{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T17:47:17Z","timestamp":1788371237575,"version":"build-2803163510"},"reference-count":51,"publisher":"Elsevier BV","issue":"23","license":[{"start":{"date-parts":[[2008,12,1]],"date-time":"2008-12-01T00:00:00Z","timestamp":1228089600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,12,1]],"date-time":"2008-12-01T00:00:00Z","timestamp":1228089600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic &amp; Medicinal Chemistry Letters"],"published-print":{"date-parts":[[2008,12]]},"DOI":"10.1016\/j.bmcl.2008.10.003","type":"journal-article","created":{"date-parts":[[2008,10,6]],"date-time":"2008-10-06T04:10:55Z","timestamp":1223266255000},"page":"6156-6160","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"title":["Comparisons of the influenza virus A M2 channel binding affinities, anti-influenza virus potencies and NMDA antagonistic activities of 2-alkyl-2-aminoadamantanes and analogues"],"prefix":"10.1016","volume":"18","author":[{"given":"Antonios","family":"Kolocouris","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Spearpoint","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen R.","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan J.","family":"Hay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"L\u00f3pez-Querol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesc X.","family":"Sureda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizaveta","family":"Padalko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Neyts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"De Clercq","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmcl.2008.10.003_bib1_1","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1038\/nature04230","volume":"437","author":"Taubenberger","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.bmcl.2008.10.003_bib1_2","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1126\/science.1090350","volume":"302","author":"Webby","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.bmcl.2008.10.003_bib2_1","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.cell.2005.10.019","volume":"123","author":"Russell","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.bmcl.2008.10.003_bib2_2","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.virol.2006.01.044","volume":"351","author":"Webster","year":"2006","journal-title":"Virology"},{"key":"10.1016\/j.bmcl.2008.10.003_bib2c","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1056\/NEJMra0707279","volume":"358","author":"Abdel-Ghafar","year":"2008","journal-title":"N. Eng. J. Med."},{"key":"10.1016\/j.bmcl.2008.10.003_bib3_1","doi-asserted-by":"crossref","first-page":"13849","DOI":"10.1073\/pnas.212519699","volume":"99","author":"Tumpey","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bmcl.2008.10.003_bib3_2","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.antiviral.2006.01.012","volume":"70","author":"Ilyushina","year":"2006","journal-title":"Antiviral Res."},{"key":"10.1016\/j.bmcl.2008.10.003_bib4_1","doi-asserted-by":"crossref","first-page":"3021","DOI":"10.1002\/j.1460-2075.1985.tb04038.x","volume":"4","author":"Hay","year":"1985","journal-title":"EMBO J."},{"key":"10.1016\/j.bmcl.2008.10.003_bib4b","first-page":"21","volume":"3","author":"Hay","year":"1992","journal-title":"Semin. Virol."},{"key":"10.1016\/j.bmcl.2008.10.003_bib5","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/0092-8674(92)90452-I","volume":"69","author":"Pinto","year":"1992","journal-title":"Cell"},{"key":"10.1016\/j.bmcl.2008.10.003_bib6","unstructured":"In Burger\u2019s Medicinal Chemistry, 5th ed.; Wolff, M. E., Eds.; John Wiley & Sons: New York; Vol. 4, pp 590\u2013591."},{"key":"10.1016\/j.bmcl.2008.10.003_bib7_1","unstructured":"Kolocouris, A. Ph.D. Thesis, University of Athens, Greece, March 1995."