{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:28:07Z","timestamp":1792783687332,"version":"4.5.0"},"reference-count":34,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000928","name":"Robert A. Welch Foundation","doi-asserted-by":"crossref","award":["N-0871"],"award-info":[{"award-number":["N-0871"]}],"id":[{"id":"10.13039\/100000928","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Veterans Affairs Merit Review Program, GRECC"},{"name":"NIH","award":["R01 AI063517-01"],"award-info":[{"award-number":["R01 AI063517-01"]}]},{"name":"NIH","award":["R01 AI062968"],"award-info":[{"award-number":["R01 AI062968"]}]},{"name":"NIH","award":["R01 GM54072"],"award-info":[{"award-number":["R01 GM54072"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry Letters"],"published-print":{"date-parts":[[2011,1]]},"DOI":"10.1016\/j.bmcl.2010.10.134","type":"journal-article","created":{"date-parts":[[2010,11,9]],"date-time":"2010-11-09T08:15:02Z","timestamp":1289290502000},"page":"387-393","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"title":["Modifications of the C6-substituent of penicillin sulfones with the goal of improving inhibitor recognition and efficacy"],"prefix":"10.1016","volume":"21","author":[{"given":"Micheal","family":"Nottingham","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher R.","family":"Bethel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sundar Ram Reddy","family":"Pagadala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Harry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abishai","family":"Pinto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zachary A.","family":"Lemons","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah M.","family":"Drawz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Focco van den","family":"Akker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul R.","family":"Carey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Bonomo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John D.","family":"Buynak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmcl.2010.10.134_b0005","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.coph.2007.08.003","volume":"7","author":"Perez","year":"2007","journal-title":"Curr. Opin. Pharmacol."},{"issue":"14","key":"10.1016\/j.bmcl.2010.10.134_b0010","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1111\/j.1469-0691.2007.01867.x","author":"Rossolini","year":"2008","journal-title":"Clin. Microbiol. Infect."},{"issue":"14","key":"10.1016\/j.bmcl.2010.10.134_b0015","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1111\/j.1469-0691.2007.01848.x","author":"Bush","year":"2008","journal-title":"Clin. Microbiol. Infect."},{"key":"10.1016\/j.bmcl.2010.10.134_b0020","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1586\/14787210.6.5.671","volume":"6","author":"Rodriguez-Bano","year":"2008","journal-title":"Expert Rev. Anti Infect. Ther."},{"key":"10.1016\/j.bmcl.2010.10.134_b0025","doi-asserted-by":"crossref","first-page":"501","DOI":"10.2217\/17460913.2.5.501","volume":"2","author":"Poirel","year":"2007","journal-title":"Future Microbiol."},{"key":"10.1016\/j.bmcl.2010.10.134_b0030","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1128\/AAC.01512-08","volume":"54","author":"Poirel","year":"2010","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.bmcl.2010.10.134_b0035","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1128\/CMR.00001-07","volume":"20","author":"Queenan","year":"2007","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.bmcl.2010.10.134_b0040","doi-asserted-by":"crossref","first-page":"3740","DOI":"10.2174\/092986709789104957","volume":"16","author":"Perez-Llarena","year":"2009","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.bmcl.2010.10.134_b0045","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/AAC.42.1.1","volume":"42","author":"Massova","year":"1998","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.bmcl.2010.10.134_b0050","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1039\/b107097p","author":"Pratt","year":"2002","journal-title":"J. Chem. Soc., Perkin Trans. 2"},{"key":"10.1016\/j.bmcl.2010.10.134_b0055","doi-asserted-by":"crossref","first-page":"9612","DOI":"10.1021\/ja034861u","volume":"125","author":"Meroueh","year":"2003","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bmcl.2010.10.134_b0060","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1111\/j.1574-6976.2008.00105.x","volume":"32","author":"Sauvage","year":"2008","journal-title":"FEMS Microbiol. Rev."},{"key":"10.1016\/j.bmcl.2010.10.134_b0065","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1006\/jmbi.2000.3740","volume":"299","author":"Gordon","year":"2000","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.bmcl.2010.10.134_b0070","unstructured":"Kellogg, M. S. Ger. Pat. DE 3039504 19810430, Chem. Abstr. 1981, 95, 480946."