{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T01:24:19Z","timestamp":1782782659300,"version":"3.54.5"},"reference-count":39,"publisher":"Elsevier BV","issue":"20","license":[{"start":{"date-parts":[[2008,10,1]],"date-time":"2008-10-01T00:00:00Z","timestamp":1222819200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,10,1]],"date-time":"2008-10-01T00:00:00Z","timestamp":1222819200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry Letters"],"published-print":{"date-parts":[[2008,10]]},"DOI":"10.1016\/j.bmcl.2008.09.056","type":"journal-article","created":{"date-parts":[[2008,9,19]],"date-time":"2008-09-19T05:05:28Z","timestamp":1221800728000},"page":"5381-5386","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"title":["Quantitative structure\u2013activity relationship studies on 1-aryl-tetrahydroisoquinoline analogs as active anti-HIV agents"],"prefix":"10.1016","volume":"18","author":[{"given":"Ke-xian","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai-ying","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zu-guang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-rong","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmcl.2008.09.056_bib1","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.tips.2007.10.013","volume":"29","author":"Men\u00e9ndez-Arias","year":"2007","journal-title":"Trends Pharmacol."},{"key":"10.1016\/j.bmcl.2008.09.056_bib2","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.ejmech.2007.04.005","volume":"43","author":"Thakur","year":"2008","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bmcl.2008.09.056_bib3","first-page":"29","volume":"25","author":"Walgate","year":"2008","journal-title":"Biotechnology"},{"key":"10.1016\/j.bmcl.2008.09.056_bib4","doi-asserted-by":"crossref","unstructured":"Andersen, J. L.; Le Rouzic, E.; Planelles, V. Exp. Mol. Pathol. 2008. doi:10.1016\/j.yexmp.2008.03.015.","DOI":"10.1016\/j.yexmp.2008.03.015"},{"key":"10.1016\/j.bmcl.2008.09.056_bib5","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1016\/j.bmcl.2007.01.103","volume":"17","author":"Ravichandran","year":"2007","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2008.09.056_bib6","doi-asserted-by":"crossref","first-page":"3008","DOI":"10.1016\/j.vaccine.2007.12.023","volume":"26","author":"Vangelista","year":"2008","journal-title":"Vaccine"},{"key":"10.1016\/j.bmcl.2008.09.056_bib7","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1002\/qsar.200760177","volume":"27","author":"Dessalew","year":"2008","journal-title":"QSAR Comb. Sci."},{"key":"10.1016\/j.bmcl.2008.09.056_bib8","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S0166-1280(00)00553-4","volume":"529","author":"Yuan","year":"2000","journal-title":"THEOCHEM"},{"key":"10.1016\/j.bmcl.2008.09.056_bib9","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.jmb.2008.04.054","volume":"380","author":"Chen","year":"2008","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.bmcl.2008.09.056_bib10","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0928-0987(02)00080-5","volume":"16","author":"Bonina","year":"2002","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.bmcl.2008.09.056_bib11","doi-asserted-by":"crossref","unstructured":"Vicini, P.; Incerti, M.; La Cola, P.; Loddo, R. Eur. J. Med. Chem. 2008. doi: 10.1016\/j.ejmech.2008.05.030.","DOI":"10.1016\/j.ejmech.2008.05.030"},{"key":"10.1016\/j.bmcl.2008.09.056_bib12","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.virusres.2008.01.003","volume":"134","author":"Jochmans","year":"2008","journal-title":"Virus Res."},{"key":"10.1016\/j.bmcl.2008.09.056_bib13","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1016\/j.ejmech.2007.01.024","volume":"42","author":"Dubey","year":"2007","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bmcl.2008.09.056_bib14","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.virusres.2007.12.021","volume":"134","author":"Martinez-Picado","year":"2008","journal-title":"Virus Res."},{"key":"10.1016\/j.bmcl.2008.09.056_bib15","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0928-0987(01)00109-9","volume":"13","author":"Alterman","year":"2001","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.bmcl.2008.09.056_bib16","doi-asserted-by":"crossref","first-page":"4467","DOI":"10.1016\/j.bmcl.2006.06.031","volume":"16","author":"Leonard","year":"2006","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2008.09.056_bib17","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1016\/j.bmc.2005.09.022","volume":"14","author":"Leonard","year":"2006","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmcl.2008.09.056_bib18","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1016\/j.jmgm.2007.08.008","volume":"26","author":"Dureja","year":"2008","journal-title":"J. Mol. Graphics Modell."