},{"key":"10.1016\/j.bmcl.2008.10.003_bib7b","doi-asserted-by":"crossref","first-page":"2896","DOI":"10.1021\/jm00044a010","volume":"37","author":"Kolocouris","year":"1994","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmcl.2008.10.003_bib7c","doi-asserted-by":"crossref","first-page":"3307","DOI":"10.1021\/jm950891z","volume":"39","author":"Kolocouris","year":"1996","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmcl.2008.10.003_bib7_4","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.1016\/S0960-894X(97)00320-X","author":"Fytas","year":"1997","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2008.10.003_bib7_5","doi-asserted-by":"crossref","first-page":"3465","DOI":"10.1016\/S0960-894X(99)00631-9","author":"Kolocouris","year":"1999","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2008.10.003_bib7_6","doi-asserted-by":"crossref","first-page":"2137","DOI":"10.1016\/S0960-894X(01)00388-2","volume":"11","author":"Stamatiou","year":"2001","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2008.10.003_bib7_7","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1177\/095632020301400305","volume":"14","author":"Zoidis","year":"2003","journal-title":"Antiviral Chem. Chemother."},{"key":"10.1016\/j.bmcl.2008.10.003_bib7_8","doi-asserted-by":"crossref","first-page":"5485","DOI":"10.1016\/j.bmc.2003.09.024","volume":"11","author":"Stamatiou","year":"2003","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmcl.2008.10.003_bib7_9","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1016\/S0960-894X(03)00231-2","volume":"13","author":"Stylianakis","year":"2003","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2008.10.003_bib7_10","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.bioorg.2006.05.004","volume":"34","author":"Setaki","year":"2006","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.bmcl.2008.10.003_bib7_11","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1016\/j.bmcl.2006.10.092","volume":"17","author":"Tataridis","year":"2007","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2008.10.003_bib8_1","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1038\/nature06528","volume":"451","author":"Stouffer","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.bmcl.2008.10.003_bib8_2","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1006\/viro.1994.1345","volume":"202","author":"Duff","year":"1994","journal-title":"Virology"},{"key":"10.1016\/j.bmcl.2008.10.003_bib8_3","doi-asserted-by":"crossref","first-page":"4335","DOI":"10.1529\/biophysj.106.090183","volume":"92","author":"Hu","year":"2007","journal-title":"Biophys. J."},{"key":"10.1016\/j.bmcl.2008.10.003_bib8_4","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1093\/protein\/6.1.65","volume":"6","author":"Sansom","year":"1993","journal-title":"Protein Eng."},{"key":"10.1016\/j.bmcl.2008.10.003_bib8_5","doi-asserted-by":"crossref","first-page":"7977","DOI":"10.1021\/jp800171m","volume":"112","author":"Yi","year":"2008","journal-title":"J. Phys. Chem. B"},{"key":"10.1016\/j.bmcl.2008.10.003_bib8_6","doi-asserted-by":"crossref","unstructured":"Intharathep, P.; Laohpongspaisan, C.; Rungrotmongkol, T.; Loisruangsin, A.; Malaisree, M.; Decha, P.; Aruksakunwong, O.; Chuenpennit, K.; Kaiyawet, N.; Sompornpisut, P.; Pianwanit, S.; Hannongbua, S. J. Mol. Graph. Model., doi:10.1016\/j.jmgm.2008.06.002.","DOI":"10.1016\/j.jmgm.2008.06.002"},{"key":"10.1016\/j.bmcl.2008.10.003_bib9_1","doi-asserted-by":"crossref","first-page":"5585","DOI":"10.1128\/jvi.67.9.5585-5594.1993","volume":"67","author":"Wang","year":"1993","journal-title":"J. Virol."},{"key":"10.1016\/j.bmcl.2008.10.003_bib9_2","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1113\/jphysiol.1996.sp021495","volume":"494","author":"Chizhmakov","year":"1996","journal-title":"J. Physiol."},{"key":"10.1016\/j.bmcl.2008.10.003_bib10_1","doi-asserted-by":"crossref","first-page":"8997","DOI":"10.1074\/jbc.R500020200","volume":"281","author":"Pinto","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bmcl.2008.10.003_bib10_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.febslet.2004.01.052","volume":"560","author":"Pinto","year":"2004","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bmcl.2008.10.003_bib10_3","first-page":"27","volume":"1561","author":"Fischer","year":"2002","journal-title":"B.B.A."},{"key":"10.1016\/j.bmcl.2008.10.003_bib10_4","unstructured":"See the articles in FEBS Lett. 2003, 552, 1."