{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T00:16:41Z","timestamp":1760833001948,"version":"build-2065373602"},"reference-count":32,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2014,2,1]],"date-time":"2014-02-01T00:00:00Z","timestamp":1391212800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,2,1]],"date-time":"2014-02-01T00:00:00Z","timestamp":1391212800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000060","name":"NIAID","doi-asserted-by":"crossref","award":["AI083146"],"award-info":[{"award-number":["AI083146"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"crossref"}]},{"name":"NIH","award":["5 T32 GM067543"],"award-info":[{"award-number":["5 T32 GM067543"]}]},{"name":"NIH","award":["GM32136"],"award-info":[{"award-number":["GM32136"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry Letters"],"published-print":{"date-parts":[[2014,2]]},"DOI":"10.1016\/j.bmcl.2013.12.039","type":"journal-article","created":{"date-parts":[[2014,1,3]],"date-time":"2014-01-03T00:01:39Z","timestamp":1388707299000},"page":"1232-1235","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Virtual screening reveals allosteric inhibitors of the Toxoplasma gondii thymidylate synthase\u2013dihydrofolate reductase"],"prefix":"10.1016","volume":"24","author":[{"given":"Hitesh","family":"Sharma","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark J.","family":"Landau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Todd J.","family":"Sullivan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vidya P.","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus K.","family":"Dahlgren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William L.","family":"Jorgensen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen S.","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmcl.2013.12.039_b0005","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1016\/S0140-6736(04)16412-X","volume":"363","author":"Montoya","year":"2004","journal-title":"Lancet"},{"key":"10.1016\/j.bmcl.2013.12.039_b0010","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1038\/clpt.2013.22","volume":"93","author":"Durand","year":"2013","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.bmcl.2013.12.039_b0015","doi-asserted-by":"crossref","first-page":"43126","DOI":"10.1074\/jbc.M206523200","volume":"277","author":"Johnson","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bmcl.2013.12.039_h0020","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1126\/science.3099389","volume":"235","author":"Hardy","year":"1987","journal-title":"Science"},{"key":"10.1016\/j.bmcl.2013.12.039_h0025","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1093\/protein\/13.8.557","article-title":"Replacement set mutagenesis of the four phosphate-binding arginine residues of thymidylate synthase","volume":"13","author":"Kawase","year":"2000","journal-title":"Protein Eng."},{"key":"10.1016\/j.bmcl.2013.12.039_h0030","doi-asserted-by":"crossref","first-page":"E542","DOI":"10.1073\/pnas.1104829108","article-title":"Protein\u2013protein interface-binding peptides inhibit the cancer therapy target human thymidylate synthase","volume":"108","author":"Cardinale","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bmcl.2013.12.039_h0035","doi-asserted-by":"crossref","first-page":"6883","DOI":"10.1021\/bi9720989","volume":"37","author":"Prasanna","year":"1998","journal-title":"Biochemistry"},{"key":"10.1016\/j.bmcl.2013.12.039_b0030","doi-asserted-by":"crossref","first-page":"7305","DOI":"10.1021\/bi400576t","volume":"52","author":"Sharma","year":"2013","journal-title":"Biochemistry"},{"key":"10.1016\/j.bmcl.2013.12.039_b0035","doi-asserted-by":"crossref","first-page":"14170","DOI":"10.1074\/jbc.M009493200","article-title":"Structure of human thymidylate synthase suggests advantages of chemotherapy with noncompetitive inhibitors","volume":"276","author":"Phan","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bmcl.2013.12.039_h0050","doi-asserted-by":"crossref","first-page":"2823","DOI":"10.1021\/bi061309j","volume":"46","author":"Lovelace","year":"2007","journal-title":"Biochemistry"},{"key":"10.1016\/j.bmcl.2013.12.039_h0055","doi-asserted-by":"crossref","first-page":"4636","DOI":"10.1021\/bi7019386","volume":"47","author":"Gibson","year":"2008","journal-title":"Biochemistry"},{"key":"10.1016\/j.bmcl.2013.12.039_h0060","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1107\/S0907444910044732","volume":"67","author":"Gibson","year":"2011","journal-title":"Acta Crystallogr., Sect. D"},{"key":"10.1016\/j.bmcl.2013.12.039_h0065","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.bbapap.2003.09.005","volume":"1696","author":"Berger","year":"2004","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bmcl.2013.12.039_h0070","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1002\/pro.171","volume":"18","author":"Lovelace","year":"2009","journal-title":"Protein Sci."