{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T18:28:52Z","timestamp":1790188132089,"version":"4.1.0"},"reference-count":45,"publisher":"Elsevier BV","issue":"22","license":[{"start":{"date-parts":[[2008,11,1]],"date-time":"2008-11-01T00:00:00Z","timestamp":1225497600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,11,1]],"date-time":"2008-11-01T00:00:00Z","timestamp":1225497600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic &amp; Medicinal Chemistry Letters"],"published-print":{"date-parts":[[2008,11]]},"DOI":"10.1016\/j.bmcl.2008.07.003","type":"journal-article","created":{"date-parts":[[2008,7,6]],"date-time":"2008-07-06T04:30:53Z","timestamp":1215318653000},"page":"5879-5883","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":51,"title":["Evaluating the potential of Vacuolar ATPase inhibitors as anticancer agents and multigram synthesis of the potent salicylihalamide analog saliphenylhalamide"],"prefix":"10.1016","volume":"18","author":[{"given":"Sylvain","family":"Lebreton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janis","family":"Jaunbergs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael G.","family":"Roth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah A.","family":"Ferguson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jef K.","family":"De Brabander","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmcl.2008.07.003_bib1_1","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1021\/np030096l","volume":"66","author":"Newman","year":"2003","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.bmcl.2008.07.003_bib1_2","doi-asserted-by":"crossref","first-page":"2141","DOI":"10.1021\/np040106y","volume":"67","author":"Butler","year":"2004","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.bmcl.2008.07.003_bib1_3","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1039\/b616808f","volume":"24","author":"Dixon","year":"2007","journal-title":"Nat. Prod. Rep."},{"key":"10.1016\/j.bmcl.2008.07.003_bib2","doi-asserted-by":"crossref","first-page":"8329","DOI":"10.1021\/jo0610053","volume":"71","author":"Wilson","year":"2006","journal-title":"J. Org. Chem."},{"key":"10.1016\/j.bmcl.2008.07.003_bib3_1","doi-asserted-by":"crossref","first-page":"8188","DOI":"10.1021\/jo971556g","volume":"62","author":"Erickson","year":"1997","journal-title":"J. Org. Chem."},{"key":"10.1016\/j.bmcl.2008.07.003_bib3b","doi-asserted-by":"crossref","first-page":"4308","DOI":"10.1002\/1521-3773(20001201)39:23<4308::AID-ANIE4308>3.0.CO;2-4","volume":"39","author":"Wu","year":"2000","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.bmcl.2008.07.003_bib4a","doi-asserted-by":"crossref","first-page":"4241","DOI":"10.1021\/ol0068086","volume":"2","author":"Wu","year":"2000","journal-title":"Org. Lett."},{"key":"10.1016\/j.bmcl.2008.07.003_bib4b","doi-asserted-by":"crossref","first-page":"3245","DOI":"10.1021\/ja0177713","volume":"124","author":"Wu","year":"2002","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bmcl.2008.07.003_bib4_3","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1021\/ol015822v","volume":"3","author":"Snider","year":"2001","journal-title":"Org. Lett."},{"key":"10.1016\/j.bmcl.2008.07.003_bib4_4","doi-asserted-by":"crossref","first-page":"2645","DOI":"10.1016\/S0040-4039(01)00278-7","volume":"42","author":"Labrecque","year":"2001","journal-title":"Tetrahedron Lett."},{"key":"10.1016\/j.bmcl.2008.07.003_bib4_5","doi-asserted-by":"crossref","first-page":"5286","DOI":"10.1002\/1521-3765(20011217)7:24<5286::AID-CHEM5286>3.0.CO;2-G","volume":"7","author":"F\u00fcrstner","year":"2001","journal-title":"Chem. Eur. J."},{"key":"10.1016\/j.bmcl.2008.07.003_bib4_6","doi-asserted-by":"crossref","first-page":"6455","DOI":"10.1016\/S0040-4020(02)00657-9","volume":"58","author":"Smith","year":"2002","journal-title":"Tetrahedron"},{"key":"10.1016\/j.bmcl.2008.07.003_bib4_7","doi-asserted-by":"crossref","first-page":"5649","DOI":"10.1002\/chem.200400617","volume":"10","author":"Herb","year":"2004","journal-title":"Chem. Eur. J."},{"key":"10.1016\/j.bmcl.2008.07.003_bib4_8","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1055\/s-2007-965970","author":"Yadav","year":"2007","journal-title":"Synthesis"},{"key":"10.1016\/j.bmcl.2008.07.003_bib4_9","doi-asserted-by":"crossref","first-page":"2200","DOI":"10.1021\/jo026798h","volume":"68","author":"Holloway","year":"2003","journal-title":"J. Org. Chem."},{"key":"10.1016\/j.bmcl.2008.07.003_bib4_10","doi-asserted-by":"crossref","first-page":"7592","DOI":"10.1021\/jo050750x","volume":"70","author":"Haack","year":"2005","journal-title":"J. Org. Chem."},{"key":"10.1016\/j.bmcl.2008.07.003_bib5_1","doi-asserted-by":"crossref","first-page":"4283","DOI":"10.1021\/cr030035s","volume":"103","author":"Yet","year":"2003","journal-title":"Chem. Rev."},{"key":"10.1016\/j.bmcl.2008.07.003_bib5_2","doi-asserted-by":"crossref","first-page":"787","DOI":"10.2174\/0929867033457827","volume":"10","author":"Beutler","year":"2003","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.bmcl.2008.07.003_bib5_3","first-page":"29","volume":"31","author":"Bowman","year":"2005","journal-title":"J. Bioenerg. Biomembr."