{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T05:56:35Z","timestamp":1760853395644,"version":"build-2065373602"},"reference-count":20,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic &amp; Medicinal Chemistry Letters"],"published-print":{"date-parts":[[2009,1]]},"DOI":"10.1016\/j.bmcl.2008.11.050","type":"journal-article","created":{"date-parts":[[2008,11,26]],"date-time":"2008-11-26T08:37:31Z","timestamp":1227688651000},"page":"438-441","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"title":["Synthesis of novel twin drug consisting of 8-oxaendoethanotetrahydromorphides with a 1,4-dioxane spacer and its pharmacological activities: \u03bc, \u03ba, and putative \u03b5 opioid receptor antagonists"],"prefix":"10.1016","volume":"19","author":[{"given":"Hideaki","family":"Fujii","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akio","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toru","family":"Nemoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minoru","family":"Narita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kan","family":"Miyoshi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsutomu","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Nagase","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmcl.2008.11.050_bib1","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/S0031-6997(25)06958-3","volume":"48","author":"Dhawan","year":"1996","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.bmcl.2008.11.050_bib2","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.2174\/092986706776360851","volume":"13","author":"Fujii","year":"2006","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.bmcl.2008.11.050_bib3a","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0163-7258(01)00160-7","volume":"92","author":"Rios","year":"2001","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.bmcl.2008.11.050_bib3b","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1146\/annurev.pharmtox.42.091701.082314","volume":"42","author":"Angers","year":"2002","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.bmcl.2008.11.050_bib3c","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1124\/pr.57.3.1","volume":"57","author":"Prinster","year":"2005","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.bmcl.2008.11.050_bib4","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/S1471-4892(02)00124-8","volume":"2","author":"Levac","year":"2002","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.bmcl.2008.11.050_bib5","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.ejphar.2004.03.056","volume":"492","author":"Contet","year":"2004","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.bmcl.2008.11.050_bib6","doi-asserted-by":"crossref","first-page":"4133","DOI":"10.1016\/j.bmc.2004.05.024","volume":"12","author":"Fujii","year":"2004","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmcl.2008.11.050_bib7","doi-asserted-by":"crossref","first-page":"4241","DOI":"10.1016\/j.bmcl.2004.06.004","volume":"14","author":"Fujii","year":"2004","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2008.11.050_bib8","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1021\/ol052883a","volume":"8","author":"Watanabe","year":"2006","journal-title":"Org. Lett."},{"key":"10.1016\/j.bmcl.2008.11.050_bib9","first-page":"251","article-title":"The Practice of Medicinal Chemistry","author":"Contreras","year":"2003"},{"key":"10.1016\/j.bmcl.2008.11.050_bib10","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1021\/jm00399a026","volume":"31","author":"Portoghese","year":"1988","journal-title":"J. Med. Chem."},{"volume":"Vol. 1","year":"1979","author":"Stoddart","key":"10.1016\/j.bmcl.2008.11.050_bib11"},{"key":"10.1016\/j.bmcl.2008.11.050_bib13","doi-asserted-by":"crossref","first-page":"2547","DOI":"10.1016\/j.tetlet.2007.02.022","volume":"48","author":"Nagase","year":"2007","journal-title":"Tetrahedron Lett."},{"key":"10.1016\/j.bmcl.2008.11.050_bib14","doi-asserted-by":"crossref","first-page":"2733","DOI":"10.1016\/S0024-3205(00)00852-3","volume":"67","author":"Mizoguch","year":"2000","journal-title":"Life Sci."},{"key":"10.1016\/j.bmcl.2008.11.050_bib15","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/0165-6147(89)90267-8","volume":"10","author":"Portoghese","year":"1989","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.bmcl.2008.11.050_bib16a","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1021\/jm00397a001","volume":"31","author":"Portoghese","year":"1998","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmcl.2008.11.050_bib16b","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1248\/cpb.46.1695","volume":"46","author":"Nagase","year":"1998","journal-title":"Chem. Pharm. Bull."},{"key":"10.1016\/j.bmcl.2008.11.050_bib16c","doi-asserted-by":"crossref","first-page":"9188","DOI":"10.1016\/j.bmc.2008.09.011","volume":"16","author":"Kawai","year":"2008","journal-title":"Bioorg. Med. Chem."},{"year":"1985","series-title":"Medicinal Chemistry, A Biochemical Approach","author":"Nogrady","key":"10.1016\/j.bmcl.2008.11.050_bib17"}],"container-title":["Bioorganic &amp; Medicinal Chemistry Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X08014327?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X08014327?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T06:00:00Z","timestamp":1760767200000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960894X08014327"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,1]]},"references-count":20,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2009,1]]}},"alternative-id":["S0960894X08014327"],"URL":"https:\/\/doi.org\/10.1016\/j.bmcl.2008.11.050","relation":{},"ISSN":["0960-894X"],"issn-type":[{"type":"print","value":"0960-894X"}],"subject":[],"published":{"date-parts":[[2009,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Synthesis of novel twin drug consisting of 8-oxaendoethanotetrahydromorphides with a 1,4-dioxane spacer and its pharmacological activities: \u03bc, \u03ba, and putative \u03b5 opioid receptor antagonists","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmcl.2008.11.050","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}