{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T11:56:17Z","timestamp":1768564577790,"version":"3.49.0"},"reference-count":39,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2014,6,1]],"date-time":"2014-06-01T00:00:00Z","timestamp":1401580800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,6,1]],"date-time":"2014-06-01T00:00:00Z","timestamp":1401580800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic &amp; Medicinal Chemistry Letters"],"published-print":{"date-parts":[[2014,6]]},"DOI":"10.1016\/j.bmcl.2014.04.077","type":"journal-article","created":{"date-parts":[[2014,4,30]],"date-time":"2014-04-30T15:00:15Z","timestamp":1398870015000},"page":"2617-2620","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"title":["Dual carbonic anhydrase\/matrix metalloproteinase inhibitors incorporating bisphosphonic acid moieties targeting bone tumors"],"prefix":"10.1016","volume":"24","author":[{"given":"Marilena","family":"Tauro","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fulvio","family":"Loiodice","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariangela","family":"Ceruso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudiu T.","family":"Supuran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Tortorella","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmcl.2014.04.077_b0005","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1007\/s10585-007-9112-8","volume":"24","author":"Clezardin","year":"2007","journal-title":"Clin. Exp. Metastasis"},{"key":"10.1016\/j.bmcl.2014.04.077_b0010","first-page":"40","volume":"1021","author":"Riihonen","year":"2007","journal-title":"Bone"},{"key":"10.1016\/j.bmcl.2014.04.077_b0015","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.bone.2010.06.007","volume":"48","author":"Lynch","year":"2011","journal-title":"Bone"},{"key":"10.1016\/j.bmcl.2014.04.077_b0020","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/nrd2467","volume":"7","author":"Supuran","year":"2008","journal-title":"Nat. Rev. Drug Disc."},{"key":"10.1016\/j.bmcl.2014.04.077_b0025","doi-asserted-by":"crossref","first-page":"2752","DOI":"10.1073\/pnas.80.9.2752","volume":"80","author":"Sly","year":"1983","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bmcl.2014.04.077_b0030","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1172\/JCI113863","volume":"83","author":"Teti","year":"1989","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bmcl.2014.04.077_b0035","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1006\/excr.1998.4071","volume":"242","author":"Lehenkari","year":"1998","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.bmcl.2014.04.077_b0040","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1093\/jnci\/94.1.17","volume":"94","author":"Nemeth","year":"2002","journal-title":"J. Natl Cancer Inst."},{"key":"10.1016\/j.bmcl.2014.04.077_b0045","doi-asserted-by":"crossref","first-page":"2949","DOI":"10.2741\/2024","volume":"11","author":"Varghese","year":"2006","journal-title":"Front. Biosci."},{"key":"10.1016\/j.bmcl.2014.04.077_b0050","doi-asserted-by":"crossref","first-page":"4226","DOI":"10.4049\/jimmunol.144.11.4226","volume":"144","author":"Kurihara","year":"1990","journal-title":"J. Immunol."},{"key":"10.1016\/j.bmcl.2014.04.077_b0055","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1002\/jcp.20147","volume":"202","author":"Dallas","year":"2005","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.bmcl.2014.04.077_b0060","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1161\/01.RES.85.10.906","volume":"85","author":"Fernandez-Patron","year":"1999","journal-title":"Circ. Res."},{"key":"10.1016\/j.bmcl.2014.04.077_b0065","doi-asserted-by":"crossref","first-page":"6456","DOI":"10.1016\/j.bmc.2013.08.054","volume":"21","author":"Tauro","year":"2013","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmcl.2014.04.077_b0070","doi-asserted-by":"crossref","first-page":"855","DOI":"10.2174\/1573406411309060009","volume":"9","author":"Zhao","year":"2013","journal-title":"Med. Chem."},{"key":"10.1016\/j.bmcl.2014.04.077_b0075","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1002\/cmdc.201000540","volume":"6","author":"Rubino","year":"2011","journal-title":"ChemMedChem"},{"key":"10.1016\/j.bmcl.2014.04.077_b0080","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1039\/B512310K","volume":"36","author":"Zhang","year":"2007","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.bmcl.2014.04.077_b0085","doi-asserted-by":"crossref","first-page":"178381","DOI":"10.1155\/2013\/178381","volume":"2013","author":"Giustiniano","year":"2013","journal-title":"J. Amino Acids"},{"key":"10.1016\/j.bmcl.2014.04.077_b0090","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.ejmech.2012.09.036","volume":"58","author":"Nicolotti","year":"2012","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bmcl.2014.04.077_b0095","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1002\/ardp.201000350","volume":"344","author":"Rubino","year":"2011","journal-title":"Arch. Pharm."