{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T11:01:25Z","timestamp":1777719685078,"version":"3.51.4"},"reference-count":19,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2009,6,1]],"date-time":"2009-06-01T00:00:00Z","timestamp":1243814400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,6,1]],"date-time":"2009-06-01T00:00:00Z","timestamp":1243814400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100014054","name":"Drugs for Neglected Diseases initiative","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry Letters"],"published-print":{"date-parts":[[2009,6]]},"DOI":"10.1016\/j.bmcl.2009.04.096","type":"journal-article","created":{"date-parts":[[2009,4,25]],"date-time":"2009-04-25T05:59:51Z","timestamp":1240639191000},"page":"2916-2919","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"title":["Discovery of new S-adenosylmethionine decarboxylase inhibitors for the treatment of Human African Trypanosomiasis (HAT)"],"prefix":"10.1016","volume":"19","author":[{"given":"Bradford","family":"Hirth","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"Robert H.","family":"Barker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cassandra A.","family":"Celatka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey D.","family":"Klinger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanlan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bakela","family":"Nare","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amarjit","family":"Nijjar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margaret A.","family":"Phillips","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edmund","family":"Sybertz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erin K.","family":"Willert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yibin","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmcl.2009.04.096_bib1","series-title":"Human African Trypanosomiasis","author":"WHO 2008, posting date","year":"2008"},{"key":"10.1016\/j.bmcl.2009.04.096_bib2","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1111\/j.1550-7408.1981.tb02798.x","volume":"28","author":"Bacchi","year":"1981","journal-title":"J. Protozool."},{"key":"10.1016\/j.bmcl.2009.04.096_bib3","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1128\/jb.131.2.657-661.1977","volume":"131","author":"Bacchi","year":"1977","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.bmcl.2009.04.096_bib4","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/978-1-4615-9281-5_21","volume":"148","author":"Snell","year":"1982","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.bmcl.2009.04.096_bib5","doi-asserted-by":"crossref","first-page":"12063","DOI":"10.1016\/S0021-9258(18)33678-0","volume":"257","author":"Markham","year":"1982","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bmcl.2009.04.096_bib6","doi-asserted-by":"crossref","first-page":"8275","DOI":"10.1073\/pnas.0701111104","volume":"104","author":"Willert","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bmcl.2009.04.096_bib7","doi-asserted-by":"crossref","first-page":"1000183","DOI":"10.1371\/journal.ppat.1000183","volume":"4","author":"Willert","year":"2008","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.bmcl.2009.04.096_bib8","doi-asserted-by":"crossref","first-page":"9111","DOI":"10.1021\/ja00207a024","volume":"111","author":"Casara","year":"1989","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bmcl.2009.04.096_bib9","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1128\/AAC.34.8.1485","volume":"34","author":"Bitonti","year":"1990","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.bmcl.2009.04.096_bib10","doi-asserted-by":"crossref","first-page":"9484","DOI":"10.1021\/bi010735w","volume":"40","author":"Tolbert","year":"2001","journal-title":"Biochemistry"},{"key":"10.1016\/j.bmcl.2009.04.096_bib12","doi-asserted-by":"crossref","first-page":"5268","DOI":"10.1021\/jo00045a051","volume":"57","author":"Hirota","year":"1992","journal-title":"J. Org. Chem."},{"key":"10.1016\/j.bmcl.2009.04.096_bib13","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1139\/v91-217","volume":"69","author":"Robins","year":"1991","journal-title":"Can. J. Chem."},{"key":"10.1016\/j.bmcl.2009.04.096_bib14","doi-asserted-by":"crossref","first-page":"2938","DOI":"10.1021\/jm00072a013","volume":"36","author":"Van Aerschot","year":"1993","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmcl.2009.04.096_bib15","doi-asserted-by":"crossref","first-page":"3245","DOI":"10.1016\/S0021-9258(18)50153-8","volume":"237","author":"Kitz","year":"1962","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bmcl.2009.04.096_bib16","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1021\/jm801126a","volume":"52","author":"McCloskey","year":"2009","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmcl.2009.04.096_bib18","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1021\/jm00059a007","volume":"36","author":"Kawasaki","year":"1993","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmcl.2009.04.096_bib19a","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1021\/jo00028a030","volume":"57","author":"Pankiewicz","year":"1992","journal-title":"J. Org. Chem."},{"key":"10.1016\/j.bmcl.2009.04.096_bib19b","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1016\/S0040-4039(00)60759-1","volume":"34","author":"Krainer","year":"1993","journal-title":"Tetrahedron Lett."},{"key":"10.1016\/j.bmcl.2009.04.096_bib22","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.ejps.2003.10.011","volume":"21","author":"Seebacher","year":"2004","journal-title":"Eur. J. Pharmcol. Sci."}],"container-title":["Bioorganic & Medicinal Chemistry Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X09006039?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X09006039?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T06:03:09Z","timestamp":1760767389000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960894X09006039"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,6]]},"references-count":19,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2009,6]]}},"alternative-id":["S0960894X09006039"],"URL":"https:\/\/doi.org\/10.1016\/j.bmcl.2009.04.096","relation":{},"ISSN":["0960-894X"],"issn-type":[{"value":"0960-894X","type":"print"}],"subject":[],"published":{"date-parts":[[2009,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Discovery of new S-adenosylmethionine decarboxylase inhibitors for the treatment of Human African Trypanosomiasis (HAT)","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmcl.2009.04.096","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}