},{"key":"10.1016\/j.bmcl.2013.12.039_h0075","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1002\/pro.539","volume":"20","author":"Luo","year":"2011","journal-title":"Protein Sci."},{"key":"10.1016\/j.bmcl.2013.12.039_h0080","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1007\/s00239-011-9433-8","volume":"72","author":"Luo","year":"2011","journal-title":"J. Mol. Evol."},{"key":"10.1016\/j.bmcl.2013.12.039_b0045","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1002\/pro.2300","volume":"22","author":"Landau","year":"2013","journal-title":"Protein Sci."},{"issue":"Database issue","key":"10.1016\/j.bmcl.2013.12.039_h0090","doi-asserted-by":"crossref","first-page":"D387","DOI":"10.1093\/nar\/gkn750","volume":"37","author":"Kiefer","year":"2009","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bmcl.2013.12.039_h0095","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1093\/bioinformatics\/bti770","volume":"22","author":"Arnold","year":"2006","journal-title":"Bioinformatics"},{"key":"10.1016\/j.bmcl.2013.12.039_h0100","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1038\/nbt0795-658","volume":"13","author":"Peitsch","year":"1995","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.bmcl.2013.12.039_h0105","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1021\/ar800236t","volume":"42","author":"Jorgensen","year":"2009","journal-title":"Acc. Chem. Res."},{"key":"10.1016\/j.bmcl.2013.12.039_h0110","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1021\/ci800324m","volume":"49","author":"Halgren","year":"2009","journal-title":"J. Chem. Inf. Model."},{"key":"10.1016\/j.bmcl.2013.12.039_h0115","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1021\/jm0306430","volume":"47","author":"Friesner","year":"2004","journal-title":"J. Med. Chem."},{"issue":"Web Server issue","key":"10.1016\/j.bmcl.2013.12.039_b0060","doi-asserted-by":"crossref","first-page":"W116","DOI":"10.1093\/nar\/gkl282","volume":"34","author":"Dundas","year":"2006","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bmcl.2013.12.039_b0065","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/1472-6807-6-19","volume":"6","author":"Huang","year":"2006","journal-title":"BMC Struct. Biol."},{"key":"10.1016\/j.bmcl.2013.12.039_b0070","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1021\/ci049714+","volume":"45","author":"Irwin","year":"2005","journal-title":"J. Chem. Inf. Model."},{"key":"10.1016\/j.bmcl.2013.12.039_h0135","doi-asserted-by":"crossref","first-page":"14092","DOI":"10.1074\/jbc.M212690200","volume":"278","author":"Atreya","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bmcl.2013.12.039_h0140","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.bmcl.2008.11.054","volume":"19","author":"Martucci","year":"2009","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2013.12.039_h0145","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.1021\/jm010533y","volume":"45","author":"McGovern","year":"2002","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmcl.2013.12.039_h0150","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1039\/b616314a","volume":"3","author":"Coan","year":"2007","journal-title":"Mol. Biosyst."},{"key":"10.1016\/j.bmcl.2013.12.039_h0155","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.drudis.2006.05.014","volume":"11","author":"Shoichet","year":"2006","journal-title":"Drug Discovery Today"},{"key":"10.1016\/j.bmcl.2013.12.039_b0085","doi-asserted-by":"crossref","first-page":"6228","DOI":"10.1016\/j.bmcl.2013.09.094","volume":"23","author":"Zaware","year":"2013","journal-title":"ACS Med. Chem. Lett."}],"container-title":["Bioorganic & Medicinal Chemistry Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X1301411X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X1301411X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T06:49:45Z","timestamp":1760770185000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960894X1301411X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2]]},"references-count":32,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,2]]}},"alternative-id":["S0960894X1301411X"],"URL":"https:\/\/doi.org\/10.1016\/j.bmcl.2013.12.039","relation":{},"ISSN":["0960-894X"],"issn-type":[{"type":"print","value":"0960-894X"}],"subject":[],"published":{"date-parts":[[2014,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Virtual screening reveals allosteric inhibitors of the Toxoplasma gondii thymidylate synthase\u2013dihydrofolate reductase","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmcl.2013.12.039","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}