{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T10:57:16Z","timestamp":1791284236735,"version":"4.1.0"},"reference-count":19,"publisher":"Elsevier BV","issue":"23","license":[{"start":{"date-parts":[[2010,12,1]],"date-time":"2010-12-01T00:00:00Z","timestamp":1291161600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,12,1]],"date-time":"2010-12-01T00:00:00Z","timestamp":1291161600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2010,12,1]],"date-time":"2010-12-01T00:00:00Z","timestamp":1291161600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2010,12,1]],"date-time":"2010-12-01T00:00:00Z","timestamp":1291161600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2010,12,1]],"date-time":"2010-12-01T00:00:00Z","timestamp":1291161600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2010,12,1]],"date-time":"2010-12-01T00:00:00Z","timestamp":1291161600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2010,12,1]],"date-time":"2010-12-01T00:00:00Z","timestamp":1291161600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry Letters"],"published-print":{"date-parts":[[2010,12]]},"DOI":"10.1016\/j.bmcl.2010.09.084","type":"journal-article","created":{"date-parts":[[2010,9,20]],"date-time":"2010-09-20T04:14:47Z","timestamp":1284956087000},"page":"7097-7101","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":40,"title":["Structure-based design, synthesis and A-site rRNA co-crystal complexes of novel amphiphilic aminoglycoside antibiotics with new binding modes: A synergistic hydrophobic effect against resistant bacteria"],"prefix":"10.1016","volume":"20","author":[{"given":"Stephen","family":"Hanessian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kandasamy","family":"Pachamuthu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janek","family":"Szychowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Gigu\u00e8re","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric E.","family":"Swayze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael T.","family":"Migawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boris","family":"Fran\u00e7ois","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiro","family":"Kondo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Westhof","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmcl.2010.09.084_b0005","unstructured":"Stuart, B. L. The Antibiotic Paradox: How the Misuse of Antibiotics Destroys Their Curative Powers. HarperCollins, 2002, ISBN-10:0738204404."},{"key":"10.1016\/j.bmcl.2010.09.084_b0010_1","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1128\/CMR.16.3.430-450.2003","volume":"16","author":"Vakulenko","year":"2003","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.bmcl.2010.09.084_b0010_2","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1021\/cr0301088","volume":"105","author":"Magnet","year":"2005","journal-title":"Chem. Rev."},{"key":"10.1016\/j.bmcl.2010.09.084_b0015","series-title":"Antimicrobial Agents: Antibacterials and Antifungals","author":"Bryskier","year":"2005"},{"key":"10.1016\/j.bmcl.2010.09.084_b0020","series-title":"Aminoglycoside Antibiotics: From Chemical Biology to Drug Discovery","author":"Arya","year":"2007"},{"key":"10.1016\/j.bmcl.2010.09.084_b0025","doi-asserted-by":"crossref","first-page":"485","DOI":"10.7164\/antibiotics.24.485","volume":"24","author":"Umezawa","year":"1971","journal-title":"J. Antibiot."},{"key":"10.1016\/j.bmcl.2010.09.084_b0030","doi-asserted-by":"crossref","first-page":"2617","DOI":"10.1016\/S0040-4039(01)96933-3","volume":"28","author":"Woo","year":"1971","journal-title":"Tetrahedron Lett."},{"key":"10.1016\/j.bmcl.2010.09.084_b0035","doi-asserted-by":"crossref","first-page":"695","DOI":"10.7164\/antibiotics.25.695","volume":"25","author":"Kawaguchi","year":"1972","journal-title":"J. Antibiot."},{"key":"10.1016\/j.bmcl.2010.09.084_b0040","doi-asserted-by":"crossref","first-page":"705","DOI":"10.7164\/antibiotics.26.705","volume":"26","author":"Kondo","year":"1973","journal-title":"J. Antibiot."},{"key":"10.1016\/j.bmcl.2010.09.084_b0045","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1146\/annurev.biochem.74.061903.155440","volume":"74","author":"Ogle","year":"2005","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.bmcl.2010.09.084_b0050","doi-asserted-by":"crossref","first-page":"6735","DOI":"10.1002\/anie.200462092","volume":"43","author":"Fran\u00e7ois","year":"2004","journal-title":"Angew. Chem., Int. Ed."},{"key":"10.1016\/j.bmcl.2010.09.084_b0055","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1002\/cmdc.200700113","volume":"2","author":"Kondo","year":"2007","journal-title":"ChemMedChem"},{"key":"10.1016\/j.bmcl.2010.09.084_b0060","unstructured":"Takayuki, N.; Susumu, N.; Soichiro, T. German Patent 2,322,576, 1973."},{"key":"10.1016\/j.bmcl.2010.09.084_b0065","doi-asserted-by":"crossref","first-page":"98","DOI":"10.7164\/antibiotics.35.98","volume":"35","author":"Battistini","year":"1982","journal-title":"J. Antibiot."},{"key":"10.1016\/j.bmcl.2010.09.084_b0070","doi-asserted-by":"crossref","first-page":"2352","DOI":"10.1021\/jm061200+","volume":"50","author":"Hanessian","year":"2007","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmcl.2010.09.084_b0080","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1016\/j.biochi.2006.05.017","volume":"88","author":"Kondo","year":"2006","journal-title":"Biochimie"},{"key":"10.1016\/j.bmcl.2010.09.084_b0090","doi-asserted-by":"crossref","first-page":"6160","DOI":"10.1021\/jm800345u","volume":"51","author":"Bera","year":"2008","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmcl.2010.09.084_b0095","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1021\/jm900615h","volume":"53","author":"Baussanne","year":"2010","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmcl.2010.09.084_b0100","doi-asserted-by":"crossref","first-page":"3626","DOI":"10.1021\/jm1000437","volume":"53","author":"Bera","year":"2010","journal-title":"J. Med. Chem."}],"container-title":["Bioorganic & Medicinal Chemistry Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X10013934?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X10013934?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T06:19:57Z","timestamp":1760768397000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960894X10013934"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,12]]},"references-count":19,"journal-issue":{"issue":"23","published-print":{"date-parts":[[2010,12]]}},"alternative-id":["S0960894X10013934"],"URL":"https:\/\/doi.org\/10.1016\/j.bmcl.2010.09.084","relation":{},"ISSN":["0960-894X"],"issn-type":[{"value":"0960-894X","type":"print"}],"subject":[],"published":{"date-parts":[[2010,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Structure-based design, synthesis and A-site rRNA co-crystal complexes of novel amphiphilic aminoglycoside antibiotics with new binding modes: A synergistic hydrophobic effect against resistant bacteria","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmcl.2010.09.084","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}