{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T12:32:17Z","timestamp":1790512337577,"version":"4.1.0"},"reference-count":70,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2013,4,1]],"date-time":"2013-04-01T00:00:00Z","timestamp":1364774400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,4,1]],"date-time":"2013-04-01T00:00:00Z","timestamp":1364774400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100009023","name":"Precursory Research for Embryonic Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009023","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002241","name":"Japan Science and Technology Agency","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002241","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic &amp; Medicinal Chemistry Letters"],"published-print":{"date-parts":[[2013,4]]},"DOI":"10.1016\/j.bmcl.2013.02.062","type":"journal-article","created":{"date-parts":[[2013,2,26]],"date-time":"2013-02-26T09:48:09Z","timestamp":1361872089000},"page":"2340-2343","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":48,"title":["Piloty\u2019s acid derivative with improved nitroxyl-releasing characteristics"],"prefix":"10.1016","volume":"23","author":[{"given":"Kazuyuki","family":"Aizawa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidehiko","family":"Nakagawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuya","family":"Matsuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kodai","family":"Kawai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoya","family":"Ieda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takayoshi","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Miyata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmcl.2013.02.062_h0245","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1146\/annurev.pharmtox.45.120403.095959","volume":"45","author":"Fukuto","year":"2005","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.bmcl.2013.02.062_h0250","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1021\/tx0496800","volume":"18","author":"Fukuto","year":"2005","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.bmcl.2013.02.062_h0255","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.pharmthera.2006.11.002","volume":"113","author":"Paolocci","year":"2007","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.bmcl.2013.02.062_h0260","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.tips.2008.08.005","volume":"29","author":"Irvine","year":"2008","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.bmcl.2013.02.062_h0265","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/j.bbabio.2009.04.015","volume":"1787","author":"Switzer","year":"2009","journal-title":"Biochim. Biophys. Acta Bioenerg."},{"key":"10.1016\/j.bmcl.2013.02.062_h0270","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1016\/j.freeradbiomed.2009.06.014","volume":"47","author":"Fukuto","year":"2009","journal-title":"Free Radical Biol. Med."},{"key":"10.1016\/j.bmcl.2013.02.062_h0275","doi-asserted-by":"crossref","first-page":"2764","DOI":"10.1016\/j.ccr.2011.04.012","volume":"255","author":"Doctorovicha","year":"2011","journal-title":"Coord. Chem. Rev."},{"key":"10.1016\/j.bmcl.2013.02.062_h0280","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1089\/ars.2011.3937","volume":"14","author":"Kemp-Harper","year":"2011","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.bmcl.2013.02.062_h0285","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1089\/ars.2010.3838","volume":"14","author":"DuMond","year":"2011","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.bmcl.2013.02.062_h0290","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1089\/ars.2010.3855","volume":"14","author":"Fukuto","year":"2011","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.bmcl.2013.02.062_h0295","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1089\/ars.2010.3841","volume":"14","author":"Flores-Santana","year":"2011","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.bmcl.2013.02.062_h0300","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1089\/ars.2010.3327","volume":"14","author":"Bullen","year":"2011","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