{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T17:47:00Z","timestamp":1788371220933,"version":"build-2803163510"},"reference-count":49,"publisher":"Elsevier BV","issue":"23","license":[{"start":{"date-parts":[[2009,12,1]],"date-time":"2009-12-01T00:00:00Z","timestamp":1259625600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,12,1]],"date-time":"2009-12-01T00:00:00Z","timestamp":1259625600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry Letters"],"published-print":{"date-parts":[[2009,12]]},"DOI":"10.1016\/j.bmcl.2009.09.086","type":"journal-article","created":{"date-parts":[[2009,10,1]],"date-time":"2009-10-01T10:26:43Z","timestamp":1254392803000},"page":"6793-6796","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Mining biologically-active molecules for inhibitors of fatty acid amide hydrolase (FAAH): Identification of phenmedipham and amperozide as FAAH inhibitors"],"prefix":"10.1016","volume":"19","author":[{"given":"Fabien","family":"Vincent","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret T.","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel E.","family":"Emerling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael G.","family":"Kelly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew A.J.","family":"Duncton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmcl.2009.09.086_bib1","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1038\/nrd2553","volume":"7","author":"Di Marzo","year":"2008","journal-title":"Nat. Rev. Drug Disc."},{"key":"10.1016\/j.bmcl.2009.09.086_bib2","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1111\/j.1365-2044.2001.02269.x","volume":"56","author":"Kumar","year":"2001","journal-title":"Anaesthesia"},{"key":"10.1016\/j.bmcl.2009.09.086_bib3","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1021\/cr0782067","volume":"108","author":"Ahn","year":"2008","journal-title":"Chem. Rev."},{"key":"10.1016\/j.bmcl.2009.09.086_bib4a","doi-asserted-by":"crossref","first-page":"5044","DOI":"10.1073\/pnas.97.10.5044","volume":"97","author":"Boger","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bmcl.2009.09.086_bib4b","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1021\/jm049614v","volume":"48","author":"Boger","year":"2005","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmcl.2009.09.086_bib5","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1038\/nm803","volume":"9","author":"Kathuria","year":"2003","journal-title":"Nat. Med."},{"key":"10.1016\/j.bmcl.2009.09.086_bib6","unstructured":"Abouabdellah, A.; Burnier, P.; Hoornaert, C.; Jeunesse, J.; Puech, F. Patent application US20060089344, 2006."},{"key":"10.1016\/j.bmcl.2009.09.086_bib7","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.chembiol.2009.02.013","volume":"16","author":"Ahn","year":"2009","journal-title":"Chem. Biol."},{"key":"10.1016\/j.bmcl.2009.09.086_bib8_1","unstructured":"Matsumoto, T.; Kori, M.; Miyazaki, J.; Kiyota, Y. Patent application WO 2006054652, 2006."},{"key":"10.1016\/j.bmcl.2009.09.086_bib8b","doi-asserted-by":"crossref","first-page":"4838","DOI":"10.1016\/j.bmcl.2008.07.081","volume":"18","author":"Keith","year":"2008","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2009.09.086_bib9a","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1021\/jm050977k","volume":"49","author":"Muccioli","year":"2006","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmcl.2009.09.086_bib9_2","unstructured":"Adams, J.; Behnke, M. L.; Castro, A. C.; Evans, C. A.; Grenier, L.; Grogan, M. J.; Liu, T.; Snyder, D. A.; Tibbits, T. T. Patent application WO2008063300, 2008."},{"key":"10.1016\/j.bmcl.2009.09.086_bib9c","doi-asserted-by":"crossref","first-page":"7057","DOI":"10.1021\/jm801051t","volume":"51","author":"Minkkila","year":"2008","journal-title":". J. Med. Chem."},{"key":"10.1016\/j.bmcl.2009.09.086_bib10","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1038\/448645a","volume":"448\/449","author":"Chong","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.bmcl.2009.09.086_bib11a","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/S0149-2918(03)80085-1","volume":"25","author":"Matthews","year":"2003","journal-title":"Clin. Ther."},{"key":"10.1016\/j.bmcl.2009.09.086_bib11b","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1358\/dot.2004.40.3.820083","volume":"40","author":"Joglekar","year":"2004","journal-title":"Drugs Today"},{"key":"10.1016\/j.bmcl.2009.09.086_bib11c","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1517\/14740338.3.1.47","volume":"3","author":"Laffitte","year":"2004","journal-title":"Exp. Opin. Drug Safety"},{"key":"10.1016\/j.bmcl.2009.09.086_bib11d","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1358\/dof.2004.029.10.863396","volume":"29","author":"Abdel-Razeq","year":"2004","journal-title":"Drugs Future"},{"key":"10.1016\/j.bmcl.2009.09.086_bib12a","first-page":"S101","volume":"61","author":"Weiss","year":"2003","journal-title":"Neurology"},{"key":"10.1016\/j.bmcl.2009.09.086_bib12b","doi-asserted-by":"crossref","first-page":"2916","DOI":"10.1016\/j.bmcl.2008.03.075","volume":"18","author":"Gillespie","year":"2008","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2009.09.086_bib12c","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1021\/jm800961g","volume":"52","author":"Gillespie","year":"2009","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmcl.2009.09.086_bib13","doi-asserted-by":"crossref","first-page":"E4009","DOI":"10.1371\/journal.pone.0004009","volume":"3","author":"Ren","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/j.bmcl.2009.09.086_bib14","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1021\/cb600362d","volume":"2","author":"Chong","year":"2007","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.bmcl.2009.09.086_bib15","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/nchembio806","volume":"2","author":"Chong","year":"2006","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.bmcl.2009.09.086_bib16","doi-asserted-by":"crossref","first-page":"19579","DOI":"10.1073\/pnas.0809763105","volume":"105","author":"Zhang","year":"2008","journal-title":"Proc. Nat. