{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T10:09:45Z","timestamp":1791281385169,"version":"4.1.0"},"reference-count":36,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T00:00:00Z","timestamp":1396310400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T00:00:00Z","timestamp":1396310400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T00:00:00Z","timestamp":1396310400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T00:00:00Z","timestamp":1396310400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T00:00:00Z","timestamp":1396310400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T00:00:00Z","timestamp":1396310400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T00:00:00Z","timestamp":1396310400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry Letters"],"published-print":{"date-parts":[[2014,4]]},"DOI":"10.1016\/j.bmcl.2014.02.057","type":"journal-article","created":{"date-parts":[[2014,3,1]],"date-time":"2014-03-01T07:01:55Z","timestamp":1393657315000},"page":"1681-1684","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"title":["Mineralocorticoid receptor antagonists: Identification of heterocyclic amide replacements in the oxazolidinedione series"],"prefix":"10.1016","volume":"24","author":[{"given":"Jason M.","family":"Cox","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong D.","family":"Chu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong C.","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhicai","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaume","family":"Balsells","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Crespo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beata","family":"Zamlynny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judyann","family":"Wiltsie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Clemas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack","family":"Gibson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Contino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JeanMarie","family":"Lisnock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaochao","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margarita","family":"Garcia-Calvo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Bateman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinchun","family":"Tong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Crook","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Sinclair","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmcl.2014.02.057_h0005","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1146\/annurev.nu.16.070196.002303","volume":"16","author":"Fardella","year":"1996","journal-title":"Annu. Rev. Nutr."},{"key":"10.1016\/j.bmcl.2014.02.057_h0010","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1002\/cmdc.200600006","volume":"1","author":"Moore","year":"2006","journal-title":"ChemMedChem"},{"key":"10.1016\/j.bmcl.2014.02.057_h0015","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1038\/nrd1551","volume":"3","author":"Gronemeyer","year":"2004","journal-title":"Nat. Rev. Drug Disc."},{"key":"10.1016\/j.bmcl.2014.02.057_h0020","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1161\/01.CIR.100.10.1056","volume":"100","author":"McKelvie","year":"1999","journal-title":"Circulation"},{"key":"10.1016\/j.bmcl.2014.02.057_h0025","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1055\/s-0031-1291318","volume":"44","author":"Catena","year":"2012","journal-title":"Horm. Metab. Res."},{"key":"10.1016\/j.bmcl.2014.02.057_h0030","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1055\/s-0031-1295461","volume":"44","author":"Fourkiotis","year":"2012","journal-title":"Horm. Metab. Res."},{"key":"10.1016\/j.bmcl.2014.02.057_h0035","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1056\/NEJM199909023411001","volume":"341","author":"The","year":"1999","journal-title":"N. Eng. J. Med."},{"key":"10.1016\/j.bmcl.2014.02.057_h0040","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1056\/NEJMoa030207","volume":"348","author":"Zannad","year":"2003","journal-title":"N. Eng. J. Med."},{"key":"10.1016\/j.bmcl.2014.02.057_h0045","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1038\/hr.2010.71","volume":"33","author":"Funder","year":"2010","journal-title":"Hypertens. Res."},{"key":"10.1016\/j.bmcl.2014.02.057_h0050","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.jash.2008.05.005","volume":"2","author":"Calhoun","year":"2008","journal-title":"J. Am. Soc. Hypertens."},{"key":"10.1016\/j.bmcl.2014.02.057_h0055","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1016\/S0002-9149(96)00465-1","volume":"78","author":"The RALES Investigators","year":"1996","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.bmcl.2014.02.057_h0060","doi-asserted-by":"crossref","first-page":"449","DOI":"10.5414\/CNP72449","volume":"72","author":"Bomback","year":"2009","journal-title":"Clin. Nephrol."},{"key":"10.1016\/j.bmcl.2014.02.057_h0065","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1038\/nrendo.2010.26","volume":"6","author":"Williams","year":"2010","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.bmcl.2014.02.057_h0070","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1007\/s11906-005-0067-3","volume":"7","author":"Nishizaka","year":"2005","journal-title":"Curr. Hypertens. Rep."