{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T08:55:06Z","timestamp":1791104106113,"version":"4.1.0"},"reference-count":46,"publisher":"Elsevier BV","issue":"18","license":[{"start":{"date-parts":[[2008,9,1]],"date-time":"2008-09-01T00:00:00Z","timestamp":1220227200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,9,1]],"date-time":"2008-09-01T00:00:00Z","timestamp":1220227200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry Letters"],"published-print":{"date-parts":[[2008,9]]},"DOI":"10.1016\/j.bmcl.2008.07.122","type":"journal-article","created":{"date-parts":[[2008,8,6]],"date-time":"2008-08-06T04:22:13Z","timestamp":1217996533000},"page":"5066-5070","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":95,"title":["Carbonic anhydrase inhibitors: Inhibition of the \u03b2-class enzymes from the fungal pathogens Candida albicans and Cryptococcus neoformans with simple anions"],"prefix":"10.1016","volume":"18","author":[{"given":"Alessio","family":"Innocenti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fritz A.","family":"M\u00fchlschlegel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca A.","family":"Hall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clemens","family":"Steegborn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Scozzafava","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudiu T.","family":"Supuran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmcl.2008.07.122_bib1","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/nrd2467","volume":"7","author":"Supuran","year":"2008","journal-title":"Nat. Rev. Drug. Discov."},{"key":"10.1016\/j.bmcl.2008.07.122_bib2","doi-asserted-by":"crossref","first-page":"48615","DOI":"10.1074\/jbc.R100045200","volume":"276","author":"Tripp","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bmcl.2008.07.122_bib3a","series-title":"Carbonic Anhydrase\u2014Its Inhibitors and Activators","first-page":"1","year":"2004"},{"key":"10.1016\/j.bmcl.2008.07.122_bib3b","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1002\/med.10025","volume":"23","author":"Supuran","year":"2003","journal-title":"Med. Res. Rev"},{"key":"10.1016\/j.bmcl.2008.07.122_bib3c","series-title":"Carbonic Anhydrase\u2014Its Inhibitors and Activators","first-page":"1","article-title":"Carbonic anhydrases catalytic mechanism distribution and physiological roles","author":"Supuran","year":"2004"},{"key":"10.1016\/j.bmcl.2008.07.122_bib3d","doi-asserted-by":"crossref","first-page":"2267","DOI":"10.1016\/j.bmcl.2008.03.012","volume":"18","author":"Innocenti","year":"2008","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2008.07.122_bib4a","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1517\/13543776.12.2.217","volume":"12","author":"Supuran","year":"2002","journal-title":"Expert Opin. Ther. Pat."},{"key":"10.1016\/j.bmcl.2008.07.122_bib4b","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1517\/13543776.14.5.667","volume":"14","author":"Scozzafava","year":"2004","journal-title":"Expert Opin. Ther. Pat."},{"key":"10.1016\/j.bmcl.2008.07.122_bib5a","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1111\/j.1574-6976.2000.tb00546.x","volume":"24","author":"Smith","year":"2000","journal-title":"FEMS Microbiol. Rev."},{"key":"10.1016\/j.bmcl.2008.07.122_bib5b","first-page":"15185","volume":"96","author":"Smith","year":"1999","journal-title":"Proc. Natl. Acad Sci. U.S.A."},{"key":"10.1016\/j.bmcl.2008.07.122_bib5c","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1128\/JB.186.3.623-630.2004","volume":"186","author":"So","year":"2004","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.bmcl.2008.07.122_bib6a","doi-asserted-by":"crossref","first-page":"5521","DOI":"10.1074\/jbc.275.8.5521","volume":"275","author":"Mitsuhashi","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bmcl.2008.07.122_bib6b","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1093\/emboj\/19.7.1407","volume":"19","author":"Kimber","year":"2000","journal-title":"EMBO J."},{"key":"10.1016\/j.bmcl.2008.07.122_bib6c","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1110\/ps.46301","volume":"10","author":"Cronk","year":"2001","journal-title":"Protein Sci."},{"key":"10.1016\/j.bmcl.2008.07.122_bib7a","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/nature06636","volume":"452","author":"Xu","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.bmcl.2008.07.122_bib7b","doi-asserted-by":"crossref","first-page":"12128","DOI":"10.1021\/bi001416s","volume":"39","author":"Cox","year":"2000","journal-title":"Biochemistry"},{"key":"10.1016\/j.bmcl.2008.07.122_bib7c","doi-asserted-by":"crossref","first-page":"4627","DOI":"10.1073\/pnas.090091397","volume":"97","author":"Lane","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bmcl.2008.07.122_bib8a","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.1016\/j.cub.2005.10.040","volume":"15","author":"Klengel","year":"2005","journal-title":"Curr. Biol."},{"key":"10.1016\/j.bmcl.2008.07.122_bib8b","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1016\/j.cub.2005.09.047","volume":"15","author":"Perfect","year":"2005","journal-title":"Curr. Biol"},{"key":"10.1016\/j.bmcl.2008.07.122_bib9a","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1128\/EC.5.1.103-111.2006","volume":"5","author":"Mogensen","year":"2006","journal-title":"Eukaryot. Cell"},{"key":"10.1016\/j.bmcl.2008.07.122_bib9b","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/j.mib.2006.09.003","volume":"9","author":"Bahn","year":"2006","journal-title":"Curr. Opin. Microbiol."