},{"key":"10.1016\/j.bmcl.2008.10.003_bib11","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/0042-6822(92)91187-Y","volume":"190","author":"Grambas","year":"1992","journal-title":"Virology"},{"key":"10.1016\/j.bmcl.2008.10.003_bib12_1","doi-asserted-by":"crossref","first-page":"4975","DOI":"10.1021\/jm0496685","volume":"47","author":"Kolocouris","year":"2004","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmcl.2008.10.003_bib12_2","doi-asserted-by":"crossref","first-page":"3947","DOI":"10.1016\/j.bmcl.2007.04.100","volume":"17","author":"Broadhurst","year":"2007","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2008.10.003_bib13_1","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.virusres.2003.10.004","volume":"99","author":"Czabotar","year":"2004","journal-title":"Virus Res."},{"key":"10.1016\/j.bmcl.2008.10.003_bib13_2","unstructured":"Spearpoint, P. Ph.D. Thesis, MRC National Institute for Medical Research, Mill Hill, London, UK, 2007."},{"key":"10.1016\/j.bmcl.2008.10.003_bib14_1","doi-asserted-by":"crossref","first-page":"4628","DOI":"10.1021\/ja00768a036","volume":"94","author":"Fry","year":"1972","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bmcl.2008.10.003_bib14_2","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1021\/jo00005a011","volume":"56","author":"Duddeck","year":"1991","journal-title":"J. Org. Chem."},{"key":"10.1016\/j.bmcl.2008.10.003_bib15","doi-asserted-by":"crossref","first-page":"3711","DOI":"10.1021\/jo01335a020","volume":"44","author":"Sasaki","year":"1979","journal-title":"J. Org. Chem."},{"key":"10.1016\/j.bmcl.2008.10.003_bib16","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1021\/jo00893a007","volume":"40","author":"Middleton","year":"1975","journal-title":"J. Org. Chem"},{"key":"10.1016\/j.bmcl.2008.10.003_bib18","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/0006-8993(94)90821-4","volume":"662","author":"Mizoguchi","year":"1994","journal-title":"Brain Res."},{"key":"10.1016\/j.bmcl.2008.10.003_bib19","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/j.neuropharm.2007.07.013","volume":"53","author":"Parsons","year":"2007","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bmcl.2008.10.003_bib20","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0014-4886(02)00029-8","volume":"180","author":"Canudas","year":"2003","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.bmcl.2008.10.003_bib21","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1128\/AAC.32.6.906","volume":"32","author":"Shigeta","year":"1988","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.bmcl.2008.10.003_bib22","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S1534-5807(03)00190-4","volume":"5","author":"Mould","year":"2003","journal-title":"Dev. Cell"},{"key":"10.1016\/j.bmcl.2008.10.003_bib23","doi-asserted-by":"crossref","first-page":"3327","DOI":"10.1073\/pnas.75.7.3327","volume":"75","author":"Ohkuma","year":"1978","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bmcl.2008.10.003_bib24","unstructured":"Unpublished results."},{"key":"10.1016\/j.bmcl.2008.10.003_bib25","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1021\/jm00107a001","volume":"34","author":"Mason","year":"1991","journal-title":"J. Med. Chem."}],"container-title":["Bioorganic &amp; Medicinal Chemistry Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X08011992?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X08011992?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T06:00:12Z","timestamp":1760767212000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960894X08011992"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,12]]},"references-count":51,"journal-issue":{"issue":"23","published-print":{"date-parts":[[2008,12]]}},"alternative-id":["S0960894X08011992"],"URL":"https:\/\/doi.org\/10.1016\/j.bmcl.2008.10.003","relation":{},"ISSN":["0960-894X"],"issn-type":[{"value":"0960-894X","type":"print"}],"subject":[],"published":{"date-parts":[[2008,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comparisons of the influenza virus A M2 channel binding affinities, anti-influenza virus potencies and NMDA antagonistic activities of 2-alkyl-2-aminoadamantanes and analogues","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmcl.2008.10.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}