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bmcl.2009.09.086_bib17","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1038\/nrd1500","volume":"3","author":"Swinney","year":"2004","journal-title":"Nat. Rev. Drug Disc."},{"key":"10.1016\/j.bmcl.2009.09.086_bib18a","series-title":"Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists","author":"Copeland","year":"2005"},{"key":"10.1016\/j.bmcl.2009.09.086_bib18b","series-title":"Enzymes. A Practical Introduction to Structure, Mechanism and Data Analysis","author":"Copeland","year":"2000"},{"key":"10.1016\/j.bmcl.2009.09.086_bib21a","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1177\/1087057106288188","volume":"11","author":"Wang","year":"2006","journal-title":"J. Biomol. Screen."},{"key":"10.1016\/j.bmcl.2009.09.086_bib21b","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.jneumeth.2006.10.006","volume":"161","author":"Kage","year":"2007","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.bmcl.2009.09.086_bib22","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.ab.2005.04.032","volume":"343","author":"Ramarao","year":"2005","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.bmcl.2009.09.086_bib23","doi-asserted-by":"crossref","first-page":"37393","DOI":"10.1074\/jbc.M303922200","volume":"278","author":"McKinney","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bmcl.2009.09.086_bib24","doi-asserted-by":"crossref","first-page":"13019","DOI":"10.1021\/bi701378g","volume":"46","author":"Ahn","year":"2007","journal-title":"Biochemistry"},{"key":"10.1016\/j.bmcl.2009.09.086_bib25","doi-asserted-by":"crossref","first-page":"2613","DOI":"10.1016\/S0960-894X(00)00528-X","volume":"10","author":"Boger","year":"2000","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2009.09.086_bib26a","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1126\/science.1076535","volume":"298","author":"Bracey","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.bmcl.2009.09.086_bib26b","doi-asserted-by":"crossref","first-page":"12820","DOI":"10.1073\/pnas.0806121105","volume":"105","author":"Mileni","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bmcl.2009.09.086_bib27","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/0005-2728(77)90157-8","volume":"460","author":"Tisher","year":"1977","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bmcl.2009.09.086_bib28","unstructured":"Environmental Protection Agency (EPA) report on Phenmedipham. Human health risk assessment, 2005."},{"key":"10.1016\/j.bmcl.2009.09.086_bib29","unstructured":"Parrott, J. A.; Compton, T. R.; Dasse, O.; Putman, D. Patent application WO2008042892, 2008."},{"key":"10.1016\/j.bmcl.2009.09.086_bib30a","doi-asserted-by":"crossref","first-page":"2865","DOI":"10.1016\/j.bmcl.2009.03.080","volume":"19","author":"Johnson","year":"2009","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2009.09.086_bib30b","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1213\/ane.0b013e31818c7cbd","volume":"108","author":"Kabarz","year":"2009","journal-title":"Anaesth. Analg."},{"key":"10.1016\/j.bmcl.2009.09.086_bib30_3","unstructured":"Ishii, T.; Sugane, T.; Maeda, J.; Narazaki, F.; Kakefuda, A.; Sato, K.; Takahashi, T.; Kanayama, T.; Saitoh, C.; Suzuki, J.; Kanai, C. Patent application WO 2006088075, 2006."},{"key":"10.1016\/j.bmcl.2009.09.086_bib31a","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1159\/000026495","volume":"37","author":"Price","year":"1998","journal-title":"Neuropsychobiology"},{"key":"10.1016\/j.bmcl.2009.09.086_bib31b","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/0091-3057(92)90392-S","volume":"43","author":"Myers","year":"1992","journal-title":"Pharmacol., Biochem. Behav."},{"key":"10.1016\/j.bmcl.2009.09.086_bib31c","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1111\/j.1600-0773.1990.tb01604.x","volume":"66","author":"Gustafsson","year":"1990","journal-title":"Pharmacol. Toxicol."},{"key":"10.1016\/j.bmcl.2009.09.086_bib31d","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/0014-2999(94)90245-3","volume":"256","author":"Tung","year":"1994","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.bmcl.2009.09.086_bib31e","doi-asserted-by":"crossref","first-page":"669","DOI":"10.2527\/jas1988.663669x","volume":"66","author":"Bjork","year":"1988","journal-title":"J. Animal Sci."},{"key":"10.1016\/j.bmcl.2009.09.086_bib32","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S0006-3223(96)00117-5","volume":"42","author":"Svartengren","year":"1997","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.bmcl.2009.09.086_bib33","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0893-133X(97)00112-7","volume":"18","author":"Arnt","year":"1998","journal-title":"Neuropsychopharmacology"}],"container-title":["Bioorganic & Medicinal Chemistry Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X09013547?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X09013547?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T06:10:21Z","timestamp":1760767821000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960894X09013547"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,12]]},"references-count":49,"journal-issue":{"issue":"23","published-print":{"date-parts":[[2009,12]]}},"alternative-id":["S0960894X09013547"],"URL":"https:\/\/doi.org\/10.1016\/j.bmcl.2009.09.086","relation":{},"ISSN":["0960-894X"],"issn-type":[{"value":"0960-894X","type":"print"}],"subject":[],"published":{"date-parts":[[2009,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mining biologically-active molecules for inhibitors of fatty acid amide hydrolase (FAAH): Identification of phenmedipham and amperozide as FAAH inhibitors","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmcl.2009.09.086","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}