{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T11:25:23Z","timestamp":1768821923186,"version":"3.49.0"},"reference-count":39,"publisher":"Elsevier BV","issue":"20","license":[{"start":{"date-parts":[[2013,10,1]],"date-time":"2013-10-01T00:00:00Z","timestamp":1380585600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,10,1]],"date-time":"2013-10-01T00:00:00Z","timestamp":1380585600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Dynano and Metoxia","award":["GM25154"],"award-info":[{"award-number":["GM25154"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry Letters"],"published-print":{"date-parts":[[2013,10]]},"DOI":"10.1016\/j.bmcl.2013.08.019","type":"journal-article","created":{"date-parts":[[2013,8,13]],"date-time":"2013-08-13T19:33:56Z","timestamp":1376422436000},"page":"5646-5649","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"title":["Effect of incorporating a thiophene tail in the scaffold of acetazolamide on the inhibition of human carbonic anhydrase isoforms I, II, IX and XII"],"prefix":"10.1016","volume":"23","author":[{"given":"Shyamasri","family":"Biswas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"McKenna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudiu T.","family":"Supuran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmcl.2013.08.019_h0005","doi-asserted-by":"crossref","first-page":"4421","DOI":"10.1021\/cr200176r","volume":"112","author":"Alterio","year":"2012","journal-title":"Chem. Rev."},{"key":"10.1016\/j.bmcl.2013.08.019_h0010","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/nrd2467","volume":"7","author":"Supuran","year":"2008","journal-title":"Nat. Rev. Drug Disc."},{"key":"10.1016\/j.bmcl.2013.08.019_h0015","doi-asserted-by":"crossref","first-page":"759","DOI":"10.3109\/14756366.2012.672983","volume":"27","author":"Supuran","year":"2012","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"10.1016\/j.bmcl.2013.08.019_h0020","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1517\/17460441.2013.795145","volume":"8","author":"De Simone","year":"2013","journal-title":"Expert Opin. Drug Discov."},{"key":"10.1016\/j.bmcl.2013.08.019_h0025","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1517\/13543776.2013.782394","volume":"23","author":"Aggarwal","year":"2013","journal-title":"Expert Opin. Ther. Pat."},{"key":"10.1016\/j.bmcl.2013.08.019_h0030","doi-asserted-by":"crossref","first-page":"267","DOI":"10.3109\/14756366.2012.737323","volume":"28","author":"Aggarwal","year":"2013","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"10.1016\/j.bmcl.2013.08.019_h0035","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1038\/nrd3554","volume":"10","author":"Neri","year":"2011","journal-title":"Nat. Rev. Drug Disc."},{"key":"10.1016\/j.bmcl.2013.08.019_h0040","doi-asserted-by":"crossref","first-page":"892","DOI":"10.3109\/14756366.2012.703185","volume":"27","author":"Capasso","year":"2012","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"10.1016\/j.bmcl.2013.08.019_h0045","doi-asserted-by":"crossref","first-page":"10046","DOI":"10.1021\/bi050610h","volume":"44","author":"Duda","year":"2005","journal-title":"Biochemistry"},{"key":"10.1016\/j.bmcl.2013.08.019_h0050","doi-asserted-by":"crossref","first-page":"3467","DOI":"10.1016\/j.bmcl.2010.05.009","volume":"20","author":"Supuran","year":"2010","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2013.08.019_h0055","doi-asserted-by":"crossref","first-page":"4894","DOI":"10.1016\/j.bmc.2009.06.006","volume":"17","author":"G\u00fczel","year":"2009","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmcl.2013.08.019_h0060","doi-asserted-by":"crossref","first-page":"3170","DOI":"10.1016\/j.bmcl.2009.04.123","volume":"19","author":"G\u00fczel","year":"2009","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2013.08.019_h0065","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1517\/13543776.2013.794788","volume":"23","author":"Masini","year":"2013","journal-title":"Expert Opin. Ther. Pat."},{"key":"10.1016\/j.bmcl.2013.08.019_h0070","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1517\/13543776.2013.780598","volume":"23","author":"Carta","year":"2013","journal-title":"Expert Opin. Ther. Pat."},{"key":"10.1016\/j.bmcl.2013.08.019_h0075","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1517\/13543776.2013.778246","volume":"23","author":"Supuran","year":"2013","journal-title":"Expert Opin. Ther. Pat."},{"key":"10.1016\/j.bmcl.2013.08.019_h0080","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1517\/13543776.2013.790957","volume":"23","author":"Scozzafava","year":"2013","journal-title":"Expert Opin. Ther. Pat."},{"key":"10.1016\/j.bmcl.2013.08.019_h0085","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1517\/13543776.13.10.1545","volume":"13","author":"Supuran","year":"2003","journal-title":"Expert Opin. Ther. Pat."