{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T13:47:37Z","timestamp":1772113657762,"version":"3.50.1"},"reference-count":29,"publisher":"Elsevier BV","issue":"17","license":[{"start":{"date-parts":[[2010,9,1]],"date-time":"2010-09-01T00:00:00Z","timestamp":1283299200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,9,1]],"date-time":"2010-09-01T00:00:00Z","timestamp":1283299200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry Letters"],"published-print":{"date-parts":[[2010,9]]},"DOI":"10.1016\/j.bmcl.2010.07.012","type":"journal-article","created":{"date-parts":[[2010,7,9]],"date-time":"2010-07-09T04:27:59Z","timestamp":1278649679000},"page":"5139-5142","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"title":["Modification at the acidic domain of RXR agonists has little effect on permissive RXR-heterodimer activation"],"prefix":"10.1016","volume":"20","author":[{"given":"Shuji","family":"Fujii","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fuminori","family":"Ohsawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shoya","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryosuke","family":"Shinozaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryosuke","family":"Fukai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"Makishima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuichi","family":"Enomoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihiro","family":"Tai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroki","family":"Kakuta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmcl.2010.07.012_bib1","doi-asserted-by":"crossref","first-page":"4625","DOI":"10.1093\/emboj\/cdg456","volume":"22","author":"Svensson","year":"2003","journal-title":"EMBO J."},{"key":"10.1016\/j.bmcl.2010.07.012_bib2","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1038\/nrd2398","volume":"6","author":"de Lera","year":"2007","journal-title":"Nat. Rev. Drug Disc."},{"key":"10.1016\/j.bmcl.2010.07.012_bib3","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1254\/jphs.09084FP","volume":"111","author":"Kanda","year":"2009","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.bmcl.2010.07.012_bib4","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1038\/nature05449","volume":"445","author":"Mitro","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.bmcl.2010.07.012_bib5","doi-asserted-by":"crossref","first-page":"2831","DOI":"10.1101\/gad.850400","volume":"14","author":"Schultz","year":"2000","journal-title":"Gene Dev."},{"key":"10.1016\/j.bmcl.2010.07.012_bib6","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1248\/cpb.48.1504","volume":"48","author":"Ohta","year":"2000","journal-title":"Chem. Pharm. Bull."},{"key":"10.1016\/j.bmcl.2010.07.012_bib7","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S0092-8674(04)00119-9","volume":"116","author":"Shulman","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.bmcl.2010.07.012_bib8","first-page":"5566","volume":"56","author":"Gottardis","year":"1996","journal-title":"Cancer Res."},{"key":"10.1016\/j.bmcl.2010.07.012_bib9","first-page":"1658","volume":"5","author":"Rizvi","year":"1999","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.bmcl.2010.07.012_bib10","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1634\/theoncologist.6-1-4","volume":"6","author":"Cohen","year":"2001","journal-title":"Oncologist"},{"key":"10.1016\/j.bmcl.2010.07.012_bib11","first-page":"12","volume":"94156","author":"Pinaire","year":"2007","journal-title":"PPAR Res."},{"key":"10.1016\/j.bmcl.2010.07.012_bib12","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/S0026-895X(24)12824-6","volume":"59","author":"Davies","year":"2001","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.bmcl.2010.07.012_bib13","doi-asserted-by":"crossref","first-page":"38317","DOI":"10.1074\/jbc.M505853200","volume":"46","author":"Li","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bmcl.2010.07.012_bib14","doi-asserted-by":"crossref","first-page":"2880","DOI":"10.1210\/endo.143.8.8930","volume":"143","author":"Liu","year":"2002","journal-title":"Endocrinology"},{"key":"10.1016\/j.bmcl.2010.07.012_bib15","doi-asserted-by":"crossref","first-page":"2991","DOI":"10.1128\/MCB.21.9.2991-3000.2001","volume":"21","author":"Yoshikawa","year":"2001","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.bmcl.2010.07.012_bib16","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1016\/j.bcp.2008.08.005","volume":"76","author":"Nishimaki-Mogami","year":"2008","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bmcl.2010.07.012_bib17","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.bmcl.2008.11.040","volume":"19","author":"Charton","year":"2009","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2010.07.012_bib18","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1248\/cpb.49.501","volume":"49","author":"Ebisawa","year":"2001","journal-title":"Chem. Pharm. Bull."},{"key":"10.1016\/j.bmcl.2010.07.012_bib19","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1002\/cmdc.200700313","volume":"3","author":"Takamatsu","year":"2008","journal-title":"ChemMedChem"},{"key":"10.1016\/j.bmcl.2010.07.012_bib20","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1248\/bpb.21.547","volume":"21","author":"Ebisawa","year":"1998","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.bmcl.2010.07.012_bib21","doi-asserted-by":"crossref","first-page":"2182","DOI":"10.1021\/jm00119a021","volume":"31","author":"Kagechika","year":"1988","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmcl.2010.07.012_bib22","doi-asserted-by":"crossref","first-page":"4637","DOI":"10.1021\/ol801935r","volume":"10","author":"Kalek","year":"2008","journal-title":"Org. Lett."},{"key":"10.1016\/j.bmcl.2010.07.012_bib23","doi-asserted-by":"crossref","first-page":"3171","DOI":"10.1016\/j.jorganchem.2008.07.020","volume":"693","author":"Belabassi","year":"2008","journal-title":"J. Organomet. Chem."},{"key":"10.1016\/j.bmcl.2010.07.012_bib24","doi-asserted-by":"crossref","first-page":"3446","DOI":"10.1021\/jo026621n","volume":"68","author":"Mal","year":"2003","journal-title":"J. Org. Chem."},{"key":"10.1016\/j.bmcl.2010.07.012_bib25","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1021\/jm00314a004","volume":"10","author":"Holland","year":"1967","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmcl.2010.07.012_bib26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1208\/ps030210","volume":"3","author":"Franz","year":"2001","journal-title":"AAPS PharmSci."},{"key":"10.1016\/j.bmcl.2010.07.012_bib27","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1021\/jo00346a005","volume":"47","author":"Brink","year":"1982","journal-title":"J. Org. Chem."},{"key":"10.1016\/j.bmcl.2010.07.012_bib28","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.1021\/jo00213a016","volume":"50","author":"Brink","year":"1985","journal-title":"J. Org. Chem."},{"key":"10.1016\/j.bmcl.2010.07.012_bib29","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.1002\/jcc.21256","volume":"30","author":"Morris","year":"2009","journal-title":"J. Comput. Chem."}],"container-title":["Bioorganic & Medicinal Chemistry Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X10009686?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X10009686?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T06:18:40Z","timestamp":1760768320000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960894X10009686"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,9]]},"references-count":29,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2010,9]]}},"alternative-id":["S0960894X10009686"],"URL":"https:\/\/doi.org\/10.1016\/j.bmcl.2010.07.012","relation":{},"ISSN":["0960-894X"],"issn-type":[{"value":"0960-894X","type":"print"}],"subject":[],"published":{"date-parts":[[2010,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Modification at the acidic domain of RXR agonists has little effect on permissive RXR-heterodimer activation","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmcl.2010.07.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}