},{"key":"10.1016\/j.bmcl.2008.07.122_bib10","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1038\/nsmb880","volume":"12","author":"Steegborn","year":"2005","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.bmcl.2008.07.122_bib11a","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1128\/CMR.9.4.499","volume":"9","author":"Fridkin","year":"1996","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.bmcl.2008.07.122_bib11b","doi-asserted-by":"crossref","first-page":"3211","DOI":"10.1099\/mic.0.2007\/010405-0","volume":"153","author":"Cannon","year":"2007","journal-title":"Microbiology"},{"key":"10.1016\/j.bmcl.2008.07.122_bib12a","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1007\/s11908-000-0015-y","volume":"2","author":"Powderly","year":"2000","journal-title":"Curr. Infect. Dis. Rep."},{"key":"10.1016\/j.bmcl.2008.07.122_bib12b","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1086\/515130","volume":"28","author":"Abadi","year":"1999","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.bmcl.2008.07.122_bib12c","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/j.femsyr.2004.04.003","volume":"4","author":"Janbon","year":"2004","journal-title":"FEMS Yeast Res."},{"key":"10.1016\/j.bmcl.2008.07.122_bib13a","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1080\/1475636031000138732","volume":"18","author":"Vullo","year":"2003","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"10.1016\/j.bmcl.2008.07.122_bib13b","doi-asserted-by":"crossref","first-page":"2857","DOI":"10.1016\/S0960-894X(03)00581-X","volume":"13","author":"Franchi","year":"2003","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2008.07.122_bib13c","doi-asserted-by":"crossref","first-page":"5435","DOI":"10.1016\/j.bmcl.2004.07.086","volume":"14","author":"Innocenti","year":"2004","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2008.07.122_bib13d","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.bmcl.2004.11.056","volume":"15","author":"Innocenti","year":"2005","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2008.07.122_bib14a","doi-asserted-by":"crossref","first-page":"4563","DOI":"10.1016\/j.bmcl.2004.06.073","volume":"14","author":"Innocenti","year":"2004","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2008.07.122_bib14b","doi-asserted-by":"crossref","first-page":"6001","DOI":"10.1016\/j.bmcl.2004.09.085","volume":"14","author":"Zimmerman","year":"2004","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2008.07.122_bib14c","doi-asserted-by":"crossref","first-page":"901","DOI":"10.2174\/156802607780636753","volume":"7","author":"Zimmerman","year":"2007","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.bmcl.2008.07.122_bib15","doi-asserted-by":"crossref","first-page":"3585","DOI":"10.1016\/j.bmcl.2007.04.063","volume":"17","author":"Nishimori","year":"2007","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2008.07.122_bib17","doi-asserted-by":"crossref","first-page":"2561","DOI":"10.1016\/S0021-9258(18)62326-9","volume":"246","author":"Khalifah","year":"1971","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bmcl.2008.07.122_bib18","doi-asserted-by":"crossref","first-page":"10299","DOI":"10.1074\/jbc.M009182200","volume":"276","author":"Strop","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bmcl.2008.07.122_bib19a","doi-asserted-by":"crossref","first-page":"6247","DOI":"10.1128\/JB.181.20.6247-6253.1999","volume":"181","author":"Smith","year":"1999","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.bmcl.2008.07.122_bib19b","doi-asserted-by":"crossref","first-page":"6605","DOI":"10.1128\/JB.182.23.6605-6613.2000","volume":"182","author":"Smith","year":"2000","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.bmcl.2008.07.122_bib19c","doi-asserted-by":"crossref","first-page":"4240","DOI":"10.1128\/JB.184.15.4240-4245.2002","volume":"184","author":"Smith","year":"2002","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.bmcl.2008.07.122_bib20","series-title":"Carbonic Anhydrase\u2014Its Inhibitors and Activators","first-page":"209","article-title":"Nonsulfonamide carbonic anhydrase inhibitors","author":"Ilies","year":"2004"},{"key":"10.1016\/j.bmcl.2008.07.122_bib21","unstructured":"The sequence alignments were performed using the following web site http:\/\/www.ebi.ac.uk\/Tools\/clustalw\/index.html."},{"key":"10.1016\/j.bmcl.2008.07.122_bib22","series-title":"Proteinase and Peptidase Inhibition Recent Potential Targets for Drug Development","first-page":"35","article-title":"Matrix metalloproteinases (MMPs)","author":"Supuran","year":"2002"},{"key":"10.1016\/j.bmcl.2008.07.122_bib23a","doi-asserted-by":"crossref","first-page":"4336","DOI":"10.1016\/j.bmc.2007.04.020","volume":"15","author":"Supuran","year":"2007","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmcl.2008.07.122_bib23b","doi-asserted-by":"crossref","first-page":"603","DOI":"10.2174\/138161208783877884","volume":"14","author":"Supuran","year":"2008","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.bmcl.2008.07.122_bib24","doi-asserted-by":"crossref","first-page":"2734","DOI":"10.2174\/092986707782360141","volume":"14","author":"Mastrolorenzo","year":"2007","journal-title":"Curr. Med. Chem."}],"container-title":["Bioorganic & Medicinal Chemistry Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X08009086?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X08009086?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T05:56:37Z","timestamp":1760766997000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960894X08009086"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,9]]},"references-count":46,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2008,9]]}},"alternative-id":["S0960894X08009086"],"URL":"https:\/\/doi.org\/10.1016\/j.bmcl.2008.07.122","relation":{},"ISSN":["0960-894X"],"issn-type":[{"value":"0960-894X","type":"print"}],"subject":[],"published":{"date-parts":[[2008,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Carbonic anhydrase inhibitors: Inhibition of the \u03b2-class enzymes from the fungal pathogens Candida albicans and Cryptococcus neoformans with simple anions","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmcl.2008.07.122","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}