","timestamp":1791141447740,"version":"4.1.0"},"reference-count":65,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2007,5,1]],"date-time":"2007-05-01T00:00:00Z","timestamp":1177977600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,5,1]],"date-time":"2007-05-01T00:00:00Z","timestamp":1177977600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry Letters"],"published-print":{"date-parts":[[2007,5]]},"DOI":"10.1016\/j.bmcl.2007.02.068","type":"journal-article","created":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T16:29:55Z","timestamp":1172766595000},"page":"2795-2801","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["Carbonic anhydrase inhibitors: The X-ray crystal structure of the adduct of N-hydroxysulfamide with isozyme II explains why this new zinc binding function is effective in the design of potent inhibitors"],"prefix":"10.1016","volume":"17","author":[{"given":"Claudia","family":"Temperini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Yves","family":"Winum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Louis","family":"Montero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Scozzafava","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudiu T.","family":"Supuran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmcl.2007.02.068_bib1_1","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1517\/13543776.16.12.1627","volume":"16","author":"Scozzafava","year":"2006","journal-title":"Expert Opin. Ther. Pat."},{"key":"10.1016\/j.bmcl.2007.02.068_bib1_2","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1002\/med.10025","volume":"23","author":"Supuran","year":"2003","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.bmcl.2007.02.068_bib1_3","doi-asserted-by":"crossref","first-page":"921","DOI":"10.2174\/138955706777934946","volume":"6","author":"Winum","year":"2006","journal-title":"Mini. Rev. Med. Chem."},{"key":"10.1016\/j.bmcl.2007.02.068_bib2_1","series-title":"Carbonic Anhydrase\u2014Its Inhibitors and Activators","first-page":"1","author":"Supuran","year":"2004"},{"key":"10.1016\/j.bmcl.2007.02.068_bib2_2","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1080\/14756360410001689540","volume":"19","author":"Pastorekova","year":"2004","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"10.1016\/j.bmcl.2007.02.068_bib3_1","doi-asserted-by":"crossref","first-page":"2286","DOI":"10.1021\/jm00013a004","volume":"38","author":"Boriack","year":"1995","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmcl.2007.02.068_bib3_2","doi-asserted-by":"crossref","first-page":"12125","DOI":"10.1021\/ja002627n","volume":"122","author":"Kim","year":"2000","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bmcl.2007.02.068_bib4_1","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/0141-8130(93)90004-6","volume":"15","author":"Vidgren","year":"1993","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.bmcl.2007.02.068_bib4_2","doi-asserted-by":"crossref","first-page":"3588","DOI":"10.1021\/jm011112j","volume":"45","author":"Gruneberg","year":"2002","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmcl.2007.02.068_bib4c","doi-asserted-by":"crossref","first-page":"3583","DOI":"10.1021\/jm011131t","volume":"45","author":"Abbate","year":"2002","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmcl.2007.02.068_bib5_1","doi-asserted-by":"crossref","first-page":"7860","DOI":"10.1021\/jm050483n","volume":"48","author":"Nishimori","year":"2005","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmcl.2007.02.068_bib5_2","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/S0960-894X(03)00091-X","volume":"13","author":"Vullo","year":"2003","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2007.02.068_bib6_1","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1016\/j.bmcl.2004.12.053","volume":"15","author":"Vullo","year":"2005","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2007.02.068_bib6_2","doi-asserted-by":"crossref","first-page":"3828","DOI":"10.1016\/j.bmcl.2005.06.055","volume":"15","author":"Nishimori","year":"2005","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2007.02.068_bib7_1","doi-asserted-by":"crossref","first-page":"8329","DOI":"10.1021\/ja061574s","volume":"128","author":"Alterio","year":"2006","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bmcl.2007.02.068_bib7b","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1021\/jm030912m","volume":"47","author":"Weber","year":"2004","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmcl.2007.02.068_bib7_3","doi-asserted-by":"crossref","first-page":"5721","DOI":"10.1021\/jm050333c","volume":"48","author":"Menchise","year":"2005","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmcl.2007.02.068_bib8_1","doi-asserted-by":"crossref","first-page":"4834","DOI":"10.1021\/jm0501073","volume":"48","author":"Cecchi","year":"2005","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmcl.2007.02.068_bib8_2","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.tips.2006.09.002","volume":"27","author":"Thiry","year":"2006","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