{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T17:13:51Z","timestamp":1791134031677,"version":"4.1.0"},"reference-count":54,"publisher":"Elsevier BV","issue":"13","license":[{"start":{"date-parts":[[2007,7,1]],"date-time":"2007-07-01T00:00:00Z","timestamp":1183248000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,7,1]],"date-time":"2007-07-01T00:00:00Z","timestamp":1183248000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["9770363"],"award-info":[{"award-number":["9770363"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004965","name":"Sixth Framework Programme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004965","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry Letters"],"published-print":{"date-parts":[[2007,7]]},"DOI":"10.1016\/j.bmcl.2007.04.063","type":"journal-article","created":{"date-parts":[[2007,4,26]],"date-time":"2007-04-26T09:03:24Z","timestamp":1177578204000},"page":"3585-3594","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":161,"title":["Carbonic anhydrase inhibitors: The \u03b2-carbonic anhydrase from Helicobacter pylori is a new target for sulfonamide and sulfamate inhibitors"],"prefix":"10.1016","volume":"17","author":[{"given":"Isao","family":"Nishimori","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoko","family":"Minakuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuhiro","family":"Kohsaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saburo","family":"Onishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Takeuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Vullo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Scozzafava","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudiu T.","family":"Supuran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmcl.2007.04.063_bib1_1","doi-asserted-by":"crossref","first-page":"2117","DOI":"10.1021\/jm0512600","volume":"49","author":"Nishimori","year":"2006","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmcl.2007.04.063_bib1_2","doi-asserted-by":"crossref","first-page":"2182","DOI":"10.1016\/j.bmcl.2006.01.044","volume":"16","author":"Nishimori","year":"2006","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2007.04.063_bib2","series-title":"Carbonic Anhydrases: Its Inhibitors and Activators","author":"Supuran","year":"2004"},{"key":"10.1016\/j.bmcl.2007.04.063_bib3","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1080\/14756360410001689540","volume":"19","author":"Pastorekova","year":"2004","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"10.1016\/j.bmcl.2007.04.063_bib4","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1002\/med.10025","volume":"23","author":"Supuran","year":"2003","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.bmcl.2007.04.063_bib5","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1517\/13543776.16.12.1627","volume":"16","author":"Scozzafava","year":"2006","journal-title":"Expert Opin. Ther. Pat."},{"key":"10.1016\/j.bmcl.2007.04.063_bib6","doi-asserted-by":"crossref","first-page":"2719","DOI":"10.1074\/jbc.M308984200","volume":"279","author":"Lehtonen","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bmcl.2007.04.063_bib7","doi-asserted-by":"crossref","first-page":"21228","DOI":"10.1074\/jbc.274.30.21228","volume":"274","author":"Fujikawa-Adachi","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bmcl.2007.04.063_bib8","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1006\/geno.1999.5938","volume":"61","author":"Fujikawa-Adachi","year":"1999","journal-title":"Genomics"},{"key":"10.1016\/j.bmcl.2007.04.063_bib9_1","doi-asserted-by":"crossref","first-page":"7860","DOI":"10.1021\/jm050483n","volume":"48","author":"Nishimori","year":"2005","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmcl.2007.04.063_bib9_2","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1021\/jm031057+","volume":"47","author":"Vullo","year":"2004","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmcl.2007.04.063_bib9_3","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1517\/13543776.13.10.1545","volume":"13","author":"Supuran","year":"2003","journal-title":"Expert Opin. Ther. Pat."