{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T21:23:59Z","timestamp":1789593839936,"version":"build-2803163510"},"reference-count":11,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2014,6,1]],"date-time":"2014-06-01T00:00:00Z","timestamp":1401580800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,6,1]],"date-time":"2014-06-01T00:00:00Z","timestamp":1401580800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic &amp; Medicinal Chemistry Letters"],"published-print":{"date-parts":[[2014,6]]},"DOI":"10.1016\/j.bmcl.2014.04.052","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T05:00:39Z","timestamp":1397970039000},"page":"2689-2692","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Identification of 2,3-disubstituted pyridines as potent, non-emetic PDE4 inhibitors"],"prefix":"10.1016","volume":"24","author":[{"given":"Motoji","family":"Kawasaki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1190-514X","authenticated-orcid":false,"given":"Akira","family":"Fusano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohiro","family":"Nigo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunya","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mari N.","family":"Ito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Teranishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Matsumoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Toda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naruaki","family":"Nomura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takaaki","family":"Sumiyoshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmcl.2014.04.052_b0005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/bj20021698","volume":"370","author":"Houslay","year":"2003","journal-title":"Biochem. J."},{"key":"10.1016\/j.bmcl.2014.04.052_b0010","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1016\/S1359-6446(05)03622-6","volume":"10","author":"Houslay","year":"2005","journal-title":"Drug Discovery Today"},{"key":"10.1016\/j.bmcl.2014.04.052_b0015","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.pharmthera.2004.12.001","volume":"106","author":"Sanz","year":"2005","journal-title":"Pharmcol. Ther."},{"key":"10.1016\/j.bmcl.2014.04.052_b0020","doi-asserted-by":"crossref","first-page":"5471","DOI":"10.1021\/jm800582j","volume":"51","author":"Kodimuthali","year":"2008","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmcl.2014.04.052_b0025","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/S0022-3565(24)29537-9","volume":"297","author":"Hatzelmann","year":"2001","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.bmcl.2014.04.052_b0030","first-page":"147","volume":"4","author":"Giembycz","year":"2010","journal-title":"Drug Des. Dev. Ther."},{"key":"10.1016\/j.bmcl.2014.04.052_b0035","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.pupt.2010.03.011","volume":"23","author":"Hatzelmann","year":"2010","journal-title":"Pulm. Pharmacol. Ther."},{"key":"10.1016\/j.bmcl.2014.04.052_b0040","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.ejphar.2005.12.059","volume":"533","author":"Chung","year":"2006","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.bmcl.2014.04.052_b0045","doi-asserted-by":"crossref","first-page":"5851","DOI":"10.1016\/j.bmc.2013.07.007","volume":"21","author":"Kato","year":"2013","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmcl.2014.04.052_b0050","unstructured":"Ochi, T.; Sawayama, Y.; Kawasaki, M.; Nigo, T.; Nakao, M.; Omodani, T.; Sumiyoshi, T. submitted for publication."},{"key":"10.1016\/j.bmcl.2014.04.052_b0060","doi-asserted-by":"crossref","first-page":"6747","DOI":"10.1021\/jo101090f","volume":"75","author":"Pilgrim","year":"2010","journal-title":"J. Org. Chem."}],"container-title":["Bioorganic &amp; Medicinal Chemistry Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X14004004?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X14004004?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T06:51:43Z","timestamp":1760770303000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960894X14004004"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6]]},"references-count":11,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2014,6]]}},"alternative-id":["S0960894X14004004"],"URL":"https:\/\/doi.org\/10.1016\/j.bmcl.2014.04.052","relation":{},"ISSN":["0960-894X"],"issn-type":[{"value":"0960-894X","type":"print"}],"subject":[],"published":{"date-parts":[[2014,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Identification of 2,3-disubstituted pyridines as potent, non-emetic PDE4 inhibitors","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmcl.2014.04.052","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}