{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T04:42:30Z","timestamp":1791348150960,"version":"4.3.1"},"reference-count":49,"publisher":"Elsevier BV","issue":"14","license":[{"start":{"date-parts":[[2012,7,1]],"date-time":"2012-07-01T00:00:00Z","timestamp":1341100800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,7,1]],"date-time":"2012-07-01T00:00:00Z","timestamp":1341100800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry Letters"],"published-print":{"date-parts":[[2012,7]]},"DOI":"10.1016\/j.bmcl.2012.05.083","type":"journal-article","created":{"date-parts":[[2012,5,30]],"date-time":"2012-05-30T06:48:59Z","timestamp":1338360539000},"page":"4681-4685","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":67,"title":["Ureido-substituted sulfamates show potent carbonic anhydrase IX inhibitory and antiproliferative activities against breast cancer cell lines"],"prefix":"10.1016","volume":"22","author":[{"given":"Jean-Yves","family":"Winum","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrizio","family":"Carta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol","family":"Ward","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Mullen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Harrison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon P.","family":"Langdon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Cecchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Scozzafava","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian","family":"Kunkler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudiu T.","family":"Supuran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmcl.2012.05.083_b0010","first-page":"54","volume":"2011","author":"Pacchiano","year":"1896","journal-title":"J. Med. Chem"},{"key":"10.1016\/j.bmcl.2012.05.083_b0015","doi-asserted-by":"crossref","first-page":"3364","DOI":"10.1158\/0008-5472.CAN-10-4261","volume":"71","author":"Lou","year":"2011","journal-title":"Cancer Res."},{"key":"10.1016\/j.bmcl.2012.05.083_b0020_1","doi-asserted-by":"crossref","unstructured":"Alterio, V.; Di Fiore, A.; D\u2019Ambrosio, K.; Supuran, C.T.; De Simone, G. Chem. Rev., in press, http:\/\/dx.doi.org\/10.1021\/cr200176r.","DOI":"10.1021\/cr200176r"},{"key":"10.1016\/j.bmcl.2012.05.083_b0025","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/nrd2467","volume":"7","author":"Supuran","year":"2008","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.bmcl.2012.05.083_b0035","doi-asserted-by":"crossref","first-page":"15184","DOI":"10.1073\/pnas.96.26.15184","volume":"96","author":"Smith","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bmcl.2012.05.083_b0040","doi-asserted-by":"crossref","first-page":"901","DOI":"10.2174\/156802607780636753","volume":"7","author":"Zimmerman","year":"2007","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.bmcl.2012.05.083_b0050","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/nature06636","volume":"452","author":"Xu","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.bmcl.2012.05.083_b0055","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1016\/j.biochi.2012.02.013","volume":"94","author":"Alterio","year":"2012","journal-title":"Biochimie"},{"key":"10.1016\/j.bmcl.2012.05.083_b0065","doi-asserted-by":"crossref","first-page":"4851","DOI":"10.1016\/j.bmcl.2009.06.022","volume":"19","author":"Ahlskog","year":"2009","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2012.05.083_b0070","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1038\/nrd3554","volume":"10","author":"Neri","year":"2011","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.bmcl.2012.05.083_b0080","doi-asserted-by":"crossref","first-page":"3467","DOI":"10.1016\/j.bmcl.2010.05.009","volume":"20","author":"Supuran","year":"2010","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2012.05.083_b0085","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1080\/14756360410001689540","volume":"19","author":"Pastorekova","year":"2004","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"10.1016\/j.bmcl.2012.05.083_b0090","unstructured":"Supuran, C.T. J. Enzyme Inhib. Med. Chem. in press."},{"key":"10.1016\/j.bmcl.2012.05.083_b0100","doi-asserted-by":"crossref","first-page":"30766","DOI":"10.1074\/jbc.M805353200","volume":"283","author":"Domsic","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bmcl.2012.05.083_b0105","doi-asserted-by":"crossref","first-page":"6223","DOI":"10.1021\/ja1097594","volume":"133","author":"Maupin","year":"2011","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bmcl.2012.05.083_b0115","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.4155\/fmc.11.69","volume":"3","author":"Supuran","year":"2011","journal-title":"Carbonic Future Med. Chem."},{"key":"10.1016\/j.bmcl.2012.05.083_b0120","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1002\/med.10025","volume":"23","author":"Supuran","year":"2003","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.bmcl.2012.05.083_b0125","doi-asserted-by":"crossref","first-page":"863","DOI":"10.3109\/14756360903571685","volume":"25","author":"Baranauskiene","year":"2010","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"10.1016\/j.bmcl.2012.05.083_b0130","doi-asserted-by":"crossref","first-page":"e28458","DOI":"10.1371\/journal.pone.0028458","volume":"6","author":"Huang","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.bmcl.2012.05.083_b0140","doi-asserted-by":"crossref","first-page":"10384","DOI":"10.1021\/bi970760v","volume":"36","author":"Briganti","year":"1997","journal-title":"Biochemistry"},{"key":"10.1016\/j.bmcl.2012.05.083_b0145","doi-asserted-by":"crossref","first-page":"7057","DOI":"10.1002\/chem.200600159","volume":"12","author":"Temperini","year":"2006","journal-title":"Chemistry"},{"key":"10.1016\/j.bmcl.2012.05.083_b0155","first-page":"48","volume":"2012","author":"Carta","year":"1868","journal-title":"Chem. Commun."