{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T03:05:29Z","timestamp":1792724729569,"version":"4.5.0"},"reference-count":32,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2009,2,1]],"date-time":"2009-02-01T00:00:00Z","timestamp":1233446400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,2,1]],"date-time":"2009-02-01T00:00:00Z","timestamp":1233446400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic &amp; Medicinal Chemistry Letters"],"published-print":{"date-parts":[[2009,2]]},"DOI":"10.1016\/j.bmcl.2008.01.043","type":"journal-article","created":{"date-parts":[[2008,1,22]],"date-time":"2008-01-22T09:58:40Z","timestamp":1200995920000},"page":"1030-1034","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":73,"title":["Development of pH-responsive core\u2013shell nanocarriers for delivery of therapeutic and diagnostic agents"],"prefix":"10.1016","volume":"19","author":[{"given":"Shangjie","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph","family":"Graeser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"Warnecke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Kratz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Hauff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Licha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rainer","family":"Haag","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmcl.2008.01.043_bib1","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1002\/cmdc.200700159","volume":"3","author":"Kratz","year":"2007","journal-title":"ChemMedChem"},{"key":"10.1016\/j.bmcl.2008.01.043_bib2","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1002\/anie.200502113","volume":"45","author":"Haag","year":"2006","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.bmcl.2008.01.043_bib3","doi-asserted-by":"crossref","first-page":"1818","DOI":"10.1126\/science.1095833","volume":"303","author":"Allen","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.bmcl.2008.01.043_bib4","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0065-2571(00)00013-3","volume":"41","author":"Maeda","year":"2001","journal-title":"Adv. Enzyme Regul."},{"key":"10.1016\/j.bmcl.2008.01.043_bib5","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1021\/bc020041f","volume":"14","author":"Jones","year":"2003","journal-title":"Bioconjugate Chem."},{"key":"10.1016\/j.bmcl.2008.01.043_bib6","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/nrd1088","volume":"2","author":"Duncan","year":"2003","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.bmcl.2008.01.043_bib7","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1021\/cr9603892","volume":"5","author":"Zeng","year":"1997","journal-title":"Chem. Rev."},{"key":"10.1016\/j.bmcl.2008.01.043_bib8","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/S1461-5347(99)00203-5","volume":"2","author":"Liu","year":"1999","journal-title":"Pharm. Sci. Technol. Today"},{"key":"10.1016\/j.bmcl.2008.01.043_bib9","doi-asserted-by":"crossref","first-page":"3492","DOI":"10.1002\/(SICI)1099-0518(19990901)37:17<3492::AID-POLA7>3.0.CO;2-0","volume":"37","author":"Liu","year":"1999","journal-title":"J. Polym. Sci. Polym. Chem."},{"key":"10.1016\/j.bmcl.2008.01.043_bib10","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0168-3659(99)00245-X","volume":"65","author":"Liu","year":"2000","journal-title":"J. Control. Release"},{"key":"10.1016\/j.bmcl.2008.01.043_bib11","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/3-540-46577-4_3","volume":"210","author":"Baars","year":"2000","journal-title":"Top. Curr. Chem."},{"key":"10.1016\/j.bmcl.2008.01.043_bib12","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1016\/S0079-6700(00)00017-4","volume":"25","author":"V\u00f6gtle","year":"2000","journal-title":"Prog. Polym. Sci."},{"key":"10.1016\/j.bmcl.2008.01.043_bib13","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/S1359-6446(01)01757-3","volume":"6","author":"Esfand","year":"2001","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.bmcl.2008.01.043_bib14","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/3-540-45003-3_3","volume":"217","author":"Zimmerman","year":"2001","journal-title":"Top. Curr. Chem."