},{"key":"10.1016\/j.bmcl.2007.04.063_bib10_1","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1021\/jm030912m","volume":"47","author":"Weber","year":"2004","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmcl.2007.04.063_bib10_2","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/j.bmcl.2003.12.029","volume":"14","author":"Pastorekova","year":"2004","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2007.04.063_bib11_1","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/j.bmcl.2004.12.052","volume":"15","author":"Vullo","year":"2005","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2007.04.063_bib11_2","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.1016\/j.bmcl.2005.03.032","volume":"15","author":"De Simone","year":"2005","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2007.04.063_bib12","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1016\/j.bmcl.2004.12.053","volume":"15","author":"Vullo","year":"2005","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2007.04.063_bib13_1","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.febslet.2004.10.043","volume":"577","author":"Svastova","year":"2004","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bmcl.2007.04.063_bib13_2","doi-asserted-by":"crossref","first-page":"4834","DOI":"10.1021\/jm0501073","volume":"48","author":"Cecchi","year":"2005","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmcl.2007.04.063_bib13_3","doi-asserted-by":"crossref","first-page":"5721","DOI":"10.1021\/jm050333c","volume":"48","author":"Menchise","year":"2005","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmcl.2007.04.063_bib14","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.bmc.2004.10.015","volume":"13","author":"Krungkrai","year":"2005","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmcl.2007.04.063_bib15_1","doi-asserted-by":"crossref","first-page":"18782","DOI":"10.1074\/jbc.M414348200","volume":"280","author":"Suarez Covarrubias","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bmcl.2007.04.063_bib15_2","doi-asserted-by":"crossref","first-page":"4993","DOI":"10.1074\/jbc.M510756200","volume":"281","author":"Suarez Covarrubias","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bmcl.2007.04.063_bib16_1","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.1016\/j.cub.2005.10.040","volume":"15","author":"Klengel","year":"2005","journal-title":"Curr. Biol."},{"key":"10.1016\/j.bmcl.2007.04.063_bib16_2","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1128\/EC.5.1.103-111.2006","volume":"5","author":"Mogensen","year":"2006","journal-title":"Eukaryot. Cell"},{"key":"10.1016\/j.bmcl.2007.04.063_bib17_1","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1016\/j.cub.2005.09.047","volume":"15","author":"Bahn","year":"2005","journal-title":"Curr. Biol."},{"key":"10.1016\/j.bmcl.2007.04.063_bib17_2","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/j.mib.2006.09.003","volume":"9","author":"Bahn","year":"2006","journal-title":"Curr. Opin. Microbiol."},{"key":"10.1016\/j.bmcl.2007.04.063_bib17_3","doi-asserted-by":"crossref","first-page":"7546","DOI":"10.1074\/jbc.M510464200","volume":"281","author":"Sawaya","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bmcl.2007.04.063_bib17_4","doi-asserted-by":"crossref","first-page":"5500","DOI":"10.1128\/AEM.00237-06","volume":"72","author":"Soto","year":"2006","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.bmcl.2007.04.063_bib18","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1056\/NEJMra020542","volume":"347","author":"Suerbaum","year":"2002","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bmcl.2007.04.063_bib19","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1046\/j.1365-2036.2002.01169.x","volume":"16","author":"Malfertheiner","year":"2002","journal-title":"Aliment. Pharmacol. Ther."},{"key":"10.1016\/j.bmcl.2007.04.063_bib20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1440-1746.1998.tb00537.x","volume":"13","author":"Lam","year":"1998","journal-title":"J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.bmcl.2007.04.063_bib21","doi-asserted-by":"crossref","first-page":"I40","DOI":"10.1136\/gut.45.2008.i40","volume":"45","author":"Huang","year":"1999","journal-title":"Gut"},{"key":"10.1016\/j.bmcl.2007.04.063_bib22","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1046\/j.1365-2036.1999.00542.x","volume":"13","author":"Laheij","year":"1999","journal-title":"Aliment. Pharmacol. Ther."},{"key":"10.1016\/j.bmcl.2007.04.063_bib23","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1111\/j.1365-2036.2004.02248.x","volume":"20","author":"Fischbach","year":"2004","journal-title":"Aliment. Pharmacol. Ther."},{"key":"10.1016\/j.bmcl.2007.04.063_bib24","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1159\/000050668","volume":"19","author":"Gisbert","year":"2001","journal-title":"Dig. Dis."},{"key":"10.1016\/j.bmcl.2007.04.063_bib25","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1046\/j.1365-2036.2003.01653.x","volume":"18","author":"Chi","year":"2003","journal-title":"Aliment. Pharmacol. Ther."