{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T13:58:57Z","timestamp":1765807137243,"version":"build-2065373602"},"reference-count":37,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry Letters"],"published-print":{"date-parts":[[2014,1]]},"DOI":"10.1016\/j.bmcl.2013.11.073","type":"journal-article","created":{"date-parts":[[2013,12,5]],"date-time":"2013-12-05T00:45:41Z","timestamp":1386204341000},"page":"54-60","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"title":["Synthesis, biological evaluation and SAR of 3-benzoates of ingenol for treatment of actinic keratosis and non-melanoma skin cancer"],"prefix":"10.1016","volume":"24","author":[{"given":"Gunnar","family":"Grue-S\u00f8rensen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xifu","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristoffer","family":"M\u00e5nsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Per","family":"Veds\u00f8","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morten","family":"Dahl S\u00f8rensen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anke","family":"Soor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Stahlhut","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malene","family":"Bertelsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen Margrethe","family":"Engell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"H\u00f6gberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmcl.2013.11.073_h0005","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1056\/NEJMoa1111170","volume":"366","author":"Lebwohl","year":"2012","journal-title":"Engl. J. Med."},{"key":"10.1016\/j.bmcl.2013.11.073_h0010","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1586\/edm.12.13","volume":"7","author":"Lebwohl","year":"2012","journal-title":"Expert Rev. Dermatol."},{"key":"10.1016\/j.bmcl.2013.11.073_h0015","doi-asserted-by":"crossref","first-page":"111","DOI":"10.2147\/CCID.S28905","volume":"5","author":"Berman","year":"2012","journal-title":"Clin. Cosmet. Invest. Dermatol."},{"key":"10.1016\/j.bmcl.2013.11.073_h0020","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1007\/s13555-012-0008-4","volume":"2","author":"Ali","year":"2012","journal-title":"Dermatol. Ther."},{"key":"10.1016\/j.bmcl.2013.11.073_h0025","doi-asserted-by":"crossref","first-page":"S39","DOI":"10.1016\/j.jaad.2012.09.050","volume":"68","author":"Martin","year":"2013","journal-title":"J. Am. Acad. Dermatol."},{"key":"10.1016\/j.bmcl.2013.11.073_h0030","doi-asserted-by":"crossref","first-page":"2397","DOI":"10.2165\/11470090-000000000-00000","volume":"72","author":"Keating","year":"2012","journal-title":"Drugs"},{"key":"10.1016\/j.bmcl.2013.11.073_h0035","doi-asserted-by":"crossref","first-page":"5115","DOI":"10.1002\/ejoc.201200733","author":"Vasas","year":"2012","journal-title":"Eur. J. Org. Chem."},{"key":"10.1016\/j.bmcl.2013.11.073_h0040","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1055\/s-2000-8568","volume":"66","author":"Hohmann","year":"2000","journal-title":"Planta Med."},{"key":"10.1016\/j.bmcl.2013.11.073_h0045","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/S0960-894X(01)81232-4","volume":"3","author":"Winkler","year":"1993","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2013.11.073_h0050","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1021\/ja9741842","volume":"121","author":"Winkler","year":"1999","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bmcl.2013.11.073_h0055","doi-asserted-by":"crossref","first-page":"185","DOI":"10.2174\/138955711795049899","volume":"11","author":"Bosco","year":"2011","journal-title":"Mini-Rev. Med. Chem."},{"key":"10.1016\/j.bmcl.2013.11.073_h0060","doi-asserted-by":"crossref","first-page":"2386","DOI":"10.2741\/3385","volume":"14","author":"Reyland","year":"2009","journal-title":"Front. Biosci."},{"key":"10.1016\/j.bmcl.2013.11.073_h0065","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1152\/physrev.00034.2007","volume":"88","author":"Steinberg","year":"2008","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.bmcl.2013.11.073_h0070","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1007\/s00262-008-0458-9","volume":"57","author":"Hampson","year":"2008","journal-title":"Cancer Immunol. Immunother."},{"key":"10.1016\/j.bmcl.2013.11.073_h0075","doi-asserted-by":"crossref","first-page":"174","DOI":"10.3390\/toxins2010174","volume":"2","author":"Ersvaer","year":"2010","journal-title":"Toxins"},{"key":"10.1016\/j.bmcl.2013.11.073_h0080","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/j.jaad.2010.12.038","volume":"3","author":"Rosen","year":"2012","journal-title":"J. Am. Acad. Dermatol."},{"key":"10.1016\/j.bmcl.2013.11.073_h0085","first-page":"1181","volume":"11","author":"Stahlhut","year":"2012","journal-title":"J. Drugs Dermatol."},{"key":"10.1016\/j.bmcl.2013.11.073_b0030","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1001\/jamadermatol.2013.2766","volume":"149","author":"Lebwohl","year":"2013","journal-title":"JAMA Dermatol."