{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T00:14:08Z","timestamp":1760832848337,"version":"build-2065373602"},"reference-count":12,"publisher":"Elsevier BV","issue":"19","license":[{"start":{"date-parts":[[2007,10,1]],"date-time":"2007-10-01T00:00:00Z","timestamp":1191196800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,10,1]],"date-time":"2007-10-01T00:00:00Z","timestamp":1191196800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry Letters"],"published-print":{"date-parts":[[2007,10]]},"DOI":"10.1016\/j.bmcl.2007.08.008","type":"journal-article","created":{"date-parts":[[2007,8,14]],"date-time":"2007-08-14T07:53:21Z","timestamp":1187078001000},"page":"5349-5352","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Structure\u2013activity relationship studies of carboxamido-biaryl ethers as opioid receptor antagonists (OpRAs). Part 1"],"prefix":"10.1016","volume":"17","author":[{"given":"Kumiko","family":"Takeuchi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William G.","family":"Holloway","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jamie H.","family":"McKinzie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Todd M.","family":"Suter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael A.","family":"Statnick","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peggy L.","family":"Surface","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul J.","family":"Emmerson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth M.","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miles G.","family":"Siegel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James E.","family":"Matt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chad N.","family":"Wolfe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles H.","family":"Mitch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmcl.2007.08.008_bib1","doi-asserted-by":"crossref","first-page":"2522","DOI":"10.1210\/jc.2004-0288","volume":"89","author":"Stein","year":"2004","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bmcl.2007.08.008_bib2_1","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1093\/ajcn\/42.5.1099","volume":"42","author":"Reid","year":"1985","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.bmcl.2007.08.008_bib2_2","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1054\/npep.1999.0050","volume":"33","author":"Glass","year":"1999","journal-title":"Neuropeptides"},{"key":"10.1016\/j.bmcl.2007.08.008_bib3_1","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1126\/science.715455","volume":"202","author":"Margules","year":"1978","journal-title":"Science"},{"key":"10.1016\/j.bmcl.2007.08.008_bib3_2","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/0006-8993(96)00151-5","volume":"721","author":"Welch","year":"1996","journal-title":"Brain Res."},{"key":"10.1016\/j.bmcl.2007.08.008_bib4_1","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1126\/science.7063865","volume":"215","author":"Mandenoff","year":"1982","journal-title":"Science"},{"key":"10.1016\/j.bmcl.2007.08.008_bib4_2","first-page":"R217","volume":"271","author":"Glass","year":"1996","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.bmcl.2007.08.008_bib5","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/S0149-7634(02)00041-6","volume":"26","author":"Yeomans","year":"2002","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.bmcl.2007.08.008_bib6_1","doi-asserted-by":"crossref","first-page":"2842","DOI":"10.1021\/jm00072a002","volume":"36","author":"Mitch","year":"1993","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmcl.2007.08.008_bib6_2","doi-asserted-by":"crossref","first-page":"R1399","DOI":"10.1152\/ajpregu.00632.2002","volume":"284","author":"Statnick","year":"2003","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.bmcl.2007.08.008_bib7","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.ejphar.2004.04.050","volume":"494","author":"Emmerson","year":"2004","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.bmcl.2007.08.008_bib8","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1089\/154065803770380986","volume":"1","author":"Rodgers","year":"2003","journal-title":"Assay Drug Dev. Technol."}],"container-title":["Bioorganic & Medicinal Chemistry Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X07009456?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X07009456?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T05:50:04Z","timestamp":1760766604000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960894X07009456"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,10]]},"references-count":12,"journal-issue":{"issue":"19","published-print":{"date-parts":[[2007,10]]}},"alternative-id":["S0960894X07009456"],"URL":"https:\/\/doi.org\/10.1016\/j.bmcl.2007.08.008","relation":{},"ISSN":["0960-894X"],"issn-type":[{"type":"print","value":"0960-894X"}],"subject":[],"published":{"date-parts":[[2007,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Structure\u2013activity relationship studies of carboxamido-biaryl ethers as opioid receptor antagonists (OpRAs). Part 1","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmcl.2007.08.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2007 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}