{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T21:38:55Z","timestamp":1791322735288,"version":"4.3.1"},"reference-count":25,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry Letters"],"published-print":{"date-parts":[[2012,1]]},"DOI":"10.1016\/j.bmcl.2011.11.018","type":"journal-article","created":{"date-parts":[[2011,11,11]],"date-time":"2011-11-11T21:38:40Z","timestamp":1321047520000},"page":"267-270","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":70,"title":["5- and 6-Membered (thio)lactones are prodrug type carbonic anhydrase inhibitors"],"prefix":"10.1016","volume":"22","author":[{"given":"Fabrizio","family":"Carta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfonso","family":"Maresca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Scozzafava","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudiu T.","family":"Supuran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmcl.2011.11.018_b0010","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/nrd2467","volume":"7","author":"Supuran","year":"2008","journal-title":"Nat. Rev. Drug Disc."},{"key":"10.1016\/j.bmcl.2011.11.018_b0015","doi-asserted-by":"crossref","first-page":"3467","DOI":"10.1016\/j.bmcl.2010.05.009","volume":"20","author":"Supuran","year":"2010","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2011.11.018_b0025","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1002\/med.10025","volume":"23","author":"Supuran","year":"2003","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.bmcl.2011.11.018_b0030","doi-asserted-by":"crossref","first-page":"3233","DOI":"10.2174\/138161210793429797","volume":"16","author":"Supuran","year":"2010","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.bmcl.2011.11.018_b0040","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1177\/1087057108315739","volume":"13","author":"Vu","year":"2008","journal-title":"J. Biomol. Screen."},{"key":"10.1016\/j.bmcl.2011.11.018_b0045","doi-asserted-by":"crossref","first-page":"3057","DOI":"10.1021\/ja809683v","volume":"131","author":"Maresca","year":"2009","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bmcl.2011.11.018_b0050","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1021\/jm901287j","volume":"53","author":"Maresca","year":"2010","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmcl.2011.11.018_b0060","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/14756360902784425","volume":"24","author":"Ebbesen","year":"2009","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"10.1016\/j.bmcl.2011.11.018_b0065","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.radonc.2009.06.019","volume":"92","author":"Dubois","year":"2009","journal-title":"Radiother. Oncol."},{"key":"10.1016\/j.bmcl.2011.11.018_b0070","doi-asserted-by":"crossref","first-page":"4851","DOI":"10.1016\/j.bmcl.2009.06.022","volume":"19","author":"Ahlskog","year":"2009","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2011.11.018_b0075","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1038\/sj.bjc.6605200","volume":"101","author":"Ahlskog","year":"2009","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.bmcl.2011.11.018_b0080","doi-asserted-by":"crossref","first-page":"5511","DOI":"10.1021\/jm1003667","volume":"53","author":"Carta","year":"2010","journal-title":"J. Med.Chem."},{"key":"10.1016\/j.bmcl.2011.11.018_b0085","series-title":"Drug Design of Zinc-Enzyme Inhibitors: Functional, Structural and Disease Applications","first-page":"73","article-title":"X-Ray Crystallography of CA Inhibitors and its Importance in Drug Design","author":"Alterio","year":"2009"},{"key":"10.1016\/j.bmcl.2011.11.018_b0095","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.febslet.2004.10.043","volume":"577","author":"\u0160vastov\u00e1","year":"2004","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bmcl.2011.11.018_b0100","doi-asserted-by":"crossref","first-page":"20473","DOI":"10.1074\/jbc.M801330200","volume":"283","author":"Swietach","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bmcl.2011.11.018_b0105","doi-asserted-by":"crossref","first-page":"1896","DOI":"10.1021\/jm101541x","volume":"54","author":"Pacchiano","year":"2011","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmcl.2011.11.018_b0110","doi-asserted-by":"crossref","first-page":"4511","DOI":"10.1016\/j.bmcl.2010.06.040","volume":"20","author":"Maresca","year":"2010","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2011.11.018_b0115","doi-asserted-by":"crossref","first-page":"7255","DOI":"10.1016\/j.bmcl.2010.10.094","volume":"20","author":"Maresca","year":"2010","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2011.11.018_b0120","doi-asserted-by":"crossref","first-page":"3364","DOI":"10.1158\/0008-5472.CAN-10-4261","volume":"71","author":"Lou","year":"2011","journal-title":"Cancer Res."},{"key":"10.1016\/j.bmcl.2011.11.018_b0125","doi-asserted-by":"crossref","first-page":"16233","DOI":"10.1073\/pnas.0908301106","volume":"106","author":"Alterio","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bmcl.2011.11.018_b0130","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1038\/nrd3554","volume":"10","author":"Neri","year":"2011","journal-title":"Nat. Rev. Drug Disc."},{"key":"10.1016\/j.bmcl.2011.11.018_b0140","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1021\/jm901524f","volume":"53","author":"Temperini","year":"2010","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmcl.2011.11.018_b0145","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1002\/prot.22144","volume":"74","author":"Di Fiore","year":"2009","journal-title":"Proteins"},{"key":"10.1016\/j.bmcl.2011.11.018_b0155","unstructured":"Manning, P.T.; Misko, T.P. Preparation of amino acid derivatives as inhibitors of inducible nitric oxide synthase for use in combination therapy with alkylating agents. WO Pat. 2005, 025620 A2."},{"key":"10.1016\/j.bmcl.2011.11.018_b0160","doi-asserted-by":"crossref","first-page":"1998","DOI":"10.1002\/hlca.19850680724","author":"Defoin","year":"1985","journal-title":"Helv. Chim. Acta"}],"container-title":["Bioorganic & Medicinal Chemistry Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X11015502?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X11015502?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T06:28:17Z","timestamp":1760768897000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960894X11015502"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,1]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,1]]}},"alternative-id":["S0960894X11015502"],"URL":"https:\/\/doi.org\/10.1016\/j.bmcl.2011.11.018","relation":{},"ISSN":["0960-894X"],"issn-type":[{"value":"0960-894X","type":"print"}],"subject":[],"published":{"date-parts":[[2012,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"5- and 6-Membered (thio)lactones are prodrug type carbonic anhydrase inhibitors","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmcl.2011.11.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}