},{"key":"10.1016\/j.bmcl.2014.02.057_h0075","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1161\/HYPERTENSIONAHA.109.141531","volume":"55","author":"Gaddam","year":"2010","journal-title":"Hypertension"},{"key":"10.1016\/j.bmcl.2014.02.057_h0080","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1093\/eurjhf\/hfq049","volume":"12","author":"Zannad","year":"2010","journal-title":"Eur. J. Heart Fail."},{"key":"10.1016\/j.bmcl.2014.02.057_b0020","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/0022-4731(89)90169-6","volume":"32","author":"De Gasparo","year":"1989","journal-title":"J. Steroid Biochem."},{"key":"10.1016\/j.bmcl.2014.02.057_b0025","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/S0022-3565(25)22580-0","volume":"240","author":"De Gasparo","year":"1987","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.bmcl.2014.02.057_h0095","doi-asserted-by":"crossref","unstructured":"Shen, H.; Cox, J. M.; Yang, C.; Wu, Z. PCT Intl. Appl. 2013, WO2013055606.","DOI":"10.1186\/1029-242X-2013-356"},{"key":"10.1016\/j.bmcl.2014.02.057_h0100","unstructured":"Shen, H.; Yang, C.; Cox, J. M.; Liu, K. PCT Intl. Appl. 2013, WO2013055607."},{"key":"10.1016\/j.bmcl.2014.02.057_h0105","unstructured":"Shen, H.; Cox, J. M.; Chu, H. D. PCT Intl. Appl. 2013, WO2013055608."},{"key":"10.1016\/j.bmcl.2014.02.057_h0110","doi-asserted-by":"crossref","first-page":"4388","DOI":"10.1016\/j.bmcl.2013.05.077","volume":"23","author":"Yang","year":"2013","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2014.02.057_h0115","doi-asserted-by":"crossref","first-page":"6239","DOI":"10.1016\/j.bmcl.2013.09.099","volume":"23","author":"Futatsugi","year":"2013","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2014.02.057_h0120","doi-asserted-by":"crossref","first-page":"7957","DOI":"10.1021\/jm300806c","volume":"55","author":"Piotrowski","year":"2012","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmcl.2014.02.057_h0125","first-page":"89","volume":"46","author":"Leftheris","year":"2011","journal-title":"Annu. Rep. Med. Chem."},{"key":"10.1016\/j.bmcl.2014.02.057_h0130","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1002\/cmdc.201200081","volume":"7","author":"Barfacker","year":"2012","journal-title":"ChemMedChem"},{"key":"10.1016\/j.bmcl.2014.02.057_h0135","doi-asserted-by":"crossref","first-page":"5983","DOI":"10.1016\/j.bmc.2013.07.043","volume":"21","author":"Hasui","year":"2013","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmcl.2014.02.057_h0140","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1097\/FJC.0b013e3182495543","volume":"59","author":"Nariai","year":"2012","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"10.1016\/j.bmcl.2014.02.057_h0145","unstructured":"Coates, D. A.; Gavardinas, K.; Jadhav, P. K. PCT Int. Appl. 2010, WO2010104721."},{"key":"10.1016\/j.bmcl.2014.02.057_h0150","unstructured":"Casimiro-Garcia, A.; Futatsugi, K.; Piotrowski, D. W. PCT Int. Appl. 2011, WO2011141848."},{"key":"10.1016\/j.bmcl.2014.02.057_h0155","doi-asserted-by":"crossref","first-page":"5979","DOI":"10.1021\/jm100505n","volume":"53","author":"Meyers","year":"2010","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmcl.2014.02.057_b0040","unstructured":"http:\/\/www.discoverx.com\/nhrs\/prod-nhrs.php."},{"key":"10.1016\/j.bmcl.2014.02.057_h0165","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/S1359-6446(04)03069-7","volume":"9","author":"Hopkins","year":"2004","journal-title":"Drug Discovery Today"},{"key":"10.1016\/j.bmcl.2014.02.057_h0170","first-page":"381","volume":"45","author":"Edwards","year":"2010","journal-title":"Annu. Rep. Med. Chem."},{"key":"10.1016\/j.bmcl.2014.02.057_h0175","first-page":"393","volume":"45","author":"Leeson","year":"2010","journal-title":"Annu. Rep. Med. Chem."},{"key":"10.1016\/j.bmcl.2014.02.057_h0180","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1038\/nrd2445","volume":"6","author":"Leeson","year":"2007","journal-title":"Nat. Rev. Drug. Disc."}],"container-title":["Bioorganic & Medicinal Chemistry Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X14001899?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X14001899?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T06:49:51Z","timestamp":1760770191000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960894X14001899"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4]]},"references-count":36,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2014,4]]}},"alternative-id":["S0960894X14001899"],"URL":"https:\/\/doi.org\/10.1016\/j.bmcl.2014.02.057","relation":{},"ISSN":["0960-894X"],"issn-type":[{"value":"0960-894X","type":"print"}],"subject":[],"published":{"date-parts":[[2014,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mineralocorticoid receptor antagonists: Identification of heterocyclic amide replacements in the oxazolidinedione series","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmcl.2014.02.057","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}