},{"key":"10.1016\/j.bmcl.2013.11.073_b0035","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1021\/np068054v","volume":"70","author":"Newman","year":"2007","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.bmcl.2013.11.073_h0100","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1097\/PAT.0b013e32835f515c","volume":"45","author":"Chen","year":"2013","journal-title":"Pathology"},{"key":"10.1016\/j.bmcl.2013.11.073_h0105","doi-asserted-by":"crossref","first-page":"e59","DOI":"10.1016\/j.jaad.2012.09.017","volume":"69","author":"Lee","year":"2013","journal-title":"J. Am. Acad. Dermatol."},{"key":"10.1016\/j.bmcl.2013.11.073_b0045","doi-asserted-by":"crossref","first-page":"5624","DOI":"10.1016\/j.bmcl.2013.08.038","volume":"23","author":"Liang","year":"2013","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2013.11.073_b0050","unstructured":"Grue-S\u00f8rensen, G.; Liang, X.; H\u00f6gberg, T.; M\u00e5nsson, K.; Veds\u00f8, P. WO 2012\/083954 A1, 2012; PCT Int. Appl. 2012."},{"key":"10.1016\/j.bmcl.2013.11.073_b0055","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1515\/znb-1982-0615","volume":"37b","author":"Sorg","year":"1982","journal-title":"Naturforsch"},{"key":"10.1016\/j.bmcl.2013.11.073_b0060","doi-asserted-by":"crossref","first-page":"2647","DOI":"10.1055\/s-0032-1317415","author":"Liang","year":"2012","journal-title":"Synlett"},{"key":"10.1016\/j.bmcl.2013.11.073_b0065","unstructured":"Grue-S\u00f8rensen, G.; Liang, X.; H\u00f6gberg, T. WO 2012\/085189 A1, 2012; PCT Int. Appl. 2012."},{"key":"10.1016\/j.bmcl.2013.11.073_h0135","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1182\/blood.V69.3.711.711","volume":"69","author":"Tauber","year":"1987","journal-title":"Blood"},{"key":"10.1016\/j.bmcl.2013.11.073_h0140","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1007\/BF00762549","volume":"20","author":"Lambeth","year":"1988","journal-title":"J. Bioenerg. Biomembr."},{"key":"10.1016\/j.bmcl.2013.11.073_b0075","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/0378-5173(81)90105-8","volume":"3","author":"Bundgaard","year":"1981","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.bmcl.2013.11.073_b0080","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/B978-1-4832-3166-2.50018-4","author":"Brown","year":"1955","journal-title":"Determ. Org. Struct. Phys. Methods"},{"key":"10.1016\/j.bmcl.2013.11.073_b0085","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1021\/jm000488e","volume":"44","author":"Pak","year":"2001","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmcl.2013.11.073_h0160","doi-asserted-by":"crossref","first-page":"641","DOI":"10.2174\/138945008785132376","volume":"9","author":"Blumberg","year":"2008","journal-title":"Curr. Drug Targets"},{"key":"10.1016\/j.bmcl.2013.11.073_h0165","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.2174\/156802611795589584","volume":"11","author":"Genn\u00e4s","year":"2011","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.bmcl.2013.11.073_b0105","unstructured":"Glide and MacroModel Were Used as Implemented in the 2012-2 Software Suite; Schr\u00f6dinger, LLC: New York, NY, 2012."},{"key":"10.1016\/j.bmcl.2013.11.073_b0110","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1021\/tx960047r","volume":"9","author":"Nicholls","year":"1996","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.bmcl.2013.11.073_b0115","first-page":"375","volume":"2","author":"Mainieri","year":"2007","journal-title":"Nat. Prod. Commun."},{"key":"10.1016\/j.bmcl.2013.11.073_b0120","unstructured":"The quantum mechanical optimisations were performed with Jaguar. DFT was used with default settings (B3LYP, 6\u201331\u2217\u2217). Solvent was set to Water (PBF model). Jaguar was used as implemented in the 2012\u20132 software Suite (Schr\u00f6dinger, LLC, New York, NY, 2012)."}],"container-title":["Bioorganic & Medicinal Chemistry Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X13013644?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X13013644?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T06:49:50Z","timestamp":1760770190000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960894X13013644"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1]]},"references-count":37,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,1]]}},"alternative-id":["S0960894X13013644"],"URL":"https:\/\/doi.org\/10.1016\/j.bmcl.2013.11.073","relation":{},"ISSN":["0960-894X"],"issn-type":[{"type":"print","value":"0960-894X"}],"subject":[],"published":{"date-parts":[[2014,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Synthesis, biological evaluation and SAR of 3-benzoates of ingenol for treatment of actinic keratosis and non-melanoma skin cancer","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmcl.2013.11.073","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}