.bmcl.2007.02.068_bib9_1","doi-asserted-by":"crossref","first-page":"5429","DOI":"10.1016\/j.bmcl.2005.08.113","volume":"15","author":"Poulsen","year":"2005","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2007.02.068_bib9_2","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/j.bmc.2005.08.030","volume":"14","author":"Poulsen","year":"2006","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmcl.2007.02.068_bib9_3","doi-asserted-by":"crossref","first-page":"6539","DOI":"10.1021\/jm060967z","volume":"49","author":"Wilkinson","year":"2006","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmcl.2007.02.068_bib9_4","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1016\/j.bmcl.2006.11.046","volume":"17","author":"Wilkinson","year":"2007","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2007.02.068_bib10_1","doi-asserted-by":"crossref","first-page":"5192","DOI":"10.1016\/j.bmcl.2005.08.102","volume":"15","author":"Cecchi","year":"2005","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2007.02.068_bib10_2","doi-asserted-by":"crossref","first-page":"2743","DOI":"10.1021\/jm0600287","volume":"49","author":"Thiry","year":"2006","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmcl.2007.02.068_bib11_1","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1021\/jm0612057","volume":"50","author":"Nishimori","year":"2007","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmcl.2007.02.068_bib11_2","doi-asserted-by":"crossref","first-page":"7683","DOI":"10.1021\/jm060705x","volume":"49","author":"Leese","year":"2006","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmcl.2007.02.068_bib12_1","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1016\/j.bmcl.2006.12.107","volume":"17","author":"Santos","year":"2007","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2007.02.068_bib12_2","doi-asserted-by":"crossref","first-page":"3102","DOI":"10.1016\/j.bmcl.2005.04.056","volume":"15","author":"Garaj","year":"2005","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2007.02.068_bib13","doi-asserted-by":"crossref","first-page":"7024","DOI":"10.1021\/jm060807n","volume":"49","author":"Winum","year":"2006","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmcl.2007.02.068_bib14","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1128\/JB.187.2.729-738.2005","volume":"187","author":"Marcus","year":"2005","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.bmcl.2007.02.068_bib15_1","doi-asserted-by":"crossref","first-page":"15184","DOI":"10.1073\/pnas.96.26.15184","volume":"96","author":"Smith","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bmcl.2007.02.068_bib15_2","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1111\/j.1574-6976.2000.tb00546.x","volume":"24","author":"Smith","year":"2000","journal-title":"FEMS Microbiol. Rev."},{"key":"10.1016\/j.bmcl.2007.02.068_bib16","doi-asserted-by":"crossref","first-page":"18782","DOI":"10.1074\/jbc.M414348200","volume":"280","author":"Suarez Covarrubias","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bmcl.2007.02.068_bib17_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mib.2006.09.003","volume":"9","author":"Bahn","year":"2006","journal-title":"Curr. Opin. Microbiol."},{"key":"10.1016\/j.bmcl.2007.02.068_bib17_2","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.1016\/j.cub.2005.10.040","volume":"15","author":"Klengel","year":"2005","journal-title":"Curr. Biol."},{"key":"10.1016\/j.bmcl.2007.02.068_bib18_1","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1128\/EC.5.1.103-111.2006","volume":"5","author":"Mogensen","year":"2006","journal-title":"Eukaryot. Cell"},{"key":"10.1016\/j.bmcl.2007.02.068_bib18_2","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1016\/j.cub.2005.09.047","volume":"15","author":"Bahn","year":"2005","journal-title":"Curr. Biol."},{"key":"10.1016\/j.bmcl.2007.02.068_bib19","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/S0020-7519(01)00172-2","volume":"31","author":"Krungkrai","year":"2001","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.bmcl.2007.02.068_bib20_1","doi-asserted-by":"crossref","first-page":"2117","DOI":"10.1021\/jm0512600","volume":"49","author":"Nishimori","year":"2006","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmcl.2007.02.068_bib20_2","doi-asserted-by":"crossref","first-page":"2182","DOI":"10.1016\/j.bmcl.2006.01.044","volume":"16","author":"Nishimori","year":"2006","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2007.02.068_bib21","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.bmc.2004.10.015","volume":"13","author":"Krungkrai","year":"2005","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmcl.2007.02.068_bib22_1","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1016\/j.mcna.2006.07.004","volume":"90","author":"Schlossberg","year":"2006","journal-title":"Med. Clin. North Am."