},{"key":"10.1016\/j.bmcl.2008.09.056_bib19","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.2174\/1568026043387331","volume":"4","author":"Musah","year":"2004","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.bmcl.2008.09.056_bib20","doi-asserted-by":"crossref","first-page":"2475","DOI":"10.1016\/j.bmcl.2008.02.040","volume":"18","author":"Cheng","year":"2008","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2008.09.056_bib21","doi-asserted-by":"crossref","first-page":"2206","DOI":"10.1021\/jm00040a013","volume":"37","author":"Oprea","year":"1994","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmcl.2008.09.056_bib22","unstructured":"Cerius2, version 4.10, A. San Diego, Inc.: CA, USA, 2005."},{"key":"10.1016\/j.bmcl.2008.09.056_bib23","doi-asserted-by":"crossref","first-page":"10024","DOI":"10.1021\/ja00051a040","volume":"114","author":"Rappe","year":"1992","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bmcl.2008.09.056_bib24","doi-asserted-by":"crossref","first-page":"3291","DOI":"10.1016\/0040-4020(80)80168-2","volume":"36","author":"Gasteiger","year":"1980","journal-title":"Tetrahedron"},{"key":"10.1016\/j.bmcl.2008.09.056_bib25","doi-asserted-by":"crossref","first-page":"5136","DOI":"10.1016\/j.bmcl.2006.07.041","volume":"16","author":"Kadam","year":"2006","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2008.09.056_bib26","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1021\/ci00020a020","volume":"34","author":"Rogers","year":"1994","journal-title":"J. Chem. Inf. Comput. Sci."},{"key":"10.1016\/j.bmcl.2008.09.056_bib27","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1021\/ci970085w","volume":"38","author":"Shi","year":"1998","journal-title":"J. Chem. Inf. Comput. Sci."},{"key":"10.1016\/j.bmcl.2008.09.056_bib28","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.ejmech.2007.02.021","volume":"43","author":"Leonard","year":"2008","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bmcl.2008.09.056_bib29","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1002\/qsar.200630090","volume":"26","author":"Ramar","year":"2007","journal-title":"QSAR Comb. Sci."},{"key":"10.1016\/j.bmcl.2008.09.056_bib30","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.ejmech.2007.03.020","volume":"43","author":"Nair","year":"2008","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bmcl.2008.09.056_bib31","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1016\/j.bmcl.2006.11.022","volume":"17","author":"Jung","year":"2007","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2008.09.056_bib32","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1016\/j.bmcl.2006.12.112","volume":"17","author":"Sivakumar","year":"2007","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2008.09.056_bib33","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1016\/j.ejmech.2006.07.001","volume":"41","author":"Deswal","year":"2006","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bmcl.2008.09.056_bib34","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.ejmech.2007.02.013","volume":"43","author":"Equbal","year":"2008","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bmcl.2008.09.056_bib35","first-page":"511","volume":"2","author":"Hirashima","year":"2003","journal-title":"Internet Electron. J. Mol. Des."},{"key":"10.1016\/j.bmcl.2008.09.056_bib36","doi-asserted-by":"crossref","unstructured":"Vijayan, R. S. K.; Ghoshal, N. J. Mol. Graphics Modell. 2008. doi:10.1016\/j.jmgm.2008.05.003.","DOI":"10.1016\/j.jmgm.2008.05.003"},{"key":"10.1016\/j.bmcl.2008.09.056_bib37","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.jmgm.2004.10.003","volume":"23","author":"Yuan","year":"2005","journal-title":"J. Mol. Graphics Modell."},{"key":"10.1016\/j.bmcl.2008.09.056_bib38","doi-asserted-by":"crossref","first-page":"3753","DOI":"10.1016\/S0968-0896(03)00313-4","volume":"11","author":"Hirashima","year":"2003","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmcl.2008.09.056_bib39","doi-asserted-by":"crossref","first-page":"5917","DOI":"10.1016\/j.bmcl.2006.06.039","volume":"16","author":"Shaikh","year":"2006","journal-title":"Bioorg. Med. Chem. Lett."}],"container-title":["Bioorganic & Medicinal Chemistry Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X08011268?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X08011268?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T05:57:07Z","timestamp":1760767027000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960894X08011268"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,10]]},"references-count":39,"journal-issue":{"issue":"20","published-print":{"date-parts":[[2008,10]]}},"alternative-id":["S0960894X08011268"],"URL":"https:\/\/doi.org\/10.1016\/j.bmcl.2008.09.056","relation":{},"ISSN":["0960-894X"],"issn-type":[{"value":"0960-894X","type":"print"}],"subject":[],"published":{"date-parts":[[2008,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Quantitative structure\u2013activity relationship studies on 1-aryl-tetrahydroisoquinoline analogs as active anti-HIV agents","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmcl.2008.09.056","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}