},{"key":"10.1016\/j.bmcl.2013.08.019_h0090","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1517\/14728214.13.2.383","volume":"13","author":"Supuran","year":"2008","journal-title":"Expert Opin. Emerg. Drugs"},{"key":"10.1016\/j.bmcl.2013.08.019_h0095","doi-asserted-by":"crossref","first-page":"6776","DOI":"10.1021\/jm300818k","volume":"55","author":"D\u2019Ambrosio","year":"2012","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmcl.2013.08.019_h0100","doi-asserted-by":"crossref","first-page":"3977","DOI":"10.1021\/jm200209n","volume":"54","author":"Hen","year":"2011","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmcl.2013.08.019_b0040","doi-asserted-by":"crossref","first-page":"3732","DOI":"10.1016\/j.bmc.2011.05.006","volume":"19","author":"Biswas","year":"2011","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmcl.2013.08.019_h0110","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1016\/j.bmc.2012.06.053","volume":"21","author":"Arechederra","year":"2013","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmcl.2013.08.019_h0115","doi-asserted-by":"crossref","first-page":"863","DOI":"10.3109\/14756360903571685","volume":"25","author":"Baranauskiene","year":"2010","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"10.1016\/j.bmcl.2013.08.019_h0120","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1517\/13543776.2013.798648","volume":"23","author":"Monti","year":"2013","journal-title":"Expert Opin. Ther. Pat."},{"key":"10.1016\/j.bmcl.2013.08.019_h0125","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1107\/S1744309109036665","volume":"65","author":"Sippel","year":"2009","journal-title":"Acta Crystallogr., F Struct. Biol. Cryst. Commun."},{"key":"10.1016\/j.bmcl.2013.08.019_h0130","doi-asserted-by":"crossref","first-page":"2561","DOI":"10.1016\/S0021-9258(18)62326-9","volume":"246","author":"Khalifah","year":"1971","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bmcl.2013.08.019_b0055","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1006\/jmbi.1994.1655","volume":"243","author":"Chakravarty","year":"1994","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.bmcl.2013.08.019_b0060","doi-asserted-by":"crossref","first-page":"13589","DOI":"10.1073\/pnas.93.24.13589","volume":"93","author":"Stams","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bmcl.2013.08.019_b0065","doi-asserted-by":"crossref","first-page":"16233","DOI":"10.1073\/pnas.0908301106","volume":"106","author":"Alterio","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bmcl.2013.08.019_b0070","doi-asserted-by":"crossref","first-page":"9545","DOI":"10.1073\/pnas.161301298","volume":"98","author":"Whittington","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bmcl.2013.08.019_b0075","doi-asserted-by":"crossref","first-page":"2930","DOI":"10.1021\/bi062066y","volume":"46","author":"Fisher","year":"2007","journal-title":"Biochemistry"},{"key":"10.1016\/j.bmcl.2013.08.019_h0160","doi-asserted-by":"crossref","first-page":"4376","DOI":"10.1016\/j.bmcl.2010.06.082","volume":"20","author":"Avvaru","year":"2010","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2013.08.019_h0165","doi-asserted-by":"crossref","first-page":"5544","DOI":"10.1021\/jm060531j","volume":"49","author":"De Simone","year":"2006","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmcl.2013.08.019_h0170","doi-asserted-by":"crossref","first-page":"3105","DOI":"10.1016\/j.bmc.2011.04.005","volume":"19","author":"Carta","year":"2011","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmcl.2013.08.019_h0175","doi-asserted-by":"crossref","first-page":"8371","DOI":"10.1039\/c0cc02707c","volume":"46","author":"Pacchiano","year":"2010","journal-title":"Chem. Commun. (Cambridge)"},{"key":"10.1016\/j.bmcl.2013.08.019_b0090","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0076-6879(97)76066-X","volume":"276","author":"Otwinowski","year":"1997","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.bmcl.2013.08.019_b0095","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1107\/S0907444909052925","volume":"66","author":"Adams","year":"2010","journal-title":"Acta Crystallogr., Sect. D Biol. Crystallogr."},{"key":"10.1016\/j.bmcl.2013.08.019_b0100","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/j.jmb.2007.05.022","volume":"372","author":"Krissinel","year":"2007","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.bmcl.2013.08.019_b0105","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1107\/S0907444909042073","volume":"66","author":"Chen","year":"2010","journal-title":"Acta Crystallogr., Sect. D Biol. Crystallogr."}],"container-title":["Bioorganic & Medicinal Chemistry Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X13009487?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X13009487?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T06:48:51Z","timestamp":1760770131000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960894X13009487"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10]]},"references-count":39,"journal-issue":{"issue":"20","published-print":{"date-parts":[[2013,10]]}},"alternative-id":["S0960894X13009487"],"URL":"https:\/\/doi.org\/10.1016\/j.bmcl.2013.08.019","relation":{},"ISSN":["0960-894X"],"issn-type":[{"value":"0960-894X","type":"print"}],"subject":[],"published":{"date-parts":[[2013,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of incorporating a thiophene tail in the scaffold of acetazolamide on the inhibition of human carbonic anhydrase isoforms I, II, IX and XII","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmcl.2013.08.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}