{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T20:50:10Z","timestamp":1780347010639,"version":"3.54.1"},"reference-count":36,"publisher":"Elsevier BV","issue":"14","license":[{"start":{"date-parts":[[2012,7,1]],"date-time":"2012-07-01T00:00:00Z","timestamp":1341100800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,7,1]],"date-time":"2012-07-01T00:00:00Z","timestamp":1341100800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry Letters"],"published-print":{"date-parts":[[2012,7]]},"DOI":"10.1016\/j.bmcl.2012.06.004","type":"journal-article","created":{"date-parts":[[2012,6,7]],"date-time":"2012-06-07T18:00:32Z","timestamp":1339092032000},"page":"4506-4516","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"title":["Discovery of nitroheterocycles active against African trypanosomes. In vitro screening and preliminary SAR studies"],"prefix":"10.1016","volume":"22","author":[{"given":"Vicente J.","family":"Ar\u00e1n","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcel","family":"Kaiser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Dardonville","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmcl.2012.06.004_b0005","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/S0140-6736(09)60829-1","volume":"375","author":"Brun","year":"2010","journal-title":"Lancet"},{"key":"10.1016\/j.bmcl.2012.06.004_b0010","unstructured":"WHO. Working to overcome the global impact of neglected tropical diseases: first WHO report on neglected tropical diseases. World Health Organization: Geneva, 2010."},{"key":"10.1016\/j.bmcl.2012.06.004_b0015","first-page":"137","volume":"2010","author":"Burri","year":"1987","journal-title":"Parasitology"},{"key":"10.1016\/j.bmcl.2012.06.004_b0020","doi-asserted-by":"crossref","first-page":"e1151","DOI":"10.1371\/journal.pntd.0001151","volume":"5","author":"Jacobs","year":"2011","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.bmcl.2012.06.004_b0025","doi-asserted-by":"crossref","first-page":"e923","DOI":"10.1371\/journal.pntd.0000923","volume":"4","author":"Torreele","year":"2010","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.bmcl.2012.06.004_b0030","doi-asserted-by":"crossref","first-page":"3324","DOI":"10.1016\/j.ejmech.2011.04.057","volume":"46","author":"Castillo-Garit","year":"2011","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bmcl.2012.06.004_b0185","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1016\/j.saa.2010.12.017","volume":"78","author":"Aguilera-Venegas","year":"2011","journal-title":"Spectrochim Acta - Part A: Mol. Biomol. Spectr."},{"key":"10.1016\/j.bmcl.2012.06.004_b0040","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1016\/j.ejmech.2008.07.018","volume":"44","author":"Rodr\u00edguez","year":"2009","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bmcl.2012.06.004_b0045","doi-asserted-by":"crossref","first-page":"8186","DOI":"10.1016\/j.bmc.2009.10.030","volume":"17","author":"Rodr\u00edguez","year":"2009","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmcl.2012.06.004_b0050","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1016\/j.ejmech.2008.06.024","volume":"44","author":"Boiani","year":"2009","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bmcl.2012.06.004_b0055","doi-asserted-by":"crossref","first-page":"1898","DOI":"10.1016\/j.bmcl.2005.12.087","volume":"16","author":"Vega","year":"2006","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2012.06.004_b0060","doi-asserted-by":"crossref","first-page":"6264","DOI":"10.1016\/j.bmc.2005.06.049","volume":"13","author":"Montero-Torres","year":"2005","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmcl.2012.06.004_b0065","doi-asserted-by":"crossref","first-page":"3197","DOI":"10.1016\/j.bmc.2005.02.043","volume":"13","author":"Ar\u00e1n","year":"2005","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmcl.2012.06.004_b0070","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1007\/s10822-008-9171-1","volume":"22","author":"Marrero-Ponce","year":"2008","journal-title":"J. Comput. Aided Mol. Des."},{"key":"10.1016\/j.bmcl.2012.06.004_b0075","doi-asserted-by":"crossref","first-page":"6502","DOI":"10.1016\/j.bmc.2006.06.016","volume":"14","author":"Marrero-Ponce","year":"2006","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmcl.2012.06.004_b0080","doi-asserted-by":"crossref","first-page":"3838","DOI":"10.1016\/j.bmcl.2005.05.124","volume":"15","author":"Meneses-Marcel","year":"2005","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2012.06.004_b0085","doi-asserted-by":"crossref","first-page":"245","DOI":"10.2174\/157016305775202955","volume":"2","author":"Marrero-Ponce","year":"2005","journal-title":"Curr. Drug Discov. Tech."