{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T23:30:21Z","timestamp":1772753421583,"version":"3.50.1"},"reference-count":30,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2008,4,1]],"date-time":"2008-04-01T00:00:00Z","timestamp":1207008000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,4,1]],"date-time":"2008-04-01T00:00:00Z","timestamp":1207008000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry Letters"],"published-print":{"date-parts":[[2008,4]]},"DOI":"10.1016\/j.bmcl.2007.07.068","type":"journal-article","created":{"date-parts":[[2007,8,22]],"date-time":"2007-08-22T07:13:26Z","timestamp":1187766806000},"page":"2509-2512","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"title":["Selective cell adhesion inhibitors: Barbituric acid based \u03b14\u03b27\u2014MAdCAM inhibitors"],"prefix":"10.1016","volume":"18","author":[{"given":"Geraldine C.","family":"Harriman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Brewer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Bennett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cyrille","family":"Kuhn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Bazin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Greg","family":"Larosa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Skerker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nancy","family":"Cochran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Debra","family":"Gallant","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deborah","family":"Baxter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominic","family":"Picarella","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce","family":"Jaffee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jay R.","family":"Luly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael J.","family":"Briskin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmcl.2007.07.068_bib1","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/0092-8674(91)90279-8","volume":"67","author":"Butcher","year":"1991","journal-title":"Cell"},{"key":"10.1016\/j.bmcl.2007.07.068_bib2","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/0092-8674(94)90337-9","volume":"65","author":"Springer","year":"1994","journal-title":"Cell"},{"key":"10.1016\/j.bmcl.2007.07.068_bib3","first-page":"1651","volume":"149","author":"Brezinschek","year":"1996","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.bmcl.2007.07.068_bib4","first-page":"74","author":"Berlin","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.bmcl.2007.07.068_bib5","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/1074-7613(95)90162-0","volume":"3","author":"Bargatze","year":"1995","journal-title":"Immunity"},{"key":"10.1016\/j.bmcl.2007.07.068_bib6","first-page":"97","volume":"151","author":"Briskin","year":"1997","journal-title":"J. Am. J. Pathol."},{"key":"10.1016\/j.bmcl.2007.07.068_bib7","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.4049\/jimmunol.158.5.2099","volume":"158","author":"Picarella","year":"1997","journal-title":"J. Immunol."},{"key":"10.1016\/j.bmcl.2007.07.068_bib8","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1053\/gast.1996.v111.pm8898653","volume":"111","author":"Hesterberg","year":"1996","journal-title":"Gastroenterology"},{"key":"10.1016\/j.bmcl.2007.07.068_bib9","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1038\/363461a0","volume":"363","author":"Briskin","year":"1993","journal-title":"Nature"},{"key":"10.1016\/j.bmcl.2007.07.068_bib10","doi-asserted-by":"crossref","first-page":"719","DOI":"10.4049\/jimmunol.156.2.719","volume":"156","author":"Briskin","year":"1996","journal-title":"J. Immunol."},{"key":"10.1016\/j.bmcl.2007.07.068_bib11","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1016\/S0960-894X(98)00286-8","volume":"8","author":"Shroff","year":"1998","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2007.07.068_bib12","doi-asserted-by":"crossref","first-page":"2495","DOI":"10.1016\/0960-894X(96)00469-6","volume":"6","author":"Shroff","year":"1996","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2007.07.068_bib13","doi-asserted-by":"crossref","first-page":"3451","DOI":"10.1021\/jm020033k","volume":"45","author":"Dubree","year":"2002","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmcl.2007.07.068_bib14","doi-asserted-by":"crossref","first-page":"2586","DOI":"10.1021\/jm0005508","volume":"44","author":"Boer","year":"2001","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmcl.2007.07.068_bib15","doi-asserted-by":"crossref","first-page":"2913","DOI":"10.1016\/S0960-894X(02)00597-8","volume":"12","author":"Georgette","year":"2002","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2007.07.068_bib16","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1016\/S0960-894X(00)00300-0","volume":"10","author":"Harriman","year":"2000","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2007.07.068_bib17","doi-asserted-by":"crossref","first-page":"601","DOI":"10.2174\/157018005774717280","volume":"2","author":"Lawson","year":"2005","journal-title":"Lett. Drug Des. Discov."},{"key":"10.1016\/j.bmcl.2007.07.068_bib18","doi-asserted-by":"crossref","first-page":"99","DOI":"10.2174\/1381612023394737","volume":"8","author":"Jackson","year":"2002","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.bmcl.2007.07.068_bib19","doi-asserted-by":"crossref","first-page":"6693","DOI":"10.1016\/j.bmc.2005.07.022","volume":"13","author":"Dyatkin","year":"2005","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmcl.2007.07.068_bib20","doi-asserted-by":"crossref","first-page":"2913","DOI":"10.1016\/S0960-894X(02)00597-8","volume":"12","author":"Castanedo","year":"2002","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2007.07.068_bib21","doi-asserted-by":"crossref","first-page":"3402","DOI":"10.1021\/jm060031q","volume":"49","author":"Gong","year":"2006","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmcl.2007.07.068_bib22","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/S0960-894X(97)00090-5","volume":"7","author":"Carson","year":"1997","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2007.07.068_bib23","doi-asserted-by":"crossref","first-page":"5752","DOI":"10.1021\/jm020487h","volume":"46","author":"Locardi","year":"2003","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmcl.2007.07.068_bib24","doi-asserted-by":"crossref","first-page":"2268","DOI":"10.1002\/eji.200535195","volume":"35","author":"Engelhardt","year":"2005","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.bmcl.2007.07.068_bib25","first-page":"57","volume":"12","author":"Yogeeswari","year":"2003","journal-title":"Med. Chem. Res."},{"key":"10.1016\/j.bmcl.2007.07.068_bib26","first-page":"2226","volume":"11","author":"Laudien","year":"2001","journal-title":"Chem. Soc., PT 2"},{"key":"10.1016\/j.bmcl.2007.07.068_bib27","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1016\/S0957-4166(03)00306-9","volume":"14","author":"Oguz","year":"2003","journal-title":"Tetrahedron: Asymmetry"},{"key":"10.1016\/j.bmcl.2007.07.068_bib28","doi-asserted-by":"crossref","first-page":"8435","DOI":"10.1016\/S0040-4039(01)01830-5","volume":"42","author":"Jursic","year":"2001","journal-title":"Tetrahedron Lett."},{"key":"10.1016\/j.bmcl.2007.07.068_bib29","doi-asserted-by":"crossref","first-page":"3709","DOI":"10.1016\/S0040-4020(03)00543-X","volume":"59","author":"Naya","year":"2003","journal-title":"Tetrahedron"},{"key":"10.1016\/j.bmcl.2007.07.068_bib31","first-page":"238","volume":"69","author":"Cooper","year":"1993","journal-title":"Lab. Invest."}],"container-title":["Bioorganic & Medicinal Chemistry Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X07008724?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X07008724?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T05:54:40Z","timestamp":1760766880000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960894X07008724"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,4]]},"references-count":30,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2008,4]]}},"alternative-id":["S0960894X07008724"],"URL":"https:\/\/doi.org\/10.1016\/j.bmcl.2007.07.068","relation":{},"ISSN":["0960-894X"],"issn-type":[{"value":"0960-894X","type":"print"}],"subject":[],"published":{"date-parts":[[2008,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Selective cell adhesion inhibitors: Barbituric acid based \u03b14\u03b27\u2014MAdCAM inhibitors","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmcl.2007.07.068","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2007 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}