},{"key":"10.1016\/j.bmcl.2007.02.068_bib22_2","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1021\/cb600215q","volume":"1","author":"Chen","year":"2006","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.bmcl.2007.02.068_bib23","series-title":"Carbonic Anhydrase\u2014Its Inhibitors and Activators","first-page":"67","article-title":"Development of sulfonamide carbonic anhydrase inhibitors","author":"Supuran","year":"2004"},{"key":"10.1016\/j.bmcl.2007.02.068_bib24","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.bmcl.2003.09.062","volume":"14","author":"Abbate","year":"2004","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2007.02.068_bib25","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/S0960-894X(03)00029-5","volume":"13","author":"Casini","year":"2003","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2007.02.068_bib26","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.1016\/j.bmcl.2005.03.032","volume":"15","author":"De Simone","year":"2005","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2007.02.068_bib27","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.bmcl.2003.11.014","volume":"14","author":"Abbate","year":"2004","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2007.02.068_bib28","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1042\/BJ20041037","volume":"385","author":"Lloyd","year":"2005","journal-title":"Biochem. J."},{"key":"10.1016\/j.bmcl.2007.02.068_bib29","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.bmcl.2003.09.064","volume":"14","author":"Abbate","year":"2004","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2007.02.068_bib30","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.bmcl.2005.09.040","volume":"16","author":"Di Fiore","year":"2006","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2007.02.068_bib31","author":"K\u00f6hler","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.bmcl.2007.02.068_bib32","doi-asserted-by":"crossref","first-page":"2353","DOI":"10.1016\/j.bmcl.2005.02.091","volume":"15","author":"Winum","year":"2005","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2007.02.068_bib33","first-page":"297","volume":"15","author":"Fenesan","year":"2000","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"10.1016\/j.bmcl.2007.02.068_bib34","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1080\/14756360410001689522","volume":"19","author":"Bonnac","year":"2004","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"10.1016\/j.bmcl.2007.02.068_bib35","doi-asserted-by":"crossref","first-page":"3496","DOI":"10.1021\/jm058279n","volume":"49","author":"Klinger","year":"2006","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmcl.2007.02.068_bib36","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.bmcl.2004.11.056","volume":"15","author":"Innocenti","year":"2005","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2007.02.068_bib38","unstructured":"Oxford Diffraction CrysAlis RED. 2006, Version 1.171.32.2. Oxford Diffraction Ltd."},{"key":"10.1016\/j.bmcl.2007.02.068_bib39","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1107\/S0108767390010224","volume":"A47","author":"Jones","year":"1991","journal-title":"Acta Crystallogr."},{"key":"10.1016\/j.bmcl.2007.02.068_bib40","first-page":"2126","volume":"D60","author":"Emsley","year":"2004","journal-title":"Acta Crystallogr."},{"key":"10.1016\/j.bmcl.2007.02.068_bib41","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1107\/S0021889892009944","volume":"26","author":"Laskowski","year":"1993","journal-title":"J. Appl. Crystallogr."},{"key":"10.1016\/j.bmcl.2007.02.068_bib42","unstructured":"The ACD Labs 8.0 pKa dB software is available at: www.acdlabs.com\/products\/phys_chem_lab\/pka."},{"key":"10.1016\/j.bmcl.2007.02.068_bib43_1","doi-asserted-by":"crossref","first-page":"6204","DOI":"10.1016\/j.bmcl.2006.09.022","volume":"16","author":"Menchise","year":"2006","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2007.02.068_bib43_2","doi-asserted-by":"crossref","first-page":"1726","DOI":"10.1016\/j.bmcl.2006.12.099","volume":"17","author":"Di Fiore","year":"2007","journal-title":"Bioorg. Med. Chem. Lett."}],"container-title":["Bioorganic & Medicinal Chemistry Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X0700265X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X0700265X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T05:47:56Z","timestamp":1760766476000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960894X0700265X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,5]]},"references-count":65,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2007,5]]}},"alternative-id":["S0960894X0700265X"],"URL":"https:\/\/doi.org\/10.1016\/j.bmcl.2007.02.068","relation":{},"ISSN":["0960-894X"],"issn-type":[{"value":"0960-894X","type":"print"}],"subject":[],"published":{"date-parts":[[2007,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Carbonic anhydrase inhibitors: The X-ray crystal structure of the adduct of N-hydroxysulfamide with isozyme II explains why this new zinc binding function is effective in the design of potent inhibitors","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmcl.2007.02.068","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2007 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}