{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T09:47:30Z","timestamp":1790588850849,"version":"4.1.0"},"reference-count":17,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2010,3,1]],"date-time":"2010-03-01T00:00:00Z","timestamp":1267401600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,3,1]],"date-time":"2010-03-01T00:00:00Z","timestamp":1267401600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry Letters"],"published-print":{"date-parts":[[2010,3]]},"DOI":"10.1016\/j.bmcl.2010.01.046","type":"journal-article","created":{"date-parts":[[2010,1,21]],"date-time":"2010-01-21T04:40:06Z","timestamp":1264048806000},"page":"1652-1656","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"title":["2-Aminothiadiazole inhibitors of AKT1 as potential cancer therapeutics"],"prefix":"10.1016","volume":"20","author":[{"given":"Qingping","family":"Zeng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew P.","family":"Bourbeau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. Erich","family":"Wohlhieter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guomin","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holger","family":"Monenschein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James T.","family":"Rider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew R.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiwen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Lofgren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Freeman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Tominey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas","family":"Hoffman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harvey","family":"Yamane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew S.","family":"Tasker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celia","family":"Dominguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vellarkad N.","family":"Viswanadhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randall","family":"Hungate","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoling","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmcl.2010.01.046_bib1","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/S1535-6108(03)00248-4","volume":"4","author":"Luo","year":"2003","journal-title":"Cancer Cell"},{"key":"10.1016\/j.bmcl.2010.01.046_bib2","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1042\/BST0350231","volume":"35","author":"Dummler","year":"2007","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.bmcl.2010.01.046_bib3","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1097\/CAD.0b013e3280cc2c6f","volume":"18","author":"LoPiccolo","year":"2007","journal-title":"Anti-Cancer Drugs"},{"key":"10.1016\/j.bmcl.2010.01.046_bib4","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1517\/13543776.17.9.1077","volume":"17","author":"Li","year":"2007","journal-title":"Expert Opin. Ther. Pat."},{"key":"10.1016\/j.bmcl.2010.01.046_bib5","first-page":"365","volume":"42","author":"Heerding","year":"2008","journal-title":"Annu. Rep. Med. Chem."},{"key":"10.1016\/j.bmcl.2010.01.046_bib6","doi-asserted-by":"crossref","first-page":"2243","DOI":"10.1021\/cr000226k","volume":"101","author":"Johnson","year":"2001","journal-title":"Chem. Rev."},{"key":"10.1016\/j.bmcl.2010.01.046_bib7","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.devcel.2008.01.013","volume":"14","author":"Besson","year":"2008","journal-title":"Dev. Cell."},{"key":"10.1016\/j.bmcl.2010.01.046_bib8","doi-asserted-by":"crossref","first-page":"5312","DOI":"10.1021\/jo01314a019","volume":"45","author":"Miller","year":"1980","journal-title":"J. Org. Chem."},{"key":"10.1016\/j.bmcl.2010.01.046_bib11","doi-asserted-by":"crossref","first-page":"2147","DOI":"10.1021\/jm701437d","volume":"51","author":"Caldwell","year":"2008","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmcl.2010.01.046_bib12","unstructured":"The coordinates for the co-crystal structures of 18 and 27 have been deposited with the RCDB and PBD. 18: RCSB ID code RCSB057006, PDB ID code 3L9M. 27: RCSB ID code RCSB057007, PDB ID code 3L9N."},{"key":"10.1016\/j.bmcl.2010.01.046_bib13","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/S0022-2836(03)00518-7","volume":"329","author":"Ga\u03b2el","year":"2003","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.bmcl.2010.01.046_bib14","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1016\/j.jmb.2007.01.004","volume":"367","author":"Davies","year":"2007","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.bmcl.2010.01.046_bib15","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1021\/ct6003406","volume":"3","author":"Lee","year":"2007","journal-title":"Chem. Theo. Comp."},{"key":"10.1016\/j.bmcl.2010.01.046_bib17","doi-asserted-by":"crossref","first-page":"10189","DOI":"10.1074\/jbc.M210837200","volume":"278","author":"Kovacina","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bmcl.2010.01.046_bib19","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/S0092-8674(00)80595-4","volume":"96","author":"Brunet","year":"1999","journal-title":"Cell"},{"key":"10.1016\/j.bmcl.2010.01.046_bib24","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1128\/MCB.21.3.952-965.2001","volume":"21","author":"Brunet","year":"2001","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.bmcl.2010.01.046_bib25","doi-asserted-by":"crossref","first-page":"13949","DOI":"10.1074\/jbc.M601384200","volume":"281","author":"Zhang","year":"2006","journal-title":"J. Biol. Chem."}],"container-title":["Bioorganic & Medicinal Chemistry Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X10000582?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X10000582?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T06:10:15Z","timestamp":1760767815000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960894X10000582"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,3]]},"references-count":17,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2010,3]]}},"alternative-id":["S0960894X10000582"],"URL":"https:\/\/doi.org\/10.1016\/j.bmcl.2010.01.046","relation":{},"ISSN":["0960-894X"],"issn-type":[{"value":"0960-894X","type":"print"}],"subject":[],"published":{"date-parts":[[2010,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"2-Aminothiadiazole inhibitors of AKT1 as potential cancer therapeutics","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmcl.2010.01.046","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}