.bmcl.2013.02.062_h0305","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1089\/ars.2010.3859","volume":"14","author":"Tocchetti","year":"2011","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.bmcl.2013.02.062_h0310","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1089\/ars.2010.3852","volume":"14","author":"Choe","year":"2011","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.bmcl.2013.02.062_h0315","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.niox.2010.12.004","volume":"25","author":"Nakagawa","year":"2011","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.bmcl.2013.02.062_h0320","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.jinorgbio.2012.10.004","volume":"118","author":"Nakagawa","year":"2013","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.bmcl.2013.02.062_h0325","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.jinorgbio.2012.09.023","volume":"118","author":"Zhang","year":"2013","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.bmcl.2013.02.062_h0330","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.jinorgbio.2012.08.027","volume":"118","author":"Fukuto","year":"2013","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.bmcl.2013.02.062_h0005","doi-asserted-by":"crossref","first-page":"3120","DOI":"10.1021\/jm00174a001","volume":"33","author":"Nagasawa","year":"1990","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmcl.2013.02.062_h0010","doi-asserted-by":"crossref","first-page":"3648","DOI":"10.1021\/jm00098a008","volume":"35","author":"Lee","year":"1992","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmcl.2013.02.062_h0015","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.1016\/S0006-2952(98)00080-X","volume":"55","author":"DeMaster","year":"1998","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bmcl.2013.02.062_b0015","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1002\/ijc.23305","volume":"122","author":"Lopez","year":"2008","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.bmcl.2013.02.062_h0025","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.ceca.2004.07.001","volume":"37","author":"Cheong","year":"2005","journal-title":"Cell Calcium"},{"key":"10.1016\/j.bmcl.2013.02.062_h0030","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1161\/01.RES.0000253904.53601.c9","volume":"100","author":"Tocchetti","year":"2007","journal-title":"Circ. Res."},{"key":"10.1016\/j.bmcl.2013.02.062_h0035","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1161\/CIRCRESAHA.108.188441","volume":"104","author":"Lancel","year":"2009","journal-title":"Circ. Res."},{"key":"10.1016\/j.bmcl.2013.02.062_h0335","doi-asserted-by":"crossref","first-page":"5537","DOI":"10.1073\/pnas.0937302100","volume":"100","author":"Paolocci","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1016\/j.bmcl.2013.02.062_h0040","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.bbrc.2010.10.030","volume":"402","author":"El-Armouche","year":"2010","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bmcl.2013.02.062_h0340","doi-asserted-by":"crossref","first-page":"8220","DOI":"10.1021\/jm050151i","volume":"48","author":"Miranda","year":"2005","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmcl.2013.02.062_h0345","doi-asserted-by":"crossref","first-page":"10463","DOI":"10.1073\/pnas.181191198","volume":"98","author":"Paolocci","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bmcl.2013.02.062_h0050","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0891-5849(02)01179-6","volume":"34","author":"Pagliaro","year":"2003","journal-title":"Free Raderic. Biol. Med."},{"key":"10.1016\/j.bmcl.2013.02.062_h0055","doi-asserted-by":"crossref","first-page":"14617","DOI":"10.1073\/pnas.96.25.14617","volume":"96","author":"Ma","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bmcl.2013.02.062_h0060","doi-asserted-by":"crossref","first-page":"4014","DOI":"10.1021\/jo100172t","volume":"75","author":"Shernab","year":"2010","journal-title":"J. Org. Chem."},{"key":"10.1016\/j.bmcl.2013.02.062_h0065","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1016\/j.freeradbiomed.2009.06.034","volume":"47","author":"Jackson","year":"2009","journal-title":"Free Radical Biol. Med."