{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T03:15:30Z","timestamp":1792984530290,"version":"4.5.0"},"reference-count":24,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2009,3,1]],"date-time":"2009-03-01T00:00:00Z","timestamp":1235865600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,3,1]],"date-time":"2009-03-01T00:00:00Z","timestamp":1235865600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry Letters"],"published-print":{"date-parts":[[2009,3]]},"DOI":"10.1016\/j.bmcl.2009.01.031","type":"journal-article","created":{"date-parts":[[2009,1,16]],"date-time":"2009-01-16T04:29:53Z","timestamp":1232080193000},"page":"1425-1427","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":51,"title":["A heterocyclic molecule with significant activity against dengue virus"],"prefix":"10.1016","volume":"19","author":[{"given":"Vasu","family":"Nair","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guochen","family":"Chi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingning","family":"Shu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin","family":"Julander","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald F.","family":"Smee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmcl.2009.01.031_bib1","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1126\/science.239.4839.476","volume":"239","author":"Halstead","year":"1988","journal-title":"Science"},{"key":"10.1016\/j.bmcl.2009.01.031_bib2","doi-asserted-by":"crossref","first-page":"887","DOI":"10.3201\/eid1206.051210","volume":"12","author":"Ooi","year":"2006","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.bmcl.2009.01.031_bib3","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S0065-3527(03)61006-7","volume":"61","author":"Thomas","year":"2003","journal-title":"Adv. Virus Res."},{"key":"10.1016\/j.bmcl.2009.01.031_bib4","doi-asserted-by":"crossref","first-page":"11418","DOI":"10.1128\/JVI.01257-06","volume":"80","author":"Clyde","year":"2006","journal-title":"J. Virol."},{"key":"10.1016\/j.bmcl.2009.01.031_bib5","doi-asserted-by":"crossref","first-page":"2986","DOI":"10.1111\/j.1742-4658.2007.05831.x","volume":"274","author":"Melino","year":"2007","journal-title":"FEBS J."},{"key":"10.1016\/j.bmcl.2009.01.031_bib6","doi-asserted-by":"crossref","first-page":"3520","DOI":"10.1073\/pnas.0611681104","volume":"104","author":"Chu","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bmcl.2009.01.031_bib7","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.2174\/138945006779025383","volume":"7","author":"Rawlinson","year":"2006","journal-title":"Curr. Drug Targets"},{"key":"10.1016\/j.bmcl.2009.01.031_bib8","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1002\/jhet.5570220569","volume":"22","author":"Anderson","year":"1985","journal-title":"J. Heterocycl. Chem."},{"key":"10.1016\/j.bmcl.2009.01.031_bib9","first-page":"509","volume":"48","author":"Heber","year":"1993","journal-title":"Pharmazie"},{"key":"10.1016\/j.bmcl.2009.01.031_bib10","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1021\/jo50006a010","volume":"16","author":"Papesch","year":"1951","journal-title":"J. Org. Chem."},{"key":"10.1016\/j.bmcl.2009.01.031_bib14","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0162-3109(00)00193-4","volume":"47","author":"Sintchak","year":"2000","journal-title":"Immunopharmacology"},{"key":"10.1016\/j.bmcl.2009.01.031_bib15","doi-asserted-by":"crossref","first-page":"9804","DOI":"10.1021\/bi0005409","volume":"39","author":"Kerr","year":"2000","journal-title":"Biochemistry"},{"key":"10.1016\/j.bmcl.2009.01.031_bib16","doi-asserted-by":"crossref","first-page":"3531","DOI":"10.1073\/pnas.96.7.3531","volume":"96","author":"Colby","year":"1999","journal-title":"Proc. Natl. Acad. Sci. .U.S.A."},{"key":"10.1016\/j.bmcl.2009.01.031_bib17","doi-asserted-by":"crossref","first-page":"599","DOI":"10.2174\/092986730607220401123801","volume":"6","author":"Franchetti","year":"1999","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.bmcl.2009.01.031_bib18","doi-asserted-by":"crossref","first-page":"519","DOI":"10.2174\/092986730607220401121237","volume":"6","author":"Goldstein","year":"1999","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.bmcl.2009.01.031_bib19","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1002\/med.20104","volume":"28","author":"Shu","year":"2008","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.bmcl.2009.01.031_bib20","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1177\/095632020701800501","volume":"18","author":"Nair","year":"2007","journal-title":"Antiviral Chem. Chemother."},{"key":"10.1016\/j.bmcl.2009.01.031_bib21","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/S0960-894X(02)01053-3","volume":"13","author":"Nair","year":"2003","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2009.01.031_bib22","first-page":"A67","volume":"65","author":"Nair","year":"2005","journal-title":"Antiviral Res."},{"key":"10.1016\/j.bmcl.2009.01.031_bib23","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.1128\/JVI.79.3.1943-1947.2005","volume":"79","author":"Leyssen","year":"2005","journal-title":"J. Virol."},{"key":"10.1016\/j.bmcl.2009.01.031_bib24","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/S0092-8674(00)81275-1","volume":"85","author":"Sintchak","year":"1996","journal-title":"Cell"},{"key":"10.1016\/j.bmcl.2009.01.031_bib25","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1006\/viro.2002.1685","volume":"304","author":"Diamond","year":"2002","journal-title":"Virology"},{"key":"10.1016\/j.bmcl.2009.01.031_bib26","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/0166-3542(96)89697-5","volume":"30","author":"Neyts","year":"1996","journal-title":"Antiviral Res."},{"key":"10.1016\/j.bmcl.2009.01.031_bib27","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0166-3542(02)00013-X","volume":"55","author":"Morrey","year":"2002","journal-title":"Antiviral Res."}],"container-title":["Bioorganic & Medicinal Chemistry Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X09000444?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X09000444?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T06:01:00Z","timestamp":1760767260000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960894X09000444"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,3]]},"references-count":24,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2009,3]]}},"alternative-id":["S0960894X09000444"],"URL":"https:\/\/doi.org\/10.1016\/j.bmcl.2009.01.031","relation":{},"ISSN":["0960-894X"],"issn-type":[{"value":"0960-894X","type":"print"}],"subject":[],"published":{"date-parts":[[2009,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A heterocyclic molecule with significant activity against dengue virus","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmcl.2009.01.031","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}