{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T21:39:33Z","timestamp":1791322773306,"version":"4.3.1"},"reference-count":36,"publisher":"Elsevier BV","issue":"24","license":[{"start":{"date-parts":[[2010,12,1]],"date-time":"2010-12-01T00:00:00Z","timestamp":1291161600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,12,1]],"date-time":"2010-12-01T00:00:00Z","timestamp":1291161600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry Letters"],"published-print":{"date-parts":[[2010,12]]},"DOI":"10.1016\/j.bmcl.2010.10.094","type":"journal-article","created":{"date-parts":[[2010,10,26]],"date-time":"2010-10-26T04:46:38Z","timestamp":1288068398000},"page":"7255-7258","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":159,"title":["7,8-Disubstituted- but not 6,7-disubstituted coumarins selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII over the cytosolic ones I and II in the low nanomolar\/subnanomolar range"],"prefix":"10.1016","volume":"20","author":[{"given":"Alfonso","family":"Maresca","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Scozzafava","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudiu T.","family":"Supuran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmcl.2010.10.094_b0010","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1177\/1087057108315739","volume":"13","author":"Vu","year":"2008","journal-title":"J. Biomol. Screen."},{"key":"10.1016\/j.bmcl.2010.10.094_b0015","doi-asserted-by":"crossref","first-page":"3057","DOI":"10.1021\/ja809683v","volume":"131","author":"Maresca","year":"2009","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bmcl.2010.10.094_b0020","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1021\/jm901287j","volume":"53","author":"Maresca","year":"2010","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmcl.2010.10.094_b0030","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/nrd2467","volume":"7","author":"Supuran","year":"2008","journal-title":"Nat. Rev. Drug Disc."},{"key":"10.1016\/j.bmcl.2010.10.094_b0035","series-title":"Carbonic anhydrase \u2013 Its Inhibitors and Activators","first-page":"67","article-title":"Development of Sulfonamide Carbonic Anhydrase Inhibitors (CAIs)","author":"Supuran","year":"2004"},{"key":"10.1016\/j.bmcl.2010.10.094_b0040_1","first-page":"15","article-title":"Carbonic Anhydrases as Drug Targets \u2013 General Presentation","author":"Supuran","year":"2009"},{"key":"10.1016\/j.bmcl.2010.10.094_b0045","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1002\/med.20112","volume":"28","author":"Winum","year":"2008","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.bmcl.2010.10.094_b0050","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1002\/med.10025","volume":"23","author":"Supuran","year":"2003","journal-title":"Med. Res. Rev."},{"issue":"S1","key":"10.1016\/j.bmcl.2010.10.094_b0060","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/14756360902784425","volume":"24","author":"Ebbesen","year":"2009","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"10.1016\/j.bmcl.2010.10.094_b0065","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.radonc.2009.06.019","volume":"92","author":"Dubois","year":"2009","journal-title":"Radiother. Oncol."},{"key":"10.1016\/j.bmcl.2010.10.094_b0070","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1158\/0008-5472.CAN-08-2470","volume":"69","author":"Chiche","year":"2009","journal-title":"Cancer Res."},{"key":"10.1016\/j.bmcl.2010.10.094_b0075","doi-asserted-by":"crossref","first-page":"4851","DOI":"10.1016\/j.bmcl.2009.06.022","volume":"19","author":"Ahlskog","year":"2009","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2010.10.094_b0080","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1038\/sj.bjc.6605200","volume":"101","author":"Ahlskog","year":"2009","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.bmcl.2010.10.094_b0085","doi-asserted-by":"crossref","first-page":"5511","DOI":"10.1021\/jm1003667","volume":"53","author":"Carta","year":"2010","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmcl.2010.10.094_b0090","first-page":"73","article-title":"X-ray Crystallography of CA Inhibitors and its Importance in Drug Design","author":"Alterio","year":"2009"},{"key":"10.1016\/j.bmcl.2010.10.094_b0095","doi-asserted-by":"crossref","first-page":"2822","DOI":"10.1016\/j.bmc.2010.03.026","volume":"18","author":"Innocenti","year":"2010","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmcl.2010.10.094_b0100","doi-asserted-by":"crossref","first-page":"4511","DOI":"10.1016\/j.bmcl.2010.06.040","volume":"20","author":"Maresca","year":"2010","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2010.10.094_b0105","doi-asserted-by":"crossref","first-page":"3467","DOI":"10.1016\/j.bmcl.2010.05.009","volume":"20","author":"Supuran","year":"2010","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2010.10.094_b0115","doi-asserted-by":"crossref","first-page":"641","DOI":"10.2174\/138161208783877947","volume":"14","author":"Supuran","year":"2008","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.bmcl.2010.10.094_b0120","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1517\/14728214.13.2.383","volume":"13","author":"Supuran","year":"2008","journal-title":"Expert