},{"key":"10.1016\/j.bmcl.2007.04.063_bib26","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1046\/j.1365-2036.2003.01759.x","volume":"18","author":"Lamouliatte","year":"2003","journal-title":"Aliment. Pharmacol. Ther."},{"key":"10.1016\/j.bmcl.2007.04.063_bib27","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1097\/00042737-200211000-00012","volume":"14","author":"Mantzaris","year":"2002","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.bmcl.2007.04.063_bib28","first-page":"429","volume":"20","author":"Sachs","year":"2005","journal-title":"Physiology (Bethesda)"},{"key":"10.1016\/j.bmcl.2007.04.063_bib29","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1128\/JB.187.2.729-738.2005","volume":"187","author":"Marcus","year":"2005","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.bmcl.2007.04.063_bib30","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.femsim.2004.10.021","volume":"44","author":"Stahler","year":"2005","journal-title":"FEMS Immunol. Med. Microbiol."},{"key":"10.1016\/j.bmcl.2007.04.063_bib31_1","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0167-4838(00)00204-1","volume":"1544","author":"Chirica","year":"2001","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bmcl.2007.04.063_bib31_2","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/S1570-9639(02)00467-3","volume":"1601","author":"Chirica","year":"2002","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bmcl.2007.04.063_bib32","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1038\/41483","volume":"388","author":"Tomb","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.bmcl.2007.04.063_bib35","doi-asserted-by":"crossref","first-page":"6001","DOI":"10.1016\/j.bmcl.2004.09.085","volume":"14","author":"Zimmerman","year":"2004","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2007.04.063_bib36","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.bmcl.2003.11.014","volume":"14","author":"Abbate","year":"2004","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2007.04.063_bib37","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.bmcl.2003.09.062","volume":"14","author":"Abbate","year":"2004","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2007.04.063_bib38","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1110\/ps.46301","volume":"10","author":"Cronk","year":"2001","journal-title":"Protein Sci."},{"key":"10.1016\/j.bmcl.2007.04.063_bib39","doi-asserted-by":"crossref","first-page":"5521","DOI":"10.1074\/jbc.275.8.5521","volume":"275","author":"Mitsuhashi","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bmcl.2007.04.063_bib40","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1093\/emboj\/19.7.1407","volume":"19","author":"Kimber","year":"2000","journal-title":"EMBO J."},{"key":"10.1016\/j.bmcl.2007.04.063_bib41","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1104\/pp.117.4.1341","volume":"117","author":"Hiltonen","year":"1998","journal-title":"Plant Physiol."},{"key":"10.1016\/j.bmcl.2007.04.063_bib42","doi-asserted-by":"crossref","first-page":"10299","DOI":"10.1074\/jbc.M009182200","volume":"276","author":"Strop","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bmcl.2007.04.063_bib43","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1111\/j.1574-6976.2000.tb00546.x","volume":"24","author":"Smith","year":"2000","journal-title":"FEMS Microbiol. Rev."}],"container-title":["Bioorganic & Medicinal Chemistry Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X07004830?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X07004830?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T05:46:54Z","timestamp":1760766414000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960894X07004830"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,7]]},"references-count":54,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2007,7]]}},"alternative-id":["S0960894X07004830"],"URL":"https:\/\/doi.org\/10.1016\/j.bmcl.2007.04.063","relation":{},"ISSN":["0960-894X"],"issn-type":[{"value":"0960-894X","type":"print"}],"subject":[],"published":{"date-parts":[[2007,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Carbonic anhydrase inhibitors: The \u03b2-carbonic anhydrase from Helicobacter pylori is a new target for sulfonamide and sulfamate inhibitors","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmcl.2007.04.063","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2007 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}