},{"key":"10.1016\/j.bmcl.2013.02.062_h0070","doi-asserted-by":"crossref","first-page":"5362","DOI":"10.1021\/bi973153g","volume":"37","author":"Wong","year":"1998","journal-title":"Biochemistry"},{"key":"10.1016\/j.bmcl.2013.02.062_h0075","doi-asserted-by":"crossref","first-page":"4206","DOI":"10.1021\/bi300015u","volume":"51","author":"Keceli","year":"2012","journal-title":"Biochemistry"},{"key":"10.1016\/j.bmcl.2013.02.062_h0080","doi-asserted-by":"crossref","first-page":"2719","DOI":"10.1021\/ol900914s","volume":"11","author":"Reisz","year":"2009","journal-title":"Org. Lett."},{"key":"10.1016\/j.bmcl.2013.02.062_h0085","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1021\/cb900302u","volume":"5","author":"Bechtold","year":"2010","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.bmcl.2013.02.062_h0090","doi-asserted-by":"crossref","first-page":"11675","DOI":"10.1021\/ja203652z","volume":"133","author":"Reisz","year":"2011","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bmcl.2013.02.062_h0095","doi-asserted-by":"crossref","first-page":"4680","DOI":"10.1021\/ja044632n","volume":"127","author":"Marti","year":"2005","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bmcl.2013.02.062_h0100","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1021\/ja907342s","volume":"132","author":"Ling","year":"2010","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bmcl.2013.02.062_h0105","doi-asserted-by":"crossref","first-page":"6283","DOI":"10.1021\/ic902319d","volume":"49","author":"Kumar","year":"2010","journal-title":"Inorg. Chem."},{"key":"10.1016\/j.bmcl.2013.02.062_h0110","doi-asserted-by":"crossref","first-page":"6955","DOI":"10.1021\/ic1007022","volume":"49","author":"Su\u00e1rez","year":"2010","journal-title":"Inorg. Chem."},{"key":"10.1016\/j.bmcl.2013.02.062_h0115","doi-asserted-by":"crossref","first-page":"4285","DOI":"10.1021\/ic00219a017","volume":"24","author":"Bazylinski","year":"1985","journal-title":"Inorg. Chem."},{"key":"10.1016\/j.bmcl.2013.02.062_h0120","doi-asserted-by":"crossref","first-page":"7340","DOI":"10.1073\/pnas.112202099","volume":"99","author":"Shafirovich","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bmcl.2013.02.062_h0125","first-page":"17","volume":"26","author":"Angeli","year":"1896","journal-title":"Gazz. Chim. Ital."},{"key":"10.1016\/j.bmcl.2013.02.062_h0130","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1002\/cber.18960290281","volume":"29","author":"Piloty","year":"1896","journal-title":"Ber. Dtsch. Chem. Ges."},{"key":"10.1016\/j.bmcl.2013.02.062_h0135","doi-asserted-by":"crossref","first-page":"16526","DOI":"10.1021\/ja106552p","volume":"132","author":"Andrei","year":"2010","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bmcl.2013.02.062_h0140","doi-asserted-by":"crossref","first-page":"6710","DOI":"10.1039\/c1cc12130h","volume":"47","author":"Nandurdikar","year":"2011","journal-title":"Chem. Commun."},{"key":"10.1016\/j.bmcl.2013.02.062_h0145","doi-asserted-by":"crossref","first-page":"10262","DOI":"10.1021\/jm301303p","volume":"55","author":"Huang","year":"2012","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmcl.2013.02.062_h0150","doi-asserted-by":"crossref","first-page":"9287","DOI":"10.1016\/S0040-4039(97)82943-7","volume":"52","author":"Atkinson","year":"1996","journal-title":"Tetrahedron Lett."},{"key":"10.1016\/j.bmcl.2013.02.062_h0155","doi-asserted-by":"crossref","first-page":"5149","DOI":"10.1039\/b811985f","volume":"41","author":"Adachi","year":"2008","journal-title":"Chem. Commun."},{"key":"10.1016\/j.bmcl.2013.02.062_h0160","doi-asserted-by":"crossref","first-page":"3788","DOI":"10.1039\/c001502d","volume":"46","author":"Matsuo","year":"2010","journal-title":"Chem. Commun."},{"key":"10.1016\/j.bmcl.2013.02.062_h0165","doi-asserted-by":"crossref","first-page":"9687","DOI":"10.1021\/ja062365a","volume":"128","author":"Sha","year":"2006","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bmcl.2013.02.062_h0170","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1021\/jm101432z","volume":"54","author":"Shoman","year":"2011","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmcl.2013.02.062_h0175","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.jinorgbio.2012.07.023","volume":"118","author":"Dumond","year":"2013","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.bmcl.2013.02.062_h0180","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1021\/ol203016c","volume":"14","author":"Sutton","year":"2012","journal-title":"Org. Lett."