{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T16:48:46Z","timestamp":1790873326380,"version":"4.1.0"},"reference-count":14,"publisher":"Elsevier BV","issue":"19","license":[{"start":{"date-parts":[[2009,10,1]],"date-time":"2009-10-01T00:00:00Z","timestamp":1254355200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,10,1]],"date-time":"2009-10-01T00:00:00Z","timestamp":1254355200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2009,10,1]],"date-time":"2009-10-01T00:00:00Z","timestamp":1254355200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2009,10,1]],"date-time":"2009-10-01T00:00:00Z","timestamp":1254355200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2009,10,1]],"date-time":"2009-10-01T00:00:00Z","timestamp":1254355200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2009,10,1]],"date-time":"2009-10-01T00:00:00Z","timestamp":1254355200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2009,10,1]],"date-time":"2009-10-01T00:00:00Z","timestamp":1254355200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry Letters"],"published-print":{"date-parts":[[2009,10]]},"DOI":"10.1016\/j.bmcl.2009.07.150","type":"journal-article","created":{"date-parts":[[2009,8,4]],"date-time":"2009-08-04T05:23:28Z","timestamp":1249363408000},"page":"5773-5777","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":66,"title":["Structure\u2013activity relationship and improved hydrolytic stability of pyrazole derivatives that are allosteric inhibitors of West Nile Virus NS2B-NS3 proteinase"],"prefix":"10.1016","volume":"19","author":[{"given":"Shyama","family":"Sidique","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergey A.","family":"Shiryaev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boris I.","family":"Ratnikov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ananda","family":"Herath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex Y.","family":"Strongin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas D.P.","family":"Cosford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmcl.2009.07.150_bib1","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/S1473-3099(02)00368-7","volume":"2","author":"Campbell","year":"2002","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.bmcl.2009.07.150_bib2","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1007\/s00705-004-0463-z","volume":"150","author":"Van der Meulen","year":"2005","journal-title":"Arch. Virol."},{"key":"10.1016\/j.bmcl.2009.07.150_bib3","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1111\/j.1749-6632.2001.tb02682.x","volume":"951","author":"Hayes","year":"2001","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.bmcl.2009.07.150_bib4","doi-asserted-by":"crossref","first-page":"12883","DOI":"10.1074\/jbc.M611318200","volume":"282","author":"Bera","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bmcl.2009.07.150_bib5","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1371\/journal.pntd.0000356","volume":"3","author":"Ekonomiuk","year":"2009","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.bmcl.2009.07.150_bib6","doi-asserted-by":"crossref","first-page":"11763","DOI":"10.1021\/bi801034f","volume":"47","author":"Tomlinson","year":"2008","journal-title":"Biochem"},{"key":"10.1016\/j.bmcl.2009.07.150_bib7","doi-asserted-by":"crossref","first-page":"5714","DOI":"10.1021\/jm800503y","volume":"51","author":"Stoermer","year":"2008","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmcl.2009.07.150_bib8","doi-asserted-by":"crossref","first-page":"3385","DOI":"10.1128\/AAC.01508-07","volume":"52","author":"Mueller","year":"2008","journal-title":"Antimicrob. Agents Chemother"},{"key":"10.1016\/j.bmcl.2009.07.150_bib9","doi-asserted-by":"crossref","first-page":"2771","DOI":"10.2174\/092986708786242804","volume":"15","author":"Chappell","year":"2008","journal-title":"Curr. Med. Chem"},{"key":"10.1016\/j.bmcl.2009.07.150_bib10","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1089\/adt.2007.101","volume":"5","author":"Johnston","year":"2007","journal-title":"Assay. Drug Dev. Technol."},{"key":"10.1016\/j.bmcl.2009.07.150_bib11","doi-asserted-by":"crossref","first-page":"4761","DOI":"10.1016\/j.bmcl.2007.06.091","volume":"17","author":"Myers","year":"2007","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2009.07.150_bib14","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1021\/ja01031a017","volume":"91","author":"Charton","year":"1969","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bmcl.2009.07.150_bib15","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1021\/ja01031a018","volume":"91","author":"Charton","year":"1969","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bmcl.2009.07.150_bib16","doi-asserted-by":"crossref","first-page":"12195","DOI":"10.1016\/j.tet.2007.09.046","volume":"63","author":"Sviridov","year":"2007","journal-title":"Tetrahedron"}],"container-title":["Bioorganic & Medicinal Chemistry Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X09011160?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X09011160?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T06:08:41Z","timestamp":1760767721000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960894X09011160"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,10]]},"references-count":14,"journal-issue":{"issue":"19","published-print":{"date-parts":[[2009,10]]}},"alternative-id":["S0960894X09011160"],"URL":"https:\/\/doi.org\/10.1016\/j.bmcl.2009.07.150","relation":{},"ISSN":["0960-894X"],"issn-type":[{"value":"0960-894X","type":"print"}],"subject":[],"published":{"date-parts":[[2009,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Structure\u2013activity relationship and improved hydrolytic stability of pyrazole derivatives that are allosteric inhibitors of West Nile Virus NS2B-NS3 proteinase","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmcl.2009.07.150","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}