{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T15:29:55Z","timestamp":1791127795029,"version":"4.1.0"},"reference-count":20,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2009,2,1]],"date-time":"2009-02-01T00:00:00Z","timestamp":1233446400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,2,1]],"date-time":"2009-02-01T00:00:00Z","timestamp":1233446400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry Letters"],"published-print":{"date-parts":[[2009,2]]},"DOI":"10.1016\/j.bmcl.2008.12.069","type":"journal-article","created":{"date-parts":[[2008,12,25]],"date-time":"2008-12-25T05:39:54Z","timestamp":1230183594000},"page":"602-605","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":53,"title":["Synthesis of 18F-labelled 2-(4\u2032-fluorophenyl)-1,3-benzothiazole and evaluation as amyloid imaging agent in comparison with [11C]PIB"],"prefix":"10.1016","volume":"19","author":[{"given":"K.","family":"Serdons","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Verduyckt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Vanderghinste","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Cleynhens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Borghgraef","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Vermaelen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Terwinghe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. Van","family":"Leuven","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. Van","family":"Laere","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Kung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Bormans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Verbruggen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmcl.2008.12.069_bib1","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1152\/physrev.2001.81.2.741","volume":"81","author":"Selkoe","year":"2001","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.bmcl.2008.12.069_bib2","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/S0140-6736(06)69113-7","volume":"368","author":"Blennow","year":"2006","journal-title":"Lancet"},{"key":"10.1016\/j.bmcl.2008.12.069_bib3","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.2174\/156802607782507402","volume":"7","author":"Furumoto","year":"2007","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.bmcl.2008.12.069_bib4","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1002\/ana.20009","volume":"55","author":"Klunk","year":"2004","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.bmcl.2008.12.069_bib5","first-page":"56P","volume":"48","author":"Mathis","year":"2007","journal-title":"J. Nucl. Med."},{"key":"10.1016\/j.bmcl.2008.12.069_bib6","doi-asserted-by":"crossref","first-page":"3375","DOI":"10.1021\/jm9600959","volume":"39","author":"Shi","year":"1996","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmcl.2008.12.069_bib7","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/S0960-894X(01)00734-X","volume":"12","author":"Mathis","year":"2002","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2008.12.069_bib9","unstructured":"Compound 1: 1H NMR (CDCl3): \u03b4 7.47 (1H, dd, 6-H); \u03b4 7.57 (1H, dd, 5-H); \u03b4 7.97 (1H, d, 4-H); \u03b4 8.14 (1H, d, 7-H); \u03b4 8.27 (2H, d, 2\u2032-H 6\u2032-H); \u03b4 8.36 (2H, d, 3\u2032-H 5\u2032-H). Accurate MS\u2013ES+ m\/z [M+H]+ 257.0356 (calcd for C13H8N2O2S 257.0379). Mp 226.1\u2013227.4\u00b0C."},{"key":"10.1016\/j.bmcl.2008.12.069_bib10","unstructured":"Compound 2: 1H NMR (CDCl3): \u03b4 7.16 (2H, dd, 3\u2032-H 5\u2032-H); \u03b4 7.38 (1H, t, 5-H); \u03b4 7.50 (1H, t, 6-H); \u03b4 7.90 (1H, d, 7-H); \u03b4 8.06 (2H, d, 2\u2032-H 6\u2032-H); \u03b4 8.10 (1H, d, 4-H). Accurate MS\u2013ES+ m\/z [M+H]+ 230.2855 (calcd for C14H10NFS 230.2856). Mp 97.2\u201398.5\u00b0C."},{"key":"10.1016\/j.bmcl.2008.12.069_bib11","doi-asserted-by":"crossref","first-page":"550","DOI":"10.2174\/157018007782794563","volume":"4","author":"Kamal","year":"2007","journal-title":"Lett. Drug Des. Discov."},{"key":"10.1016\/j.bmcl.2008.12.069_bib12","doi-asserted-by":"crossref","first-page":"4345","DOI":"10.1016\/j.tetlet.2005.04.090","volume":"46","author":"Mu","year":"2005","journal-title":"Tetrahedron Lett."},{"key":"10.1016\/j.bmcl.2008.12.069_bib14","series-title":"Fluorine-18 Labeling of Radiopharmaceuticals. Nuclear Science Series","author":"Kilbourn","year":"1990"},{"key":"10.1016\/j.bmcl.2008.12.069_bib15","first-page":"31P","volume":"47","author":"Serdons","year":"2006","journal-title":"J. Nucl. Med."},{"key":"10.1016\/j.bmcl.2008.12.069_bib16","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.chroma.2007.10.084","volume":"1189","author":"Chitneni","year":"2007","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.bmcl.2008.12.069_bib17","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.brainres.2004.08.004","volume":"1025","author":"Kung","year":"2004","journal-title":"Brain Res."},{"key":"10.1016\/j.bmcl.2008.12.069_bib18","unstructured":"All animal experiments were approved by the local Ethical Committee."},{"key":"10.1016\/j.bmcl.2008.12.069_bib20","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1002\/jlcr.1536","volume":"51","author":"Serdons","year":"2008","journal-title":"J. Label. Compd. Radiopharm."},{"key":"10.1016\/j.bmcl.2008.12.069_bib21","first-page":"1030","volume":"24","author":"Dishino","year":"1983","journal-title":"J. Nucl. Med."},{"key":"10.1016\/j.bmcl.2008.12.069_bib24","doi-asserted-by":"crossref","first-page":"10598","DOI":"10.1523\/JNEUROSCI.2990-05.2005","volume":"25","author":"Klunk","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bmcl.2008.12.069_bib25","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1007\/s00259-005-1780-5","volume":"32","author":"Toyama","year":"2005","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"}],"container-title":["Bioorganic & Medicinal Chemistry Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X0801593X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X0801593X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T05:59:38Z","timestamp":1760767178000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960894X0801593X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,2]]},"references-count":20,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2009,2]]}},"alternative-id":["S0960894X0801593X"],"URL":"https:\/\/doi.org\/10.1016\/j.bmcl.2008.12.069","relation":{},"ISSN":["0960-894X"],"issn-type":[{"value":"0960-894X","type":"print"}],"subject":[],"published":{"date-parts":[[2009,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Synthesis of 18F-labelled 2-(4\u2032-fluorophenyl)-1,3-benzothiazole and evaluation as amyloid imaging agent in comparison with [11C]PIB","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmcl.2008.12.069","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}