Opin. Emerg. Drugs"},{"key":"10.1016\/j.bmcl.2010.10.094_b0125","doi-asserted-by":"crossref","first-page":"655","DOI":"10.2174\/138161208783877820","volume":"14","author":"De Simone","year":"2008","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.bmcl.2010.10.094_b0130","first-page":"139","article-title":"Antiglaucoma Carbonic Anhydrase Inhibitors as Ophthalomologic Drugs","author":"Mincione","year":"2009"},{"key":"10.1016\/j.bmcl.2010.10.094_b0135","doi-asserted-by":"crossref","first-page":"631","DOI":"10.2174\/138161208783877901","volume":"14","author":"Krungkrai","year":"2008","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.bmcl.2010.10.094_b0140","doi-asserted-by":"crossref","first-page":"2397","DOI":"10.1016\/S0968-0896(99)00190-X","volume":"7","author":"Borras","year":"1999","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmcl.2010.10.094_b0150","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.tips.2006.09.002","volume":"27","author":"Thiry","year":"2006","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.bmcl.2010.10.094_b0155","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.febslet.2004.10.043","volume":"577","author":"Svastova","year":"2004","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bmcl.2010.10.094_b0160","doi-asserted-by":"crossref","first-page":"16233","DOI":"10.1073\/pnas.0908301106","volume":"106","author":"Alterio","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bmcl.2010.10.094_b0170","doi-asserted-by":"crossref","first-page":"4336","DOI":"10.1016\/j.bmc.2007.04.020","volume":"15","author":"Supuran","year":"2007","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmcl.2010.10.094_b0175","doi-asserted-by":"crossref","first-page":"2567","DOI":"10.1016\/j.bmcl.2008.03.051","volume":"18","author":"Temperini","year":"2008","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2010.10.094_b0180","doi-asserted-by":"crossref","first-page":"603","DOI":"10.2174\/138161208783877884","volume":"14","author":"Supuran","year":"2008","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.bmcl.2010.10.094_b0185","doi-asserted-by":"crossref","first-page":"2499","DOI":"10.1039\/b800767e","volume":"6","author":"Temperini","year":"2008","journal-title":"Org. Biomol. Chem."},{"key":"10.1016\/j.bmcl.2010.10.094_b0190","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1021\/jm801386n","volume":"52","author":"Temperini","year":"2009","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmcl.2010.10.094_b0195","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1016\/j.bmc.2008.12.023","volume":"17","author":"Temperini","year":"2009","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmcl.2010.10.094_b0200","doi-asserted-by":"crossref","first-page":"8375","DOI":"10.1016\/j.tet.2003.08.059","volume":"42","author":"Sabui","year":"2003","journal-title":"Tetrahedron"},{"key":"10.1016\/j.bmcl.2010.10.094_b0205","doi-asserted-by":"crossref","first-page":"2551","DOI":"10.1021\/cr800278z","volume":"109","author":"Kumara Swamy","year":"2009","journal-title":"Chem. Rev."},{"key":"10.1016\/j.bmcl.2010.10.094_b0215","doi-asserted-by":"crossref","first-page":"2561","DOI":"10.1016\/S0021-9258(18)62326-9","volume":"246","author":"Khalifah","year":"1971","journal-title":"J. Biol. Chem."}],"container-title":["Bioorganic & Medicinal Chemistry Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X10015556?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X10015556?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T06:21:08Z","timestamp":1760768468000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960894X10015556"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,12]]},"references-count":36,"journal-issue":{"issue":"24","published-print":{"date-parts":[[2010,12]]}},"alternative-id":["S0960894X10015556"],"URL":"https:\/\/doi.org\/10.1016\/j.bmcl.2010.10.094","relation":{},"ISSN":["0960-894X"],"issn-type":[{"value":"0960-894X","type":"print"}],"subject":[],"published":{"date-parts":[[2010,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"7,8-Disubstituted- but not 6,7-disubstituted coumarins selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII over the cytosolic ones I and II in the low nanomolar\/subnanomolar range","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmcl.2010.10.094","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}