},{"key":"10.1016\/j.bmcl.2012.06.004_b0090","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1002\/qsar.200610165","volume":"28","author":"Rivera-Borroto","year":"2009","journal-title":"QSAR Comb. Sci."},{"key":"10.1016\/j.bmcl.2012.06.004_b0095","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1002\/cmdc.200800176","volume":"4","author":"Martins Alho","year":"2009","journal-title":"ChemMedChem."},{"key":"10.1016\/j.bmcl.2012.06.004_b0100","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.ejmech.2005.12.010","volume":"41","author":"Montero-Torres","year":"2006","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bmcl.2012.06.004_b0105","doi-asserted-by":"crossref","first-page":"5171","DOI":"10.1021\/jf0704211","volume":"55","author":"Reino","year":"2007","journal-title":"J. Agr. Food Chem."},{"key":"10.1016\/j.bmcl.2012.06.004_b0110","doi-asserted-by":"crossref","first-page":"2314","DOI":"10.1002\/ejoc.200300028","author":"Chicharro","year":"2003","journal-title":"Eur. J. Org. Chem."},{"key":"10.1016\/j.bmcl.2012.06.004_b0115","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1039\/b109725c","author":"De Castro","year":"2002","journal-title":"J. Chem. Soc., Perkin Trans. 1"},{"key":"10.1016\/j.bmcl.2012.06.004_b0120","doi-asserted-by":"crossref","first-page":"2229","DOI":"10.1039\/a701103b","author":"Ar\u00e1n","year":"1997","journal-title":"J. Chem. Soc. Perkin Trans. 1"},{"key":"10.1016\/j.bmcl.2012.06.004_b0125","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1002\/jlac.199619960507","author":"Ar\u00e1n","year":"1996","journal-title":"Liebigs Ann."},{"key":"10.1016\/j.bmcl.2012.06.004_b0130","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1002\/jlac.1995199505119","author":"Ar\u00e1n","year":"1995","journal-title":"Liebigs Ann."},{"key":"10.1016\/j.bmcl.2012.06.004_b0135","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1002\/jlac.199419940708","author":"Ruiz","year":"1994","journal-title":"Liebigs Ann."},{"key":"10.1016\/j.bmcl.2012.06.004_b0140","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1039\/P19930001119","author":"Ar\u00e1n","year":"1993","journal-title":"J. Chem. Soc. Perkin Trans. 1"},{"key":"10.1016\/j.bmcl.2012.06.004_b0145","first-page":"1322","author":"Ar\u00e1n","year":"1993","journal-title":"J. Chem. Res. (M)"},{"key":"10.1016\/j.bmcl.2012.06.004_b0150","unstructured":"De Castro, S. Degree Thesis, Universidad Aut\u00f3noma de Madrid, September, 2000."},{"key":"10.1016\/j.bmcl.2012.06.004_b0155","unstructured":"The synthesis of 31, and 53\u201356 will be published elsewhere."},{"key":"10.1016\/j.bmcl.2012.06.004_b0160","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0001-706X(97)00079-X","volume":"68","author":"R\u00e4z","year":"1997","journal-title":"Acta Trop."},{"key":"10.1016\/j.bmcl.2012.06.004_b0165","doi-asserted-by":"crossref","first-page":"5022","DOI":"10.1073\/pnas.0711014105","volume":"105","author":"Wilkinson","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bmcl.2012.06.004_b0170","doi-asserted-by":"crossref","first-page":"2893","DOI":"10.1128\/AAC.00332-10","volume":"54","author":"Sokolova","year":"2010","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.bmcl.2012.06.004_b0175","doi-asserted-by":"crossref","first-page":"13088","DOI":"10.1074\/jbc.M111.230847","volume":"286","author":"Hall","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bmcl.2012.06.004_b0180","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1128\/AAC.05135-11","volume":"56","author":"Hall","year":"2012","journal-title":"Antimicrob. Agents Chemother."}],"container-title":["Bioorganic & Medicinal Chemistry Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X12007421?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X12007421?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T06:35:52Z","timestamp":1760769352000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960894X12007421"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,7]]},"references-count":36,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2012,7]]}},"alternative-id":["S0960894X12007421"],"URL":"https:\/\/doi.org\/10.1016\/j.bmcl.2012.06.004","relation":{},"ISSN":["0960-894X"],"issn-type":[{"value":"0960-894X","type":"print"}],"subject":[],"published":{"date-parts":[[2012,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Discovery of nitroheterocycles active against African trypanosomes. In vitro screening and preliminary SAR studies","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmcl.2012.06.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}