},{"key":"10.1016\/j.bmcl.2014.04.077_b0100","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1002\/cmdc.200800324","volume":"4","author":"Rubino","year":"2009","journal-title":"ChemMedChem"},{"key":"10.1016\/j.bmcl.2014.04.077_b0105","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/j.bmc.2006.10.047","volume":"15","author":"Biasone","year":"2007","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmcl.2014.04.077_b0110","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1021\/jm050787+","volume":"49","author":"Pochetti","year":"2006","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmcl.2014.04.077_b0115","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.bmcl.2005.09.057","volume":"16","author":"Campestre","year":"2006","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2014.04.077_b0120","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/S1359-6446(04)03163-0","volume":"9","author":"Morphy","year":"2004","journal-title":"Drug Discovery Today"},{"key":"10.1016\/j.bmcl.2014.04.077_b0125","doi-asserted-by":"crossref","first-page":"3635","DOI":"10.1016\/j.bbagen.2013.02.011","volume":"1830","author":"Gao","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bmcl.2014.04.077_b0130","doi-asserted-by":"crossref","first-page":"3677","DOI":"10.1021\/jm000027t","volume":"43","author":"Scozzafava","year":"2000","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmcl.2014.04.077_b0135","doi-asserted-by":"crossref","first-page":"7968","DOI":"10.1021\/jm800964f","volume":"51","author":"Marques","year":"2008","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmcl.2014.04.077_b0140","doi-asserted-by":"crossref","first-page":"2298","DOI":"10.1016\/j.bmc.2007.01.023","volume":"15","author":"Nuti","year":"2007","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmcl.2014.04.077_b0145","doi-asserted-by":"crossref","first-page":"3623","DOI":"10.1016\/j.bmcl.2010.04.109","volume":"20","author":"Esteves","year":"2010","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2014.04.077_b0150","doi-asserted-by":"crossref","first-page":"7875","DOI":"10.1021\/jm300981b","volume":"55","author":"Reich","year":"2012","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmcl.2014.04.077_b0155","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1016\/j.bmcl.2005.01.049","volume":"15","author":"Winum","year":"2005","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2014.04.077_b0160","doi-asserted-by":"crossref","first-page":"2561","DOI":"10.1016\/S0021-9258(18)62326-9","volume":"246","author":"Khalifah","year":"1971","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bmcl.2014.04.077_b0165","doi-asserted-by":"crossref","first-page":"6208","DOI":"10.1016\/j.bmcl.2010.08.110","volume":"20","author":"Innocenti","year":"2010","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2014.04.077_b0170","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.bmc.2013.10.045","volume":"22","author":"Del Prete","year":"2014","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmcl.2014.04.077_b0175","doi-asserted-by":"crossref","first-page":"880","DOI":"10.3109\/14756366.2011.637202","volume":"27","author":"Kazanc\u0131o\u011flu","year":"2012","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"10.1016\/j.bmcl.2014.04.077_b0180","doi-asserted-by":"crossref","first-page":"148","DOI":"10.3109\/14756366.2011.629198","volume":"27","author":"Cavdar","year":"2012","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"10.1016\/j.bmcl.2014.04.077_b0185","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1016\/j.bmc.2012.12.004","volume":"21","author":"Alafeefy","year":"2013","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmcl.2014.04.077_b0190","doi-asserted-by":"crossref","first-page":"7487","DOI":"10.1021\/jm051236m","volume":"49","author":"Greig","year":"2006","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmcl.2014.04.077_b0195","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1359\/jbmr.1998.13.11.1668","volume":"13","author":"Luckman","year":"1998","journal-title":"J. Bone Miner. Res."}],"container-title":["Bioorganic &amp; Medicinal Chemistry Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X1400434X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X1400434X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T06:52:53Z","timestamp":1760770373000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960894X1400434X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6]]},"references-count":39,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2014,6]]}},"alternative-id":["S0960894X1400434X"],"URL":"https:\/\/doi.org\/10.1016\/j.bmcl.2014.04.077","relation":{},"ISSN":["0960-894X"],"issn-type":[{"value":"0960-894X","type":"print"}],"subject":[],"published":{"date-parts":[[2014,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dual carbonic anhydrase\/matrix metalloproteinase inhibitors incorporating bisphosphonic acid moieties targeting bone tumors","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmcl.2014.04.077","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}