},{"key":"10.1016\/j.bmcl.2010.10.134_b0075","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/S0960-894X(99)00106-7","volume":"9","author":"Bitha","year":"1999","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2010.10.134_b0080","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1016\/S0960-894X(99)00107-9","volume":"9","author":"Bitha","year":"1999","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2010.10.134_b0085","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1016\/j.bmcl.2003.12.037","volume":"14","author":"Buynak","year":"2004","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2010.10.134_b0090","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.7164\/antibiotics.53.1022","volume":"53","author":"Golemi","year":"2000","journal-title":"J. Antibiot."},{"key":"10.1016\/j.bmcl.2010.10.134_b0095","doi-asserted-by":"crossref","first-page":"2515","DOI":"10.1021\/ol900668k","volume":"11","author":"Testero","year":"2009","journal-title":"Org. Lett."},{"key":"10.1016\/j.bmcl.2010.10.134_b0100","doi-asserted-by":"crossref","first-page":"7435","DOI":"10.1021\/ja9609718","volume":"118","author":"Maveyraud","year":"1996","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bmcl.2010.10.134_b0105","doi-asserted-by":"crossref","first-page":"9382","DOI":"10.1021\/ja9817996","volume":"120","author":"Mourey","year":"1998","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bmcl.2010.10.134_b0110","doi-asserted-by":"crossref","first-page":"2138","DOI":"10.1007\/s00018-008-7591-7","volume":"65","author":"Pratt","year":"2008","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.bmcl.2010.10.134_b0115","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1128\/AAC.32.6.925","volume":"32","author":"Moosdeen","year":"1988","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.bmcl.2010.10.134_b0120","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1093\/infdis\/167.2.448","volume":"167","author":"Urban","year":"1993","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.bmcl.2010.10.134_b0125","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1111\/j.1574-6968.1995.tb07357.x","volume":"125","author":"Urban","year":"1995","journal-title":"FEMS Microbiol. Lett."},{"key":"10.1016\/j.bmcl.2010.10.134_b0130","unstructured":"Akkerboom, P. J.; Oldenhof, C. US patent 4,422,971. Chem. Abstr. 1981, 95, 587244."},{"key":"10.1016\/j.bmcl.2010.10.134_b0135","doi-asserted-by":"crossref","first-page":"3344","DOI":"10.1021\/jo00138a035","volume":"47","author":"Volkmann","year":"1982","journal-title":"J. Org. Chem."},{"key":"10.1016\/j.bmcl.2010.10.134_b0140","doi-asserted-by":"crossref","first-page":"1766","DOI":"10.1128\/AAC.01410-08","volume":"53","author":"Rodriguez-Martinez","year":"2009","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.bmcl.2010.10.134_b0150","first-page":"311","volume":"158","author":"Batchelor","year":"1963","journal-title":"Proc. R. Soc. London"},{"key":"10.1016\/j.bmcl.2010.10.134_b0155","doi-asserted-by":"crossref","first-page":"11257","DOI":"10.1073\/pnas.90.23.11257","volume":"90","author":"Lobkovsky","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bmcl.2010.10.134_b0160","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1042\/bj2550119","volume":"255","author":"Galleni","year":"1988","journal-title":"Biochem. J."},{"key":"10.1016\/j.bmcl.2010.10.134_b0165","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1042\/bj2550123","volume":"255","author":"Galleni","year":"1988","journal-title":"Biochem. J."},{"key":"10.1016\/j.bmcl.2010.10.134_b0170","doi-asserted-by":"crossref","first-page":"2726","DOI":"10.1021\/bi00513a004","volume":"20","author":"Fisher","year":"1981","journal-title":"Biochemistry"},{"key":"10.1016\/j.bmcl.2010.10.134_b0175","doi-asserted-by":"crossref","first-page":"10196","DOI":"10.1021\/bi901416t","volume":"48","author":"Kalp","year":"2009","journal-title":"Biochemistry"}],"container-title":["Bioorganic & Medicinal Chemistry Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X10016057?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X10016057?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T06:23:16Z","timestamp":1760768596000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960894X10016057"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,1]]},"references-count":34,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,1]]}},"alternative-id":["S0960894X10016057"],"URL":"https:\/\/doi.org\/10.1016\/j.bmcl.2010.10.134","relation":{},"ISSN":["0960-894X"],"issn-type":[{"value":"0960-894X","type":"print"}],"subject":[],"published":{"date-parts":[[2011,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Modifications of the C6-substituent of penicillin sulfones with the goal of improving inhibitor recognition and efficacy","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmcl.2010.10.134","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}