},{"key":"10.1016\/j.bmcl.2013.02.062_h0185","doi-asserted-by":"crossref","first-page":"1962","DOI":"10.1021\/ja2103923","volume":"134","author":"Guthrie","year":"2012","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bmcl.2013.02.062_h0190","doi-asserted-by":"crossref","first-page":"10804","DOI":"10.1021\/jo3020837","volume":"77","author":"Biswas","year":"2012","journal-title":"J. Org. Chem."},{"key":"10.1016\/j.bmcl.2013.02.062_h0195","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1248\/cpb.c12-00348","volume":"60","author":"Matsuo","year":"2012","journal-title":"Chem. Pharm. Bull."},{"key":"10.1016\/j.bmcl.2013.02.062_b0060","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S0076-6879(99)01092-7","volume":"301","author":"Hughes","year":"1999","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.bmcl.2013.02.062_h0205","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1016\/j.freeradbiomed.2011.02.008","volume":"50","author":"Cline","year":"2011","journal-title":"Free Radical Biol. Med."},{"key":"10.1016\/j.bmcl.2013.02.062_j0020","unstructured":"Toscano, J. P.; Brookfield, F. A.; Cohen, A. D.; Courtney, S. M.; Frost, L. M.; Kalish, V. J. PCT\/US2007\/006710, 2007."},{"key":"10.1016\/j.bmcl.2013.02.062_j0025","unstructured":"Toscano, J. P.; Brookfield, F. A.; Cohen, A. D.; Courtney, S. M.; Frost, L. M.; Kalish, V. J. Toscano, J. P.; Brookfield, F. A.; Cohen, A. D.; Courtney, S. M.; Frost, L. M.; Kalish, V. J. U.S. PCT\/US2008\/078024, 2009."},{"key":"10.1016\/j.bmcl.2013.02.062_b0070","doi-asserted-by":"crossref","first-page":"11248","DOI":"10.1021\/ja803344v","volume":"130","author":"Olson","year":"2008","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bmcl.2013.02.062_b0075","doi-asserted-by":"crossref","first-page":"1872","DOI":"10.1021\/jm00011a006","volume":"38","author":"Nagasawa","year":"1995","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmcl.2013.02.062_b0080","doi-asserted-by":"crossref","first-page":"2514","DOI":"10.1021\/ic00038a038","volume":"31","author":"Bonner","year":"1992","journal-title":"Inorg. Chem."},{"key":"10.1016\/j.bmcl.2013.02.062_b0085","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.jinorgbio.2012.10.008","volume":"118","author":"Sirsalmath","year":"2013","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.bmcl.2013.02.062_b0090","doi-asserted-by":"crossref","first-page":"6861","DOI":"10.1021\/jp070959+","volume":"111","author":"Lymar","year":"2007","journal-title":"J. Phys. Chem. B"},{"key":"10.1016\/j.bmcl.2013.02.062_b0095","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1042\/bj3120333","volume":"312","author":"Zamora","year":"1995","journal-title":"Biochem. J."},{"key":"10.1016\/j.bmcl.2013.02.062_b0100","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.1248\/cpb.35.1770","volume":"35","author":"Nose","year":"1987","journal-title":"Chem. Pharm. Bull."}],"container-title":["Bioorganic &amp; Medicinal Chemistry Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X13002382?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X13002382?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T06:42:16Z","timestamp":1760769736000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960894X13002382"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4]]},"references-count":70,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2013,4]]}},"alternative-id":["S0960894X13002382"],"URL":"https:\/\/doi.org\/10.1016\/j.bmcl.2013.02.062","relation":{},"ISSN":["0960-894X"],"issn-type":[{"value":"0960-894X","type":"print"}],"subject":[],"published":{"date-parts":[[2013,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Piloty\u2019s acid derivative with improved nitroxyl-releasing characteristics","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmcl.2013.02.062","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}