},{"key":"10.1016\/j.bmcl.2008.07.003_bib6","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/S0022-3565(24)29517-3","volume":"297","author":"Boyd","year":"2001","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.bmcl.2008.07.003_bib7","doi-asserted-by":"crossref","first-page":"19755","DOI":"10.1074\/jbc.M313796200","volume":"279","author":"Xie","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bmcl.2008.07.003_bib8","doi-asserted-by":"crossref","first-page":"9635","DOI":"10.1016\/j.tet.2004.06.146","volume":"60","author":"Lebreton","year":"2004","journal-title":"Tetrahedron"},{"key":"10.1016\/j.bmcl.2008.07.003_bib9_1","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S1359-6446(99)01321-5","volume":"4","author":"Farina","year":"1999","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.bmcl.2008.07.003_bib9b","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1385\/CBB:40:2:185","volume":"40","author":"Sennoune","year":"2004","journal-title":"Cell Biochem. Biophys."},{"key":"10.1016\/j.bmcl.2008.07.003_bib9c","doi-asserted-by":"crossref","first-page":"10627","DOI":"10.1158\/0008-5472.CAN-07-1805","volume":"67","author":"Fais","year":"2007","journal-title":"Cancer Res."},{"key":"10.1016\/j.bmcl.2008.07.003_bib9_4","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1038\/nrm2272","volume":"8","author":"Forgac","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bmcl.2008.07.003_bib10","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1124\/jpet.107.128587","volume":"324","author":"Supina","year":"2008","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.bmcl.2008.07.003_bib11","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1189\/jlb.69.4.522","volume":"69","author":"Lardner","year":"2001","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.bmcl.2008.07.003_bib12a","first-page":"439","volume":"61","author":"Paglin","year":"2001","journal-title":"Cancer Res."},{"key":"10.1016\/j.bmcl.2008.07.003_bib12_2","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1038\/nrc1738","volume":"5","author":"Kroemer","year":"2005","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.bmcl.2008.07.003_bib12_3","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1038\/nrc1692","volume":"5","author":"Kondo","year":"2005","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.bmcl.2008.07.003_bib12_4","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1038\/nrc2254","volume":"7","author":"Mathew","year":"2007","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.bmcl.2008.07.003_bib13","doi-asserted-by":"crossref","first-page":"20013","DOI":"10.1074\/jbc.M210077200","volume":"278","author":"Su","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bmcl.2008.07.003_bib14","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S0378-1119(02)00542-5","volume":"289","author":"Imai-Senga","year":"2002","journal-title":"Gene"},{"key":"10.1016\/j.bmcl.2008.07.003_bib16","doi-asserted-by":"crossref","first-page":"5262","DOI":"10.1038\/sj.onc.1208760","volume":"24","author":"Herbert","year":"2005","journal-title":"Oncogene"},{"key":"10.1016\/j.bmcl.2008.07.003_bib17","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1038\/nature05697","volume":"446","author":"Whitehurst","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.bmcl.2008.07.003_bib18_1","doi-asserted-by":"crossref","first-page":"6496","DOI":"10.1021\/ja970402f","volume":"119","author":"Myers","year":"1997","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bmcl.2008.07.003_bib18_2","doi-asserted-by":"crossref","first-page":"9274","DOI":"10.1021\/jo034964v","volume":"68","author":"Fettes","year":"2003","journal-title":"J. Org. Chem."},{"key":"10.1016\/j.bmcl.2008.07.003_bib19_1","doi-asserted-by":"crossref","first-page":"2267","DOI":"10.1016\/S0040-4039(99)00222-1","volume":"40","author":"Harris","year":"1999","journal-title":"Tetrahedron Lett."},{"key":"10.1016\/j.bmcl.2008.07.003_bib19_2","doi-asserted-by":"crossref","first-page":"5249","DOI":"10.1021\/ja010039j","volume":"123","author":"Lee","year":"2001","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bmcl.2008.07.003_bib20","doi-asserted-by":"crossref","first-page":"4663","DOI":"10.1016\/S0040-4020(01)85588-5","volume":"46","author":"Paterson","year":"1990","journal-title":"Tetrahedron"},{"key":"10.1016\/j.bmcl.2008.07.003_bib21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1055\/s-1981-29317","author":"Mitsunobu","year":"1981","journal-title":"Synthesis"},{"key":"10.1016\/j.bmcl.2008.07.003_bib22","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1002\/anie.200462577","volume":"44","author":"Soltani","year":"2005","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.bmcl.2008.07.003_bib24","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1021\/ar000114f","volume":"34","author":"Trnka","year":"2001","journal-title":"Acc. Chem. Res."},{"key":"10.1016\/j.bmcl.2008.07.003_bib25","doi-asserted-by":"crossref","first-page":"7277","DOI":"10.1021\/ja00019a027","volume":"113","author":"Dess","year":"1991","journal-title":"J. Am. Chem. Soc."}],"container-title":["Bioorganic &amp; Medicinal Chemistry Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X08007683?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X08007683?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T05:57:27Z","timestamp":1760767047000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960894X08007683"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,11]]},"references-count":45,"journal-issue":{"issue":"22","published-print":{"date-parts":[[2008,11]]}},"alternative-id":["S0960894X08007683"],"URL":"https:\/\/doi.org\/10.1016\/j.bmcl.2008.07.003","relation":{},"ISSN":["0960-894X"],"issn-type":[{"value":"0960-894X","type":"print"}],"subject":[],"published":{"date-parts":[[2008,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Evaluating the potential of Vacuolar ATPase inhibitors as anticancer agents and multigram synthesis of the potent salicylihalamide analog saliphenylhalamide","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmcl.2008.07.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}