{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T14:04:20Z","timestamp":1772892260028,"version":"3.50.1"},"reference-count":20,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100005181","name":"Atomic Energy Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005181","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry Letters"],"published-print":{"date-parts":[[2008,1]]},"DOI":"10.1016\/j.bmcl.2007.11.007","type":"journal-article","created":{"date-parts":[[2007,11,6]],"date-time":"2007-11-06T07:20:30Z","timestamp":1194333630000},"page":"120-123","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"title":["(2S,2\u2032R)-Analogue of LG190178 is a major active isomer"],"prefix":"10.1016","volume":"18","author":[{"given":"Wataru","family":"Hakamata","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukiko","family":"Sato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haruhiro","family":"Okuda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinobu","family":"Honzawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nozomi","family":"Saito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seishi","family":"Kishimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Yamashita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takayuki","family":"Sugiura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Kittaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaaki","family":"Kurihara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmcl.2007.11.007_bib1","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S1097-2765(00)80413-X","volume":"5","author":"Rochel","year":"2000","journal-title":"Mol. Cell."},{"key":"10.1016\/j.bmcl.2007.11.007_bib2_1","doi-asserted-by":"crossref","first-page":"2619","DOI":"10.1021\/ol006222j","volume":"2","author":"Kittaka","year":"2000","journal-title":"Org. Lett."},{"key":"10.1016\/j.bmcl.2007.11.007_bib2_2","doi-asserted-by":"crossref","first-page":"4247","DOI":"10.1021\/jm000261j","volume":"43","author":"Konno","year":"2000","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmcl.2007.11.007_bib2_3","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1016\/S1074-5521(01)00062-X","volume":"8","author":"Fujishima","year":"2001","journal-title":"Chem. Biol."},{"key":"10.1016\/j.bmcl.2007.11.007_bib2_4","doi-asserted-by":"crossref","first-page":"8760","DOI":"10.1021\/jo010375i","volume":"66","author":"Suhara","year":"2001","journal-title":"J. Org. Chem."},{"key":"10.1016\/j.bmcl.2007.11.007_bib2_5","doi-asserted-by":"crossref","first-page":"3533","DOI":"10.1016\/S0960-894X(02)00800-4","volume":"12","author":"Suhara","year":"2002","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2007.11.007_bib2_6","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1248\/cpb.51.357","volume":"51","author":"Kittaka","year":"2003","journal-title":"Chem. Pharm. Bull."},{"key":"10.1016\/j.bmcl.2007.11.007_bib2_7","doi-asserted-by":"crossref","first-page":"3503","DOI":"10.1016\/S0960-894X(03)00739-X","volume":"13","author":"Honzawa","year":"2003","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2007.11.007_bib2_8","doi-asserted-by":"crossref","first-page":"7463","DOI":"10.1021\/jo0491051","volume":"69","author":"Saito","year":"2004","journal-title":"J. Org. Chem."},{"key":"10.1016\/j.bmcl.2007.11.007_bib2_9","doi-asserted-by":"crossref","first-page":"4131","DOI":"10.1016\/j.bmcl.2004.06.038","volume":"14","author":"Kurihara","year":"2004","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2007.11.007_bib2_10","doi-asserted-by":"crossref","first-page":"11253","DOI":"10.1016\/j.tet.2005.08.116","volume":"61","author":"Honzawa","year":"2005","journal-title":"Tetrahedron"},{"key":"10.1016\/j.bmcl.2007.11.007_bib3_1","doi-asserted-by":"crossref","first-page":"13795","DOI":"10.1021\/ja0268377","volume":"124","author":"Swann","year":"2002","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bmcl.2007.11.007_bib3_2","doi-asserted-by":"crossref","first-page":"2060","DOI":"10.1210\/me.2004-0417","volume":"19","author":"Perakyla","year":"2005","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.bmcl.2007.11.007_bib3_3","doi-asserted-by":"crossref","first-page":"4327","DOI":"10.1016\/j.bmcl.2005.06.044","volume":"15","author":"Hosoda","year":"2005","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2007.11.007_bib3_4","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1172\/JCI25901","volume":"116","author":"Ma","year":"2006","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bmcl.2007.11.007_bib4_1","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S1074-5521(99)80072-6","volume":"6","author":"Boehm","year":"1999","journal-title":"Chem. Biol."},{"key":"10.1016\/j.bmcl.2007.11.007_bib4_2","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1002\/pros.1138","volume":"49","author":"Polek","year":"2001","journal-title":"Prostate"},{"key":"10.1016\/j.bmcl.2007.11.007_bib5","doi-asserted-by":"crossref","first-page":"5489","DOI":"10.1016\/j.bmc.2006.04.039","volume":"14","author":"Hosoda","year":"2006","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmcl.2007.11.007_bib6","unstructured":"A docking model of ligands bound to VDR (1DB1) was constructed by conformational search by MacroModel (ver. 8.1). AMBER* was used as force field. Differences of potential energy are estimated by molecular mechanics calculation."},{"key":"10.1016\/j.bmcl.2007.11.007_bib7","doi-asserted-by":"crossref","first-page":"6142","DOI":"10.1021\/ja00093a011","volume":"116","author":"William","year":"1994","journal-title":"J. Am. Chem. Soc."}],"container-title":["Bioorganic & Medicinal Chemistry Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X07013157?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X07013157?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T05:50:52Z","timestamp":1760766652000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960894X07013157"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,1]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,1]]}},"alternative-id":["S0960894X07013157"],"URL":"https:\/\/doi.org\/10.1016\/j.bmcl.2007.11.007","relation":{},"ISSN":["0960-894X"],"issn-type":[{"value":"0960-894X","type":"print"}],"subject":[],"published":{"date-parts":[[2008,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"(2S,2\u2032R)-Analogue of LG190178 is a major active isomer","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmcl.2007.11.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2007 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}