},{"key":"10.1016\/j.bmcl.2012.05.083_b0160","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/j.bmcl.2011.12.033","volume":"22","author":"Monti","year":"2012","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2012.05.083_b0165","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1021\/jm300031j","volume":"55","author":"Carta","year":"2012","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmcl.2012.05.083_b0170","doi-asserted-by":"crossref","first-page":"895","DOI":"10.3109\/14756366.2011.554415","volume":"26","author":"Kolayli","year":"2011","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"10.1016\/j.bmcl.2012.05.083_b0350_1","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.jinorgbio.2011.11.017","volume":"111","author":"De Simone","year":"2012","journal-title":"Inorg. Biochem."},{"key":"10.1016\/j.bmcl.2012.05.083_b0350_2","doi-asserted-by":"crossref","first-page":"3551","DOI":"10.1039\/c2cc30359k","volume":"48","author":"Parkkila","year":"2012","journal-title":"Chem. Commun."},{"key":"10.1016\/j.bmcl.2012.05.083_b0190","doi-asserted-by":"crossref","first-page":"5511","DOI":"10.1021\/jm1003667","volume":"53","author":"Carta","year":"2010","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmcl.2012.05.083_b0200","doi-asserted-by":"crossref","first-page":"3057","DOI":"10.1021\/ja809683v","volume":"131","author":"Maresca","year":"2009","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bmcl.2012.05.083_b0205","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1021\/jm901287j","volume":"53","author":"Maresca","year":"2010","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmcl.2012.05.083_b0215","doi-asserted-by":"crossref","first-page":"4511","DOI":"10.1016\/j.bmcl.2010.06.040","volume":"20","author":"Maresca","year":"2010","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2012.05.083_b0220","doi-asserted-by":"crossref","first-page":"7255","DOI":"10.1016\/j.bmcl.2010.10.094","volume":"20","author":"Maresca","year":"2010","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2012.05.083_b0225","doi-asserted-by":"crossref","first-page":"8271","DOI":"10.1021\/jm200983e","volume":"54","author":"Touisni","year":"2011","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmcl.2012.05.083_b0235","doi-asserted-by":"crossref","first-page":"3660","DOI":"10.1200\/JCO.2001.19.16.3660","volume":"19","author":"Chia","year":"2001","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.bmcl.2012.05.083_b0240","first-page":"7075","volume":"60","author":"Wykoff","year":"2000","journal-title":"Cancer Res."},{"key":"10.1016\/j.bmcl.2012.05.083_b0250","doi-asserted-by":"crossref","first-page":"6160","DOI":"10.1158\/0008-5472.CAN-03-2224","volume":"64","author":"Robertson","year":"2004","journal-title":"Cancer Res."},{"key":"10.1016\/j.bmcl.2012.05.083_b0255","doi-asserted-by":"crossref","first-page":"3392","DOI":"10.1074\/jbc.M111.286062","volume":"287","author":"Svastova","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bmcl.2012.05.083_b0260","doi-asserted-by":"crossref","first-page":"7558","DOI":"10.1158\/0008-5472.CAN-11-2520","volume":"71","author":"Ditte","year":"2011","journal-title":"Cancer Res."},{"key":"10.1016\/j.bmcl.2012.05.083_b0265","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.radonc.2011.05.045","volume":"99","author":"Dubois","year":"2011","journal-title":"Radiother. Oncol."},{"key":"10.1016\/j.bmcl.2012.05.083_b0275","doi-asserted-by":"crossref","first-page":"5471","DOI":"10.1021\/jm030911u","volume":"46","author":"Winum","year":"2003","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmcl.2012.05.083_b0280","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1021\/jm021124k","volume":"46","author":"Winum","year":"2003","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmcl.2012.05.083_b0290","doi-asserted-by":"crossref","first-page":"5721","DOI":"10.1021\/jm050333c","volume":"48","author":"Menchise","year":"2005","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmcl.2012.05.083_b0295","doi-asserted-by":"crossref","first-page":"8329","DOI":"10.1021\/ja061574s","volume":"128","author":"Alterio","year":"2006","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bmcl.2012.05.083_b0300","doi-asserted-by":"crossref","first-page":"4201","DOI":"10.1016\/j.bmcl.2007.05.045","volume":"17","author":"Alterio","year":"2007","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2012.05.083_b0305","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.bmcl.2003.09.064","volume":"14","author":"Abbate","year":"2004","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2012.05.083_b0315","doi-asserted-by":"crossref","first-page":"8371","DOI":"10.1039\/c0cc02707c","volume":"46","author":"Pacchiano","year":"2010","journal-title":"Chem. Commun."},{"key":"10.1016\/j.bmcl.2012.05.083_b0320","doi-asserted-by":"crossref","first-page":"3105","DOI":"10.1016\/j.bmc.2011.04.005","volume":"19","author":"Carta","year":"2011","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmcl.2012.05.083_b0325","doi-asserted-by":"crossref","first-page":"3977","DOI":"10.1021\/jm200209n","volume":"54","author":"Hen","year":"2011","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmcl.2012.05.083_b0335","series-title":"Polypharmacology in Drug Discovery","first-page":"457","article-title":"Carbonic anhydrases: off-targets, add-on activities, or emerging novel targets ?","author":"Supuran","year":"2012"}],"container-title":["Bioorganic & Medicinal Chemistry Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X12006956?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X12006956?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T06:37:09Z","timestamp":1760769429000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960894X12006956"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,7]]},"references-count":49,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2012,7]]}},"alternative-id":["S0960894X12006956"],"URL":"https:\/\/doi.org\/10.1016\/j.bmcl.2012.05.083","relation":{},"ISSN":["0960-894X"],"issn-type":[{"value":"0960-894X","type":"print"}],"subject":[],"published":{"date-parts":[[2012,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ureido-substituted sulfamates show potent carbonic anhydrase IX inhibitory and antiproliferative activities against breast cancer cell lines","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmcl.2012.05.083","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}