},{"key":"10.1016\/j.bmcl.2008.01.043_bib15","doi-asserted-by":"crossref","first-page":"4252","DOI":"10.1002\/1521-3773(20021115)41:22<4252::AID-ANIE4252>3.0.CO;2-F","volume":"41","author":"Kr\u00e4mer","year":"2002","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.bmcl.2008.01.043_bib16","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1002\/1521-3773(20020415)41:8<1329::AID-ANIE1329>3.0.CO;2-P","volume":"41","author":"Stiriba","year":"2002","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.bmcl.2008.01.043_bib17","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1002\/(SICI)1521-3773(20000403)39:7<1285::AID-ANIE1285>3.0.CO;2-F","volume":"39","author":"Baars","year":"2000","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.bmcl.2008.01.043_bib18","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1021\/bc0000583","volume":"11","author":"Kojima","year":"2000","journal-title":"Bioconjugate Chem."},{"key":"10.1016\/j.bmcl.2008.01.043_bib19","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1097\/00001813-199206000-00001","volume":"3","author":"Duncan","year":"1992","journal-title":"Anti-cancer Drug"},{"key":"10.1016\/j.bmcl.2008.01.043_bib20","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1021\/bc00017a001","volume":"3","author":"Maeda","year":"1992","journal-title":"Bioconjugate Chem."},{"key":"10.1016\/j.bmcl.2008.01.043_bib21","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/0168-3659(93)90172-2","volume":"24","author":"Kataoka","year":"1993","journal-title":"J. Control. Release"},{"key":"10.1016\/j.bmcl.2008.01.043_bib22","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1615\/CritRevTherDrugCarrierSyst.v16.i3.10","volume":"16","author":"Kratz","year":"1999","journal-title":"Crit. Rev. Ther. Drug Carrier Syst."},{"key":"10.1016\/j.bmcl.2008.01.043_bib23","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1126\/science.124.3215.269","volume":"124","author":"Warburg","year":"1956","journal-title":"Science"},{"key":"10.1016\/j.bmcl.2008.01.043_bib24","first-page":"4373","volume":"49","author":"Tannock","year":"1989","journal-title":"Cancer Res."},{"key":"10.1016\/j.bmcl.2008.01.043_bib25","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1002\/mabi.200700066","volume":"7","author":"Xu","year":"2007","journal-title":"Macromol. Biosci."},{"key":"10.1016\/j.bmcl.2008.01.043_bib26","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1002\/marc.200700589","volume":"29","author":"Xu","year":"2008","journal-title":"Macromol. Rapid Commun."},{"key":"10.1016\/j.bmcl.2008.01.043_bib27","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1016\/j.addr.2005.01.021","volume":"57","author":"Licha","year":"2005","journal-title":"Adv. Drug Delivery Rev."},{"key":"10.1016\/j.bmcl.2008.01.043_bib28","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/0041-008X(85)90139-5","volume":"79","author":"Bertazzoli","year":"1985","journal-title":"Toxicol. Appl. Pharm."},{"key":"10.1016\/j.bmcl.2008.01.043_bib29","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1007\/s10895-005-2636-x","volume":"15","author":"Perlitz","year":"2005","journal-title":"J. Fluoresc."},{"key":"10.1016\/j.bmcl.2008.01.043_bib30","doi-asserted-by":"crossref","first-page":"4240","DOI":"10.1021\/ma990090w","volume":"32","author":"Sunder","year":"1999","journal-title":"Macromolecules"},{"key":"10.1016\/j.bmcl.2008.01.043_bib31","unstructured":"Haag, R.; Mecking, S.; T\u00fcrk, H. Patent Application DE10211664A1, 2002."},{"key":"10.1016\/j.bmcl.2008.01.043_bib32","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/s11030-005-8117-y","volume":"9","author":"Roller","year":"2005","journal-title":"Mol. Divers."}],"container-title":["Bioorganic &amp; Medicinal Chemistry Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X08000589?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X08000589?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T05:59:26Z","timestamp":1760767166000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960894X08000589"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,2]]},"references-count":32,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2009,2]]}},"alternative-id":["S0960894X08000589"],"URL":"https:\/\/doi.org\/10.1016\/j.bmcl.2008.01.043","relation":{},"ISSN":["0960-894X"],"issn-type":[{"value":"0960-894X","type":"print"}],"subject":[],"published":{"date-parts":[[2009,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Development of pH-responsive core\u2013shell nanocarriers for delivery of therapeutic and diagnostic agents","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmcl.2008.01.043","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}